期刊文献+
共找到12篇文章
< 1 >
每页显示 20 50 100
Nutrition and physical activity in NAFLD:An overview of the epidemiological evidence 被引量:33
1
作者 Shira Zelber-Sagi Ran Oren +1 位作者 Zelber-Sagi Vlad Ratziu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第29期3377-3389,共13页
Nonalcoholic fatty liver disease(NAFLD)has been recognized as a major health burden.The high prevalence of NAFLD is probably due to the contemporary epidemics of obesity,unhealthy dietary pattern,and sedentary lifesty... Nonalcoholic fatty liver disease(NAFLD)has been recognized as a major health burden.The high prevalence of NAFLD is probably due to the contemporary epidemics of obesity,unhealthy dietary pattern,and sedentary lifestyle.The efficacy and safety profile of pharmacotherapy in the treatment of NAFLD remains uncertain and obesity is strongly associated with hepatic steatosis;therefore,the first line of treatment is lifestyle modification.The usual management of NAFLD includes gradual weight reduction and increased physical activity(PA)leading to an improvement in serum liver enzymes,reduced hepatic fatty infiltration,and,in some cases,a reduced degree of hepatic inflammation and fibrosis.Nutrition has been demonstrated to be associated with NAFLD and Non-alcoholic steatohepatitis(NASH)in both animals and humans,and thus serves as a major route of prevention and treatment.However,most human studies are observational and retrospective,allowing limited inference about causal associations.Large prospective studies and clinical trials are now needed to establish a causal relationship.Based on available data,patients should optimally achieve a 5%-10%weight reduction.Setting realistic goals is essential for long-term successful lifestyle modification and more effort must be devoted to informing NAFLD patients of the health benefits of even a modest weight reduction.Furthermore,all NAFLD patients,whether obese or of normal weight,should be informed that a healthy diet has benefits beyond weight reduction.They should be advised to reduce saturated/trans fat and increase polyunsaturated fat,with special emphasize on omega-3 fatty acids.They should reduce added sugar to its minimum,try to avoid soft drinks containing sugar,including fruit juices that contain a lot of fructose,and increase their fiber intake.For the heavy meat eaters,especially those of red and processed meats,less meat and increased fish intake should be recommended.Minimizing fast food intake will also help maintain a healthy diet.PA should be integrated into behavioral therapy in NAFLD,as even small gains in PA and fitness may have significant health benefits.Potentially therapeutic dietary supplements are vitamin E and vitamin D,but both warrant further research.Unbalanced nutrition is not only strongly associated with NAFLD,but is also a risk factor that a large portion of the population is exposed to.Therefore,it is important to identify dietary patterns that will serve as modifiable risk factors for the prevention of NAFLD and its complications. 展开更多
关键词 流行病学 营养 体力 多不饱和脂肪 脂肪肝病 证据 饮食模式 生活方式
下载PDF
Comparison of fatty liver index with noninvasive methods for steatosis detection and quantification 被引量:10
2
作者 Shira Zelber-Sagi Muriel Webb +7 位作者 Nimer Assy Laurie Blendis Hanny Yeshua Moshe Leshno Vlad Ratziu Zamir Halpern Ran Oren Erwin Santo 《World Journal of Gastroenterology》 SCIE CAS 2013年第1期57-64,共8页
AIM:To compare noninvasive methods presently used for steatosis detection and quantification in nonalcoholic fatty liver disease(NAFLD).METHODS:Cross-sectional study of subjects from the general population,a subgroup ... AIM:To compare noninvasive methods presently used for steatosis detection and quantification in nonalcoholic fatty liver disease(NAFLD).METHODS:Cross-sectional study of subjects from the general population,a subgroup from the First Israeli National Health Survey,without excessive alcohol consumption or viral hepatitis.All subjects underwent anthropometric measurements and fasting blood tests.Evaluation of liver fat was performed using four noninvasive methods:the SteatoTest;the fatty liver index(FLI);regular abdominal ultrasound(AUS);and the hepatorenal ultrasound index(HRI).Two of the noninvasive methods have been validated vs liver biopsy and were considered as the reference methods:the HRI,the ratio between the median brightness level of the liver and right kidney cortex;and the SteatoTest,a biochemical surrogate marker of liver steatosis.The FLI is calculated by an algorithm based on triglycerides,body mass index,γ-glutamyl-transpeptidase and waist circumference,that has been validated only vs AUS.FLI < 30 rules out and FLI ≥ 60 rules in fatty liver.RESULTS:Three hundred and thirty-eight volunteers met the inclusion and exclusion criteria and had valid tests.The prevalence rate of NAFLD was 31.1% according to AUS.The FLI was very strongly correlated with SteatoTest(r = 0.91,P < 0.001) and to a lesser but significant degree with HRI(r = 0.55,P < 0.001).HRI and SteatoTest were significantly correlated(r = 0.52,P < 0.001).The κ between diagnosis of fatty liver by SteatoTest(≥ S2) and by FLI(≥ 60) was 0.74,which represented good agreement.The sensitivity of FLI vs SteatoTest was 85.5%,specificity 92.6%,positive predictive value(PPV) 74.7%,and negative predictive value(NPV) 96.1%.Most subjects(84.2%) with FLI < 60 had S0 and none had S3-S4.The κ between diagnosis of fatty liver by HRI(≥ 1.5) and by FLI(≥ 60) was 0.43,which represented only moderate agreement.The sensitivity of FLI vs HRI was 56.3%,specificity 86.5%,PPV 57.0%,and NPV 86.1%.The diagnostic accuracy of FLI for steatosis > 5%,as predicted by SteatoTest,yielded an area under the receiver operating characteristic curve(AUROC) of 0.97(95% CI:0.95-0.98).The diagnostic accuracy of FLI for steatosis> 5%,as predicted by HRI,yielded an AUROC of 0.82(95% CI:0.77-0.87).The κ between diagnosis of fatty liver by AUS and by FLI(≥ 60) was 0.48 for the entire sample.However,after exclusion of all subjects with an intermediate FLI score of 30-60,the κ between diagnosis of fatty liver by AUS and by FLI either ≥ 60 or < 30 was 0.65,representing good agreement.Excluding all the subjects with an intermediate FLI score,the sensitivity of FLI was 80.3% and the specificity 87.3%.Only 8.5% of those with FLI < 30 had fatty liver on AUS,but 27.8% of those with FLI ≥ 60 had normal liver on AUS.CONCLUSION:FLI has striking agreement with SteatoTest and moderate agreements with AUS or HRI.However,if intermediate values are excluded FLI has high diagnostic value vs AUS. 展开更多
关键词 STEATOSIS Hepatorenal ultrasound INDEX SteatoTest FATTY liver INDEX SCREENING AGREEMENT Sensitivity SPECIFICITY
下载PDF
A new category of “future planning” in the activity card sort: Continuity versus novelty in old age
3
作者 Tsameret Ricon Pola Weissman Naor Demeter 《Health》 2013年第2期179-187,共9页
The Activity Card Sort (ACS) is a widely used measure for assessing participation in instrumental, leisure, and social-cultural activities. The ACS addresses previous and current activities but not future activity pla... The Activity Card Sort (ACS) is a widely used measure for assessing participation in instrumental, leisure, and social-cultural activities. The ACS addresses previous and current activities but not future activity plans. The purpose of the study was to extend the ACS to include future planning. Previous research indicates that participation in activities and future planning is positively related to life satisfaction, and increased well-being and that these positive effects were most pronounced for adults 60 years and older. The current study participants were 60 Israeli adults aged 55 - 74 years. The research finds future planning to be widespread, common and significant among older adults. Moreover, it was found that older people planned to continue previous activities more that they planned new activities for the future, indicating more continuity than innovation among the participants in this study. Participants with higher current or past activity levels planed a greater number of future activities. Construct validity using known group method showed the extended ACS to have discriminant validity with respect to age (younger participants were more active) and gender (highly physical activities were favored by men). MANOVA repeated measures and Pearson correlations demonstrated moderate-high test-retest reliability for the extended ACS. 展开更多
关键词 Activity CARD SORT CONTINUITY Innovation OLDER ADULTS Reliability & Validity
下载PDF
Sub-Grouping Healthy Subjects’ Sensitivity to Pain and Its Relationship to Personality Traits: Results of a Cluster Analysis
4
作者 Dorit Pud Roi Treister Elon Eisenberg 《Applied Mathematics》 2014年第11期1705-1712,共8页
Objective: Individual differences in the sensitivity to pain and the factors that may contribute to these differences are well studied. Nevertheless, there is no single test that can reliably classify subjects as bein... Objective: Individual differences in the sensitivity to pain and the factors that may contribute to these differences are well studied. Nevertheless, there is no single test that can reliably classify subjects as being sensitive or insensitive to pain. Methods: In the present study, hierarchical clustering and K-means cluster analysis was used to identify subgroups among 191 healthy subjects (105 females, 86 males) according to their sensitivity to pain. Group determination was based on the subjects’ response to experimental noxious stimuli of heat (pain intensity), cold (cold pain threshold, tolerance, and intensity), and conditioned pain modulation (CPM, tested by co-administering repeated short painful heat stimuli and a conditioning tonic cold pain stimulation). In addition, in order to determine if the subjects in these subgroups differed on personality traits scores on Cloninger’s Tridimensional Personality Questionnaire (TPQ, outcome measure) for the three dimensions of personality: Novelty Seeking (NS);Harm Avoidance (HA);and Reward Dependence (RD) were calculated. Results: Based on pain scores, subjects were grouped as low pain (57%) with a low level of sensitivity in pain parameters, or high pain (43%) cluster members. The high pain had significant higher scores of HA (p = 0.05) and RD (p = 0.05) than the low pain group. Conclusions: This method of sub-grouping may be useful for identifying the mechanisms underlying individual variability in the sensitivity to pain and may point to groups at risk for experiencing high levels of clinical pain. 展开更多
关键词 CLUSTER Analysis COLD Pressor Test Experimental PAIN Human PERSONALITY TRAITS
下载PDF
Neurophysiological Manifestations of Auditory Hypersensitivity Correlate with Daily Life Experiences
5
作者 Sharon Zlotnik Joseph Attias +1 位作者 Hillel Pratt Batya Engel-Yeger 《Neuroscience & Medicine》 2018年第1期29-45,共17页
Background: This study aimed to compare the neurophysiological responses to sound in adults with hypersensitivity compared to adults without hypersensitivity, and correlate the daily-life experiences to the neurophysi... Background: This study aimed to compare the neurophysiological responses to sound in adults with hypersensitivity compared to adults without hypersensitivity, and correlate the daily-life experiences to the neurophysiological manifestations. Material and Methods: The Adolescent/Adult Sensory Profile (AASP) was administered to 27 adults, separated by their cut-off scores. Differences in neurophysiological responses were measured by N1-P2 Event-Related Potentials (ERP) in response to auditory changes in frequency and intensity. Reactions to daily sounds were measured by the hyperacusis questionnaire. Correlations between AASP, hyperacusis questionnaire, and ERP were measured. Results: The basic ability to detect a change in stimuli manifested in N1 waveform was not significantly different. However, participants with hypersensitivity presented a stronger P2 response and a higher hyperacusis score. Daily expressions of auditory hypersensitivity correlated (p = 0.05 - p = 0.01) with larger ERP responses. Conclusions: Auditory hypersensitivity as reflected in daily scenarios is evident in neurophysiological manifestations measured by ERPs. Understanding the relationship between the neural mechanisms of auditory hyper-ensitivity and its daily expressions, may optimize participation and wellbeing for people with hypersensitivity. 展开更多
关键词 SENSORY HYPERSENSITIVITY HYPERACUSIS EVENT-RELATED Potentials (ERP) Daily Life Adult
下载PDF
Overview of Intervention Programs for Parents of Young Children (0 - 6)
6
作者 Merav Goldblatt Rivka Yahav Tsameret Ricon 《Open Journal of Pediatrics》 2014年第3期185-207,共23页
In most of the world’s societies and cultures, the biological mother and father bear primary responsibility to?care for their child’s needs and to guide him or her through the process of entry into society [1]. The ... In most of the world’s societies and cultures, the biological mother and father bear primary responsibility to?care for their child’s needs and to guide him or her through the process of entry into society [1]. The parent serves, for the most part, as the significant figure with the greatest amount of influence over the child’s life. Through his parent, the child learns the skills necessary to experience the world and function in it, whether the skills are in relation to survival needs such as eating, washing and mobility or developmental and social needs such as forming social relationships and developing the capacity to think and learn through play and supervision [2]. Thus the parent plays a critical but complex role in the development of his or her child, a role that requires development of a wide range of new behavioral, communicational, cognitive and emotional skills and capabilities in order to understand and cope with the challenges of child-rearing. Similarly, parenting styles and characteristics are influenced by a number of variables: The parent, the child, the interaction between them, and environmental variables such as culture, socio-economic status, and the existing family unit [2]. When children who suffer from behavioral difficulties do not receive the parental care they need, there is reasonable cause for concern that difficulties will develop in adulthood in a range of life areas that will have an impact on their lives and well-being and on their ability to adapt to society and contribute to it [3]. Accordingly, over the past 50 years parent-training programs have been developed to strengthen parents through learning and providing tools of experience and developmental knowledge, for the purpose of promoting the child’s sense of wellbeing and quality of life [2] [4]. Objective: The purpose of this review is to provide an overview of evidence-based interventions for parents of young children (0 - 6), programs that are currently active in Israel and in the world, and to explicate the significant characteristics common to them that contribute to their effectiveness and success. 展开更多
关键词 Interventions for PARENTS EARLY Development YOUNG CHILDREN REVIEW
下载PDF
The Changes in the Neck Meridian Test Scores Induced by Self-Administered Acupressure: A Secondary Analysis of Data from a Randomized Controlled Trial of Self-Administered Acupressure
7
作者 Satoshi Horiuchi Yasuhiro Honda 《Chinese Medicine》 2017年第1期10-17,共8页
In the neck meridian test, the examinee stretches his or her neck in four directions and rates the intensity of pain and/or symptoms on a four point Likert scale. The four responses are summed to calculate the test sc... In the neck meridian test, the examinee stretches his or her neck in four directions and rates the intensity of pain and/or symptoms on a four point Likert scale. The four responses are summed to calculate the test score. This study conducted secondary analyses of data from a randomized controlled trial of self-administered acupressure. The study aimed to examine the change of the neck meridian test score induced by self-administered acupressure. The data of 54 (male, n = 34;female, n = 20) students, who were randomly assigned to an intervention group (IG) and a control group (CG), were subjected to secondary analyses. The IG participants were asked to complete a self-administered acupressure intervention for two weeks;the CG participants were not. In the IG, the perceived stress decreased significantly over time, while the neck meridian test score decreased significantly;in contrast, this score increased in the CG. A significant positive correlation was found between the changes in the perceived stress and neck meridian test scores. These results supported validity of the neck meridian test as a tool for assessing perceived stress. 展开更多
关键词 NECK MERIDIAN Test PERCEIVED Stress Qi IMBALANCE ACUPRESSURE MERIDIAN Theory
下载PDF
The Effectiveness of a Multimedia Messaging Service Reminder System in the Management of Knee Osteoarthritis: A Pilot Study
8
作者 Gali Dar Yaron Marx +1 位作者 Emma Ioffe Einat Kodesh 《International Journal of Clinical Medicine》 2014年第9期483-489,共7页
Background: Patient compliance to home exercise programs is significantly linked to improved treatment outcomes. Finding ways of encouraging patient conformity to these programs is imperative. For patients with osteoa... Background: Patient compliance to home exercise programs is significantly linked to improved treatment outcomes. Finding ways of encouraging patient conformity to these programs is imperative. For patients with osteoarthritis (OA) of the knee, a condition that causes pain, disability and lessens the quality of life, exercise is essential for effective control of the condition. Aim: to investigate the effectiveness of multimedia messaging services (MMS) in improving patient adherence and functional outcome to home based exercise programs for patients suffering from knee OA. Methods: Fourteen patients diagnosed with knee OA and were referred to an exercise group therapy (for a total of six sessions) participated in this pilot study. The patients were randomly assigned to either the research or control group. The research group received MMS messages additional to the exercise sessions (video of exercises up to 10 seconds in length) to their mobile phone. Outcome measurement included the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire, combined Focus On Therapeutic Outcomes (FOTO) questionnaire, Visual Analog Scale for Pain (VAS), Fear-Avoidance Beliefs Questionnaire (FABQ) and a general questionnaire. Results: The research group had baseline scores representing slightly higher disability, pain and fear avoidance than the control group as observed by the lower FOTO score and the higher FABQ, VAS and WOMAC scores. Analyzing the difference between initial and final scores revealed that the research group had a slightly higher perceived functional improvement. Conclusions: This study addressed the feasibility of short video messaging via mobile phones in increasing compliance to home exercise programs prescribed to patients suffering from knee OA. This pilot study provides an indication for the potential of success and a larger sample study should be conducted. 展开更多
关键词 OSTEOARTHRITIS MULTIMEDIA Physical THERAPY REHABILITATION EXERCISES
下载PDF
Participation in Daily Activities among Working Women Following Breast Cancer
9
作者 Khawla Loubani-Hawaita Naomi Schreuer Uzi Milman 《Open Journal of Therapy and Rehabilitation》 2016年第3期150-162,共13页
Introduction: This study aimed to identify the variables explaining retained activity level for working women with breast cancer;the variables correlating with their performance in daily activities they prioritize;and... Introduction: This study aimed to identify the variables explaining retained activity level for working women with breast cancer;the variables correlating with their performance in daily activities they prioritize;and factors facilitating or restricting their return to work. Method: Sixty working women with breast cancer aged 25 - 65 years completed a personal data questionnaire, the modified Activity Card Sort, the Canadian Occupational Performance Measure;and two open- ended questions about facilitators and barriers to work. Results: Activity levels dropped by a quarter following BC treatments. Most women (67%) decreased their weekly working hours, although a third identified work as their highest priority. A higher total retained activity level was explained by fewer limitations on the range of motion (upper extremity), age younger than 45 years, and higher educational attainment. Cognitive limitations and limited range of motion negatively correlated with retained activity level at work. Personal and disease factors, job demands, and environmental factors facilitated or restricted return to work. Conclusion: Interventions should focus on physical and cognitive rehabilitation to regain functioning in the context of work and productive daily activities. Special attention should be paid to the greater needs of younger women. 展开更多
关键词 Breast Cancer PARTICIPATION Meaningful Daily Activities Working Women
下载PDF
Cardiovascular morbidity and mortality as a confounder of prognosis in thyroid cancer
10
作者 Elena Izkhakov Lital Keinan-Boker Naftali Stern 《Journal of Cancer Metastasis and Treatment》 2021年第1期345-352,共8页
Thyroid cancer(TC)constitutes more than 95%of all endocrine tumors.Differentiated thyroid carcinoma(DTC),which includes the papillary and follicular types,constitutes about 90%of all TCs and 2.1%of all cancers.The inc... Thyroid cancer(TC)constitutes more than 95%of all endocrine tumors.Differentiated thyroid carcinoma(DTC),which includes the papillary and follicular types,constitutes about 90%of all TCs and 2.1%of all cancers.The incidence of DTC has increased significantly worldwide,with papillary cancer leading this trend and being the most prevalent.Whereas the prognosis of patients with DTC is generally favorable,with the overall 5-year survival rate reaching up to 95%,long-term follow-up also discloses increased propensity for cardiovascular and cerebrovascular risk factors,morbidity,and mortality.Cardiovascular events are linked to TC particularly in subjects aged 45 years or more.The present review and analysis seek to highlight the significance of cardiovascular disease in the overall prognosis among TC survivors and explore potential mechanisms which might link treatment choices in DTC to cardiovascular risk and disease outcome. 展开更多
关键词 Thyroid cancer cardiovascular morbidity cardiovascular mortality cardiovascular risk factors
原文传递
Polymeric nanocarriers for nose-to-brain drug delivery in neurodegenerative diseases and neurodevelopmental disorders 被引量:2
11
作者 Rania Awad Avi Avital Alejandro Sosnik 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2023年第5期1866-1886,共21页
Neurodegenerative diseases are progressive conditions that affect the neurons of the central nervous system(CNS)and result in their damage and death.Neurodevelopmental disorders include intellectual disability,autism ... Neurodegenerative diseases are progressive conditions that affect the neurons of the central nervous system(CNS)and result in their damage and death.Neurodevelopmental disorders include intellectual disability,autism spectrum disorder,and attention-deficit/hyperactivity disorder and stem from the disruption of essential neurodevelopmental processes.The treatment of neurodegenerative and neurodevelopmental conditions,together affecting~120 million people worldwide,is challenged by the blood—brain barrier(BBB)and the blood—cerebrospinal fluid barrier that prevent the crossing of drugs from the systemic circulation into the CNS.The nose-to-brain pathway that bypasses the BBB and increases the brain bioavailability of intranasally administered drugs is promising to improve the treatment of CNS conditions.This pathway is more efficient for nanoparticles than for solutions,hence,the research on intranasal nano-drug delivery systems has grown exponentially over the last decade.Polymeric nanoparticles have become key players in the field owing to the high design and synthetic flexibility.This review describes the challenges faced for the treatment of neurodegenerative and neurodevelopmental conditions,the molecular and cellular features of the nasal mucosa and the contribution of intranasal nano-drug delivery to overcome them.Then,a comprehensive overview of polymeric nanocarriers investigated to increase drug bioavailability in the brain is introduced. 展开更多
关键词 Neurodegenerative diseases Neurodevelopmental disorders Central nervous system Blood—brain barrier Nano-drug delivery systems Nose-to-brain pathway Intranasal administration Polymeric nanoparticles Polymeric micelles DENDRIMERS
原文传递
Significant exercise limitations after recovery from MIS-C related myocarditis 被引量:1
12
作者 Gur Mainzer Merav Zucker-Toledano +2 位作者 Moneera Hanna Ronen Bar-Yoseph Einat Kodesh 《World Journal of Pediatrics》 SCIE CSCD 2023年第12期1149-1154,共6页
Background Myocarditis is one of the presentations of multisystemic infammatory syndrome in children(MIS-C)following coronavirus disease 2019(COVID-19).Although the reported short-term prognosis is good,data regarding... Background Myocarditis is one of the presentations of multisystemic infammatory syndrome in children(MIS-C)following coronavirus disease 2019(COVID-19).Although the reported short-term prognosis is good,data regarding medium-term functional capacity and limitations are scarce.This study aimed to evaluate exercise capacity as well as possible cardiac and respiratory limitations in children recovered from MIS-C related myocarditis.Methods Fourteen patients who recovered from MIS-C related myocarditis underwent spirometry and cardiopulmonary exercise testing(CPET),and their results were compared with an age-,sex-,weight-and activity level-matched healthy control group(n=14).Results All participants completed the CPET with peak oxygen uptake(peak.V O2),and the results were within the normal range(MIS-C 89.3%±8.9%and Control 87.9%±13.7%predicted.V O2).Five post-MIS-C patients(35%)had exerciserelated cardio-respiratory abnormalities,including oxygen desaturation and oxygen-pulse fattening,compared to none in the control group.The MIS-C group also had lower peak exercise saturation(95.6±3.5 vs.97.6±1.1)and lower breathing reserve(17.4%±7.5%vs.27.4%±14.0%of MVV).Conclusions Patients who recovered from MIS-C related myocarditis may present exercise limitations.Functional assessment(e.g.,CPET)should be included in routine examinations before allowing a return to physical activity in post-MIS-C myocarditis.Larger,longer term studies assessing functional capacity and focusing on physiological mechanisms are needed. 展开更多
关键词 Cardiopulmonary exercise testing COVID 19 HYPOXEMIA MYOCARDITIS
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部