Characteristics of MOF, MWCNT and graphene containing materials for hydrogen storage: A review

Hydrogen is a generally abundant, safe, clean and environmentally apt alternative fuel, which replenishes the void generated by depleting fossil fuel reserves. The adoption of hydrogen as an energy source has been restricted to low levels due to the complications associated with its viable storage and usage. Existing technologies, such as storage of hydrogen in compressed and liquefied forms are not adequate to meet the broad on-board applications. The gravimetric energy density(120 MJ/kg) of hydrogen is three times higher than that of gasoline products, so solid-state hydrogen storage is advantageous.Metal-organic frameworks(MOFs), multi-walled carbon nanotubes(MWCNTs) and graphene are solid adsorbents majorly employed for efficient H_2 storage. The prominent features of MOFs such as permanent porosity, structural rigidity, and surface area are attractive and ideal for hydrogen storage. In addition,nanostructured carbon materials(MWCNTs and graphene) and their composites have demonstrated significant hydrogen storage capacities. Some important parameters for the success of the hydrogen economy include high storage density, adsorption/desorption temperature and cycling time. Cryo-hydrogen storage was achieved in MOFs and their composites with carbon structures, but storage at ambient temperature and acceptable pressures is a major hurdle. This review discusses various strategies and mechanisms in the design of adsorbents explored to improve H_2 storage capacities and afford opportunities to develop new sustainable hydrogen technologies to meet energy targets.

Determination of genotoxic alkyl methane sulfonates and alkyl paratoluene sulfonates in lamivudine using hyphenated techniques

Two highly sensitive methods for the determination of genotoxic alkyl methane sulfonates (AMSs) and alkyl paratoluene sulfonates (APTSs) in lamivudine using hyphenated techniques have been presented. AMSs were determined by GC-MS method using GSBPINOWAX (30 m 0.25 mm 0.25 mm) column. Temperature program was set by maintaining at 100 1C initially for 3 min, then rised to 220 1C at the rate of 15 1C/min and maintained at 220 1C for 16 min. N,N-dimethyl formamide was used as diluent. APTSs were determined by LC-MS using Zorbax, Rx C8, 250 mm 4.6 mm, 5 mm column as stationary phase. 0.01 M ammonium acetate is used as buffer. The mixture of buffer and methanol in 75:25 (v/v) ratio was used as mobile phase A and mixture of buffer and methanol in 5:95 (v/v) ratio was used as mobile phase B. The gradient program (T/%B) was set as 0/28, 16/50, 17/100, 23/100, 27/28 and 40/28. Both the methods were validated as per International Conference on Harmonization guidelines. Limit of quantitation was found 1.5 mg/mL for AMSs and was in the range of 1.0-1.5 mg/mL for APTSs.

A Validated Stability-Indicating UHPLC Method for Determination of Naproxen and Its Related Compounds in Bulk Drug Samples

A simple, rapid, precise, accurate, rugged and robust stability-indicating ultra-fast high performance liquid chromatographic (UHPLC) method has been developed for the estimation of related compounds (imp-A, imp-B, imp-C, imp-D and imp-E) in Naproxen and also the assay of Naproxen from bulk drug samples. The stability indicating capability of the method was proven by subjecting the samples to stress conditions such as acid, base, oxidation, photolysis and thermal degradation. The efficient chromatographic separation was achieved using mobile phase solution A prepared as buffer solution 10 mM monobasic potassium phosphate pH 4.0 ± 0.05 adjusted with diluted ortho phosphoric acid solution and solution B acetonitrile with linear gradient elution on poroshell 120 EC-C18 shot column (50 mm × 4.6 mm, 2.7 μm) and UV detection at 235 nm at a flow rate 1.0 mL/min, column oven temperature was set to 25?C. The above are all known impurities and degradation impurities are well resolved with Naproxen peak and these are eluted within a 10 min runtime of HPLC. The photo diode array detector was used for peak homogeneity testing during stress study experiments and the overall mass balance was found to be 99.2% to 100.2% in all stress conditions. The linear calibration range was found to be 0.05 μg/mL to 0.75 μg/mL for related compounds and 50 μg/mL to 150 μg/mL for Naproxen and the accuracy of the method was found to be 91.5% to 98.5% recovery for the related substance method and 95.4% to 97.4% recovery for the assay method. The Naproxen and related compounds were found to be stable up to 48 hours and the method validation data show excellent results for precision, linearity, specificity, limit of detection, limit of quantitation and robustness. The present method can be successfully used for routine QC and stability studies and it will help to reduce the analysis cost, time and effluent load compared to conventional HPLC methods.

A comparative pharmacological and phytochemical analysis of in vivo & in vitro propagated Crotalaria species

Objective:To compare the efficacy for phytochemical.antibacterial and antioxidant activities of petroleum ether,chloroform,ethanol,and aqueous extracts of in vitro propagated plants and field grown plants of Crotalaria sps.,for against five human pathogens.Methods:The preliminary pbytochemistry,antimicrobial and antioxidant activities were evaluated using disc diffusion and DPPH radical scavenging methods.Results:The ethanolic extract of in vitro raised Crotalaria retusa（C.retusa） was effective on tested microorganisms and optimal ZOI values of 38 mm was obtained against Pseudomonas aeruginosa（P.aeruginosa）.The optimal concentration (IC50 required for 50%inhibition of the DPPH radical scavenging was 57.6μg/mL obtained for ethanolic extract of in vitro propagated C.retusa.The in vitro propagated C.retusa has significant pharmacological activities while the Crotalaria prostrate（C.prostrate） and Crotalaria medicaginea（C.medicaginea） has low pharmacological activites.It was cleared that ethanolic extract of in vitro regenerated plants was most effective.Conclusions:These findings indicate compounds isolated from ethanolic extracts of Crotalaria sps..possesses pharmacological properties and potential to develop natural compounds based pharmaceutical products.The IC50 values for ethanolic extracts of Crotalaria sps.was evaluated through the Linear regression analysis（R2≤1）.

Hepatoprotective activity of Macrothelypteris torresiana (Gaudich.) aerial parts against CCl4-induced hepatotoxicity in rodents and analysis of polyphenolic compounds by HPTLC

Macrothelypteris torresiana is a fern species belonging to the family Thelypteridaceae. The present study was conducted to evaluate hepatoprotective potential of ethanol extract from M. torresiana aerial parts(EEMTAP)and detect the polyphenolic compounds present in the extract using high performance thin layer chromatography(HPTLC). Hepatoprotective potential of EEMTAP were tested at doses of 300 and 600 mg/kg, per os(p.o.), on Wistar albino rats. The extract and silymarin treated animal groups showed significant decrease in activities of different biochemical parameters like serum glutamic oxaloacetic transaminase(SGOT), serum glutamate-pyruvate transaminase(SGPT), and alkaline phosphatase(ALP), which were elevated by carbon tetrachloride(CCl_4) intoxication. The levels of total bilirubin and total protein along with the liver weight were also restored to normalcy by EEMTAP and silymarin treatment. After CCl_4 administration, the levels of hepatic antioxidant enzymes such as glutathione(GSH) and catalase(CAT) were decreased whereas the level of hepatic lipid peroxidation(LPO) was elevated. The levels of these hepatic antioxidant enzymes were also brought to normalcy by EEMTAP and silymarin treatment. Histological studies supported the biochemical findings, and treatment with EEMTAP at doses of 300 and 600 mg/kg, p.o. was found to be effective in restoring CCl_4-induced hepatotoxicity in rats. A simple HPTLC analysis was conducted for the detection of polyphenolic compounds in EEMTAP, and the result revealed the presence of caffeic acid as phenolic acid and quercetin as flavonoid. The proposed HPTLC method is simple and concise and provides a good resolution of caffeic acid and quercetin from other constituents present in EEMTAP.

Biological Treatability of Low Total Dissolved Solids (LTDS) Using SBR as a Pre-Treatment for Reverse Osmosis

Huge quantity of effluents is generated from pharmaceutical industries attributed to their wide array of manufacturing and maintenance processes. Wastewaters from pharmaceuticals are characterized by the presence of solids, pH, temperature, biodegradable organic compounds, unusual turbidity, hardness and conductivity. Wastewater from pharmaceutical industry arising from various units is categorised as low total dissolved solids (LTDS) and high total dissolved solids (HTDS) based on the concentration of total dissolved solids. The present study focuses on treatment of LTDS using a combination of biological treatment followed by membrane process, reverse osmosis. This research presents the results from the pilot-scale studies focussed on biological treatment using SBR as pre-treatment for RO towards the removal of LTDS effluent. Three-month data on a daily basis is presented. The efficiency of the process was tested with a reduction in parameters like total dissolved solids and chemical oxygen demand. SBR tested for its suitability as a preliminary treatment for the Reverse Osmosis process during the months of August-October. The highest and lowest TDS reduction was recorded as 9.72% and ?4.67% in the month of August. The highest and least COD reduction was recorded as 87.28% and 80.66% in the same month. The highest and lowest TDS reduction was recorded as 0.84% and ?7.92% in the month of September. The highest and least COD reduction was recorded as 87.07% and 83.28% in the same month. The performance of RO tested for its efficiency in removing the TDS and COD after SBR as pre-treatment. The highest and lowest TDS reduction was recorded as 94.93% and 93.27% in the month of August. The highest and least COD reduction was recorded as 96.84% and 90.19% in the same month. The highest and lowest TDS reduction was recorded at 96.53% and 91.25% in the month of October. The highest and least COD reduction was recorded as 94.31% and 72.57% in the same month. SBR has proved to be a promising solution for pre-treatment removing all substances that might result in membrane fouling. Hence, the present study concludes that a combination of SBR and RO will be a promising solution for effective removal of TDS and COD from pharmaceutical wastewaters.

Structural and Dielectric Properties of Sn Doped Barium Magnesuim Zirconium Titanate Perovskite Ceramics

Perovskite type ceramics (Ba0.9Mg0.1)(SnxZr0.4-xTi0.6)O3 (with x = 0.01, 0.02, 0.03 and 0.04) relaxor composition prepared through solid state reaction route and calcinated at temperature is 1150°C for 5 hrs with intermediate mixing. The room temperature XRD study suggests that all the samples have the single phase cubic symmetry with space group pm 3 m. The pellets were sintered at 1500°C for 4 hrs. Scanning Electron Microscope (SEM) observations revealed enhanced micro structural uniformity and retarded grain growth with decreasing Sn content. The dielectric measurements at constant frequency show that dielectric constant increases with Sn content. Loss factor and dielectric constant decreased with increasing frequency but at very high frequencies it was independent.

DC Electrical Conductivity Studies of GeO₂Doped Lead Vanadate Glass System

Temperature dependent DC electrical conductivity studies of GeO2 substituted lead vanadate glass systems xGeO2(50-x)PbO:50V2O5 (x = 5, 10, 15 mole%) were carried out and the results are reported. X-ray diffraction results reveal that all samples are perfect amorphous in nature. DSC results indicate that the substituent GeO2 is replacing PbO in the glass network in such a way that the eutectic composition is maintained. DC electrical conductivity studies of the glass samples indicate that the systems are characterized by different activation energies in different temperature ranges which in turn depend on the annealing temperature. These results are interpreted in terms of temperature dependent microstructural changes in these glass systems.

Role of PET-CT (Positron Emission Tomography-Computed Tomography) in Cancer Evaluation and Treatment

Context: Positron emission tomography is a nuclear medicine imaging that deals with physiological function using radioisotopes. With the most PET (Positron Emission Tomography) scanners in integration with the CT scanners of late, this technology has registered phenomenal growth. The small amount of radioactive material is called Radiotracers. Objective: Like 18F- Fluro-deoxy-2-glucose has widely used. In this article, the author introduced clinical applications of PET out of 25 patients who studied hypermetabolic lesions in lymph nodes. Methods: PET imaging is coincidence imaging which is different from the other imaging technique PET image formed from multiple rings of detector crystals. Each decay positron travel in tissue annihilation reaction is going on. FDG is the most commonly used radiotracer to detect and stage various types of malignancies. Result: The field of PET/CT imaging cares for many oncology patients. PET improved localization of malignant lesions. It improved staging biopsy and therapy. Conclusion: Finally, studies to data showed 4% to 10% improvement in the overall accuracy of staging/restaging in lesions. If we use Monte Carlo simulation, OLINDA/EXM software may improve further with widely used.

Pilot Scale Biological Treatment as Pre-Treatment for Reverse Osmosis

Treatment of pharmaceutical wastewaters is a challenging task owing to their complexity and pollution load, variability in strength of waste streams accompanied with shock loads. Since no single treatment system is a viable option, integration of existing systems with advanced physical/chemical processes has been gaining attention for treatment of pharmaceutical wastewater. In the present study, two biological treatment methods were evaluated for their efficiency as pre-treatment system for RO which are sequencing batch reactor and membrane bioreactor. Efficiency of biological treatments tested SBR and MBR was pre-sented in terms of percentage removal of physico-chemical parameters. Total dissolved solids removal by SBR was 31.82% while MBR showed 29.25% reduction. Chemical oxygen demand removal by SBR was 69.54% while MBR showed 30.35% removal. Efficiency of combined treatments SBR-RO and MBR-RO was presented in terms of removal of total dissolved solids, COD and ammonia. TDS removal was the highest in the combination of SBR-RO with 95.94% removal, while MBR-RO combination resulted in 87.29% removal. Chemical oxygen demand was achieved maximum with the combination of MBR-RO 92.33% while competitive results were achieved with the combination SBR-RO also with 88.62% removal. Removal of ammonia was maximum with the combination SBR-RO 87.5%, while competitive results were obtained with MBR-RO 85.51%. From the results, it can be understood that SBR was efficient in removing ammonia, total dissolved solids and was equally competent in removing chemical oxygen demand. This study concludes that combined treatment of SBR-RO proves to be promising in treating pharmaceutical wastewaters.

Data Categorization and Noise Analysis in Mobile Communication Using Machine Learning Algorithms

Machine learning and pattern recognition contains well-defined algorithms with the help of complex data, provides the accuracy of the traffic levels, heavy traffic hours within a cluster. In this paper the base stations and also the noise levels in the busy hour can be predicted. J48 pruned tree contains 23 nodes with busy traffic hour provided in east Godavari. Signal to noise ratio has been predicted at 55, based on CART results. About 53% instances provided inside the cluster and 47% provided outside the cluster. DBScan clustering provided maximum noise from srikakulam. MOR (Number of originating calls successful) predicted as best associated attribute based on Apriori and Genetic search 12:1 ratio.