See related article,pp 357-363Several decades have passed since programmedcell death(PCD)was identified.Apoptosis was first defined by Kerr in 1972,and later described by the Nobel Prices in Physiology or Medicine 200...See related article,pp 357-363Several decades have passed since programmedcell death(PCD)was identified.Apoptosis was first defined by Kerr in 1972,and later described by the Nobel Prices in Physiology or Medicine 2002,Sydney Brenner,John Sulston and Robert Horwitz,who defined genetic regulators of apoptosis(Diamantis et al.,2008).However,it was in 1858 when the German pathologist and biologist Rudolf Virchow identified for the first time the phenomenon of apoptosis,which he named necrobiosis,arguing that this form of cell death was completely different from the uncontrolled necrosis,suggesting the existence of two different types of cell death.Today,the knowledge in the field of cell death regulation is extensive,but still under continuous expansion.展开更多
Axonal regeneration after injuries to the nervous system has been extensively studied due to its implication in motor and sensory functional recovery. Distinct types of regeneration has been identified, such as canoni...Axonal regeneration after injuries to the nervous system has been extensively studied due to its implication in motor and sensory functional recovery. Distinct types of regeneration has been identified, such as canonical axonal regeneration, defined as the growth of axons from the transected axonal stump to reinnervate the original target, or regenerative sprouting, in which the growth occurs from a region of the damaged axon either close or far from the injury site(Tuszynski and Steward, 2012).展开更多
基金supported by grants from the Geroscience Centerfor Brain Health and Metabolism,FONDA P-15150012(to FAC)Fondo Nacional de Desarrollo Cientifico y Tecnologico(FONDECYT)No.1150766(to FAC)Agencia Nacional de Investigación y Desarrollo(ANID)FONDECYT Iniciación N°11220120(to MSA)。
文摘See related article,pp 357-363Several decades have passed since programmedcell death(PCD)was identified.Apoptosis was first defined by Kerr in 1972,and later described by the Nobel Prices in Physiology or Medicine 2002,Sydney Brenner,John Sulston and Robert Horwitz,who defined genetic regulators of apoptosis(Diamantis et al.,2008).However,it was in 1858 when the German pathologist and biologist Rudolf Virchow identified for the first time the phenomenon of apoptosis,which he named necrobiosis,arguing that this form of cell death was completely different from the uncontrolled necrosis,suggesting the existence of two different types of cell death.Today,the knowledge in the field of cell death regulation is extensive,but still under continuous expansion.
文摘Axonal regeneration after injuries to the nervous system has been extensively studied due to its implication in motor and sensory functional recovery. Distinct types of regeneration has been identified, such as canonical axonal regeneration, defined as the growth of axons from the transected axonal stump to reinnervate the original target, or regenerative sprouting, in which the growth occurs from a region of the damaged axon either close or far from the injury site(Tuszynski and Steward, 2012).
