Objective To investigate the hypocholesterolemic activity of red yeast rice （RYR） and its underlying mechanism. Methods Three groups of hamsters were fed either the control diet or one of the two experimental diets ...Objective To investigate the hypocholesterolemic activity of red yeast rice （RYR） and its underlying mechanism. Methods Three groups of hamsters were fed either the control diet or one of the two experimental diets containing by weight 0.1% RYR （0.1RYR） or 0.3% RYR （0.3RYR）. Blood （0.5 mL） was collected from the retro-orbital sinus into a heparinized capillary tube at the end of week 0, 3, and 6. Plasma lipoproteins were measured using enzymatic kits, while fecal neutral and acidic sterols were quantified using a gas-liquid chromatography. Results Plasma total cholesterol was reduced by 12% in 0.1RYR group and by 18% in 0.3RYR group compared with the control value. Similarly, plasma triacylglycerol was decreased by 11% in 0.1RYR group and by 24% in 0.3RYR group. Western blotting analysis demonstrated that RYR had no effect on sterol regulatory element binding protein 2, fiver X receptor, 3-hydroxy-3-methylglutary-CoA reductase, LDL receptor, and cholesterol-7α-hydroxylase. HPLC analysis confirmed that RYR contained 0.88% monacolin K. It was recently found that RYR supplementation increased excretion of fecal acidic sterols by 34 folds compared with the conlrol value. Conclusion Hypocholesterolemic activity of RYR is mediated at least partially by enhancement of acidic sterol excretion.展开更多
This paper presents the development of dynamic simulation of a flexible plate structure with various boundary conditions. A flexible square plate is considered. A finite-difference method is used to discretise the gov...This paper presents the development of dynamic simulation of a flexible plate structure with various boundary conditions. A flexible square plate is considered. A finite-difference method is used to discretise the governing partial differential equation formulation describing its dynamic behaviour. The model thus developed has been validated against characteristic parameters of the plate. The model thus developed is further formulated using discrete state-space representation, to allow easy and fast implementation for simulating the dynamic behaviour of the plate with various boundary conditions. The simulation algorithm thus developed is validated, and accurate results with representation of the first five modes of vibration of the plate have been achieved. The algorithm thus developed is used in subsequent research work as a platform for development and verification of suitable control strategies for vibration suppression of flexible plate structures.展开更多
文摘Objective To investigate the hypocholesterolemic activity of red yeast rice （RYR） and its underlying mechanism. Methods Three groups of hamsters were fed either the control diet or one of the two experimental diets containing by weight 0.1% RYR （0.1RYR） or 0.3% RYR （0.3RYR）. Blood （0.5 mL） was collected from the retro-orbital sinus into a heparinized capillary tube at the end of week 0, 3, and 6. Plasma lipoproteins were measured using enzymatic kits, while fecal neutral and acidic sterols were quantified using a gas-liquid chromatography. Results Plasma total cholesterol was reduced by 12% in 0.1RYR group and by 18% in 0.3RYR group compared with the control value. Similarly, plasma triacylglycerol was decreased by 11% in 0.1RYR group and by 24% in 0.3RYR group. Western blotting analysis demonstrated that RYR had no effect on sterol regulatory element binding protein 2, fiver X receptor, 3-hydroxy-3-methylglutary-CoA reductase, LDL receptor, and cholesterol-7α-hydroxylase. HPLC analysis confirmed that RYR contained 0.88% monacolin K. It was recently found that RYR supplementation increased excretion of fecal acidic sterols by 34 folds compared with the conlrol value. Conclusion Hypocholesterolemic activity of RYR is mediated at least partially by enhancement of acidic sterol excretion.
文摘This paper presents the development of dynamic simulation of a flexible plate structure with various boundary conditions. A flexible square plate is considered. A finite-difference method is used to discretise the governing partial differential equation formulation describing its dynamic behaviour. The model thus developed has been validated against characteristic parameters of the plate. The model thus developed is further formulated using discrete state-space representation, to allow easy and fast implementation for simulating the dynamic behaviour of the plate with various boundary conditions. The simulation algorithm thus developed is validated, and accurate results with representation of the first five modes of vibration of the plate have been achieved. The algorithm thus developed is used in subsequent research work as a platform for development and verification of suitable control strategies for vibration suppression of flexible plate structures.
