We have read with a great interest the review published by Singh et al, on the treatment options in alcoholic and non-alcoholic fatty liver disease, including various new targeted therapies that are currently under in...We have read with a great interest the review published by Singh et al, on the treatment options in alcoholic and non-alcoholic fatty liver disease, including various new targeted therapies that are currently under investigation. Recently, we described the health effects of the Mediterranean diet associated to an antioxidant complex rich in silymarin, to improve in overweight patients anthropometric parameters, glucose and lipid metabolism and intra-hepatic fat accumulation.展开更多
Yields in the irrigated rice areas have improved remarkably over the last three decades. Farmers with access to assured water supply have adopted improved varieties, resulting in higher yields and improved income in
Nonalcoholic fatty liver disease(NAFLD)has recently become an emerging health problem worldwide(1).The pathogenetic mechanisms involved in the development and progression of NAFLD are due to genetic predisposition tha...Nonalcoholic fatty liver disease(NAFLD)has recently become an emerging health problem worldwide(1).The pathogenetic mechanisms involved in the development and progression of NAFLD are due to genetic predisposition that expresses a metabolic profile associated with high energy food intake(2).The most accurate estimate of the worldwide prevalence of NAFLD is 24–25%of the general population,and ranges from 5–18%in Asia to 20–30%in the Western countries(1,3).Nowadays,the reason for this variability is not clear yet.However,it is plausible that genetic factors could play a major role in pathogenesis and the advances in genomics,transcriptomics,and proteomics have highlighted new pathogenic pathways.In fact,increasing literature data support the role of single nucleotide polymorphisms(SNPs),and in particular the SNPs of genes involved in insulin signaling,lipid homeostasis,and oxidative stress,not only in the susceptibility to develop NAFLD,but also in the severity of liver damage and in the etiology of multisystemic metabolic disorders(4).The development of the Genome Wide Association Study technology has allowed the identification of many SNPs involved in the onset of NAFLD,since they can change the stages of development,the rate of progression,and the efficacy of treatment(5).Recently,Tricòet al.investigate the clinical and genetic features associated with pediatric NAFLD in a prospective study in a large multiethnic cohort of obese adolescents(6).A total of 503 subjects,identified as"The Yale Pediatric NAFLD cohort",were enrolled,including 191(38.0%)Caucasians,134(26.6%)African Americans,and 178(35.4%)Hispanics.展开更多
文摘We have read with a great interest the review published by Singh et al, on the treatment options in alcoholic and non-alcoholic fatty liver disease, including various new targeted therapies that are currently under investigation. Recently, we described the health effects of the Mediterranean diet associated to an antioxidant complex rich in silymarin, to improve in overweight patients anthropometric parameters, glucose and lipid metabolism and intra-hepatic fat accumulation.
文摘Yields in the irrigated rice areas have improved remarkably over the last three decades. Farmers with access to assured water supply have adopted improved varieties, resulting in higher yields and improved income in
文摘Nonalcoholic fatty liver disease(NAFLD)has recently become an emerging health problem worldwide(1).The pathogenetic mechanisms involved in the development and progression of NAFLD are due to genetic predisposition that expresses a metabolic profile associated with high energy food intake(2).The most accurate estimate of the worldwide prevalence of NAFLD is 24–25%of the general population,and ranges from 5–18%in Asia to 20–30%in the Western countries(1,3).Nowadays,the reason for this variability is not clear yet.However,it is plausible that genetic factors could play a major role in pathogenesis and the advances in genomics,transcriptomics,and proteomics have highlighted new pathogenic pathways.In fact,increasing literature data support the role of single nucleotide polymorphisms(SNPs),and in particular the SNPs of genes involved in insulin signaling,lipid homeostasis,and oxidative stress,not only in the susceptibility to develop NAFLD,but also in the severity of liver damage and in the etiology of multisystemic metabolic disorders(4).The development of the Genome Wide Association Study technology has allowed the identification of many SNPs involved in the onset of NAFLD,since they can change the stages of development,the rate of progression,and the efficacy of treatment(5).Recently,Tricòet al.investigate the clinical and genetic features associated with pediatric NAFLD in a prospective study in a large multiethnic cohort of obese adolescents(6).A total of 503 subjects,identified as"The Yale Pediatric NAFLD cohort",were enrolled,including 191(38.0%)Caucasians,134(26.6%)African Americans,and 178(35.4%)Hispanics.
