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Rising utilization of stable isotopes in tree rings for climate change and forest ecology 被引量:1
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作者 Ru Huang Chenxi Xu +3 位作者 Jussi Grießinger Xiaoyu Feng Haifeng Zhu Achim Bräuning 《Journal of Forestry Research》 SCIE EI CAS CSCD 2024年第1期103-116,共14页
Analyses of stable isotopes(C,O,H)in tree rings are increasingly important cross-disciplinary programs.The rapid development in this field documented in an increasing number of publications requires a comprehensive re... Analyses of stable isotopes(C,O,H)in tree rings are increasingly important cross-disciplinary programs.The rapid development in this field documented in an increasing number of publications requires a comprehensive review.This study includes a bibliometric analysis-based review to better understand research trends in tree ring stable isotope research.Overall,1475 publications were selected from the Web of Science Core Collection for 1974-2023.The findings are that:(1)numbers of annual publications and citations increased since 1974.From 1974 to 1980,there were around two relevant publications per year.However,from 2020 to 2022,this rose sharply to 109 publications per year.Likewise,average article citations were less than four per year before 1990,but were around four per article per year after 2000;(2)the major subjects using tree ring stable isotopes include forestry,geosciences,and environmental sciences,contributing to 42.5%of the total during 1974-2023;(3)the top three most productive institutions are the Chinese Academy of Sciences(423),the Swiss Federal Institute for Forest,Snow and Landscape Research(227),and the University of Arizona(204).These achievements result from strong collaborations;(4)review papers,for example,(Dawson et al.,Annu Rev Ecol Syst 33:507-559,2002)and(McCarroll and Loader,Quat Sci Rev 23:771-801,2004),are among the most cited,with more than 1000 citations;(5)tree ring stable isotope studies mainly focus on climatology and ecology,with atmospheric CO_(2) one of the most popular topics.Since 2010,precipitation and drought have received increasing attention.Based on this analysis,the research stages,key findings,debated issues,limitations and direc-tions for future research are summarized.This study serves as an important attempt to understand the progress on the use of stable isotopes in tree rings,providing scientific guid-ance for young researchers in this field. 展开更多
关键词 Tree rings Stable isotopes Web of Science BIBLIOMETRIC
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Crosstalk among canonical Wnt and Hippo pathway members in skeletal muscle and at the neuromuscular junction
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作者 Said Hashemolhosseini Lea Gessler 《Neural Regeneration Research》 SCIE CAS 2025年第9期2464-2479,共16页
Skeletal muscles are essential for locomotion,posture,and metabolic regulation.To understand physiological processes,exercise adaptation,and muscle-related disorders,it is critical to understand the molecular pathways... Skeletal muscles are essential for locomotion,posture,and metabolic regulation.To understand physiological processes,exercise adaptation,and muscle-related disorders,it is critical to understand the molecular pathways that underlie skeletal muscle function.The process of muscle contra ction,orchestrated by a complex interplay of molecular events,is at the core of skeletal muscle function.Muscle contraction is initiated by an action potential and neuromuscular transmission requiring a neuromuscular junction.Within muscle fibers,calcium ions play a critical role in mediating the interaction between actin and myosin filaments that generate force.Regulation of calcium release from the sarcoplasmic reticulum plays a key role in excitation-contraction coupling.The development and growth of skeletal muscle are regulated by a network of molecular pathways collectively known as myogenesis.Myogenic regulators coordinate the diffe rentiation of myoblasts into mature muscle fibers.Signaling pathways regulate muscle protein synthesis and hypertrophy in response to mechanical stimuli and nutrient availability.Seve ral muscle-related diseases,including congenital myasthenic disorders,sarcopenia,muscular dystrophies,and metabolic myopathies,are underpinned by dys regulated molecular pathways in skeletal muscle.Therapeutic interventions aimed at preserving muscle mass and function,enhancing regeneration,and improving metabolic health hold promise by targeting specific molecular pathways.Other molecular signaling pathways in skeletal muscle include the canonical Wnt signaling pathway,a critical regulator of myogenesis,muscle regeneration,and metabolic function,and the Hippo signaling pathway.In recent years,more details have been uncovered about the role of these two pathways during myogenesis and in developing and adult skeletal muscle fibers,and at the neuromuscular junction.In fact,research in the last few years now suggests that these two signaling pathways are interconnected and that they jointly control physiological and pathophysiological processes in muscle fibers.In this review,we will summarize and discuss the data on these two pathways,focusing on their concerted action next to their contribution to skeletal muscle biology.However,an in-depth discussion of the noncanonical Wnt pathway,the fibro/a dipogenic precursors,or the mechanosensory aspects of these pathways is not the focus of this review. 展开更多
关键词 canonical Wnt"Wingless-related integration site"pathway beta-catenin(CTNNB1) Hippo pathway MYOGENESIS MYOTUBE neuromuscular junction satellite cell skeletal muscle fiber transcriptional co-activator with PDZ-binding motif(TAZ) T-cell-specific transcription factor/lymphoid enhancer-binding factor(TCF/LEF) TEA domain family member(TEAD) transducin-like enhancer of split(TLE) yes-associated protein 1(YAP1)
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Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
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作者 Morten S.Hansen Kaja Madsen +6 位作者 Maria Price Kent Søe Yasunori Omata Mario M.Zaiss Caroline M.Gorvin Morten Frost Alexander Rauch 《Bone Research》 SCIE CAS CSCD 2024年第1期180-198,共19页
Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone formation.As novel antiosteoporotic therapeutic... Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone formation.As novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment targets.This study aimed to provide an overview of transcriptional reprogramming during human osteoclast differentiation.Osteoclasts were differentiated from CD14+monocytes from eight female donors.RNA sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across donors.These patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on RNA from iliac crest biopsies and bone mineral density SNPs.Network analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional networks.The donor-specific expression patterns revealed genes at the monocyte stage,such as filamin B(FLNB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the resorptive activity of mature osteoclasts.The expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density SNPs,suggesting that they play a pivotal role in osteoclast differentiation and activity.The regulatory effects of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(C5AR1),somatostatin receptor 2(SSTR2),and free fatty acid receptor 4(FFAR4/GPR120).Activating C5AR1 enhanced osteoclast formation,while activating SSTR2 decreased the resorptive activity of mature osteoclasts,and activating FFAR4 decreased both the number and resorptive activity of mature osteoclasts.In conclusion,we report the occurrence of transcriptional reprogramming during human osteoclast differentiation and identified SSTR2 and FFAR4 as antiresorptive G-protein coupled receptors and FLNB and LOX-1 as potential molecular markers of osteoclast activity.These data can help future investigations identify molecular regulators of osteoclast differentiation and activity and provide the basis for novel antiosteoporotic targets. 展开更多
关键词 OSTEOCLAST PROGRAMMING identif
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空间飞行微重力降低裸藻光合电子传递并改变光合能量分配(英文) 被引量:1
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作者 李小燕 李根保 +6 位作者 李敦海 郝宗杰 王高鸿 RICHTER R. Peter SCHUSTER Martin LEBERT Michael 刘永定 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2016年第9期887-894,共8页
利用神舟8号飞船的SIMBOX发射机会,对真实微重力影响裸藻光合作用活性进行了研究.我们发现,微重力降低了光合活性(Fv/Fm),提高了细胞内叶绿素a和胡萝卜素含量.快速叶绿素荧光动力学研究显示微重力降低了叶绿素荧光强度,但快速叶绿素荧... 利用神舟8号飞船的SIMBOX发射机会,对真实微重力影响裸藻光合作用活性进行了研究.我们发现,微重力降低了光合活性(Fv/Fm),提高了细胞内叶绿素a和胡萝卜素含量.快速叶绿素荧光动力学研究显示微重力降低了叶绿素荧光强度,但快速叶绿素荧光动力学曲线的形状(O-J-I-P)没有改变.在微重力处理下裸藻的最大光化学效率(φPo)、用于电子传递的量子产额(φEo)和光合作用性能指数(PIABS and PICS)都明显降低,但单位反应中心吸收的光能(ABS/RC)和单位反应中心耗散的能量(DIo/RC)都明显升高.77K低温荧光光谱实现微重力改变了能量在PSⅠ和PSⅡ之间的分配并出现了红移现象.这些结果表明真实微重力降低光合作用的活性有可能通过两个途径,即抑制裸藻抑制光合电子传递中PSⅡ的受体端和改变PSⅠ的结构从而引起流向PSⅠ的能量传递减少. 展开更多
关键词 微重力 光合作用 叶绿素荧光 纤细裸藻 空间飞行
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Highly Sensitive Ultrathin Flexible Thermoplastic Polyurethane/Carbon Black Fibrous Film Strain Sensor with Adjustable Scaffold Networks 被引量:26
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作者 Xin Wang Xianhu Liu Dirk W.Schubert 《Nano-Micro Letters》 SCIE EI CAS CSCD 2021年第4期159-177,共19页
In recently years,high-performance wearable strain sensors have attracted great attention in academic and industrial.Herein,a conductive polymer composite of electrospun thermoplastic polyurethane(TPU)fibrous film mat... In recently years,high-performance wearable strain sensors have attracted great attention in academic and industrial.Herein,a conductive polymer composite of electrospun thermoplastic polyurethane(TPU)fibrous film matrix-embedded carbon black(CB)particles with adjustable scaffold network was fabricated for high-sensitive strain sensor.This work indicated the influence of stereoscopic scaffold network structure built under various rotating speeds of collection device in electrospinning process on the electrical response of TPU/CB strain sensor.This structure makes the sensor exhibit combined characters of high sensitivity under stretching strain(gauge factor of 8962.7 at 155%strain),fast response time(60 ms),outstanding stability and durability(>10,000 cycles)and a widely workable stretching range(0–160%).This high-performance,wearable,flexible strain sensor has a broad vision of application such as intelligent terminals,electrical skins,voice measurement and human motion monitoring.Moreover,a theoretical approach was used to analyze mechanical property and a model based on tunneling theory was modified to describe the relative change of resistance upon the applied strain.Meanwhile,two equations based from this model were first proposed and offered an effective but simple approach to analyze the change of number of conductive paths and distance of adjacent conductive particles. 展开更多
关键词 Strain sensor ELECTROSPINNING Electronic skin Fitting model
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Ni Flower/MXene-Melamine Foam Derived 3D Magnetic/Conductive Networks for Ultra-Efficient Microwave Absorption and Infrared Stealth 被引量:21
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作者 Haoran Cheng Yamin Pan +5 位作者 Xin Wang Chuntai Liu Changyu Shen Dirk W.Schubert Zhanhu Guo Xianhu Liu 《Nano-Micro Letters》 SCIE EI CAS CSCD 2022年第4期142-157,共16页
The development of multifunctional and efficient electromagnetic wave absorbing materials is a challenging research hotspot.Here,the magnetized Ni flower/MXene hybrids are successfully assembled on the surface of mela... The development of multifunctional and efficient electromagnetic wave absorbing materials is a challenging research hotspot.Here,the magnetized Ni flower/MXene hybrids are successfully assembled on the surface of melamine foam(MF)through electrostatic self-assembly and dip-coating adsorption process,realizing the integration of microwave absorption,infrared stealth,and flame retardant.Remarkably,the Ni/MXene-MF achieves a minimum reflection loss(RLmin)of−62.7 dB with a corresponding effective absorption bandwidth(EAB)of 6.24 GHz at 2 mm and an EAB of 6.88 GHz at 1.8 mm.Strong electromagnetic wave absorption is attributed to the three-dimensional magnetic/conductive networks,which provided excellent impedance matching,dielectric loss,magnetic loss,interface polarization,and multiple attenuations.In addition,the Ni/MXene-MF endows low density,excellent heat insulation,infrared stealth,and flame-retardant functions.This work provided a new development strategy for the design of multifunctional and efficient electromagnetic wave absorbing materials. 展开更多
关键词 Ni-MXene/Melamine foam Microwave absorption Heat insulation Infrared stealth FLAME-RETARDANT
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Chronic peripheral inflammation: a possible contributor to neurodegenerative diseases 被引量:4
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作者 Patrick Süβ Addison J.Lana Johannes C.M.Schlachetzki 《Neural Regeneration Research》 SCIE CAS CSCD 2021年第9期1711-1714,共4页
The contribution of chronic peripheral inflammation to the pathogenesis of neurodegenerative diseases is an outstanding question. Sustained activation of the peripheral innate and adaptive immune systems occurs in the... The contribution of chronic peripheral inflammation to the pathogenesis of neurodegenerative diseases is an outstanding question. Sustained activation of the peripheral innate and adaptive immune systems occurs in the context of a broad array of disorders ranging from chronic infectious diseases to autoimmune and metabolic diseases. In addition, progressive systemic inflammation is increasingly recognized during aging. Peripheral immune cells could potentially modulate the cellular brain environment via the secretion of soluble molecules. There is an ongoing debate whether peripheral immune cells have the potential to migrate into the brain under certain permissive circumstances. In this perspective, we discuss the possible contribution of chronic peripheral inflammation to the pathogenesis of age-related neurodegenerative diseases with a focus on microglia, the resident immune cells of the brain parenchyma. 展开更多
关键词 aging Alzheimer's disease INFLAMMATION innate immune system MICROGLIA NEURODEGENERATION Parkinson's disease
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Estrogen-mediated downregulation of HIF-1αsignaling in B lymphocytes influences postmenopausal bone loss 被引量:7
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作者 Xianyi Meng Zhen Lin +11 位作者 Shan Cao Iga Janowska Koshiro Sonomoto Darja Andreev Knab Katharina Jinming Wen Karl Xaver Knaup Michael Sean Wiesener Gerhard Krönke Marta Rizzi Georg Schett Aline Bozec 《Bone Research》 SCIE CAS CSCD 2022年第2期326-337,共12页
In the bone marrow, B cells and bone-resorbing osteoclasts colocalize and form a specific microenvironment. How B cells functionally influence osteoclasts and bone architecture is poorly understood. Using genetically ... In the bone marrow, B cells and bone-resorbing osteoclasts colocalize and form a specific microenvironment. How B cells functionally influence osteoclasts and bone architecture is poorly understood. Using genetically modified mice and highthroughput analyses, we demonstrate that prolonged HIF-1α signaling in B cells leads to enhanced RANKL production and osteoclast formation. In addition, deletion of HIF-1α in B cells prevents estrogen deficiency-induced bone loss in mice.Mechanistically, estrogen controls HIF-1α protein stabilization through HSP70-mediated degradation in bone marrow B cells.The stabilization of HIF-1α protein in HSP70-deficient bone marrow B cells promotes RANKL production and osteoclastogenesis.Induction of HSP70 expression by geranylgeranylacetone(GGA) administration alleviates ovariectomy-induced osteoporosis.Moreover, RANKL gene expression has a positive correlation with HIF1 A expression in human B cells. In conclusion, HIF-1αsignaling in B cells is crucial for the control of osteoclastogenesis, and the HSP70/HIF-1α axis may serve as a new therapeutic target for osteoporosis. 展开更多
关键词 MEDIATED LYMPHOCYTES stabilization
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Comparison of Hemospray~? and Endoclot? for the treatment of gastrointestinal bleeding 被引量:2
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作者 Francesco Vitali Andreas Naegel +5 位作者 Raja Atreya Steffen Zopf Clemens Neufert Juergen Siebler Markus F Neurath Timo Rath 《World Journal of Gastroenterology》 SCIE CAS 2019年第13期1592-1602,共11页
BACKGROUND Gastrointestinal(GI) bleeding is a common indication for endoscopy. For refractory cases, hemostatic powders(HP) represent "touch-free" agents.AIM To analyze short term(ST-within 72 h-) and long-t... BACKGROUND Gastrointestinal(GI) bleeding is a common indication for endoscopy. For refractory cases, hemostatic powders(HP) represent "touch-free" agents.AIM To analyze short term(ST-within 72 h-) and long-term(LT-within 30 d-) success for achieving hemostasis with HP and to directly compare the two agents Hemospray(HS) and Endoclot(EC).METHODS HP was applied in 154 consecutive patients(mean age 67 years) with GI bleeding.Patients were followed up for 1 mo(mean follow-up: 3.2 mo).RESULTS Majority of applications were in upper GI tract(89%) with following bleeding sources: peptic ulcer disease(35%), esophageal varices(7%), tumor bleeding(11.7%), reflux esophagitis(8.7%), diffuse bleeding and erosions(15.3%). Overall ST success was achieved in 125 patients(81%) and LT success in 81 patients(67%). Re-bleeding occurred in 27% of all patients. In 72 patients(47%), HP was applied as a salvage hemostatic therapy, here ST and LT success were 81% and64%, with re-bleeding in 32%. As a primary hemostatic therapy, ST and LT success were 82% and 69%, with re-bleeding occurring in 22%. HS was more frequently applied for upper GI bleeding(P = 0.04)CONCLUSION Both HP allow for effective hemostasis with no differences in ST, LT success and re-bleeding. 展开更多
关键词 Hemostatic POWDER GASTROINTESTINAL BLEEDING Hemospray Endoclot HAEMOSTASIS
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Detecting abrupt change in land cover in the eastern Hindu Kush region using Landsat time series(1988-2020) 被引量:1
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作者 Saeed A.KHAN Kim A.VANSELOW +1 位作者 Oliver SASS Cyrus SAMIMI 《Journal of Mountain Science》 SCIE CSCD 2022年第6期1699-1716,共18页
Land cover change in the semi-arid environment of the eastern Hindu Kush region is driven by anthropogenic activities and environmental change impacts. Natural hazards, such as floods presumably influenced by climatic... Land cover change in the semi-arid environment of the eastern Hindu Kush region is driven by anthropogenic activities and environmental change impacts. Natural hazards, such as floods presumably influenced by climatic change, cause abrupt change of land cover. So far, little research has been conducted to investigate the spatiotemporal aspects of this abrupt change in the valleys. In order to explore the abrupt change in land cover and floods as its possible drivers in the eastern Hindu Kush, a semi-arid mountain region characterized by complex terrain, vegetation variation, and precipitation seasonality, we analyzed long-term Landsat image time series from 1988 to 2020 using Breaks For Additive Seasonal and Trend(BFAST). Overall, BFAST effectively detected abrupt change by using Landsat-derived Modified Soil Adjusted Vegetation Index(MSAVI). The results of our study indicate that approximately 95% of the study area experienced at least one abrupt change during 1988-2020. The years 1991, 1995, 1998, 2007, and 2016 were detected as the peak years, with the peaks occurring in different seasons. The annual trend of abrupt change is decreasing for the study area. The seasonality of abrupt change at the catchment level shows an increasing trend in the spring season for the southern catchments of Panjkora and Swat. The spatial distribution patterns show that abrupt change is primarily concentrated in the floodplains indicating that flooding is the primary driver of the land cover change in the region. We also demonstrated the accurate detection of past flood events(2015) based on the two case examples of Ayun, Rumbur, and Kalash valleys. The detection of the flood events was verified by fieldwork and historical high-resolution Google Earth imagery. Finally, our study provides an example of applying Landsat time series in a dry mountain region to detect abrupt changes in land cover and analyze impact of natural hazards such as floods. 展开更多
关键词 Land cover change Floods Natural hazards BFAST Chitral Pakistan
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气溶胶喷印在精细电子印刷中的应用 被引量:1
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作者 Christian Goth Sonja Putzo +1 位作者 Joerg Franke 王晓芳 《中国印刷与包装研究》 CAS 2013年第2期76-80,共5页
三维模塑互连器件(3D—MID)技术是指在注塑成型的塑料壳体的表面上,制作具有电气功能的三维立体电路及互联器件的技术。激光直接成型(LDS)技术是制造3D—MID的一种新型、经济的工艺技术。采用LDS技术制造3D—MID的工艺流程主要分... 三维模塑互连器件(3D—MID)技术是指在注塑成型的塑料壳体的表面上,制作具有电气功能的三维立体电路及互联器件的技术。激光直接成型(LDS)技术是制造3D—MID的一种新型、经济的工艺技术。采用LDS技术制造3D—MID的工艺流程主要分为三步:①注塑成型,采用可激光活化的改性塑料为原料,用普通的注塑成型技术注射出塑料本体;②激光活化,采用聚焦激光束照射到塑料表面需要制作导电图形的部位,活化、粗糙图形部位的表面;③金属镀覆,用化学方法将导电金属沉积到被激光活化的图形表面,从而实现在三维塑料上制造导电图形,形成互连器件。 展开更多
关键词 气溶胶 成型技术 改性塑料 注塑成型 应用 印刷 电子 工艺流程
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Retrograde inspection vs standard forward view for the detection of colorectal adenomas during colonoscopy: A back-to-back randomized clinical trial 被引量:1
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作者 Timo Rath Lukas Pfeifer +5 位作者 Clemens Neufert Andreas Kremer Moritz Leppkes Arthur Hoffman Markus F Neurath Steffen Zopf 《World Journal of Gastroenterology》 SCIE CAS 2020年第16期1962-1970,共9页
BACKGROUND The adenoma detection rate(ADR)is inversely associated with the incidence of interval colorectal cancer and serves as a benchmark quality criterion during screening colonoscopy.However,adenoma miss rates re... BACKGROUND The adenoma detection rate(ADR)is inversely associated with the incidence of interval colorectal cancer and serves as a benchmark quality criterion during screening colonoscopy.However,adenoma miss rates reach up to 26%and studies have shown that a second inspection of the right colon in retroflected view(RFV)can increase ADR.AIM To assess whether inspection of the whole colon in RFV compared to standard forward view(SFV)can increase ADR.METHODS Patients presenting for screening or surveillance colonoscopy were invited to participate in this randomized controlled trial and randomized into two arms.In RFV arm colonoscopy was initially performed with SFV,followed by a second inspection of the whole colon in RFV.In the SFV arm first withdrawal was performed with SFV,followed by a second inspection of the whole colon again with SFV.Number,size and morphology of polyps found during first and second inspection in each colonic segment were recorded and all polyps were removed and sent for histopathology in separate containers.RESULTS Two hundred and five patients were randomly assigned to the RFV(n=101)and SFV(n=104)arm.In the RFV arm,both polyp detection rate(PDR)and ADR were increased under second inspection in RFV(PDR 1st SFV:39.8%,PDR 2nd RFV:46.6%;ADR 1st SFV:35.2%,ADR 2nd RFV:42%).Likewise,in the SFV arm,PDR and ADR were increased under second inspection(PDR 1st SFV:37.5%,PDR 2nd SFV:46.6%;ADR 1st SFV:34.1%,ADR 2nd SFV:44.3%)with no significant differences in ADR and PDR between the SFV and RFV arm.Mean number of adenomas per patient(APP)was increased in the RFV and SFV(APP RFV arm:1st SFV:1.71;2nd RFV:2.38;APP SFV arm:1st SFV:1.83,2nd SFV:2.2).The majority of adenomas additionally found during second inspection in RFV or in SFV were located in the transverse and left-sided colon and were>5 mm in size.CONCLUSION Second inspection of the whole colon leads to increased adenoma detection with no differences between SFV and RFV.Hence,increased detection is most likely a feature of the second inspection itself but not of the inspection mode. 展开更多
关键词 COLORECTAL cancer ADENOMA ADENOMA DETECTION rate COLONOSCOPY
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Correction to: Ni Flower/MXene-Melamine Foam Derived 3D Magnetic/Conductive Networks for Ultra-Efficient Microwave Absorption and Infrared Stealth 被引量:1
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作者 Haoran Cheng Yamin Pan +5 位作者 Xin Wang Chuntai Liu Changyu Shen Dirk W.Schubert Zhanhu Guo Xianhu Liu 《Nano-Micro Letters》 SCIE EI CAS CSCD 2022年第7期177-178,共2页
The original version of this article unfortunately contained some mistakes.The corrections are updated as follows:Error 1:We found that Equations 3,4 and 6 were wrong in the published paper:Error 2:In the page 7,“Sin... The original version of this article unfortunately contained some mistakes.The corrections are updated as follows:Error 1:We found that Equations 3,4 and 6 were wrong in the published paper:Error 2:In the page 7,“Since N Ni/MXene-MF possessed numer-ous heterogeneous interfaces and abundant functional groups,the dielectric loss mechanism was explored.” 展开更多
关键词 INFRARED CORRECTION DIELECTRIC
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Virtual Anatomy: The Dissecting Theatre of the Future—Implementation of Cinematic Rendering in a Large 8 K High-Resolution Projection Environment 被引量:1
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作者 Franz A. Fellner Klaus Engel Christoph Kremer 《Journal of Biomedical Science and Engineering》 2017年第8期367-375,共9页
Modern computer techniques have been in use for several years to generate three-dimensional visualizations of human anatomy. Very good 3-D computer models of the human body are now available and used routinely in anat... Modern computer techniques have been in use for several years to generate three-dimensional visualizations of human anatomy. Very good 3-D computer models of the human body are now available and used routinely in anatomy instruction. These techniques are subsumed under the heading “virtual anatomy” to distinguish them from the conventional study of anatomy entailing cadavers and anatomy textbooks. Moreover, other imaging procedures (X-ray, angiography, CT and MR) are also used in virtual anatomy instruction. A recently introduced three-dimensional post-processing technique named Cinematic Rendering now makes it possible to use the output of routine CT and MR examinations as the basis for highly photo-realistic 3-D depictions of human anatomy. We have installed Cinematic Rendering (enabled for stereoscopy) in a high-definition 8K 3-D projection space that accommodates an audience of 150. The space’s projection surface measures 16 × 9 meters;images can be projected on both the front wall and the floor. A game controller can be used to operate Cinematic Rendering software so that it can generate interactive real-time depictions of human anatomy on the basis of CT and MR data sets. This prototype installation was implemented without technical problems;in day-to-day, real-world use over a period of 22 months, there were no impairments of service due to software crashes or other technical problems. We are already employing this installation routinely for educational offerings open to the public, courses for students in the health professions, and (continuing) professional education units for medical interns, residents and specialists—in, so to speak, the dissecting theater of the future. 展开更多
关键词 Virtual Anatomy Education CINEMATIC RENDERING (CR) Volume RENDERING (VR) HIGH-RESOLUTION 3D Display COMPUTED Tomography (CT) Magnetic Resonance (MR)
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Large Scale Mass Movements Triggered by the Kashmir Earthquake 2005,Pakistan
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作者 Muhammad BASHARAT Joachim ROHN +2 位作者 Mirza Shahid BAIG Muhammad Rustam KHAN Markus SCHLEIER 《Journal of Mountain Science》 SCIE CSCD 2014年第1期19-30,共12页
The SPOT image analysis in Muzaffarabad Azad Kashmir,northwest Himalayas,Pakistan reveals that the Kashmir earthquake 2005 triggered a number of coseismic mass movements along the hanging wall block of the Muzaffaraba... The SPOT image analysis in Muzaffarabad Azad Kashmir,northwest Himalayas,Pakistan reveals that the Kashmir earthquake 2005 triggered a number of coseismic mass movements along the hanging wall block of the Muzaffarabad Fault.The Neelidandi and Langarpura rock falls have been identified as two major reactivated mass movements with an estimated volume of 3.1 × 106m3and 5.76 × 106m3,respectively.The Neelidandi and Langarpura mass movements were initiated during earthquake in the direction of northwest-southeast extension and northeastsouthwest directed thrusting,respectively.The Neelidandi rock fall occurred in sheared cherty dolomites and limestones of the Cambrian Muzaffarabad Formation,whereas the Langarpura rock fall occurred in alternating clays,shales,claystones,siltstones and sandstones of the Miocene Murree Formation.These rock units along the fault are highly fractured and jointed.The geotechnical maps and geological longitudinal profiles show the relationship between the geometrical characteristics and mechanism of these mass movements.Their characteristics were analyzed according to the role of topographic,seismic,geological and tectonic factors.The steep topography,sheared rocks,lithology,coseismic uplift and strong ground shaking of the hanging wall block along Muzaffarabad Fault facilitated the gravity collapse of these mass movements. 展开更多
关键词 COSEISMIC mass movements HIMALAYAS Muzaffarabad Fault GEOLOGICAL and TECTONIC factors EARTHQUAKE Rock FALL
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CT and MR Imaging Findings in the Joubert Syndrome,a“Ciliopathy” 被引量:1
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作者 Kaveh Akbari Christine M.Fellner +1 位作者 Daniel Flory Franz A.Fellner 《Journal of Biomedical Science and Engineering》 2015年第10期695-699,共5页
A 7-year-old boy presented with cerebellar ataxia with reduced tonicity, deficits of the fine and gross motor coordination skills and vestibular stimulus processing, as well as significantly delayed language developme... A 7-year-old boy presented with cerebellar ataxia with reduced tonicity, deficits of the fine and gross motor coordination skills and vestibular stimulus processing, as well as significantly delayed language development. MR imaging showed the so-called “molar tooth sign”, which was highly pathognomonic for the Joubert-Syndrome—an inherited cerebellar ataxia with a variety of clinical symptoms—and related entities. It is caused by a complex malformation of the cerebellar vermis and the midbrain. The cerebellar vermis is hypoplastic or completely absent;at the same time, the superior cerebellar peduncles are thickened. There is a lack of normal decussation of the fiber tracts in mesencephalon, which follow an abnormal horizontal course, as well as a lack of the decussation of the corticospinal fiber tracts in the caudal medulla oblongata and deformity of the 4th ventricle. Clinically, the triad of cerebellar ataxia, developmental retardation, and abnormal eye movements is indicating a related syndrome of this spectrum. The appearance of the involved children is characterized by dysmorphic facial features with epicanthus, broad nose bridge, low set ears and typically triangularly shaped and opened mouth. The diagnosis is usually made by imaging and clinical findings. Recently, advantages were made in genetic research on the Joubert syndrome and interesting findings published about diffusion tensor imaging and tractography. However, standard MR imaging, applying an adequate imaging protocol including sequences with excellent T1 contrast and 3D imaging with isotropic spatial resolution allowing reconstructions in all orientations, remains an essential tool for making this diagnosis. 展开更多
关键词 Joubert Syndrome CILIOPATHY Cerebellar Ataxia Molar Tooth Sign Magnetic Resonance(MR)Imaging
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Jejunitis and brown bowel syndrome with multifocal carcinogenesis of the small bowel
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作者 Martin Raithel Tilman T Rau +4 位作者 Alexander F Hagel Heinz Albrecht Thomas de Rossi Thomas Kirchner Eckhart G Hahn 《World Journal of Gastroenterology》 SCIE CAS 2015年第36期10461-10467,共7页
This is the first report describing a case where prolonged,severe malabsorption from brown bowel syndrome progressed to multifocally spread small bowel adenocarcinoma. This case involves a female patient who was initi... This is the first report describing a case where prolonged,severe malabsorption from brown bowel syndrome progressed to multifocally spread small bowel adenocarcinoma. This case involves a female patient who was initially diagnosed with chronic jejunitis associated with primary diffuse lymphangiectasia at the age of 26 years. The course of the disease was clinically,endoscopically,and histologically followed for 21 years until her death at the age 47 due to multifocal,metastasizing adenocarcinoma of the small bowel. Multiple lipofuscin deposits(so-called brown bowel syndrome) and severe jejunitis were observed microscopically,and sections of the small bowel showed dense lymphoplasmacytic infiltration of the lamina propria as well as blocked lymphatic vessels. After several decades,multifocal nests of adenocarcinoma cells and extensive,flat,neoplastic mucosal proliferations were found only in the small bowel,along with a loss of the mismatch repair protein MLH1 as a long-term consequence of chronic jejunitis with malabsorption. No evidence was found for hereditary nonpolyposis colon carcinoma syndrome. This article demonstrates for the first time multifocal carcinogenesis in the small bowel in a malabsorption syndrome in an enteritis-dysplasia-carcinoma sequence. 展开更多
关键词 BROWN BOWEL SYNDROME CARCINOGENESIS of the small b
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Domain Decomposition of an Optimal Control Problem for Semi-Linear Elliptic Equations on Metric Graphs with Application to Gas Networks
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作者 Günter Leugering 《Applied Mathematics》 2017年第8期1074-1099,共26页
We consider optimal control problems for the flow of gas in a pipe network. The equations of motions are taken to be represented by a semi-linear model derived from the fully nonlinear isothermal Euler gas equations. ... We consider optimal control problems for the flow of gas in a pipe network. The equations of motions are taken to be represented by a semi-linear model derived from the fully nonlinear isothermal Euler gas equations. We formulate an optimal control problem on a given network and introduce a time discretization thereof. We then study the well-posedness of the corresponding time-discrete optimal control problem. In order to further reduce the complexity, we consider an instantaneous control strategy. The main part of the paper is concerned with a non-overlapping domain decomposition of the semi-linear elliptic optimal control problem on the graph into local problems on a small part of the network, ultimately on a single edge. 展开更多
关键词 Optimal Control Gas Networks Euler’s Equation HIERARCHY of Models SEMI-LINEAR APPROXIMATION Non-Overlapping DOMAIN DECOMPOSITION
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Analysis of Electronic Circuits with the Signal Flow Graph Method
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作者 Feim Ridvan Rasim Sebastian M. Sattler 《Circuits and Systems》 2017年第11期261-274,共14页
In this work a method called “signal flow graph (SFG)” is presented. A signal-flow graph describes a system by its signal flow by directed and weighted graph;the signals are applied to nodes and functions on edges. ... In this work a method called “signal flow graph (SFG)” is presented. A signal-flow graph describes a system by its signal flow by directed and weighted graph;the signals are applied to nodes and functions on edges. The edges of the signal flow graph are small processing units, through which the incoming signals are processed in a certain form. In this case, the result is sent to the outgoing node. The SFG allows a good visual inspection into complex feedback problems. Furthermore such a presentation allows for a clear and unambiguous description of a generating system, for example, a netview. A Signal Flow Graph (SFG) allows a fast and practical network analysis based on a clear data presentation in graphic format of the mathematical linear equations of the circuit. During creation of a SFG the Direct Current-Case (DC-Case) was observed since the correct current and voltage directions was drawn from zero frequency. In addition, the mathematical axioms, which are based on field algebra, are declared. In this work we show you in addition: How we check our SFG whether it is a consistent system or not. A signal flow graph can be verified by generating the identity of the signal flow graph itself, illustrated by the inverse signal flow graph (SFG&minus;1). Two signal flow graphs are always generated from one circuit, so that the signal flow diagram already presented in previous sections corresponds to only half of the solution. The other half of the solution is the so-called identity, which represents the (SFG&minus;1). If these two graphs are superposed with one another, so called 1-edges are created at the node points. In Boolean algebra, these 1-edges are given the value 1, whereas this value can be identified with a zero in the field algebra. 展开更多
关键词 ANALOG FEEDBACK Network Theory SYMBOLIC ANALYSIS Signal Flow GRAPH TRANSFER Function
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Numerical Simulation of Foaming Processes
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作者 Katharina Gladbach Antonio Delgado Cornelia Rauh 《World Journal of Mechanics》 2017年第11期297-322,共26页
The literature model studied in this article describes bubble formation and growth in a highly viscous polymer liquid with support of a gaseous matter dispersed under pressure before foaming. The foam growth is induce... The literature model studied in this article describes bubble formation and growth in a highly viscous polymer liquid with support of a gaseous matter dispersed under pressure before foaming. The foam growth is induced by the application of vacuum and mass transport of volatile components dissolved in the polymer liquid. Based on this literature model, aeration processes are calculated for intermediate viscosity and low viscosity biological systems, as they are of interest for biomatter foams, in particular for food foams in industrial processes. At the end of this article, the numerical results are presented and discussed. 展开更多
关键词 FOAMING Process CONSERVATION EQUATIONS Finite DIFFERENCE Method Convergence Analysis REYNOLDS Number NEWTONIAN Liquids
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