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Machine learning identifies the risk of complications after laparoscopic radical gastrectomy for gastric cancer
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作者 Qing-Qi Hong Su Yan +18 位作者 Yong-Liang Zhao Lin Fan Li Yang Wen-Bin Zhang Hao Liu He-Xin Lin Jian Zhang Zhi-Jian Ye Xian Shen Li-Sheng Cai Guo-Wei Zhang Jia-Ming Zhu Gang Ji Jin-Ping Chen Wei Wang Zheng-Rong Li Jing-Tao Zhu Guo-Xin Li Jun You 《World Journal of Gastroenterology》 SCIE CAS 2024年第1期79-90,共12页
BACKGROUND Laparoscopic radical gastrectomy is widely used,and perioperative complications have become a highly concerned issue.AIM To develop a predictive model for complications in laparoscopic radical gastrectomy f... BACKGROUND Laparoscopic radical gastrectomy is widely used,and perioperative complications have become a highly concerned issue.AIM To develop a predictive model for complications in laparoscopic radical gastrectomy for gastric cancer to better predict the likelihood of complications in gastric cancer patients within 30 days after surgery,guide perioperative treatment strategies for gastric cancer patients,and prevent serious complications.METHODS In total,998 patients who underwent laparoscopic radical gastrectomy for gastric cancer at 16 Chinese medical centers were included in the training group for the complication model,and 398 patients were included in the validation group.The clinicopathological data and 30-d postoperative complications of gastric cancer patients were collected.Three machine learning methods,lasso regression,random forest,and artificial neural networks,were used to construct postoperative complication prediction models for laparoscopic distal gastrectomy and laparoscopic total gastrectomy,and their prediction efficacy and accuracy were evaluated.RESULTS The constructed complication model,particularly the random forest model,could better predict serious complications in gastric cancer patients undergoing laparoscopic radical gastrectomy.It exhibited stable performance in external validation and is worthy of further promotion in more centers.CONCLUSION Using the risk factors identified in multicenter datasets,highly sensitive risk prediction models for complications following laparoscopic radical gastrectomy were established.We hope to facilitate the diagnosis and treatment of preoperative and postoperative decision-making by using these models. 展开更多
关键词 Gastric cancer Laparoscopic radical gastrectomy Postoperative complications Laparoscopic total gastrectomy
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Genetic and immunologic characteristics of colorectal cancer patients with KRAS mutations and predictive significance of tumor immune microenvironment in adjuvant chemotherapy
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作者 Zhengqi Wen Wenliang Li +8 位作者 Chengmin Shi Junrui Ma Sihui Zhao Ruize Zhou Xihong Liu Rong Yang Zhiping Zhang Hushan Zhang Bo Li 《Genes & Diseases》 SCIE CSCD 2024年第3期43-46,共4页
Colorectal cancer(CRC)is one of the most common cancers around the world,and it is one of the leading causes of cancer-related death.1 Although anti-EGFR therapy and immune checkpoint inhibitor(ICl)therapy are becomin... Colorectal cancer(CRC)is one of the most common cancers around the world,and it is one of the leading causes of cancer-related death.1 Although anti-EGFR therapy and immune checkpoint inhibitor(ICl)therapy are becoming more and more important for colorectal therapy,however,clinical outcomes of current treatments for metastatic CRC,especially with ICls,have been shown to be affected by the status of KRAS.Therefore,KRAS mutation status detection has become a very important diagnostic factor for managing metastatic CRC patients. 展开更多
关键词 KRAS COLORECTAL patients
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Emerging role of long noncoding RNAs in recurrent hepatocellular carcinoma 被引量:2
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作者 Yuan Fang Yang Yang +2 位作者 Na Li Xiao-Li Zhang Han-Fei Huang 《World Journal of Clinical Cases》 SCIE 2021年第32期9699-9710,共12页
Hepatocellular carcinoma(HCC)remains one of the most frequent types of liver cancer and is characterized by a high recurrence rate.Recent studies have proposed that long non-coding RNAs(lncRNAs)are potential biomarker... Hepatocellular carcinoma(HCC)remains one of the most frequent types of liver cancer and is characterized by a high recurrence rate.Recent studies have proposed that long non-coding RNAs(lncRNAs)are potential biomarkers in several recurrent tumor types.It is now well understood that invasion,migration,and metastasis are important factors for tumor recurrence.Moreover,some of the known risk factors for HCC may affect the expression levels of several types of lncRNAs and thus affect the recurrence of liver cancer through lncRNA regulation.In this paper,we review the biological functions,molecular mechanisms,and roles of lncRNAs in HCC and summarize current knowledge about lncRNAs as potential biomarkers in recurrent HCC. 展开更多
关键词 Long non-coding RNAs Hepatocellular carcinoma Liver cancer BIOMARKER RECURRENCE
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Short-term and oncological outcomes of natural orifice specimen extraction surgery(NOSES)for colorectal cancer in China:a national database study of 5055 patients 被引量:29
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作者 Xu Guan Xiyue Hu +46 位作者 Zheng Jiang Ye Wei Donghui Sun Miao Wu Haitao Zhou Hongliang Yao Junmin Song Guiyu Wang Junhong Hu Mingyang Ren Qing Xu Jianchun Cai Jian Peng Dan Ma Yangchun Zheng Qingsi He Bo Jiang Zejun Wang Taiyuan Li Su Yan Luchuan Chen Tiegang Li Zhiguo Xiong Pan Chi Liang Kang Gang Yu Xiaodong Deng Hong Zhang Ming Xie Jianbao Wei Hongyan Gong Xuejun Sun Weidong Zang Yongmao Song Peng He Zhengqi Wen Chunxu Zhang Yusheng Wang Yinggang Chen Guangwei Xie Mingzhang Li Shaojun Yu Haiying Liu Min Pu Chuangang Fu Xishan Wang on behalf of China NOSES Alliance 《Science Bulletin》 SCIE EI CSCD 2022年第13期1331-1334,M0003,共5页
经自然腔道取标本手术(NOSES)通过无切口理念与常规手术器械的结合,表现出极佳的微创效果,并带给患者全新的就医感受.目前,尽管NOSES已广泛用于结直肠肿瘤治疗,大量研究也表明相比常规腹腔镜手术,NOSES具有恢复快、创伤小、疼痛轻等优势... 经自然腔道取标本手术(NOSES)通过无切口理念与常规手术器械的结合,表现出极佳的微创效果,并带给患者全新的就医感受.目前,尽管NOSES已广泛用于结直肠肿瘤治疗,大量研究也表明相比常规腹腔镜手术,NOSES具有恢复快、创伤小、疼痛轻等优势,但绝大多数研究均为小样本、单中心回顾性研究.本研究旨在通过分析我国5055例结直肠肿瘤NOSES患者数据,进一步探讨NOSES的短期疗效与预后.研究对象中,经直肠NOSES占整体比例的90.3%,经阴道NOSES占9.7%.NOSES术后短期并发症发生率为14.1%,吻合口瘘发生率为4.9%,腹盆腔感染率为1.9%.患者3年总生存率为93.2%,无病生存率为82.2%,局部复发率为3.6%.研究结果提示NOSES具有较好的安全性与可行性,为其应用于结直肠肿瘤治疗提供了证据. 展开更多
关键词 结直肠肿瘤 肿瘤学 并发症发生率 无病生存率 吻合口瘘 回顾性研究 总生存率 经直肠
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Prognostic significance of regional lymphadenectomy in T1b gallbladder cancer:Results from 24 hospitals in China 被引量:6
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作者 Tai Ren Yong-Sheng Li +34 位作者 Xue-Yi Dang Yang Li Zi-Yu Shao Run-Fa Bao Yi-Jun Shu Xu-An Wang Wen-Guang Wu Xiang-Song Wu Mao-Lan Li Hong Cao Kun-Hua Wang Hong-Yu Cai Chong Jin Hui-Han Jin Bo Yang Xiao-Qing Jiang Jian-Feng Gu Yun-Fu Cui Zai-Yang Zhang Chun-Fu Zhu Bei Sun Chao-Liu Dai Lin-Hui Zheng Jing-Yu Cao Zhe-Wei Fei Chang-Jun Liu Bing Li Jun Liu Ye-Ben Qian Yi Wang Ya-Wei Hua Xi Zhang Chang Liu Wan-Yee Lau Ying-Bin Liu 《World Journal of Gastrointestinal Surgery》 SCIE 2021年第2期176-186,共11页
BACKGROUND Whether regional lymphadenectomy(RL)should be routinely performed in patients with T1b gallbladder cancer(GBC)remains a subject of debate.AIM To investigate whether RL can improve the prognosis of patients ... BACKGROUND Whether regional lymphadenectomy(RL)should be routinely performed in patients with T1b gallbladder cancer(GBC)remains a subject of debate.AIM To investigate whether RL can improve the prognosis of patients with T1b GBC.METHODS We studied a multicenter cohort of patients with T1b GBC who underwent surgery between 2008 and 2016 at 24 hospitals in 13 provinces in China.The logrank test and Cox proportional hazards model were used to compare the overall survival(OS)of patients who underwent cholecystectomy(Ch)+RL and those who underwent Ch only.To investigate whether combined hepatectomy(Hep)improved OS in T1b patients,we studied patients who underwent Ch+RL to compare the OS of patients who underwent combined Hep and patients who did not.RESULTS Of the 121 patients(aged 61.9±10.1 years),77(63.6%)underwent Ch+RL,and 44(36.4%)underwent Ch only.Seven(9.1%)patients in the Ch+RL group had lymph node metastasis.The 5-year OS rate was significantly higher in the Ch+RL group than in the Ch group(76.3%vs 56.8%,P=0.036).Multivariate analysis showed that Ch+RL was significantly associated with improved OS(hazard ratio:0.51;95%confidence interval:0.26-0.99).Among the 77 patients who underwent Ch+RL,no survival improvement was found in patients who underwent combined Hep(5-year OS rate:79.5%for combined Hep and 76.1%for no Hep;P=0.50).CONCLUSION T1b GBC patients who underwent Ch+RL had a better prognosis than those who underwent Ch.Hep+Ch showed no improvement in prognosis in T1b GBC patients.Although recommended by both the National Comprehensive Cancer Network and Chinese Medical Association guidelines,RL was only performed in 63.6%of T1b GBC patients.Routine Ch+RL should be advised in T1b GBC. 展开更多
关键词 Gallbladder cancer LYMPHADENECTOMY HEPATECTOMY STAGING PROGNOSIS SURGERY
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Application of Nutritional Support in the Comprehensive Treatment of Gastric Cancer: A Case Report
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作者 Yue Li Zun Yue Zhang +3 位作者 Hua Wei Wang Jing Jiao Zhao Shi Tao Geng Kun Hua Wang 《Journal of Nutritional Oncology》 2020年第4期196-200,共5页
Objective To relieve long-term malnutrition caused by a malignant tumor affecting the pylorus and to prolong the patient survival.Methods A patient presented with complete pyloric obstruction due to pyloric tumors,and... Objective To relieve long-term malnutrition caused by a malignant tumor affecting the pylorus and to prolong the patient survival.Methods A patient presented with complete pyloric obstruction due to pyloric tumors,and achieved good therapeutic effects through nutritional support and effective chemotherapy.Results After about 40 days of treatment,all physiological indicators were improving.After chemotherapy,the pyloric tumor shrank and the complete obstruction was relieved.The patient was able to eat and drink normally.Conclusion Nutritional support,combined with chemotherapy,may effectively treat complete pyloric obstruction caused by advanced tumors. 展开更多
关键词 Nutritional support Gastric cancer Pyloric obstruction Advanced gastric cancer
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Hepatoid adenocarcinoma of the rectal
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作者 Sitong Zhou Ziqi Wang +2 位作者 Hao Sun Shuo Han Pengda Sun 《Hepatobiliary Surgery and Nutrition》 SCIE 2023年第6期987-990,共4页
We would here like to present a treatment experience of an interesting case of hepatoid adenocarcinoma(HAC),which is a very rare clinical malignancy of the gastrointestinal tract.A 58-year-old male was admitted to our... We would here like to present a treatment experience of an interesting case of hepatoid adenocarcinoma(HAC),which is a very rare clinical malignancy of the gastrointestinal tract.A 58-year-old male was admitted to our hospital with intermittent hematochezia for 1 month.A computed tomography(CT)of the abdomen revealed the thickened anterior wall and nodules of the middle rectum,the lumen of which was narrowed. 展开更多
关键词 admitted ADENOCARCINOMA CLINICAL
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Examined lymph node numbers influence prognosis in rectal cancer treated with neoadjuvant therapy
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作者 Liyu Zhu Lin Wang +10 位作者 Zhidong Gao Yujian Zeng Kaixiong Tao Quan Wang Xinming Li Huanhu Zhang Zhanlong Shen Jing Zhou Kai Shen Yingjiang Ye Aiwen Wu 《Cancer Pathogenesis and Therapy》 2023年第3期168-176,共9页
Background:The number of lymph nodes examined(LNe)is often insufficient in patients with rectal cancer(RC)treated with neoadjuvant therapy;however,its prognostic value remains controversial.Thus,we retrospectively exp... Background:The number of lymph nodes examined(LNe)is often insufficient in patients with rectal cancer(RC)treated with neoadjuvant therapy;however,its prognostic value remains controversial.Thus,we retrospectively explored whether LNe had an influence on staging and prognosis and investigated whether there was a cut-off value for better prognosis in patients with RC treated with neoadjuvant therapy.Methods:Data were collected from seven prospective hospital databases in China from July 2002 to May 2018.Binary logistic regression models were used to predict lymph node metastasis.The cut-off value for LNe was determined using X-tile 3.6.1.Survival outcomes and risk factors were analyzed using the log-rank test and Cox regression model.Results:A total of 482 patients were included,of whom 459 had complete overall survival(OS)information.Using the percentile method,the total number of lymph nodes examined(TLNe)was 14-16(40th-60th percentile),and the proportion of patients with lymph node metastasis reached a maximum of 48.1%.Cox multivariate analysis showed that the odds ratio(OR)remained the highest when TLNe was 14-16(OR=3.379,P=0.003).The 3-year and 5-year OS were 85.4% and 77.8%,respectively.Negative lymph nodes examined(NLNe)of≤6 was an independent risk factor for 3-year and 5-year OS(3-year OS 71.1%vs.85.9%,P=0.004;5-year OS 66.3%vs.74.3%,P=0.035).Subgroup analysis for patients with ypN+showed that higher 3-year and 5-year OS were achieved when the TLNe was>10,78.8%vs.54.0%(P=0.005),and 60.8%vs.36.0%(P=0.012),respectively.Patients with ypN0M0 had a higher 5-year OS when the TLNe was>19(P=0.055).Conclusion:The TLNe and NLNe influenced the staging accuracy and demonstrated prognostic value in patients with RC treated with neoadjuvant therapy. 展开更多
关键词 Lymph nodes examined PROGNOSIS Staging accuracy Rectal cancer Neoadjuvant therapy
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