Two new labdane diterpenes isolated from the rhizomes of Hedychium forrestii were determined by spectroscopic evidence to be labda-8(17), 11, 13-trien-7β-hydroxyl-15(16)-olide (1, hedyforrestin B) and labda-8(17), 11...Two new labdane diterpenes isolated from the rhizomes of Hedychium forrestii were determined by spectroscopic evidence to be labda-8(17), 11, 13-trien-7β-hydroxyl-15(16)-olide (1, hedyforrestin B) and labda-8(17), 11, 13-trien-7β,16-dihydroxyl-16(15)-olide (2, hedyforrestin C).展开更多
AIM: To evaluate the hepatic function in patients with severe acute respiratory syndrome (SARS) and possible causes of hepatic disorder in these patients. METHODS: One hundred and eighty-two patients with SARS were em...AIM: To evaluate the hepatic function in patients with severe acute respiratory syndrome (SARS) and possible causes of hepatic disorder in these patients. METHODS: One hundred and eighty-two patients with SARS were employed in a retrospective study that investigated hepatic dysfunction. Liver alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactic dehydrogenase (LDH) were analyzed in these patients. Patients with different hospital treatments were further investigated. RESULTS: Of the 182 patients, 128(70.3%) had abnormal ALT activity, 57(31.3%) had abnormal AST activity and 87(47.8%) had abnormal LDH activity. The peak of elevated hepatic enzyme activities occurred between the sixth day and the tenth day after the first day of reported fever. Of the 182 patients, 160(87.9%) had been treated with antibiotics, 137(75.2%) with Ribavirin, and 115(63.2%) with methylpredisolone. There was no statistically significant correlation between the duration of Ribavirin treatement and hepatic dysfunction. CONCLUSION: Abnormal liver functions were common in patients with SARS and could be associated with virus replication in the liver.展开更多
Two novel bis—labdanic diterpenoids named calcaratarin G and calcaratarin H were isolated from the rhizomes of Alpinia calcarata Rosc．Their structures were elucidated to be a pair of stereoiso-mers on the basis of t...Two novel bis—labdanic diterpenoids named calcaratarin G and calcaratarin H were isolated from the rhizomes of Alpinia calcarata Rosc．Their structures were elucidated to be a pair of stereoiso-mers on the basis of the spectral evidence．The 2D NMR techniques including’H-1H COSY，HMQC，HMBC，NOESY and HRFABMS were extensively applied to establish the structures．展开更多
Hedychenone (1), a diterpene containing a, B-unsaturated keto group, was reduced by aluminum-mercury alloy, and a dimerized product (2) was obtained as the major product. The coupling occurred at B position of the ket...Hedychenone (1), a diterpene containing a, B-unsaturated keto group, was reduced by aluminum-mercury alloy, and a dimerized product (2) was obtained as the major product. The coupling occurred at B position of the keto group.展开更多
With overall analysis of symptoms and signs of myasthenia gravis(MG)basing on “Pi(Spleen) Deficiency”(脾虚)theory and with years of our clinical experience in treating MG,we performed a pharmacological study of Astr...With overall analysis of symptoms and signs of myasthenia gravis(MG)basing on “Pi(Spleen) Deficiency”(脾虚)theory and with years of our clinical experience in treating MG,we performed a pharmacological study of Astragalus saponins and Buzhong Yiqi Compound(Tonic granulae invigorating vital energy) in 14 peripheral blood mononuclear cell(PBMNC)cultures from 10 MG patients.展开更多
基金Program granted by the Laboratory of Phytochemstry,Kunming Institute of Botany,the Chinese Academy of Sciences
文摘Two new labdane diterpenes isolated from the rhizomes of Hedychium forrestii were determined by spectroscopic evidence to be labda-8(17), 11, 13-trien-7β-hydroxyl-15(16)-olide (1, hedyforrestin B) and labda-8(17), 11, 13-trien-7β,16-dihydroxyl-16(15)-olide (2, hedyforrestin C).
文摘AIM: To evaluate the hepatic function in patients with severe acute respiratory syndrome (SARS) and possible causes of hepatic disorder in these patients. METHODS: One hundred and eighty-two patients with SARS were employed in a retrospective study that investigated hepatic dysfunction. Liver alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactic dehydrogenase (LDH) were analyzed in these patients. Patients with different hospital treatments were further investigated. RESULTS: Of the 182 patients, 128(70.3%) had abnormal ALT activity, 57(31.3%) had abnormal AST activity and 87(47.8%) had abnormal LDH activity. The peak of elevated hepatic enzyme activities occurred between the sixth day and the tenth day after the first day of reported fever. Of the 182 patients, 160(87.9%) had been treated with antibiotics, 137(75.2%) with Ribavirin, and 115(63.2%) with methylpredisolone. There was no statistically significant correlation between the duration of Ribavirin treatement and hepatic dysfunction. CONCLUSION: Abnormal liver functions were common in patients with SARS and could be associated with virus replication in the liver.
文摘Two novel bis—labdanic diterpenoids named calcaratarin G and calcaratarin H were isolated from the rhizomes of Alpinia calcarata Rosc．Their structures were elucidated to be a pair of stereoiso-mers on the basis of the spectral evidence．The 2D NMR techniques including’H-1H COSY，HMQC，HMBC，NOESY and HRFABMS were extensively applied to establish the structures．
文摘Hedychenone (1), a diterpene containing a, B-unsaturated keto group, was reduced by aluminum-mercury alloy, and a dimerized product (2) was obtained as the major product. The coupling occurred at B position of the keto group.
文摘With overall analysis of symptoms and signs of myasthenia gravis(MG)basing on “Pi(Spleen) Deficiency”(脾虚)theory and with years of our clinical experience in treating MG,we performed a pharmacological study of Astragalus saponins and Buzhong Yiqi Compound(Tonic granulae invigorating vital energy) in 14 peripheral blood mononuclear cell(PBMNC)cultures from 10 MG patients.
