We devoted this short piece to highlight one recent article published in Science,which revisited the anti-cancer efficacy of high-dose vitamin C.Using isogeneic KRAS-and BRAF-mutated colorectal cell lines,the authors ...We devoted this short piece to highlight one recent article published in Science,which revisited the anti-cancer efficacy of high-dose vitamin C.Using isogeneic KRAS-and BRAF-mutated colorectal cell lines,the authors were able to demonstrate selective antitumor effects among the KRAS-and BRAF-mutated cells in culture and in ex-planted animal models treated with high-dose vitamin C.Their elegant and in-depth studies unequivocally tied the tumoricidal effect to the heightened sensitivity of the mutant cells due to the increased vitamin C uptake,leading to lethal accumulation of reactive oxygen species(ROS).This report will certainly rekindle enthusiasm in revisiting the case of vitamin C,pushing for more definitive cancer therapy trials.展开更多
This manuscript provides a comprehensive review and highlights of the 2015 San Antonio Breast Cancer Symposium by the leading breast cancer specialists and investigators in the field.
基金Work in Dr.Zhang’s laboratory was supported in part by research grants from the National Institutes of Health of the USA(R01CA106348,R01CA172136 and R01CA203028)。
文摘We devoted this short piece to highlight one recent article published in Science,which revisited the anti-cancer efficacy of high-dose vitamin C.Using isogeneic KRAS-and BRAF-mutated colorectal cell lines,the authors were able to demonstrate selective antitumor effects among the KRAS-and BRAF-mutated cells in culture and in ex-planted animal models treated with high-dose vitamin C.Their elegant and in-depth studies unequivocally tied the tumoricidal effect to the heightened sensitivity of the mutant cells due to the increased vitamin C uptake,leading to lethal accumulation of reactive oxygen species(ROS).This report will certainly rekindle enthusiasm in revisiting the case of vitamin C,pushing for more definitive cancer therapy trials.
文摘This manuscript provides a comprehensive review and highlights of the 2015 San Antonio Breast Cancer Symposium by the leading breast cancer specialists and investigators in the field.
