Parasitoids of dipterous collected in cattle dung in the Regions Southern and Central of Goiás, Brazil

This study had the objective of determining the species of parasitoids of Diptera from May 2003 to June 2004 in the Region Southern and from March 2012 to February 2013 in the Region Central of (Goiania) Goiás, Brazil. The dipterous pupae were obtained by the flotation method. They were individually placed in gelatin capsules until the emergence of the flies and/or their parasitoids. The percentage of parasitism in the Region South was 12.4% and in the Region Central was 6.4%. The species more frequent were: Gnathopleura quadridentata Wharton, 1986 (Hymenoptera: Braconidae) with 25.6% in the Region Southern and Aleochara notula Erichson, 1839 (Coleoptera: Staphylinidae) with 26.1% in the Region Central.

Salivary biomarkers: novel noninvasive tools to diagnose chronic inflammation

Several chronic disorders including type 2 diabetes(T2D),obesity,heart disease and cancer are preceded by a state of chronic lowgrade inflammation.Biomarkers for the early assessment of chronic disorders encompass acute phase proteins(APP),cytokines and chemokines,pro-inflammatory enzymes,lipids and oxidative stress mediators.These substances enter saliva through the blood flow and,in some cases。

Is there a place for serum laminin determination in patients with liver disease and cancer?

Laminin is a glycoprotein which has an important role in the mechanism of fibrogenesis and is,thus,related to hepatic fibrosis in addition to presenting increased levels in several types of neoplasias. However,its determination is not routinely considered in the study of hepatic fibrosis. In this review,the authors critically comment on the role of this glycoprotein compared to other markers of fibrosis through non-invasive procedures(Fibroscan). They also consider its clinical investigational potential and believe that the continuation of these investigations might contribute to a better understanding of the fibrogenic mechanism,which could in turn either lead to the identification of patients at risk of developing fibrosis non-alcoholic fatty liver disease(NAFLD) and non-alcoholic steatohepatitis(NASH) or at least be used as an indicator for hepatic biopsy in such patients. Finally,the authors believe that serum laminin determination might contribute to the diagnosis of epithelial tumor metastasis and peritoneal carcinomatosis.

Menopause and cognitive impairment:A narrative review of current knowledge

A severe impairment of cognitive function characterizes dementia.Mild cognitive impairment represents a transition between normal cognition and dementia.The frequency of cognitive changes is higher in women than in men.Based on this fact,hormonal factors likely contribute to cognitive decline.In this sense,cognitive complaints are more common near menopause,a phase marked by a decrease in hormone levels,especially estrogen.Additionally,a tendency toward worsened cognitive performance has been reported in women during menopause.Vasomotor symptoms(hot flashes,sweating,and dizziness),vaginal dryness,irritability and forgetfulness are common and associated with a progressive decrease in ovarian function and a subsequent reduction in the serum estrogen concentration.Hormone therapy(HT),based on estrogen with or without progestogen,is the treatment of choice to relieve menopausal symptoms.The studies conducted to date have reported conflicting results regarding the effects of HT on cognition.This article reviews the main aspects of menopause and cognition,including the neuroprotective role of estrogen and the relationship between menopausal symptoms and cognitive function.We present and discuss the findings of the central observational and interventional studies on HT and cognition.

Baru almonds from different regions of the Brazilian Savanna: Implications on physical and nutritional characteristics

While some reports show that physical characteristics of the baru fruits (Dipteryx alata Vog.) differ within and among the Brazilian Savanna regions, a study shows that there are differences in the nutritional composition of baru almonds from different trees from the same Savanna area. It is unknown, however, whether the Savanna’s region influences the nutritional quality of this native almond. Thus, we evaluated the influence of East, Southeast and West regions of the Brazilian Savanna on physical characteristics, nutrient composition and protein quality of the baru almond. Chemical composition and amino acid profile were analyzed, and Amino Acid Score (AAS), Net Protein Ratio (NPR), and Protein Digestibility–Corrected Amino Acid Score (PDCAAS) were estimated. The physical characteristics significantly differed within but not among regions. The protein (310 g kg-1), lipid (410 g·kg-1), fiber (120 g·kg-1) and calcium (1,300 mg·kg-1) contents of baru almonds were high, with significant differences among regions for insoluble fiber content (94.3 - 128.3 g·kg-1) and amino acid profile (AAS = 77% - 89%). The relative NPR (RNPR) values were similar among regions (mean value of RNPR = 71%), and the PDCAAS values ranged from 65 to 73%. The region of the Brazilian Savanna influences the fiber and amino acid profiles, but not the total content of nutrients, the protein quality and the physical characteristics of the native baru almonds. The baru almond is a potential food as source of complementary protein for healthy diets and as a nutritious raw material for various food systems.

Influence of Water Content on the Quality of Pigeonpea Seeds

The species Cajanus cajan L. where pigeonpea is from presents a harvest potential in tropical regions for it is used as human and animal feed, besides being used as green fertilizer. However, the harvest area of this Fabaceae is still insignificant, due to especially the lack of quality seeds. In this context, it is possible to affirm that drying and store are portrayed as important steps for obtaining superior quality seeds. The aim of this study is to evaluate the physiologic quality of dwarf pigeonpea seeds, with different water content during storage. A factorial scheme 3 × 6 was adopted in the delimitation completely randomized, with four replications. Treatments were constituted by the combination of lots of seeds containing three different water contents (11%, 14% and 16%), submitted to a 10-month storage period, with evaluations every two months (0, 2, 4, 6, 8 and 10). Seeds were stocked in a bag type kraft under normal lab conditions, that is, no control. Physiologic quality of the seeds was evaluated through the following tests: Germination Pattern Test—GPT, first count of germination, accelerated aging and electric conductivity. It can be concluded that pigeonpea with hard seeds containing water content at 11% existing superior physiologic quality throughout the 10-month storage, under no controlled condition, certainly promoted by the less intense breathing from the reserves cumulated in the seed lot. Pigeonpea seeds storage with water content superior to 14% promotes a sharp decrease of physiologic quality, due to an increase in metabolic activity.

Cytokines and T Helper Cells in Diabetic Nephropathy Pathogenesis

Diabetic Nephropathy (DN) is considered the main cause of end stage kidney disease around the world. However, its pathogenesis is not completely established. More than just a direct consequence of chronic glycemic changes, recent studies had suggested Diabetic Nephropathy could be considered an inflammatory disease. It has been shown that concentrations of pro-inflammatory cytokines, as IL-1, IL-6, IL-18, IL-33, IFN-γ and TNF-α actively participate in development and progression of DN, and thus, are involved in pathogenesis. Besides, changes in acquired immune response, especially the presence of cellular immune response profiles of pro-inflammatory and effector nature, mainly Th1 and Th17, as the imbalance between interaction of cytokines and T regulatory cells, foment the onset and progression of DN. Here we summarize the main evidences that support the critical role of the immune system in this condition. These new conceptual advances in DN understanding are essential for development of new the rapeutical strategies and prognostic factors, which could be protagonists or adjuvants to the current ones, leading ultimately to a better clinical management of DN patients.

The Role of Physical and Political Factors on the Conservation of Native Vegetation in the Brazilian Forest-Savanna Ecotone

The AraguaiaRiver Basincovers a considerable extent of Brazilian Savanna (locally called Cerrado) and part of Amazon Tropical Rainforest, embracing high biodiversity and a vast flooding area. This region has been converted to agricultural lands since 1970s, for the past four decades, leading to a fragmented landscape that holds one of the few large remaining blocks of Cerrado primary vegetation. Therefore, to assess the degree of preservation of this area a 2007 primary vegetation map was derived through Boolean operations using land use and land cover maps from 1975, 1985, 1996 and 2007, from digital classification of Landsat MSS and TM images. To evaluate the role of driving factors on the presence of pristine vegetation, a logistic regression analyses was performed. Tested factors were: distance from roads and cities, terrain slope, land tenure, soil fertility and flooding. We found statistical significant values (p nous lands, wetlands and areas with low fertility have positive influence on the presence and maintenance of these pristine areas. The occurrence of original vegetation in many cases is associated with environmental constraints that difficult or do not allow agricultural use. Analysis of physical and political factors, which may have direct or indirect influence on the conservation and degradation of native vegetation are very important for the comprehension of the dynamics of regional land use, and provide supporting information for a more efficient and sustainable regional landscape planning.

Genetic and Phenotypic Parameters in the Selection of Upland Rice Genotypes

To assist in upland rice breeding programs, estimated genetic and phenotypic parameters are extremely important in the selection of superior lines. Thus, the objective of this study was estimate the genetic and phenotypic parameters of upland rice lines of the breeding program of UFLA in partnership with Embrapa Arroz e Feijao and Epamig. The experiment was installed in an experimental area of the Department of Agriculture at UFLA. It was evaluated 36 upland rice lines of the preliminary trial of the 2014/15 season, in randomized blocks, with three replications and plots consisted of five rows and each row has four meters. For this, it was evaluated the characters: plant height (cm), yield (kg·ha-1), 100-grain weight, days until flowering, percentage of filled grains and rice blast severity. The variance analysis and genetic parameters were estimated using the software SAS. To evaluate the experimental precision was estimated the accuracy, which varied between 63% and 98%, showing experimental precision, moderate to high. The lines differed significantly for all characters, meaning there is genetic variability among genotypes evaluated. With intensity of selection of 10% of lines, it was obtained a genetic gain of 325.29 kg·ha-1 in the character productivity, a plant height (cm) reduction in 5.50 cm, and days until flowering, with a reduction of 9.23 days, with selection of earlier plants. The estimated values for heritability ranged from 38% - 96%. Estimates confirm the possible success with the selection of the upland rice lines for these characters.

Surgical risk for patients with Chagasic achalasia and its correlation with the degree of esophageai dilation

AIM： To analyze the risk of cardiovascular complications in patients with indication for surgical treatment of Chagasic esophageal achalasia and to correlate the surgical risks with the degree of esophageal dilation, thereby proposing a risk scale index. METHODS： One hundred and twenty-four patients with Chagasic esophageal achalasia, who received surgical treatment at the Hospital das Clinicas of the Federal University of Goiás, were included in this study. The patients were mostly related to the postoperative complications due to the cardiovascular system. All the patients were submitted to： （1） clinical history to define the cardiac functional class （New York Heart Association）; （2） conventional 12-lead electrocardiogram at rest; and （3） contrast imaging of the esophagus to determine esophageal dilatation according to Rezende＇s classification of Chagasic megaesophagus. RESULTS： An assessment of the functional classification （FC） of heart failure during the preoperative period determined that 67 patients （54.03%） were assigned functional class Ⅰ （FC Ⅰ）, 46 patients （37.09%） were assigned functional class Ⅱ （FC Ⅱ）, and 11 patients （8.87%） were assigned functional class Ⅲ （FC Ⅲ）. None of the patients were assigned to functional class Ⅳ （FC Ⅳ）. There was a positive correlation between the functional class and the postoperative complications （FC Ⅰ×FC Ⅱ： P〈0.001; FC Ⅰ×FC Ⅲ： P〈0.001）. The ECG was normal in 44 patients （35.48%） and presented abnormalities in 80 patients （64.52%）. There was a significant statistical correlation between abnormal ECG （arrhythmias and primary change in ventricular repolarization） and postoperative complications （P〈0.001）. With regard to the classification of the Chagasic esophageal achalasia, the following distribution was observed： group Ⅱ, 53 patients （42.74%）; group Ⅲ, 37 patients （29.83%）; and group Ⅳ, 34 patients （27.41%）. There was a positive correlation between the degree of esophageal dilation and the increase in postoperative complications （grade Ⅱ×grade Ⅲ achalasia： P〈0.001; grade Ⅱ×grade Ⅳ achalasia： P〈0.001; and grade Ⅲ×grade Ⅳ achalasia： P = 0.017）. Analyzing these results and using a multivariate regression analysis associated with the probability decision analysis, a risk scale was proposed as follows： up to 21 points （mild risk）; from 22 to 34 points （moderate risk）; and more than 34 points （high risk）. The scale had 82.4% accuracy for mild risk patients and up to 94.6% for the high risk cases. CONCLUSION： The preoperative evaluation of the cardiovascular system, through a careful anamnesis, an ECG and contrast imaging of the esophagus, makes possible to estimate the surgical risks for Chagas＇ disease patients who have to undergo surgical treatment for esophageal achalasia.

Average Rainfall Estimation: Methods Performance Comparison in the Brazilian Semi-Arid

Considering the rainfall’s importance in hydrological modeling, the objective of this study was the performance comparison, in convergence terms, of techniques often used to estimate the average rainfall over an area: Thiessen Polygon (TP) Method;Reciprocal Distance Squared (RDS) Method;Kriging Method (KM) and Multiquadric Equations (ME) Method. The comparison was done indirectly, using GORE and BALANCE index to assess the convergence results from each method by increasing the rain gauges density in a region, through six scenarios. The Coremas/Mae D’água Watershed employed as study area, with an area of 8385 km2, is situated on Brazilian semi-arid. The results showed the TP, as RDS and ME techniques to be employed successfully to obtain the average rainfall over an area, highlighting the MEM. On the other hand, KM, using two variograms models, had an unstable behavior, pointing the prior study of data and variogram’s choice as a need to practical applying.

Edible Seeds and Nuts Grown in Brazil as Sources of Protein for Human Nutrition

Edible seeds and nuts can contribute to an adequate intake of protein, particularly in vegetable-based diets. However, there are relatively few reports with insufficient data regarding the protein quality of these foods, especially of edible seeds and nuts from Brazil. The aim of this study was to investigate the chemical composition and in vivo protein quality of two edible seeds (baru almond and peanut) and two nuts (Brazil nut and cashew nut) grown in Brazil. The proximate composition and the amino acid profile were analyzed. The true protein digestibility and the protein quality of these foods were evaluated by bioassay with male weanling Wistar rats over a period of 14 days, and the Protein Digestibility Corrected Amino Acid Score (PDCAAS) was estimated. Edible seeds and nuts presented high contents of proteins (16.3 to 32.3 g/100g), lipids (42.7 to 57.9 g/100g) and dietary fibers (6.5 to 14.3 g/100g). Lysine was found to be the limiting amino acid in baru almond, peanut and Brazil nut, which had amino acid scores ranging from 71% to 76%. Cashew nut had no limiting amino acid. These foods showed high protein digestibility (around 90%) except for baru almond (75%), and their PDCAAS values varied significantly (57%, for baru almond, and 90%, for cashew nut). The edible seeds and nuts grown in Brazil provide a high density of energy and nutrients and they can be used as complementary sources of proteins.

Characteristics and Diversity of Cyanobacteria in Periphyton from Lentic Tropical Ecosystem, Brazil

This study aimed to perform the taxonomic survey of the species of periphytic Cyanobacteria in a lentic tropical environment, seeking to contribute to the knowledge on biodiversity and their distribution. This study was conducted at the Samambaia Reservoir, which is located at Federal University of Goiás, Goiania, Central West region of Brazil. In general, the water of the Samambaia Reservoir is characterized as more turbid and the increased biochemical oxygen demand as well as a higher concentration of coliforms in the rainy season. Twenty six samples were collected, ten in the dry season (09/2010 and 11/2010;07/2012) and ten in the rainy season (01/2011 and 03/2011;01/2013). Periphyton was collected from stems of aquatic plants (Cyperaceae), which were in the marginal area of the reservoir. With the floristic survey, 38 taxa of Cyanobacteria were identified in periphyton of the Samambaia Reservoir. Phormidium (family Phormidiaceae) and Aphanocapsa (Merismopediaceae) are among genera with the highest species richness. Regarding morphological types, many species of filamentous cyanobacteria were identified, followed by colonial taxa. In relation to the frequency of occurrence and the seasonal period, 14 taxa were classified in the rare category, 12 in common category and 12 in constant category. Regarding the seasonal period, Cyanophyceae were the greatest wealth in the rainy season (97.4%).

Atypical Hemolytic Uremic Syndrome in a Post-COVID-19 Child: Its Differential Diagnosis with COVID-19, Multisystemic Inflammatory Syndrome and Outcome

Pediatric Multisystemic Inflammatory Syndrome (MIS-C) is one of the most severe manifestations of SARS-CoV-2 in pediatrics [1]. This is a report of MIS-C with clinical presentation in infants with atypical Hemolytic Uremic Syndrome (aHUS).

Factors Associated with Umbilical Cord Stump Healing Practices: Literature Review

Objective: To analyze the evidence in the evolution of scientific production on the factors associated with curative practices of the umbilical stump. Materials and Methods: The study data collection took place in April 2017. The electronic databases used to search the articles were: PubMed (National Library of Medicine and National Institutes of Health) and VHL (Virtual Health Library). We used the keywords “perinatal care”, “umbilical cord”, “patient care team”, “neonatology”, “newborn”, in the Portuguese, English and Spanish languages, accompanied by the expression AND and selected through DeCS (Descriptors in Health Sciences). Results: A final sample of 9 articles was obtained from the PubMed and VHL databases, which met the inclusions criteria. It has been found that traditional umbilical stump care practices are still present in many communities, however, have been replaced by appropriate practices, the most recommended being: chlorhexidine 4% sanitation, soap and water and alcohol antisepsis 70%. Conclusions: There is a need for multi-professional involvement, approaching these women since pregnancy, with detailed information and accessible language about proper care with the newborn and the umbilical stump.

Integration of Theory of Constraints Thinking Process and Lean Production for Troubleshooting on a Contractor

The thinking process of TOC （Theory of Constraints） was an important consolidated tool to the systematization of the companies＇ necessities because of its competitive advantage. The lean thinking proposed by Taiichi Ohno and developed by Toyota Company has been tested and found effective in several production processes. This paper aims to propose a method of problem solving through the integration of the principles of lean thinking and the TPTOC （Thinking Process of the Theory of Constraints）. The method was implemented on a civil contractor, using the research methodology and the action research. We concluded that, after the research, the core problem regarding the company is the technical failure of the administrative staff, which causes delay in the construction works and financial loss. We also concluded that the obstacles that could prevent the achievement of objectives are related to lack of a vision from senior management regarding financial return when investing in employee training. The goal was accomplished with the integration of two philosophies, TPTOC and lean. And only the tools proposed by Fl^vio Augusto Picchi were not enough for executing the action, so new lean actions were verbalized.

Retrieving dental instruments through endoscopy: A literature review

Clinical accidents involving dental instruments and materials inside the oral cavity are reported in the medical literature. Specifically, ingestion and aspiration of foreign bodies have greater prevalence in the routine of medicine and dentistry. Despite being less harmful than aspirations, the accidental ingestion of dental instruments does not always culminate in favorable prognoses. Mostly, complex conditions require medical intervention through endoscopy or surgical approaches. The present research aims to review the literature pointing out the specialties of dentistry most involved with accidental ingestion of dental instruments, highlighting the important role of endoscopy for accurately locating and retrieving foreign bodies. Prosthodontics, operative dentistry, orthodontics, and maxillofacial surgery arose as the specialties in which these accidents are more prevalent. Based on that, general dentists and specialists must be aware for the essential care to avoid such clinical accidents, as well as to know the available tools, such as endoscopy, to overcome these situations in the routine of dentistry.

Geoprocessing Applied in the Estimate of Infiltration and Surface Runoff in HPP’s Contribution Watershed

The knowledge of the hydrological regime contributes to the prediction of periods of higher or lower water supply as a function of the frequency and volume of rainfall in relation to the pedological, land cover, and land use conditions. This work aims at evaluating the spatio-temporal variability of the infiltration and runoff potential of an area formed by 4 sub-basins tributary to the São Marcos River in Cristalina (GO). The SCS/NRCS-USDA (2004) method was used, using geoprocessing resources, considering soils in dry, semi-humid and humid conditions. The estimates indicate that rainfall with an average of 6.83 mm, in the September-October transition, in the face of soils in the dry condition does not provide surface runoff. Thus, the variability of pedological characteristics associated with the various conditions of coverage and land use indicates that even the areas with lower infiltration potential begin to contribute effectively with their respective channels in the transition from October to November, when rainfall events are more frequent and significant, and the soils are already in conditions of greater humidity.

Protective Properties in Hymenaea martiana Hayne against Multi-drug-resistant Staphylococcus aureus

Antibiotic resistance represents a widespread problem in milk production.The identification of compounds for a topically applied ointment used in mastitis therapy remains elusive.Compounds from the genus Hymenaea can be administered in cases of multi-drugresistant Staphylococcus aureus infection for ruminant species,but the protective properties are not well known.Wi this research the aim is verify the protective effects of H.martiana against S.aureus infection in bovine mammary epithelial cell line(MAC-T)and to obtain an antioxidant profile evaluation in vitro.The MAC-T cells were challenged with S.aureus after being exposed to the extract of the H.martiana in the protective assay.For the verification of the viability of the MAC-T cells,the MTT assay was performed,and was used dilutions of the plant extract,starting at 2.5%.The extract of H.martiana was evaluated for antioxidant aspect in different dilutions by FRAP,ORAC and DPPH.A variety of flavonoids(quercetin,luteolin,etc.)have been identified as the main components by using mass spectrometry,reinforcing our in vitro findings that flavonoids,especially quercetin,have a medicinal profile capable of killing mastitis-causing bacteria.An excellent antioxidant pattern was observed in the 2.5%solution;however,membrane integrity in MAC-T cells was compromised.Those findings suggest low dilutions of H.martiana extract has a desirable protective effect from S.aureus pathogenesis.Our in vitro studies can be gleaned upon for further in vivo studies.

Influence of Glass Fiber wt% and Silanization on Mechanical Flexural Strength of Reinforced Acrylics

The aim is to evaluate the flexural strength of acrylic resin bars depending on the addiction of glass fibers with or without previous 3-methacryloxypropyl-trimethoxysilane (silane) application. Short fibers (3 mm) were treated and added to an acrylic resin powder, being further mixed with acrylic liquid to create bars (25 × 2 × 2 mm) of 11 experimental groups (N = 10), according to the interaction of experimental factors: weight % of glass fibers: (0.5;1;3;4;6 and 7) and silane application (with silane (S) or without silane (N)). Flexural strength and scanning microscopy evaluation were performed (SEM). Data (MPa) were submitted to ANOVA and Tukey (α = 5%). A significant difference between groups was observed (p = 0.001): S7%(128.85 ± 35.76)a, S6% (119.31 ± 11.97)ab, S4% (116.98 ± 25.23)ab, N4% (107.85 ± 24.88)abc, S1% (96.29 ± 20.65)bc, S0.5% (89.29 ± 7.33)cd, S3% (89.0 ± 11.27)cd, N3% (86.79 ± 17.63)cd, N1% (85.43 ± 16.44)cd, Control (73.29 ± 25.0)de, N0.5% (59.58 ± 19.46)e. For N groups, it was not possible to include more than 4%wt fibers. SEM showed better fiber-resin interaction for S groups, and fractures around fibers on N groups. Previous silane application enables the addiction of greater quantity of glass fibers and better interaction with the acrylic resin resulting in higher flexural strength. Without silane, fibers seem to act as initial crack points due to poor interaction.