Objective:To establish non-inferiority of gonadotropin-releasing hormone degarelix compared with goserelin in suppressing and maintaining castrate testosterone levels from Day 28 to Day 364 in Chinese patients with pr...Objective:To establish non-inferiority of gonadotropin-releasing hormone degarelix compared with goserelin in suppressing and maintaining castrate testosterone levels from Day 28 to Day 364 in Chinese patients with prostate cancer.Methods:This is an open-label,multi-centre study in which men aged18 years were randomised in a 1:1 ratio to once-a-month subcutaneous injection of either degarelix(240/80 mg)or goserelin(3.6 mg)for 12 months.The primary endpoint was difference in 1-year cumulative probability of suppressing testosterone to ≤0.5 ng/mL.Non-inferiority was to be established if the lower 95% confidence interval(CI)limit for difference in cumulative probability between the treatment arms was greater than -10%.Secondary endpoints included cumulative probability of prostate-specific-antigen-progression-free-survival(PSA-PFS).Safety was also assessed.Results:Baseline demographics and disease characteristics were similar between degarelix(n=142)and goserelin(n=141)treatment arms.The difference in cumulative probability of maintaining castrate levels from Day 28-364 was 3.6%(95%CI:-1.5%,8.7%),demonstrating non-inferiority of degarelix.The cumulative probability of PSA-PFS at Day 364 was higher for degarelix(82.3%,95%CI:74.7%,87.7%)versus goserelin(71.7%,95%CI:63.2%,78.5%,p=0.038).Adverse events(AEs)were similar between treatment arms,except for more injection site reactions with degarelix versus goserelin.Four(2.8%)and nine(6.4%)patients discontinued due to AEs in degarelix and goserelin groups,respectively.展开更多
In this work,we intended to connect clinimetrics with holism in traditional Chinese medicine towards multidimensional assessment of post-stroke sequelae in real-world setting,as a bridge between inheritance and innova...In this work,we intended to connect clinimetrics with holism in traditional Chinese medicine towards multidimensional assessment of post-stroke sequelae in real-world setting,as a bridge between inheritance and innovation.Firstly,a systematic search of current evidence that supported integrated treatment of traditional Chinese and Western medicine for post-stroke sequelae sufferers was performed.Secondly,on the basis of available evidence,we presented couples of implications.Lastly,as psychosomatic perspective is one of the main academic paradigms of traditional Chinese medicine holism,we chiefly proposed comprehensive assessment for both motor and non-motor severities to probably match consonance with traditional Chinese medicine practice that treats psycho-/somatic-complains simultaneously.展开更多
In May 2022,the world witnessed the re-emergence of the zoonotic disease monkeypox.While this was not the first epidemic of this disease,what differentiated the outbreak was the rapid global spread and increase of cas...In May 2022,the world witnessed the re-emergence of the zoonotic disease monkeypox.While this was not the first epidemic of this disease,what differentiated the outbreak was the rapid global spread and increase of cases,which led the WHO to declare monkeypox a global health emergency.Although the disease spreads mainly through inadequately cooked meat of various rodent species,this virus also shows droplet,respiratory,sexual,and even vertical transmission.Monkeypox further multiplies in lymphoproliferative organs and presents with a classical smallpox-like rash,fever,headache,and muscle aches.Diagnosis is confirmed with a polymerase-chain-reaction test and is managed largely supportively with possible usage of some antivirals and immunoglobulins.Moreover,some pre-exposure and postexposure prophylactic vaccines have been developed.This paper aims to conduct an in-depth review of the historical epidemics,transmission,pathophysiology,clinical presentation,and management of the monkeypox disease.展开更多
To the Editor,IgG4‐related disease(IgG4‐RD)is a multisystem auto‐immune disorder with propensity to involve the kidneys.The clinical presentation,1 diagnostic classification criteria 2 and grading of disease activi...To the Editor,IgG4‐related disease(IgG4‐RD)is a multisystem auto‐immune disorder with propensity to involve the kidneys.The clinical presentation,1 diagnostic classification criteria 2 and grading of disease activity(Responder Index)3 of IgG4‐RD have been well established,however there is scarce data on histological evolution of this disease entity ensuing immunosuppressive treatment.There is a concern that the dense fibrotic lesions of IgG4‐RD could remain obstinate,notwithstanding immunosuppressive therapy,4 thereby leaving the affected organ with permanent scarring.We present the case of a 57‐year‐old man with multi‐system IgG4‐RD in whom the dense lympho‐plasmocytic intersti-tial inflammation and the typical whorl‐like storiform fibrosis observed in initial kidney biopsy showed a near complete resolution following 4 months of immuno-suppressive therapy.展开更多
文摘Objective:To establish non-inferiority of gonadotropin-releasing hormone degarelix compared with goserelin in suppressing and maintaining castrate testosterone levels from Day 28 to Day 364 in Chinese patients with prostate cancer.Methods:This is an open-label,multi-centre study in which men aged18 years were randomised in a 1:1 ratio to once-a-month subcutaneous injection of either degarelix(240/80 mg)or goserelin(3.6 mg)for 12 months.The primary endpoint was difference in 1-year cumulative probability of suppressing testosterone to ≤0.5 ng/mL.Non-inferiority was to be established if the lower 95% confidence interval(CI)limit for difference in cumulative probability between the treatment arms was greater than -10%.Secondary endpoints included cumulative probability of prostate-specific-antigen-progression-free-survival(PSA-PFS).Safety was also assessed.Results:Baseline demographics and disease characteristics were similar between degarelix(n=142)and goserelin(n=141)treatment arms.The difference in cumulative probability of maintaining castrate levels from Day 28-364 was 3.6%(95%CI:-1.5%,8.7%),demonstrating non-inferiority of degarelix.The cumulative probability of PSA-PFS at Day 364 was higher for degarelix(82.3%,95%CI:74.7%,87.7%)versus goserelin(71.7%,95%CI:63.2%,78.5%,p=0.038).Adverse events(AEs)were similar between treatment arms,except for more injection site reactions with degarelix versus goserelin.Four(2.8%)and nine(6.4%)patients discontinued due to AEs in degarelix and goserelin groups,respectively.
基金supported by Guangdong Medical Science Foundation(Grant No.A2020370A2021199)Guangdong Administration of Traditional Chinese Medicine Project(Grant No.20211328).
文摘In this work,we intended to connect clinimetrics with holism in traditional Chinese medicine towards multidimensional assessment of post-stroke sequelae in real-world setting,as a bridge between inheritance and innovation.Firstly,a systematic search of current evidence that supported integrated treatment of traditional Chinese and Western medicine for post-stroke sequelae sufferers was performed.Secondly,on the basis of available evidence,we presented couples of implications.Lastly,as psychosomatic perspective is one of the main academic paradigms of traditional Chinese medicine holism,we chiefly proposed comprehensive assessment for both motor and non-motor severities to probably match consonance with traditional Chinese medicine practice that treats psycho-/somatic-complains simultaneously.
文摘In May 2022,the world witnessed the re-emergence of the zoonotic disease monkeypox.While this was not the first epidemic of this disease,what differentiated the outbreak was the rapid global spread and increase of cases,which led the WHO to declare monkeypox a global health emergency.Although the disease spreads mainly through inadequately cooked meat of various rodent species,this virus also shows droplet,respiratory,sexual,and even vertical transmission.Monkeypox further multiplies in lymphoproliferative organs and presents with a classical smallpox-like rash,fever,headache,and muscle aches.Diagnosis is confirmed with a polymerase-chain-reaction test and is managed largely supportively with possible usage of some antivirals and immunoglobulins.Moreover,some pre-exposure and postexposure prophylactic vaccines have been developed.This paper aims to conduct an in-depth review of the historical epidemics,transmission,pathophysiology,clinical presentation,and management of the monkeypox disease.
文摘To the Editor,IgG4‐related disease(IgG4‐RD)is a multisystem auto‐immune disorder with propensity to involve the kidneys.The clinical presentation,1 diagnostic classification criteria 2 and grading of disease activity(Responder Index)3 of IgG4‐RD have been well established,however there is scarce data on histological evolution of this disease entity ensuing immunosuppressive treatment.There is a concern that the dense fibrotic lesions of IgG4‐RD could remain obstinate,notwithstanding immunosuppressive therapy,4 thereby leaving the affected organ with permanent scarring.We present the case of a 57‐year‐old man with multi‐system IgG4‐RD in whom the dense lympho‐plasmocytic intersti-tial inflammation and the typical whorl‐like storiform fibrosis observed in initial kidney biopsy showed a near complete resolution following 4 months of immuno-suppressive therapy.
