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Insights from an academic endeavor into central nervous system drug discovery
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作者 Lieve van Veggel An M.Voets +1 位作者 Tim Vanmierlo Rudy Schreiber 《Neural Regeneration Research》 SCIE CAS 2025年第6期1717-1718,共2页
Historically,"big pharma"did most central nervous system drug discovery R&D in-house.Yet,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to(... Historically,"big pharma"did most central nervous system drug discovery R&D in-house.Yet,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to(late)development,regulatory approval,and marketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governments and patient-organizations and a shift of research to academia(Mazzucato,2013). 展开更多
关键词 ACADEMIC APPROVAL consequences
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How the Brain Process Stimulus-Response Conflict? New Insights from Lateralized Readiness Potentials Scalp Topography and Reaction Times
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作者 Marc E. Lavoie Johannes E. A. Stauder 《Journal of Behavioral and Brain Science》 2013年第1期150-155,共6页
Stimulus-Response Compatibility (SRC) refers to the fact that some tasks are performed easier and better than others because of the way stimuli and responses are paired with each other. To assess the brain responses t... Stimulus-Response Compatibility (SRC) refers to the fact that some tasks are performed easier and better than others because of the way stimuli and responses are paired with each other. To assess the brain responses to stimulus-response conflicts, we investigated the behavioral (accuracy and Reaction Times: RTs) as well as the physiological response (Lateralized Readiness Potentials: LRP) modulations in a positional blocked and a conditional mixed design in twelve university students. Results revealed that the performance was less accurate and the RTs, as well as the LRP onset, were delayed under the mixed conditional design. A greater compatibility effect was also noted on accuracy, RTs and LRP onset latency in the mixed design. Consistent with these findings, smaller peak activation at fronto-central areas suggests that more selective inhibition is needed in a mixed design context. Despite a smaller activation, the topographical distribution is similar in both designs. These results indicate that the translation time between stimulus- and response codes are greater under the mixed instruction, while the similar LRP topography suggests that common neural structures underlie LRPs in response to both type of designs. 展开更多
关键词 Lateralized READINESS POTENTIALS Mixed-Blocked Designs STIMULUS Response-Compatibility Reaction Times
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Chemogenetic and Optogenetic Manipulations of Microglia in Chronic Pain 被引量:1
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作者 Sebastian Parusel Min-Hee Yi +1 位作者 Christine L.Hunt Long-Jun Wu 《Neuroscience Bulletin》 SCIE CAS CSCD 2023年第3期368-378,共11页
Chronic pain relief remains an unmet medical need.Current research points to a substantial contribution of glia-neuron interaction in its pathogenesis.Particularly,microglia play a crucial role in the development of c... Chronic pain relief remains an unmet medical need.Current research points to a substantial contribution of glia-neuron interaction in its pathogenesis.Particularly,microglia play a crucial role in the development of chronic pain.To better understand the microglial contribution to chronic pain,specific regional and temporal manipulations of microglia are necessary.Recently,two new approaches have emerged that meet these demands.Chemogenetic tools allow the expression of designer receptors exclusively activated by designer drugs(DREADDs)specifically in microglia.Similarly,optogenetic tools allow for microglial manipulation via the activation of artificially expressed,light-sensitive proteins.Chemo-and optogenetic manipulations of microglia in vivo are powerful in interrogating microglial function in chronic pain.This review summarizes these emerging tools in studying the role of microglia in chronic pain and highlights their potential applications in microglia-related neurological disorders. 展开更多
关键词 Chronic pain MICROGLIA OPTOGENETICS Chemogenetics DREADDs ReaChR
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中文阅读障碍儿童的时间加工缺陷:来自知觉学习干预研究的证据 被引量:5
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作者 张曼莉 孟祥芝 郑小蓓 《心理与行为研究》 CSSCI 北大核心 2018年第5期583-593,623,共12页
前人研究指出,阅读障碍群体具有听觉通道内的时间加工缺陷,但截止目前为止,该缺陷的非模态性、跨语言一般性、干预前景及具体机制尚不明确。本文通过综述三项在中文阅读障碍儿童中开展的听觉、视觉时间加工知觉训练,以及它们对阅读成绩... 前人研究指出,阅读障碍群体具有听觉通道内的时间加工缺陷,但截止目前为止,该缺陷的非模态性、跨语言一般性、干预前景及具体机制尚不明确。本文通过综述三项在中文阅读障碍儿童中开展的听觉、视觉时间加工知觉训练,以及它们对阅读成绩的迁移效应,对时间加工技能与阅读障碍的关系,及其影响阅读发展的认知机制进行了探讨和分析,并在此基础上,提出了未来的研究构想,以充实该领域的理论建构。 展开更多
关键词 发展性阅读障碍 时间加工缺陷 知觉学习训练
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Ontogeny of vocal rhythms in harbor seal pups: an exploratory study
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作者 Andrea RAViGNANi Christopher T. Kello +6 位作者 Koen de Reus Sonja A KoTz Simone Dalla BELLA Margarita Mendez-Arostegui Beatriz Rapado-Tamarit Ana Rubio-Garcia Bart de BoER 《Current Zoology》 SCIE CAS CSCD 2019年第1期107-120,共14页
Puppyhood is a very active social and vocal period in a harbor seal's life Ph oca vitulina. An important feature of vocalizations is their temporal and rhythmic structure, and understanding vocal timing and rhythm... Puppyhood is a very active social and vocal period in a harbor seal's life Ph oca vitulina. An important feature of vocalizations is their temporal and rhythmic structure, and understanding vocal timing and rhythms in harbor seals is critical to a cross-species hypothesis in evolutionary neuroscience that links vocal learning, rhythm perception, and synchronization. This study utilized analytical techniques that may best capture rhythmic structure in pup vocalizations with the goal of examining whether (1) harbor seal pups show rhythmic structure in their calls and (2) rhythms evolve over time. Calls of 3 wild-born seal pups were recorded daily over the course of 1-3 weeks;3 temporal features were analyzed using 3 complementary techniques. We identified temporal and rhythmic structure in pup calls across different time windows. The calls of harbor seal pups exhibit some degree of temporal and rhythmic organization, which evolves over puppyhood and resembles that of other species' in teractive comm un icati on. We suggest n ext steps for investigating call structure in harbor seal pups and propose comparative hypotheses to test in other pinniped species. 展开更多
关键词 BIOACOUSTICS PINNIPEDS rhythm timing VOCAL development
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