Obesity is positively Associated with Depression in Older Adults:Role of Systemic Inflammation

Objective We aimed to explore the association between obesity and depression and the role of systemic inflammation in older adults.Methods Adults≥65 years old(n=1,973)were interviewed at baseline in 2018 and 1,459 were followed up in 2021.General and abdominal obesity were assessed,and serum C-reactive protein(CRP)levels were measured at baseline.Depression status was assessed at baseline and at follow-up.Logistic regression was used to analyze the relationship between obesity and the incidence of depression and worsening of depressive symptoms,as well as the relationship between obesity and CRP levels.The associations of CRP levels with the geriatric depression scale,as well as with its three dimensions,were investigated using multiple linear regressions.Results General obesity was associated with worsening depression symptoms and incident depression,with an odds ratio(OR)[95%confidence interval(CI)]of 1.53(1.13-2.12)and 1.80(1.23-2.63),especially among old male subjects,with OR(95%CI)of 2.12(1.25-3.58)and 2.24(1.22-4.11),respectively;however,no significant relationship was observed between abdominal obesity and depression.In addition,general obesity was associated with high levels of CRP,with OR(95%CI)of 2.58(1.75-3.81),especially in subjects free of depression at baseline,with OR(95%CI)of 3.15(1.97-5.04),and CRP levels were positively correlated with a score of specific dimension(life satisfaction)of depression,P<0.05.Conclusion General obesity,rather than abdominal obesity,was associated with worsening depressive symptoms and incident depression,which can be partly explained by the systemic inflammatory response,and the impact of obesity on depression should be taken more seriously in the older male population.

Protective effects of baicalin on amyloid beta 25-35-induced apoptosis in human neuroblastoma SH-SY5Y cells

Baicalin, a type of flavanoid, effectively prevents cellular apoptosis induced by various factors. However, little evidence is available regarding its role on amyloid β （Aβ） -induced neuronal apoptosis. The present study investigated the protective mechanisms of baicalin on Aβ-induced neuronal apoptosis. Flow cytometry and cation dye 5, 5＇, 6, 6＇-tetrachloro-1, 1＇, 3, 3＇-tetraethyl- benzimidazoly lcarbocyanine iodide （JC-1） were employed to measure mitochondrial membrane potential, and nitric oxide secretion and apoptotic-related factors, such as caspase-3, were comprehensively analyzed. Results demonstrated a protective effect of baicalin on Aβ-treated SH-SY5Y cell viability; the rate of apoptosis decreased, nitric oxide generation and expression of caspase-3 were effectively inhibited, and mitochondrial membrane potential was effectively protected. Baicalin inhibited Aβ-induced neuronal apoptosis via multiple targets and multiple pathways, such as the inhibition of free radical damage, reduction of caspase-3 expression, and protection of normal mitochondrial functions.

Resistin might not be a risk factor for carotid artery atherosclerosis in elderly Chinese males

ObjectiveTo 在注册的老中国 males.MethodsThe 学习调查在浆液 resistin 水平和颈动脉动脉动脉粥样硬化之间的关联 235 老中国男性[中部的年龄 76 (范围 60-97 ) 年] 为颈动脉动脉匾的超声检查和颈动脉动脉 intima 媒介厚度(CIMT ) 的决心安排了。他们被划分成颈动脉动脉粥样硬化患者匾(帽子) 和颈动脉动脉粥样硬化患者没有匾(没有帽子) 组根据超声结果。他们的临床的侧面被收集，并且浆液 resistin 和另外的血生物化学层次是 determined.ResultsThe 帽子组更旧并且比没有帽子的组有更厚的吝啬的 CIMT。然而，在在这些组之间的浆液 resistin 水平没有差别。CIMT 断然与年龄被相关(r = 0.299， P &#x0003c；0.001 ) 。浆液 resistin 水平没与 CIMT 被相关，甚至在好久控制以后。多重线性回归分析揭示了那年龄(&#x003b2；= 0.001， P &#x0003c；0.001 ) 并且身体团索引(&#x003b2；= 0.002， P = 0.015 ) 显著地并且断然与吝啬的 CIMT 被相关。仅仅变老[机会比率(或) ：1.159；95% 信心间隔(CI ) ：1.078-1.183， P &#x0003c；0.001 ] 与颈动脉动脉动脉粥样硬化患者的存在被联系匾。浆液 resistin 水平没与吝啬的 CIMT 被相关或与颈动脉动脉动脉粥样硬化患者 plaque.ConclusionThe 结果的存在联系了建议 resistin 可能不是为在老中国男性的动脉粥样硬化的一个风险因素。

Long-term outcomes of high-risk elderly male patients with multivessel coronary disease： optimal medical therapy versus revascularization

BackgroundMany 研究显示了那医药治疗和经皮的冠的干预与稳定的冠的动脉疾病以病人的长期的预后有类似的效果。这研究与高风险的 angina.MethodsIn 在老病人调查了最佳的医药治疗(OMT ) 和 revascularization-plus-OMT 的效果这未来的非使随机化的研究，有 angiographically 证实的 multivessel 疾病的 241 个连续高风险的老男病人(65-92 岁) 从 2004 年 1 月在登记被注册到 2005 年4月。这些， 98 个病人经历了 OMT ， 143 加后续的 OMT.ResultsAfter 6.5 年经历了 revascularization 治疗，我们发现长期的心脏的死亡的率在比在经历了 revascularization 的那些经历了 OMT 的病人是显著地更高的(6.5年的 unadjusted 死亡率，14.3%为 OMT 对7.0%为 revascularization 病人；木头等级 P = 0.04 ) 。然而，主要不利心脏的脑血管的事件(MACCE ) 的全面风险在所有病人之中是类似的(6.5 年的 unadjusted 死亡率， 29.6% 为 OMT 对 27.3% 为 revascularization 病人；木头等级 P = 0.67 ).ConclusionsOMT 与心脏的死亡的增加被联系但是 MACCE 的类似的 6.5 年的风险与在有冠的 multivessel 的高风险的老男病人的 revascularization 相比疾病。

Tacit Knowledge Mining:The Key Traditional Chinese Medical Inheritance

Traditional Chinese medicine(TCM)is a treasure of traditional Chinese culture and a gift to the world.TCM tacit knowledge refers to the knowledge and experiences formed in the process of learning and practice of TCM.The objective of this study is to discuss the importance of TCM tacit knowledge in the inheritance and education of TCM.As the essence of the TCM,TCM tacit knowledge has the characteristics of massive,complicated,relativistic,highly individualized,constantly innovative,the dependence of cultural background and the regional environment,as well as difficult to explicate.It exists in every aspect of the TCM theory and the process of dialectical treatment.Besides the traditional master‑apprentice,family‑based,school‑based,and inheritance and education methods,together with the inheritance based on the books,images,and network platforms,in the process of TCM modernization,a variety of modern theoretical models and computing techniques have also been used in the mining of the TCM tacit knowledge.In this study,we introduced the usage of SECI model,complexity adaptive system,latent variable model,and some of the data mining technologies in the TCM tacit knowledge mining.An accurate and efficient inheritance of TCM tacit knowledge is the key to maintain the vitality and innovative development of TCM.Under the reasonable application and combination of the traditional education methods,modern mining methods,and further the artificial intelligence,the explicit and inheritance of TCM tacit knowledge will get tremendous development,and it could extremely improve the efficiency and accuracy of the TCM inheritance and the TCM modernization.

Prevalence of and risk factors for aspirin resistance in elderly patients with coronary artery disease

Objective To assess the prevalence of and related risk factors for aspirin resistance in elderly patients with coronary artery disease (CAD). Methods Two hundred and forty-six elderly patients (75.9 ±7.4 years) with CAD who received daily aspirin therapy (≥75 mg) over one month were recruited. The effect of aspirin was assessed using light transmission aggregometry (LTA) and thrombelastography platelet mapping assay (TEG). Aspirin resistance was defined as ≥20% arachidonic acid (AA)-induced aggregation and ≥70% adenosine diphosphate (ADP)-induced aggregation in the LTA assay. An aspirin semi-responder was defined as meeting one (but not both) of the criteria described above. Based on the results of TEG, aspirin resistance was defined as ≥50% aggregation induced by AA. Results As determined by LTA, 23 (9.3%) of the elderly CAD patients were resistant to aspirin therapy; 91 (37.0%) were semi-responders. As determined by TEG, 61 patients (24.8%) were aspirin resistant. Of the 61 patients who were aspirin resistant by TEG, 19 were aspirin resistant according to LTA results. Twenty-four of 91 semi-responders by LTA were aspirin resistant by TEG. Multivariate logistic regression analysis revealed that elevated fasting serum glucose level (Odds ratio: 1.517; 95% CI: 1.176–1.957; P = 0.001) was a significant risk factor for aspirin resistance as determined by TEG. Conclusions A significant number of elderly patients with CAD are resistant to aspirin therapy. Fasting blood glucose level is closely associatedwith aspirin resistance in elderlyCAD patients.

Interleukin-15 is a significant predictor of sarcopenia in human immunodeficiency virus infected patients on antiretroviral therapy:A cross-sectional study

Objective:To identify the relationship between interleukin(IL)-15 levels and sarcopenia in human immunodeficiency virus(HIV)-infected patients who have received antiretroviral therapy.Methods:This study was a cross-sectional design with 70 participants conducted from January to March 2021.All the participants were assessed for sarcopenia and the IL-15 levels.Sarcopenia was established based on the the Asian Working Group for Sarcopenia(AWGS)2019 criteria.Plasma IL-15 was determined.This analysis was carried out by means of 2×2 tabulation and the statistical test used is Chi-square.Results:Seventy patients received antiretroviral therapy>6 months and showed a good clinical response.Among them,36(51.4%)took zidovudine-based antiretroviral therapy with a median duration of illness of 5 years.The proportion of sarcopenia in patients with HIV infection was 32.9%.The median CD4 cell count was 395.5 cells/L(range:203-937 cells/L).Logistic regression analysis revealed that age>50 years(aOR 8.3,95%CI 1.6-44.5),underweight(aOR 7.7,95%CI 1.5-40.5),IL-15≥150.5 ng/L(aOR 4.9,95%CI 1.3-19.0)and female(aOR 4.8,95%CI 1.2-18.3 were significant and independent adverse predictors of sarcopenia in subjects with HIV infection.Conclusions:There is an association between high levels of IL-15 and sarcopenia in HIV-infected patients on antiretroviral therapy for more than 6 months with good clinical response.

High Sensitivity C-Reactive Protein Associated with Different Health Predictors in Middle-Aged and oldest old Chinese

Objective To describe the distribution of plasma high sensitivity C-reactive protein （hsCRP） and explore the relationship between hsCRP and metabolic risk factors among residents living in longevity areas of China. Methods 268 individuals aged between 40 and 59 years and 506 individuals aged over 90 years were selected from 5 longevity areas of China to participate in a cross section longitudinal cohort study. The participants were interviewed with general health related questionnaire to collect their demographic, behavioral and lifestyle data, as well as their chronic conditions, and meanwhile their physical and biomedical parameters including waist circumference （WC）, blood pressure （BP）, hsCRP, plasma lipids, and fasting blood glucose （FBG） were measured. Results The median of hsCRP was 0.99 mg/L in the middle-aged group and 2.76 mg/L in the oldest old group. No significant gender difference was observed between the above two groups. Among the oldest old individuals, 36.56% had an hsCRP level 〉3.0 mg/L. The prevalence of high hsCRP was 26.79% in the middle-aged group. The results of stepwise multiple linear regression analyses showed that HDL-C was independently associated with In （hsCRP） concentration in the middle-aged group, whereas In （TG）, HDL-C and FBG were correlated after adjustment for gender, study site, smoking, drinking, education and BMI in the oldest old group. Conclusion HDL-C is a stronger predictor of elevated hsCRP than other metabolic factors in the middle-aged population. For the oldest old persons, high TG, low HDL-C, and FBG predict elevated plasma hsCRP.

Epidemiology,etiology,and outcomes of in-hospital cardiac arrest in Lebanon

BACKGROUND In-hospital cardiac arrest(IHCA)constitutes a significant cause of morbidity and mortality.As data is scarce in the Middle East and Lebanon,we devised this study to shed some light on it to better inform both hospitals and policymakers about the magnitude and quality of IHCA care in Lebanon.METHODS We analyzed retrospective data from 680 IHCA events at the American University of Beirut Medical Center between July 1,2016 and May 2,2019.Sociodemographic variables included age and sex,in addition to the comorbidities listed in the Charlson comorbidity index.IHCA event variables were day,event location,time from activation to arrival,initial cardiac rhythm,and the total number of IHCA events.We also looked at the months and years.We considered the return of spontaneous circulation(ROSC)and survival to discharge(StD)to be our outcomes of interest.RESULTS The incidence of IHCA was 6.58 per 1,000 hospital admissions(95%CI:6.09−7.08).Non-shockable rhythms were 90.7%of IHCAs.Most IHCA cases occurred in the closed units(87.9%)(intensive care unit,respiratory care unit,neurology care unit,and cardiology care unit)and on weekdays(76.5%).ROSC followed more than half the IHCA events(56%).However,only 5.4%of IHCA events achieved StD.Both ROSC and StD were higher in cases with a shockable rhythm.Survival outcomes were not significantly different between day,evening,and nightshifts.ROSC was not significantly different between weekdays and weekends;however,StD was higher in events that happened during weekdays than weekends(6.7%vs.1.9%,P=0.002).CONCLUSIONS The incidence of IHCA was high,and its outcomes were lower compared to other developed countries.Survival outcomes were better for patients who had a shockable rhythm and were similar between the time of day and days of the week.These findings may help inform hospitals and policymakers about the magnitude and quality of IHCA care in Lebanon.

中国老年人口多维度健康状况分析

目的分析中国老年人口的多维度健康状况。方法采用非等比例抽样方法，从我国22个省（市、自治区）抽取65岁以上老人16219名。调查其日常生活自理能力（ADL）、躯体功能、认知功能、自评健康和自评生活满意度。分别从年龄、城乡、性别角度进行中国老年人口多维度健康状况的对比分析。结果65～、70～、80～、90～与100～岁年龄段男性老人生活完全自理的比率分别为98．8％（730／739）、95．2％（1445／1518）、89．1％（1913／2147）、76．3％（1447／1897）和51．6％（329／638），女性老人分别为98．1％（654／667）、94．9％（1291／1361）、87．2％（1851／2124）、70．0％（1888／2699）和46．8％（1136／2428）（x2性别=293．00，P〈0．01）；相应年龄段城镇老人生活完全自理的比率分别为98．0％（561／572）、93．6％（1090／1165）、85．5％（1413／1653）、69．3％（1311／1892）、37．4％（434／1161），农村老人分别为98．7％（823／834）、96．O％（1646／1714）、89．8％（2351／2618）、74．9％（2024／2704）、54．1％（1031／1905）（x城乡=85．97，P〈0．01）。65～、70～、80～、90～与100～岁年龄段男性老人认知功能良好的比率分别为96．5％（713／739）、90．0％（1364／1516）、72．1％（1547／2145）、49．2％（929／1890）和35．0％（218／623），女性老人分别为94．1％（627／666）、81．9％（1113／1359）、57．2％（1211／2116）、32．4％（870／2688）和17．5％（418／2395）（x2性别=893．89，P〈0．01）；相应年龄段城镇老人认知功能良好的比率分别为97．0％（555／572）、87．9％（1023／1164）、68．5％（1129／1648）、43．6％（820／1881）、23．0％（258／1124），农村老人分别为94．2％（785／833）、85．0％（1454／1711）、62．3％（1629／2613）、36．3％（979／2679）、20．0％（378／1894）（x2城乡=57．92，P〈0．01）。65～、70～、80～、90～和100-年龄段男性老人自评健康好的比率分别为56．3％（416／739）、50．7％（770／1518）、46．O％（988／2148）、42．7％（809／1897）和43．1％（175／638），女性老人自评健康好的比率分别为48．7％（325／667）、46．1％（627／1361）、43．0％（914／2124）、39．3％（1061／2699）和34．5％（838／2428），各年龄段男性老人自评健康等级优于女性（x2=233．91，P〈0．01）。65～、70～、80～、90～和100～岁年龄段男性老人对目前生活较满意的比率分别为56．2％（415／739）、56．0％（850／1518）、55．7％（1194／2418）、52．9％（1003／1897）和50．5％（322／638），女性老人分别为54．9％（366／667），55．8％（759／1361），53．9％（1144／2124），50．6％（1365／2699）和43．4％（1054／2428）。65一岁年龄段男女老人自评生活满意度差异没有统计学意义（x2=0．51，P=0．916）；70岁以上男性老人的自评生活满意度优于女性（x2=218．25，P〈0．01）。结论老人生理健康和认知功能良好的比例均随年龄增长而下降；老人的自评健康和自评生活满意度随年龄增长而下降的趋势比较缓慢。农村老人的ADL明显优于城镇老人。男性老人ADL、躯体功能、认知功能和自评健康优于同年龄段女性老人。

老龄健康影响因素的跨学科研究国际动态

本文从四方面综述并讨论老龄健康跨学科研究的国际新动态与进展:(1)发达国家高度重视和不断加强对老龄健康跨学科研究及其研究策略选择;(2)老龄健康的社会行为和环境影响因素研究;(3)老龄健康相关遗传基因研究;(4)社会行为、环境、遗传因素的交互作用对老龄健康影响研究.同时阐述国际上关于老龄健康跨学科研究的若干案例以及我国关于老龄健康影响因素调查和健康长寿候选基因研究方面取得的一些可喜进展与仍然十分薄弱的现状.最后对今后如何开展老龄健康的跨自然与社会科学综合交叉研究提出思考与展望,认为积极推进我国老龄健康跨学科研究势在必行,而我国学者可望为人类应对人口老化严峻挑战做出突出贡献.

马尔萨斯人口论仍然是错的

针对Science杂志列为125个最具挑战性科学前沿问题之一的关于"马尔萨斯是否仍然是错的?"议题,从历史回顾、客观现实和新的挑战等方面进行分析讨论,以及基于各方面的实证研究,得出结论:马尔萨斯人口论在过去、现在和将来都是错的.同时,在我国人口增长大大减缓并在十多年后进入负增长的今天和明天,除了积极推进清洁能源开发,节能减排,有效应对全球气候变化,防治土壤和水资源污染与保护生物多样性的科技创新及大力应用推广外,必须高度重视家庭户数量结构分布变化对能源消费、人口老化和可持续发展影响的科学研究与政策应对.为了减少家庭小型化产生大量独居者(尤其是空巢老人),家庭户数快速上升导致能源消费大幅增长,有效应对人口老化严峻挑战并实现区域均衡发展,建议参照新加坡的成功经验:国家出台优惠政策,在全国范围内鼓励支持成年子女与老人同住或近邻居住模式,尤其积极鼓励西北部迁移到东南部的中青年回归家乡发展,与老年父母团聚,或农村留守老人、孩子来城镇团聚,实现老人及子女互助"双赢",并减少家庭小型化导致家庭户数快速增长对能源消费、环境保护和人口老化的负面影响,将利于我国西北部和东南部的可持续发展.

Prevalence and Risk Factors of Atrial Fibrillation in Chinese Elderly： Results from the Chinese Longitudinal Healthy Longevity Survey

Background： Prevalence of atrial fibrillation （AF） is increasing as the world ages. AF is associated with higher risk of mortality and disease, including stroke, hypertension, heart failure, and dementia. Prevalence of AF differs with each population studied, and research on non-Western populations and the oldest old is scarce. Methods： We used data from the 2012 wave of the Chinese Longitudinal Healthy Longevity Survey, a community-based study in eight longevity areas in China, to estimate AF prevalence in an elderly Chinese population （n = 1418, mean age = 85.6 years） and to identify risk factors. We determined the presence olAF in our participants using single-lead electrocardiograms. The weighted prevalence olAF was estimated in subjects stratified according to age groups （65-74, 75 84, 85-94, 95 years and above） and gender. We used logistic regressions to determine the potential risk factors of AF. Results： The overall prevalence of AF was 3.5%; 2.4% of men and 4.5% of women had AF （P 〈 0.05）. AF was associated with weight extremes of being underweight or overweight/obese. Finally, advanced age （85 94 years）, history of stroke or heart disease, low high-density lipoprotein levels, low triglyceride levels, and lack of regular physical activity were associated with AF. Conclusions： In urban elderly AF prevalence increased with age （P 〈 0.05）, and in rural elderly, women had higher AF prevalence （P 〈 0.05）. Further exploration of population-specific risk factors is needed to address the AF epidemic.

Gender Differences in Familial Status,Socioeconomics,Functional Capacities and Wellbeing Among Oldest-Old Aged 80 Years and Above—China,1998–2018

Summary What is already known on this topic?Little is known about gender differences in health,family,and socioeconomics among oldest-old in China,What is added by this report?This study aims to fill this knowledge gap through analyzing gender differences in familial status,socioeconomics,functional capacities,and self-reported wellbeing using the 1998,2008–2009,and 2017–2018 waves of the Chinese Longitudinal Healthy Longevity Survey.

Dynamics of family households and elderly living arrangements in China,1990-2010

This article presents analyses on dynamics of family households and elderly living arrangements in China mainly based on the micro data of 2010,2000 and 1990 censuses.We demonstrate and discuss the trends and rural-urban differentials of largely declined household size,quickly increasing one-person and one-couple-only households,substantially increased proportions of elderly living alone or with spouse only.It is strikingly interesting that proportion of three-generation family households increased by 18.9%in rural area but decreased by 23.7%in urban areas in 2010 compared to 1990,due to rural-urban differences in demographic effects of large fertility decline and socioeconomic/attitude changes.We also present and discuss two interesting demographic phenomenon which were relatively overlooked in the literature.First,increase in number of households is much larger than population growth,due to shrinking of the household size and decomposition of larger families into smaller ones,and very much slowed-down population growth.Second,increases in numbers of elderly(especially oldest-old)who live alone or with spouse only are dramatically larger than the increase in the corresponding proportions,due to the effects of rapid population aging,while later and larger birth cohorts become old.Such trends have important implications for the analyses on the current and future market demands of the products and services,of which households are the consumption units.We recommend that the studies on home-based energy use and sustainable development should be based on analyses of family household dynamics rather than population growth.

Reversible dysphagia due to gabapentin-induced jaw myoclonus

An 89-year-old woman was admitted with a 3-day history of dysphagia and lower jaw twitching. She had a history of hypertension, diabetes mellitus, surgically corrected left proximal humeral fracture, and right C5 dermatome postherpetic neuralgia. The jaw twitching had caused dysphagia with an inability to drink liquids. Physical examination confirmed the persistent lower jaw myoclonus (Supplementary Video;http://links.lww.com/CM9/A48). The patient was fully conscious and had no twitching or nystagmus in any of her other extremities. The results of neurological examination and biochemical analysis (including complete blood profile, electrolyte level, random glucose concentration, renal function test, and liver function test) were all within the normal range. Computed tomography of the brain was unremarkable and an electroencephalogram showed no evidence of seizure. A careful review of her prescribed medications revealed the following: the patient complained of allodynia over the right C5 dermatome around 3 months prior and was prescribed gabapentin. The dosage of gabapentin was increased to 300 mg total dissolved solids (TDS) around 2 months prior. Creatinine levels were normal but her glomerular filtration rate, as estimated by the Cockcroft-Gault equation, was 36 mL/min.[1] Since the patient’s relatives supervised her medication intake, overdosage was not possible. Gabapentin was discontinued and replaced with pregabalin 50 mg BD and the patient was prescribed valium 2 mg TDS transiently. The jaw myoclonus subsided on the second day. After a consultation with a speech therapist, the patient resumed oral intake and remained tolerant of a normal diet. Upon review after 1 month, the patient remained free from jaw myoclonus.

FFAR4 improves the senescence of tubular epithelial cells by AMPK/SirT3 signaling in acute kidney injury

Acute kidney injury(AKI)is a serious clinical complication with high morbidity and mortality rates.Despite substantial progress in understanding the mechanism of AKI,no effective therapy is available for treatment or prevention.We previously found that G protein-coupled receptor(GPCR)family member free fatty acid receptor 4(FFAR4)agonist TUG891 alleviated kidney dysfunction and tubular injury in AKI mice.However,the versatile role of FFAR4 in kidney has not been well characterized.In the study,the expression of FFAR4 was abnormally decreased in tubular epithelial cells(TECs)of cisplatin,cecal ligation/perforation and ischemia/reperfusion injury-induced AKI mice,respectively.Systemic and conditional TEC-specific knockout of FFAR4 aggravated renal function and pathological damage,whereas FFAR4 activation by TUG-891 alleviated the severity of disease in cisplatin-induced AKI mice.Notably,FFAR4,as a key determinant,was firstly explored to regulate cellular senescence both in injured kidneys of AKI mice and TECs,which was indicated by senescence-associatedβ-galactosidase(SA-β-gal)activity,marker protein p53,p21,Lamin B1,phospho-histone H2A.X,phospho-Rb expression,and secretory phenotype IL-6 level.Mechanistically,pharmacological activation and overexpression of FFAR4 reversed the decrease of aging-related SirT3 protein,where FFAR4 regulated SirT3 expression to exhibit anti-senescent effect via Gq subunit-mediated CaMKKβ/AMPK signaling in cisplatin-induced mice and TECs.These findings highlight the original role of tubular FFAR4 in cellular senescence via AMPK/SirT3 signaling and identify FFAR4 as a potential drug target against AKI.

老年人的不合理用药与多重用药 计算机工具虽可辅助制定处方,但合理开具处方的关键是医、患、社会的多方合作

虽然不合理用药和多重用药现象十分普遍,但并未得到社会关注。此外,尽管有无数人承受着该现象带来的负面影响,尤其是老年人首当其冲,但这一问题仍没有通行且有效的解决方法。