Type 2 diabetes(T2D)is a multifaceted and heterogeneous syndrome associated with complications such as hypertension,coronary artery disease,and notably,breast cancer(BC).The connection between T2D and BC is establishe...Type 2 diabetes(T2D)is a multifaceted and heterogeneous syndrome associated with complications such as hypertension,coronary artery disease,and notably,breast cancer(BC).The connection between T2D and BC is established through processes that involve insulin resistance,inflammation and other factors.Despite this comprehension the specific cellular and molecular mechanisms linking T2D to BC,especially through microRNAs(miRNAs),remain elusive.miRNAs are regulators of gene expression at the post-transcriptional level and have the function of regulating target genes by modulating various signaling pathways and biological processes.However,the signaling pathways and biological processes regulated by miRNAs that are associated with T2D and BC have not yet been elucidated.This review aims to identify dysregulated miRNAs in both T2D and BC,exploring potential signaling pathways and biological processes that collectively contribute to the development of BC.展开更多
The number of deaths associated with cardiovascular events remains constant in many countries due to new therapeutic approaches for prevention and treatment of atherosclerosis. This condition is widely attributable to...The number of deaths associated with cardiovascular events remains constant in many countries due to new therapeutic approaches for prevention and treatment of atherosclerosis. This condition is widely attributable to unhealthy outcomes in its association with risk factors such as smoking and sedentary behavior. Risk factors play a significant role in the progression of coronary artery disease. We conducted a review of the literature with the purpose of identifying primary risk factors for coronary disease, lifestyle change interventions, and expectations for a reduction in cardiovascular events on the basis of evidence-based health education strategies. In addition, we sought to contextualize this review so that nurses are trained to use these findings in their practice at different levels of care.展开更多
基金Supported by Sao Paulo Research Foundation,No.2022/02339-4Conselho Nacional de Desenvolvimento Científico e Tecnológico,No.313376/2021-2 and No.313479/2017-8.
文摘Type 2 diabetes(T2D)is a multifaceted and heterogeneous syndrome associated with complications such as hypertension,coronary artery disease,and notably,breast cancer(BC).The connection between T2D and BC is established through processes that involve insulin resistance,inflammation and other factors.Despite this comprehension the specific cellular and molecular mechanisms linking T2D to BC,especially through microRNAs(miRNAs),remain elusive.miRNAs are regulators of gene expression at the post-transcriptional level and have the function of regulating target genes by modulating various signaling pathways and biological processes.However,the signaling pathways and biological processes regulated by miRNAs that are associated with T2D and BC have not yet been elucidated.This review aims to identify dysregulated miRNAs in both T2D and BC,exploring potential signaling pathways and biological processes that collectively contribute to the development of BC.
文摘The number of deaths associated with cardiovascular events remains constant in many countries due to new therapeutic approaches for prevention and treatment of atherosclerosis. This condition is widely attributable to unhealthy outcomes in its association with risk factors such as smoking and sedentary behavior. Risk factors play a significant role in the progression of coronary artery disease. We conducted a review of the literature with the purpose of identifying primary risk factors for coronary disease, lifestyle change interventions, and expectations for a reduction in cardiovascular events on the basis of evidence-based health education strategies. In addition, we sought to contextualize this review so that nurses are trained to use these findings in their practice at different levels of care.
