Abdominal and pelvic pain of psychogenic origin is a widespread, disabling, difficult to identify, and often inadequately treated medical condition. This condition is often associated with poor quality of life due to ...Abdominal and pelvic pain of psychogenic origin is a widespread, disabling, difficult to identify, and often inadequately treated medical condition. This condition is often associated with poor quality of life due to high pain interference with daily activities. Cognitive behavioral psychological therapy and neuromodulation with biofeedback are validated therapies for the treatment of this condition. Aim of the present research work is the validation of a therapeutic protocol that involves the use of both techniques in combination. 20 patients diagnosed with psychogenic abdominal pain, of both sexes, aged between 18 and 60 years who had not benefited from pharmacological therapies were enrolled. 10 patients were randomly assigned to the control group (psychological treatment only), another 10 patients were assigned to the study group (neuromodulation with biofeedback-Galvanic skin response-extinction in combination with psychological therapy). For both groups, the pain score, interference of pain with daily living activities, pain relief, and the share of anxiety associated with the pain condition were evaluated (pre- and post-treatment). The patients who underwent the combined treatment achieved statistically significant better scores than patients in the control group, respectively −4.9 ± 0.9 vs −1.0 ± 0.4 for Pain;−5.1 ± 1.1 vs −0.9 ± 0.3 for Interference with life;−7.2 ± 3.7 vs −2.2 ± 2.1 for HAMA;4.6 ± 1.2 vs 1.1 ± 0.6 for Relief.展开更多
Background: Pancreaticoduodenectomy is the standard treatment for resectable periampullary cancer. Surgical site infections(SSI) are common complications with increased morbidity. The study aimed to describe the preva...Background: Pancreaticoduodenectomy is the standard treatment for resectable periampullary cancer. Surgical site infections(SSI) are common complications with increased morbidity. The study aimed to describe the prevalence, risk factors, microbiology, and outcomes of SSI among patients undergoing pancreaticoduodenectomy. Methods: We conducted a retrospective study in a referral cancer center between January 2015 and June 2021. We analyzed baseline patient characteristics and SSI occurrence. Culture results and susceptibility patterns were described. Multivariate logistic regression was used to determine risk factors, proportional hazards model to evaluate mortality, and Kaplan-Meier analysis to assess long-term survival. Results: A total of 219 patients were enrolled in the study;101(46%) developed SSI. Independent factors for SSI were diabetes mellitus, preoperative albumin level, biliary drainage, biliary prostheses, and clinically relevant postoperative pancreatic fistula. The main pathogens were Enterobacteria and Enterococci. Multidrug-resistance rate in SSI was high but not associated with increased mortality. Infected patients had higher odds of sepsis, longer hospital stay and intensive care unit stay, and readmission rate. Neither 30-day mortality nor long-term survival was significantly different between infected and non-infected patients. Conclusions: SSI prevalence among patients undergoing pancreaticoduodenectomy was high and largely caused by resistant microorganisms. Most risk factors were related to preoperative instrumentation of the biliary tree. SSI was associated with greater risk of unfavorable outcomes;however, survival was unaffected.展开更多
The dissolution kinetics of synthetic molybdite(MoO3)in a potassium hydroxide(KOH)medium was studied by varying the system temperature,KOH concentration,and particle size.Additionally,the effects of the stirring rate ...The dissolution kinetics of synthetic molybdite(MoO3)in a potassium hydroxide(KOH)medium was studied by varying the system temperature,KOH concentration,and particle size.Additionally,the effects of the stirring rate and different reagents such as barium hydroxide(Ba(OH)2),calcium hydroxide(Ca(OH)2),and sodium hydroxide(NaOH)were also evaluated.The experiments were performed in a reactor with controlled temperature and agitation.The results indicated that the dissolution reaction mechanism of molybdite generates potassium molybdate(K2MoO4)without intermediate compounds.Temperature(6-80°C),KOH concentration(0.0005-0.025mol/L),and particle size(5-40μm)positively affected the dissolution of molybdite.The maximum Mo recovery was67.5%in0.25h for80°C and0.01mol/L KOH.At the lowest temperature(6°C),which is near the freezing point of water(0°C),a substantial amount of Mo was recovered(17.8%in45min).The kinetics equation describing the molybdite dissolution in a KOH environment indicated that diffusion occurs through the porous layer.The activation energy was calculated to be47.81kJ/mol.A reaction order of1.0with respect to KOH concentration was obtained and was found to be inversely proportional to the squared particle size.The kinetics equation was obtained.The dissolution of molybdite resulting from the oxidation of a molybdenite concentrate(MoS2)led to a low molybdenum recovery,which was primarily caused by the consumption of KOH by impurities such as CaCO3and Cr(MO4)3.展开更多
文摘Abdominal and pelvic pain of psychogenic origin is a widespread, disabling, difficult to identify, and often inadequately treated medical condition. This condition is often associated with poor quality of life due to high pain interference with daily activities. Cognitive behavioral psychological therapy and neuromodulation with biofeedback are validated therapies for the treatment of this condition. Aim of the present research work is the validation of a therapeutic protocol that involves the use of both techniques in combination. 20 patients diagnosed with psychogenic abdominal pain, of both sexes, aged between 18 and 60 years who had not benefited from pharmacological therapies were enrolled. 10 patients were randomly assigned to the control group (psychological treatment only), another 10 patients were assigned to the study group (neuromodulation with biofeedback-Galvanic skin response-extinction in combination with psychological therapy). For both groups, the pain score, interference of pain with daily living activities, pain relief, and the share of anxiety associated with the pain condition were evaluated (pre- and post-treatment). The patients who underwent the combined treatment achieved statistically significant better scores than patients in the control group, respectively −4.9 ± 0.9 vs −1.0 ± 0.4 for Pain;−5.1 ± 1.1 vs −0.9 ± 0.3 for Interference with life;−7.2 ± 3.7 vs −2.2 ± 2.1 for HAMA;4.6 ± 1.2 vs 1.1 ± 0.6 for Relief.
文摘Background: Pancreaticoduodenectomy is the standard treatment for resectable periampullary cancer. Surgical site infections(SSI) are common complications with increased morbidity. The study aimed to describe the prevalence, risk factors, microbiology, and outcomes of SSI among patients undergoing pancreaticoduodenectomy. Methods: We conducted a retrospective study in a referral cancer center between January 2015 and June 2021. We analyzed baseline patient characteristics and SSI occurrence. Culture results and susceptibility patterns were described. Multivariate logistic regression was used to determine risk factors, proportional hazards model to evaluate mortality, and Kaplan-Meier analysis to assess long-term survival. Results: A total of 219 patients were enrolled in the study;101(46%) developed SSI. Independent factors for SSI were diabetes mellitus, preoperative albumin level, biliary drainage, biliary prostheses, and clinically relevant postoperative pancreatic fistula. The main pathogens were Enterobacteria and Enterococci. Multidrug-resistance rate in SSI was high but not associated with increased mortality. Infected patients had higher odds of sepsis, longer hospital stay and intensive care unit stay, and readmission rate. Neither 30-day mortality nor long-term survival was significantly different between infected and non-infected patients. Conclusions: SSI prevalence among patients undergoing pancreaticoduodenectomy was high and largely caused by resistant microorganisms. Most risk factors were related to preoperative instrumentation of the biliary tree. SSI was associated with greater risk of unfavorable outcomes;however, survival was unaffected.
文摘The dissolution kinetics of synthetic molybdite(MoO3)in a potassium hydroxide(KOH)medium was studied by varying the system temperature,KOH concentration,and particle size.Additionally,the effects of the stirring rate and different reagents such as barium hydroxide(Ba(OH)2),calcium hydroxide(Ca(OH)2),and sodium hydroxide(NaOH)were also evaluated.The experiments were performed in a reactor with controlled temperature and agitation.The results indicated that the dissolution reaction mechanism of molybdite generates potassium molybdate(K2MoO4)without intermediate compounds.Temperature(6-80°C),KOH concentration(0.0005-0.025mol/L),and particle size(5-40μm)positively affected the dissolution of molybdite.The maximum Mo recovery was67.5%in0.25h for80°C and0.01mol/L KOH.At the lowest temperature(6°C),which is near the freezing point of water(0°C),a substantial amount of Mo was recovered(17.8%in45min).The kinetics equation describing the molybdite dissolution in a KOH environment indicated that diffusion occurs through the porous layer.The activation energy was calculated to be47.81kJ/mol.A reaction order of1.0with respect to KOH concentration was obtained and was found to be inversely proportional to the squared particle size.The kinetics equation was obtained.The dissolution of molybdite resulting from the oxidation of a molybdenite concentrate(MoS2)led to a low molybdenum recovery,which was primarily caused by the consumption of KOH by impurities such as CaCO3and Cr(MO4)3.
