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SARS尸检的肺部病理改变 被引量:17
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作者 陈杰 谢永强 +8 位作者 张宏图 万建伟 王德田 卢朝辉 王青峙 薛新华 司文学 罗玉风 邱红梅 《中国医学科学院学报》 CAS CSCD 北大核心 2003年第3期360-362,T005,共4页
目的通过研究严重急性呼吸综合征(severeacuterespiratorysyndrome,SARS)患者的尸检肺部标本,总结SARS的肺部病变特点及发病机制。方法详细检查SARS患者肺脏标本的大体特点,并用常规方法研究显微光镜下SARS累及各肺叶的病变特点。结果7... 目的通过研究严重急性呼吸综合征(severeacuterespiratorysyndrome,SARS)患者的尸检肺部标本,总结SARS的肺部病变特点及发病机制。方法详细检查SARS患者肺脏标本的大体特点,并用常规方法研究显微光镜下SARS累及各肺叶的病变特点。结果7例SARS患者的双肺均明显膨胀,镜下表现以弥漫性肺泡损伤(DAD)不同时期的病变为主。7例均有肺水肿及透明膜形成,肺水肿尤以早期明显。病程超过3周者开始有肺泡内机化及肺间质纤维化,造成肺泡的纤维性闭塞。几乎每例都可见到小血管内的微血栓和肺出血、散在的小叶性肺炎、肺泡上皮脱落、增生等病变。2例可见曲霉菌感染,1例累及左全肺及右肺部分区域,1例出现在肺门淋巴结。肺门淋巴结多表现为充血、出血及淋巴组织减少,窦组织细胞增多。结论SARS肺可能为SARS病毒造成的弥漫性肺泡损伤,表现为肺泡上皮及毛细血管的严重损伤导致肺水肿和肺泡及细支气管的纤维素性渗出性炎症,出现透明膜,继而出现肺泡内机化及肺泡间隔的成纤维细胞增生,共同使肺泡萎陷、机化,最终形成纤维化实变。肺门淋巴组织的减少可能是此病影响免疫系统的又一形态学表现。 展开更多
关键词 严重急性呼吸综合征 病理改变
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脂多糖致衰老大鼠急性肺损伤及心肌组织ATP酶等的变化 被引量:3
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作者 张健 杜烨玮 +1 位作者 孙仁宇 王士雯 《中国医学科学院学报》 CAS CSCD 北大核心 2003年第3期320-323,共4页
目的观察给衰老大鼠静脉或左心室内注入脂多糖(lipopolysaccharide,LPS)后,是否发生急性肺损伤(acutelunginjury,ALI)以及心肌组织ATP酶等的改变情况。方法雄性Wistar大鼠40只复制成衰老模型。然后随机分成对照组(静脉注射生理盐水,n=8)... 目的观察给衰老大鼠静脉或左心室内注入脂多糖(lipopolysaccharide,LPS)后,是否发生急性肺损伤(acutelunginjury,ALI)以及心肌组织ATP酶等的改变情况。方法雄性Wistar大鼠40只复制成衰老模型。然后随机分成对照组(静脉注射生理盐水,n=8),ALI组(静脉注射5mg/kg体重LPS,n=16),及LPS组(左心室内注入相同剂量LPS,n=16)。注射后2h或6h收集血并取肺、心。制备肺、心组织匀浆。测肺湿/干重量比,用比色法测定蛋白、乳酸(LA)、一氧化氮(NO)和丙二醛(MDA)含量以及谷胱甘肽过氧化物酶(GSH-PX)、Na+-K+-ATPase和Ca2+-Mg2+-ATPase活性。结果ALI组大鼠在静脉注射LPS后2h,肺泡灌洗液中蛋白含量及肺湿/干重量比显著升高(P<0.01);血中LA、NO2-/NO3-和MDA含量也显著升高(P<0.01);同时,肺组织中NO2-/NO3-含量显著升高(P<0.01),而GSH-PX及Na+-K+-ATPase活性均显著下降(P<0.01)。上述变化持续至注射后6h时。但在心肌组织中,直至注射LPS后6h才出现MDA含量的显著升高(P<0.01),和GSH-PX、Na+-K+-ATPase及Ca2+-Mg2+-ATPase活性的显著下降(P<0.01)。而在LPS组,注射LPS后2h的血和2h、6h时的肺组织NO2-/NO3-含量均显著升高(P<0.05);注射后2h时肺组织中Na+-K+-ATPase活性显著下降(P<0.05)。其它指标无显著改变。结论给衰老大鼠静脉注? 展开更多
关键词 急性肺损伤 脂多糖 心肌受损 衰老
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Off-pump coronary artery bypass grafting versus on-pump coronary artery bypass grafting: which is better in patients with chronic obstructive pulmonary disease? 被引量:9
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作者 朱亚彬 许建屏 +3 位作者 刘志勇 杨丹宁 李旭东 李鸿雁 《Journal of Zhejiang University Science》 CSCD 2004年第8期1005-1008,共4页
To evaluate the clinic outcome of off-pump coronary bypass grafting (OPCABG) of patients with coronary heart disease and chronic obstructive pulmonary disease, we collected and analyzed 1998-2002 data on 28 patients w... To evaluate the clinic outcome of off-pump coronary bypass grafting (OPCABG) of patients with coronary heart disease and chronic obstructive pulmonary disease, we collected and analyzed 1998-2002 data on 28 patients with these two diseases who had received off-pump coronary bypass operation in our hospital, and compared with data on those who also had the same two diseases but received on-pump coronary artery bypass at same time. There were no operation-related death;one died of respiratory failure 14 days after operation while staying in hospital; there were more respiratory complications in the conventional coronary artery bypass grafting group (CCABG) than in the OPCABG group; and the PaO2/FiO2 in the CCABG group was higher than that in the OPCABG group during operation because of CPB, but lower than that in the OPCABG group 6-12 hours after operation. OPCABG seemed more suitable than CCABG for coronary artery disease patients with chronic obstructive pulmonary disease due to less damage to their oxygen-exchange capability and the fewer respiratory complications. 展开更多
关键词 Chronic obstructive pulmonary disease Coronary artery heart disease Off-pump bypass On-pump bypass Respiratory function
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Clinical features of probable severe acute respiratory syndrome in Beijing 被引量:1
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作者 Hai-YingLu Xiao-YuanXu +5 位作者 YuLei Yang-FengWu Bo-WenChen FengXiao Gao-QiangXie De-MinHan 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第19期2971-2974,共4页
AIM: To summarize clinical features of probable severe acute respiratory syndrome (SARS) in Beijing.METHODS: Retrospective cases involving 801 patients admitted to hospitals in Beijing between March and June 2003, wit... AIM: To summarize clinical features of probable severe acute respiratory syndrome (SARS) in Beijing.METHODS: Retrospective cases involving 801 patients admitted to hospitals in Beijing between March and June 2003, with a diagnosis of probable SARS, moderate type.The series of clinical manifestation, laboratory and radiograph data obtained from 801 cases were analyzed. RESULTS: One to three days after the onset of SARS, the major clinical symptoms were fever (in 88.14% of patients), fatigue, headache, myalgia, arthralgia (25-36%), etc. The counts of WBC (in 22.56% of patients) lymphocyte (70.25%)and CD3, CD4, CD8 positive T cells (70%) decreased. From 4-7 d, the unspecific symptoms became weak; however, the rates of low respiratory tract symptoms, such as cough (24.18%), sputum production (14.26%), chest distress (21.04%) and shortness of breath (9.23%) increased, so did the abnormal rates on chest radiograph or CT. The low counts of WBC, lymphocyte and CD3, CD4, CD8 positiveT cells touched bottom. From 8 to 16 d, the patients presented progressive cough (29.96%), sputum production (13.09%), chest distress (29.96%) and shortness of breath (35.34%). All patients had infiltrates on chest radiograph or CT, some even with multi-infiltrates. Two weeks later, patients' respiratory symptoms started to alleviate, the infiltrates on the lung began to absorb gradually, the counts of WBC, lymphocyte and CD3, CD4, CD8 positive T cells were restored to normality.CONCLUSION: The data reported here provide evidence that the course of SARS could be divided into four stages, namely the initial stage, progressive stage, fastigium and convalescent stage. 展开更多
关键词 SARS Clinical features Clinical stage
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Impact of operator experience and volume on outcomes after left main coronary artery percutaneous coronary intervention 被引量:10
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作者 Changdong Guan Bo Xu +7 位作者 Yuejin Yang Shubin Qiao Yongjian Wu Jue Chen Haibo Liu Jilin Chen Runlin Gao Philippe Genereux 《中国循环杂志》 CSCD 北大核心 2016年第z1期-,共1页
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Difference of urine-derived human induced pluripotent stem cells to alveolar typeⅡepithelial cells 被引量:7
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作者 Chen Wang Zhihai Ju +1 位作者 Jie Yu Feilong Hei 《中国循环杂志》 CSCD 北大核心 2016年第z1期-,共1页
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RADIOFREQUENCY ABLATION OF IDIOPATHIC RIGHT VENTRICULAR TACHYCARDIA
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作者 华伟 JituBohra 《Chinese Medical Sciences Journal》 CAS CSCD 1998年第1期37-41,共5页
This paper presents our experience with radioreqencey ablation (RFA) for idiopathic ventricular tachycardia (VT) arising from right ventricle in 12 patients (pts.). The age range of patients was 21-50, with a mean of ... This paper presents our experience with radioreqencey ablation (RFA) for idiopathic ventricular tachycardia (VT) arising from right ventricle in 12 patients (pts.). The age range of patients was 21-50, with a mean of 38.5 years. Ten out of 12 were females, 1 patient had candia failure due to almost incessant VT while the rest had normal left ventricular function. Twelve pts had VT arising from the right ventricle; of those, 9 were from the outflow truct, 2 from the RV apex, and 1 from the RV inflow. In all pts the diagnostic study and therapeutic RFA were combined in a single procedure. Pacemapping and local activition time were used to guide the site of RFA in pts with VT arising from the right ventricle. RFA was successful in 11 of the 12 pts(91 % ). Number of RF applications were 1 -27, mean 9. 6;fluo- roscopy time were 4-75, mean 26. 9 minutes. RFA for idiopathic RV has a high success rate. This mode of treatment should be considered as a nonpharmacological curative treatment for symptomatic pts. 展开更多
关键词 radiofrequency ablation idiopathic VT right ventricle
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Association between angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral vascular disease:a meta-analysis 被引量:1
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作者 Chao Han Xikun Han +1 位作者 Dongfeng Gu Jianfeng Huang 《中国循环杂志》 CSCD 北大核心 2016年第z1期-,共1页
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Central aortic pressure responses to low-sodium diet among residents in northern rural China 被引量:1
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作者 Xiaolong Xing Chen Huang Jianfeng Huang 《中国循环杂志》 CSCD 北大核心 2016年第z1期-,共1页
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Combined use of atorvastatin and atorvastatin-pretreated mesenchymal stem cells improves the cardiac performance after acute myocardial infarction by targeting CXCL-12/CXCR4 axis 被引量:1
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作者 Xiaqiu Tian Yuejin Yang +1 位作者 Qing Li Peisen Huang 《中国循环杂志》 CSCD 北大核心 2016年第z1期-,共1页
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Freetriiodothyroninelevel correlates with myocardial perfusion/metabolism abnormalities in idiopathic dilated cardiomyopathy:evidence from cardiac 99mTc-MIBI SPECT/18F-FDG PET imaging 被引量:1
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作者 Shimin An Wenyao Wang +5 位作者 Kuo Zhang Siyuan Wang Jing Chen Xuan Zhang Wei Fang Yida Tang 《中国循环杂志》 CSCD 北大核心 2016年第z1期-,共1页
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The expression of IGF1 signaling related proteins and its clinical significance in hypertrophic cardiomyopathy
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作者 Shijie Li Changsheng Zhu +2 位作者 Shuiyun Wang Jizheng Wang Lei Song 《中国循环杂志》 CSCD 北大核心 2016年第z1期-,共1页
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Antithrombotic strategy and prognostic study for post-PCI patients with atrial fibrillation
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作者 Xun Yuan Wenyao Wang +1 位作者 Kuo Zhang Yida Tang 《中国循环杂志》 CSCD 北大核心 2016年第z1期-,共1页
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Ascending aorta dilation protects against coronary artery disease in aortic valvulopathy patient with tricuspid not bicuspid valve
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作者 Xinshuang Ren Kun Liu +6 位作者 Zhe Zheng Zhihui Hou Yang Gao Weihua Yin Zhennan Li Xuejing Duan Bin Lv 《中国循环杂志》 CSCD 北大核心 2016年第z1期-,共1页
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Safety and efficacy of a novel abluminal groove-filled biodegradable polymer sirolimus-eluting stent for the treatment of de novo coronary lesions:four-year results of the patient-level pooled analysis from TARGET I and TARGET II trials
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作者 Changdong Guan Bo Xu +1 位作者 Yuejin Yang Runlin Gao 《中国循环杂志》 CSCD 北大核心 2016年第z1期-,共2页
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Comparing the rate of side branch occlusion between coronary bifurcation lesions with low and high carina angle:validating the hypothesis of carina shift by using a consecutive cohort of 1200 coronary bifurcation lesions
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作者 Changzhe Chen Dong Zhang +1 位作者 Bo Xu Kefei Dou 《中国循环杂志》 CSCD 北大核心 2016年第z1期-,共1页
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Feasibility of three dimensional printing of aortic valve disease models before transapical aortic valve implantation
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作者 Kun Liu Xinshuang Ren +2 位作者 Xu Wang Wei Wang Bin Lv 《中国循环杂志》 CSCD 北大核心 2016年第z1期-,共1页
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High Neutrophil to Lymphocyte Ratio Level is Independently Associated with the Extent of Coronary Artery Calcification in Chinese Population Undergoing Coronary Computed Tomography Angiograp
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作者 Tiewei Li 《中国循环杂志》 CSCD 北大核心 2016年第z1期-,共1页
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Decreased C1q/C3a ratio correlates with the extent of coronary artery disease
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作者 Fei Song Mengyue Yu 《中国循环杂志》 CSCD 北大核心 2016年第z1期-,共1页
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The application of tipping-point display in handling missing data in clinical study
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作者 Shengjie Zhang Yang Wang Wei Li 《中国循环杂志》 CSCD 北大核心 2016年第z1期-,共2页
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