After proving safety in animal and human models, a series of clinical trials were conducted to examine the administration of 1 mg/mL bid of an undenatured beta-glucan on the immune system;and on self-perceived effects...After proving safety in animal and human models, a series of clinical trials were conducted to examine the administration of 1 mg/mL bid of an undenatured beta-glucan on the immune system;and on self-perceived effects on subjects’ quality of life (QoL) using a Visual Analogue Scale (VAS). In one study, a subject population that was self-perceived to be fatigued was administered an undetaured beta-glucan, to determine if this supplementation affected their quality-of-life as a result of an increased immune system response. 44 subjects were administered 1 mg/mL bid of the undenatured beta-glucan (Lentinex<sup>®</sup>) for four weeks. Prior to the beginning of the administration, and following the four-week administration period, the subjects were asked to fill out a quality-of-life VAS questionnaire. The changes in the two questionnaires revealed differences that occurred as a result of the beta-glucan administration. More than 75% of the subjects scored “better” (more than 1 cm on the VAS) with regard to feeling in a good mood, and feeling rested. More than 60% increased their energy and reduced their tiredness and exhaustion, and 70% felt less stressed. In a second study, subjects aged 40 years and older, believed to be in good general health, seeking therapy for tiredness/exhaustion/fatigue or similar conditions (neurasthenia) which were administered 1 mg/mL bid Lentinex<sup>®</sup>. The overall results indicated that the subjects felt significantly better (mean VAS = 5.91) after the last week of the study compared to how they felt initially (VAS = 4.73) (p < 0.0001). A statistically significant (p < 0.0001) change in distribution favoring a better situation after 4 weeks intake of supplement, with a remarkable fall in number of subjects scoring below normal (from 61.4% to 18.2%) accompanied by a significant shift in subjects feeling above normal, from 9.2% to 50.0%. These clinical studies, and others, showed that Lentinex<sup>®</sup> administration improved the perceived quality-of-life of subjects whose immune system was probably not functioning at optimal levels.展开更多
文摘After proving safety in animal and human models, a series of clinical trials were conducted to examine the administration of 1 mg/mL bid of an undenatured beta-glucan on the immune system;and on self-perceived effects on subjects’ quality of life (QoL) using a Visual Analogue Scale (VAS). In one study, a subject population that was self-perceived to be fatigued was administered an undetaured beta-glucan, to determine if this supplementation affected their quality-of-life as a result of an increased immune system response. 44 subjects were administered 1 mg/mL bid of the undenatured beta-glucan (Lentinex<sup>®</sup>) for four weeks. Prior to the beginning of the administration, and following the four-week administration period, the subjects were asked to fill out a quality-of-life VAS questionnaire. The changes in the two questionnaires revealed differences that occurred as a result of the beta-glucan administration. More than 75% of the subjects scored “better” (more than 1 cm on the VAS) with regard to feeling in a good mood, and feeling rested. More than 60% increased their energy and reduced their tiredness and exhaustion, and 70% felt less stressed. In a second study, subjects aged 40 years and older, believed to be in good general health, seeking therapy for tiredness/exhaustion/fatigue or similar conditions (neurasthenia) which were administered 1 mg/mL bid Lentinex<sup>®</sup>. The overall results indicated that the subjects felt significantly better (mean VAS = 5.91) after the last week of the study compared to how they felt initially (VAS = 4.73) (p < 0.0001). A statistically significant (p < 0.0001) change in distribution favoring a better situation after 4 weeks intake of supplement, with a remarkable fall in number of subjects scoring below normal (from 61.4% to 18.2%) accompanied by a significant shift in subjects feeling above normal, from 9.2% to 50.0%. These clinical studies, and others, showed that Lentinex<sup>®</sup> administration improved the perceived quality-of-life of subjects whose immune system was probably not functioning at optimal levels.
