1.Objective The Fankou giant zinc(Zn)-lead(Pb)deposit in Guangdong Province is well-known for its huge reserves of over 10 Mt(million ton)Zn+Pb metals and high ore-grade with Zn+Pb exceeding 15%(Guangdong Fankou Depos...1.Objective The Fankou giant zinc(Zn)-lead(Pb)deposit in Guangdong Province is well-known for its huge reserves of over 10 Mt(million ton)Zn+Pb metals and high ore-grade with Zn+Pb exceeding 15%(Guangdong Fankou Deposit Investigation Group,1980;Zhu XY et al.,2017).After 60 years of exploration and exploitation,the deposit has accumulated millions of tons of tailings.One interesting question is that what components are hosted in these tailings,and whether some key and critical metals such as gallium and germanium are extremely enriched and worth further comprehensive utilization.This motivated us to conduct an integrated set of field investigation,sampling,major-trace element analyses and reserve assessments about the Fankou tailings.In this contribution,we discover that the tailings contain a variety of metal elements such as zinc,lead and gallium with comprehensive utilization potential.These data can act as a scientific guidance for further exploration and utilization of the Fankou tailings,and aid to enhance the utilization efficiency of the key mineral resource in China.Our study also provide demonstration for future green mine construction in China.展开更多
Guangdong Supply and Marketing Cooperative serves as an important institution for the“Three Rural Areas”in the Guangdong-Hong Kong-Macao Greater Bay Area.Its digital transformation and optimization serve as powerful...Guangdong Supply and Marketing Cooperative serves as an important institution for the“Three Rural Areas”in the Guangdong-Hong Kong-Macao Greater Bay Area.Its digital transformation and optimization serve as powerful supports for rural revitalization.This paper systematically reviews the main practices and effectiveness of the digital transformation within the Guangdong Supply and Marketing Cooperative.It also analyzes the current development dilemmas faced in the construction of digital supply and marketing.Additionally,it proposes targeted solutions,including building a big data resource base,optimizing the digital supply and marketing cloud platform,developing digital publictype agricultural social service applications,establishing a new model of rural e-commerce,enhancing the traceability management system for agricultural products,and strengthening the construction of the digital human resources system.These proposals aim to further promote the strategy for revitalizing the countryside.展开更多
Objective This study aimed to understand the epidemic status and phylogenetic relationships of rotavirus group A(RVA)in the Pearl River Delta region of Guangdong Province,China.Methods This study included individuals ...Objective This study aimed to understand the epidemic status and phylogenetic relationships of rotavirus group A(RVA)in the Pearl River Delta region of Guangdong Province,China.Methods This study included individuals aged 28 days–85 years.A total of 706 stool samples from patients with acute gastroenteritis collected between January 2019 and January 2020 were analyzed for 17 causative pathogens,including RVA,using a Gastrointestinal Pathogen Panel,followed by genotyping,virus isolation,and complete sequencing to assess the genetic diversity of RVA.Results The overall RVA infection rate was 14.59%(103/706),with an irregular epidemiological pattern.The proportion of co-infection with RVA and other pathogens was 39.81%(41/103).Acute gastroenteritis is highly prevalent in young children aged 0–1 year,and RVA is the key pathogen circulating in patients 6–10 months of age with diarrhea.G9P[8](58.25%,60/103)was found to be the predominant genotype in the RVA strains,and the 41 RVA-positive strains that were successfully sequenced belonged to three different RVA genotypes in the phylogenetic analysis.Recombination analysis showed that gene reassortment events,selection pressure,codon usage bias,gene polymorphism,and post-translational modifications(PTMs)occurred in the G9P[8]and G3P[8]strains.Conclusion This study provides molecular evidence of RVA prevalence in the Pearl River Delta region of China,further enriching the existing information on its genetics and evolutionary characteristics and suggesting the emergence of genetic diversity.Strengthening the surveillance of genotypic changes and gene reassortment in RVA strains is essential for further research and a better understanding of strain variations for further vaccine development.展开更多
A new horned toad species,Boulenophrys elongata sp.nov.,is described from Mt.Lianhua,Huidong County,eastern Guangdong,China.The new species is phylogenetically closest to B.brachykolos,which is restricted to the east ...A new horned toad species,Boulenophrys elongata sp.nov.,is described from Mt.Lianhua,Huidong County,eastern Guangdong,China.The new species is phylogenetically closest to B.brachykolos,which is restricted to the east of the Pearl River Estuary(i.e.,Shenzhen City and Hong Kong SAR).The new species can be distinguished from all recognized congeners by a combination of morphological characters and genetic divergences in the combined mitochondrial 16S,12S and CO1 genes.We recommend the new species be listed as Data Deficient(DD)in the IUCN categorization,pending further investigation.展开更多
In this paper, the CMA-TRAMS tropical high-resolution system was used to forecast a typical hot weather process in Guangdong, China with different horizontal resolutions and surface coverage. The results of resolution...In this paper, the CMA-TRAMS tropical high-resolution system was used to forecast a typical hot weather process in Guangdong, China with different horizontal resolutions and surface coverage. The results of resolutions of 0.02° and 0.06° were presented with the same surface coverage of the GlobeLand30 V2020, companies with the results of resolution 0.02° with the USGS global surface coverage. The results showed that, on the overall assessment the 2 km model performed better in forecasting 2 m temperature, while the 6 km model was more accurate in predicting 10 m wind speed. In the evaluation of representative stations, the 2 km model performed better in forecasting 2 m temperature and 2 m relative humidity at the coastal stations, and the 2 km model was also better in forecasting 2 m pressure at the representative stations. However, the 6 km model performed better in forecasting 10 m wind speed at the representative stations. Furthermore, the 2 km model, owing to its higher horizontal resolution, presented a more detailed stratification of various meteorological field maps, allowing for a more pronounced simulation of local meteorological element variations. And the use of the surface coverage data of the GlobeLand30 V2020 improved the forecasting of 2 m temperature, and 10 m wind speed compared to the USGS surface coverage data.展开更多
This study explores the development trajectory of digital financial inclusion in 21 cities in Guangdong Province through fuzzy-set qualitative comparative analysis(fsQCA).The findings emphasize that the success of dig...This study explores the development trajectory of digital financial inclusion in 21 cities in Guangdong Province through fuzzy-set qualitative comparative analysis(fsQCA).The findings emphasize that the success of digital financial inclusion goes beyond individual dimensions,forming a systematic initiative marked by multifaceted interaction among different disciplines.In the trajectory of high-level digital inclusive finance development,the study identifies economic prosperity and technological innovation as crucial elements,highlighting their centrality,and elucidates the synergistic collaboration between market mechanisms and government guidance.Furthermore,the study emphasizes the government’s pivotal role in supporting market mechanisms and guiding policies,highlighting the need to achieve a nuanced equilibrium in the digital financial inclusion strategy.In contrast,non-high-level development paths of digital inclusive finance show a spectrum of diversities,emphasizing the critical roles played by economic fundamentals,government regulation,market mechanisms,and other contextual factors in different trajectories.Regarding policy implications,the study emphasizes the comprehensive and systemic nature inherent in the development of digital inclusive finance.It proposes four policy recommendations,including integrating development strategies,emphasizing scientific and technological innovation and economic development,achieving a delicate balance between market mechanisms and government guidance,and providing precise policy support.These insights provide valuable lessons for shaping digital inclusive financial policies in Guangdong Province and beyond,offering profound insights for strategically constructing robust digital financial ecosystems.展开更多
By using the methods of literature review,questionnaire survey,and expert interview,this paper discusses and analyzes the deep integration mechanism of national fitness campaign and college physical education teaching...By using the methods of literature review,questionnaire survey,and expert interview,this paper discusses and analyzes the deep integration mechanism of national fitness campaign and college physical education teaching,in order to promote the development of college physical education teaching reform,expand ideas,explore new fields,and provide novel development directions.The purpose is to enhance the national physical quality,improve the public service system,enhance the health awareness of the citizens,and provide guidelines for promoting the development of sports.展开更多
The comprehensive reform of“three-wide education”is important to achieve inheritance and innovation in ideological education in colleges and universities.The Guangdong University of Petrochemical Technology aims to ...The comprehensive reform of“three-wide education”is important to achieve inheritance and innovation in ideological education in colleges and universities.The Guangdong University of Petrochemical Technology aims to address the practical problems of a weak ideological education team,incomplete system and mechanism,and insufficient resource mobilization in“three-wide education.”It actively explores the“three-wide education”based on the university’s existing foundation and advantages.Comprehensive,innovative ideas for reform,practice,and promotion of unique practices and paths are necessary,to continuously deepen education reforms and strive to build a new“three-wide education”work pattern to help the country’s modern talent cultivation work.展开更多
The impact of sea surface temperature(SST)on winter haze in Guangdong province(WHDGD)was analyzed on the interannual scale.It was pointed out that the northern Indian Ocean and the northwest Pacific SST play a leading...The impact of sea surface temperature(SST)on winter haze in Guangdong province(WHDGD)was analyzed on the interannual scale.It was pointed out that the northern Indian Ocean and the northwest Pacific SST play a leading role in the variation of WHDGD.Cold(warm)SST anomalies over the northern Indian Ocean and the Northwest Pacific stimulate the eastward propagation of cold(warm)Kelvin waves through the Gill forced response,causing Ekman convergence(divergence)in the western Pacific,inducing abnormal cyclonic(anticyclonic)circulation.It excites the positive(negative)Western Pacific teleconnection pattern(WP),which results in the temperature and the precipitation decrease(increase)in Guangdong and forms the meteorological variables conditions that are conducive(not conducive)to the formation of haze.ENSO has an asymmetric influence on WHDGD.In El Niño(La Niña)winters,there are strong(weak)coordinated variations between the northern Indian Ocean,the northwest Pacific,and the eastern Pacific,which stimulate the negative(positive)phase of WP teleconnection.In El Niño winters,the enhanced moisture is attributed to the joint effects of the horizontal advection from the surrounding ocean,vertical advection from the moisture convergence,and the increased atmospheric apparent moisture sink(Q2)from soil evaporation.The weakening of the atmospheric apparent heat source(Q1)in the upper layer is not conducive to the formation of inversion stratification.In contrast,in La Niña winters,the reduced moisture is attributed to the reduced upward water vapor transport and Q2 loss.Due to the Q1 increase in the upper layer,the temperature inversion forms and suppresses the diffusion of haze.展开更多
The ecological suitability of marine resources and environmental conditions for marine ranching in Guangdong,South China was evaluated.Niche theory was used to establish an ecological suitability evaluation model for ...The ecological suitability of marine resources and environmental conditions for marine ranching in Guangdong,South China was evaluated.Niche theory was used to establish an ecological suitability evaluation model for marine ranching site selection,and suitability evaluation of marine ranching was conducted in.Results show that the ecological suitability index of marine ranching site selection was greater than 64.0 in 20 sites,including offshore Shantou Bay,offshore Zhanjiang Port,and Longdou Bay etc.,which are the priority areas for marine ranching.In other 13 sites,the ecological suitability index ranged between 8.0 and 32.0,including Houjiang Bay,Haimen Bay,and Jieshi Bay etc.,indicating the suitability for marine ranching.However,the ecological suitability index was 0 in Shantou Bay,Zhujiang(Pearl)River estuary,Huangmao Sea,Guanghai Bay,Zhanjiang Port,Qiongzhou Strait,and Anpu Port.These sites are thus unsuitable for marine ranching.This study provides a theoretical basis for site selection and planning of marine ranching in Guangdong Province.展开更多
The Guangdong-Hong Kong-Macao Greater Bay Area is witnessing a surge in economic development,showcasing robust resilience in the co-agglomeration of producer services and manufacturing industries,along with the increa...The Guangdong-Hong Kong-Macao Greater Bay Area is witnessing a surge in economic development,showcasing robust resilience in the co-agglomeration of producer services and manufacturing industries,along with the increasingly evident impact generated by such co-agglomeration.Based on the panel data collected from ten cities in the Guangdong-Hong Kong-Macao Greater Bay Area(excluding Zhaoqing)spanning from 2010 to 2020,we examined the formation mechanism for industrial co-agglomeration in the area from three dimensions:industrial correlation,spatial correlation,and policy guidance.Our analysis was based on a vertical correlation model and was validated using the seemingly unrelated regressions(SUR)method.The findings are as follows:(a)There currently exists no spatial correlation between the producer services and manufacturing sectors in the area,and the correlation between the two remains limited to the former providing specialized services to the latter.(b)Policy guidance has a positive impact on the location selection of industries within the area.By implementing a comprehensive range of favorable policies,local governments can provide effective and scientifically guided recommendations regarding the location of producer services and manufacturing sectors.Therefore,it is crucial to foster the collaboration between producer services and manufacturing sectors and further enhance the co-agglomeration between the two sectors.In addition,the government authorities should also strive to enhance its economic governance capacity,thereby facilitating the formation of such co-agglomeration.展开更多
Innovation capitalization is a new concept in innovation geography research.Extant research on a city scale has proven that innovation is an important factor affecting housing prices and verified that innovation has a...Innovation capitalization is a new concept in innovation geography research.Extant research on a city scale has proven that innovation is an important factor affecting housing prices and verified that innovation has a capitalization effect.However,few studies investigate the spatial heterogeneity of innovation capitalization.Thus,case verification at the urban agglomeration scale is needed.Therefore,this study proposes a theoretical framework for the spatial heterogeneity of innovation capitalization at the urban agglomeration scale.Examining the Guangdong-Hong Kong-Macao Greater Bay Area(GHMGBA),China as a case study,the study investigated the spatial heterogeneity of the influence of high-tech firms,representing innovation,on housing prices.This work verified the spatial heterogeneity of innovation capitalization.The study constructed a data set influencing housing prices,comprising 11 factors in 5 categories(high-tech firms,convenience of living facilities,built environment,the natural environment,and the fundamentals of the districts)for 419 subdistricts in the GHMGBA.On the global scale,the study finds that high-tech firms have a significant and positive influence on housing prices,with the housing price increasing by 0.0156%when high-tech firm density increases by 1%.Furthermore,a semi-geographically weighted regression(SGWR)analysis shows that the influence of high-tech firms on housing prices has spatial heterogeneity.The areas where high-tech firms have a significant and positive influence on housing prices are mainly in the GuangzhouFoshan metropolitan area,western Shenzhen-Dongguan,north-central Zhongshan-Nansha district,and Guangzhou—all areas with densely distributed high-tech firms.These results confirm the spatial heterogeneity of innovation capitalization and the need for further discussion of its scale and spatial limitations.The study offers implications for relevant GHMGBA administrative authorities for spatially differentiated development strategies and housing policies that consider the role of innovation in successful urban development.展开更多
By deconstructing the dimensions of rural tourism and rural revitalization and constructing a coupled conceptual model,a coupled evaluation model is constructed.Yannanfei Tea Field Resort in Guangdong is taken as a re...By deconstructing the dimensions of rural tourism and rural revitalization and constructing a coupled conceptual model,a coupled evaluation model is constructed.Yannanfei Tea Field Resort in Guangdong is taken as a research case for empirical analysis,to explore the coupled development trend of the two.The results show that①the tourism development of Guangdong Yannanfei Tea Field Resort has a good synergistic relationship with rural revitalization.The two complement and promote each other,and rural tourism has significantly promoted the development of rural revitalization.②The coupling development of tourism development and rural revitalization in Guangdong Yannanfei Tea Field Resort is divided into coupling imbalance period and coupling coordination period.The results indicate that the coordination between the two has not yet reached a level of good coordination and high-quality coordination.It is recommended that the resort should fully utilize the opportunity of rural revitalization strategy,increase investment in rural tourism,promote the transformation and upgrading of the resort,impel the integration of tea and tourism,and develop new business model of tea-tourism rural vacation.展开更多
As one of the four largest bay areas with strong economic activities in the world,the Guangdong-Hong Kong-Macao Greater Bay Area(GHMGBA)is located in the zone of interaction between the South China Block(SCB)and the S...As one of the four largest bay areas with strong economic activities in the world,the Guangdong-Hong Kong-Macao Greater Bay Area(GHMGBA)is located in the zone of interaction between the South China Block(SCB)and the South China Sea(SCS).Under the influence of complex geologic evolution,basin-range structures,fault systems and hot springs are well developed here.However,the characteristics of geological structures and the genetic mechanism of these geological phenomena are still unclear.Therefore,we performed ambient noise tomography to obtain 3-D upper crust(0-7.5 km)S-wave velocity structures of the GHMGBA by using 40-day continuous waveform data from 130 seismic stations in the GHMGBA.Our results show that sedimentary basins in the GHMGBA are mainly characterized by low-velocity anomalies.S-wave velocities of sediment formation in basins are about 2.8-3.1 km/s.Rapid changes in velocity appear at the edges of the basins,which correspond to the NE-,NEE-,and NW-trending faults,indicating prominent basin-controlling effects of the faults.The Sanshui Basin(SSB),the largest in the GHMGBA,has a developmental depth of about 4 km,and there is a significant difference in velocity gradient between the east and west sides of the basin,indicating that SSB has experienced east-west asymmetric expansion.Moreover,there are prominent low-velocity anomalies at a depth of about 4.5 km beneath the hot springs at the west of the Zhujiang(Pearl)River estuary(ZRE).We infer that the low-velocity anomalies are fluid reservoirs of the hot springs,which lead to the development of the hot springs on the surface.In addition,the distribution of main cities in the GHMGBA shows a spatial correlation with low-velocity areas at shallow depths(<3 km).The population development trend in the GHMGBA in the past 20 years is also mainly concentrated in the structural province of relatively low-velocity.In combination with the GHMGBA basin structures and drainage distribution characteristics,we suggest that the basic geological environment to some extent affects the habitability of the human settlement and thus determines the distribution and development trend of the main urban context.We believe that the 3-D S-wave velocity structure of the upper crust of the GHMGBA obtained in this study,as well as the deep structural characteristics of the basins and hot springs,will provide support to urban construction planning and geological hazards research of the GHMGBA.展开更多
BACKGROUND Neonatal hyperbilirubinemia is one of the common diseases of newborns that typically presents with yellow staining of skin,resulting in sequelaes such as hearing loss,motor and intellectual development diso...BACKGROUND Neonatal hyperbilirubinemia is one of the common diseases of newborns that typically presents with yellow staining of skin,resulting in sequelaes such as hearing loss,motor and intellectual development disorders,and even death.The pathogenic factors of neonatal hyperbilirubinemia are complex.Different cases of hyperbilirubinemia may have a single or mixed etiology.AIM To explore the etiological characteristics of severe hyperbilirubinemia in term newborns of eastern Guangdong of China.METHODS Term newborns with severe hyperbilirubinemia in one hospital from January 2012 to December 2021 were retrospectively analyzed.The etiology was determined according to the laboratory results and clinical manifestations.RESULTS Among 1602 term newborns with hyperbilirubinemia in eastern Guangdong of China,32.20%(580/1602)was severe hyperbilirubinemia.Among the causes of severe hyperbilirubinemia,neonatal hemolysis accounted for 15.17%,breast milk jaundice accounted for 12.09%,infection accounted for 10.17%,glucose-6-phosphate dehydrogenase(G6PD)deficiency accounted for 9.14%,and the coexistence of multiple etiologies accounted for 6.55%,unknown etiology accounted for 41.72%.ABO hemolysis and G6PD deficiency were the most common causes in the 20 cases with bilirubin encephalopathy.94 severe hyperbilirubinemia newborns were tested for uridine diphosphate glucuronosyl transferase 1A1(UGT1A1)*6 variant(rs4148323,c.211G>A,p.Arg71Gly),9 cases were 211 G to A homozygous variant,37 cases were 211 G to A heterozygous variant,and 48 cases were wild genotypes.CONCLUSION The main cause for severe hyperbilirubinemia and bilirubin encephalopathy in eastern Guangdong of China were the hemolytic disease of the newborns,G6PD deficiency and infection.UGT1A1 gene variant was also a high-risk factor for neonatal hyperbilirubinemia.Targeted prevention and treatment according to the etiology may reduce the occurrence of bilirubin encephalopathy and kernicterus.展开更多
While heavy rainfall frequently takes place in southern China during summer monsoon seasons,quantitative precipitation forecast skills are relatively poor.Therefore,detailed knowledge about the raindrop size distribut...While heavy rainfall frequently takes place in southern China during summer monsoon seasons,quantitative precipitation forecast skills are relatively poor.Therefore,detailed knowledge about the raindrop size distribution(DSD)is useful in improving the quantitative precipitation estimation and forecast.Based on the data during 2018-2022 from 86stations in a ground-based optical disdrometer measurement network,the characteristics of the DSD in Guangdong province are investigated in terms of the particle size distribution(N(D)),mass-weighted mean diameter(Dm) and other integral DSD parameters such as radar reflectivity(Z),rainfall rate(R) and liquid water content(LWC).In addition,the effects of geographical locations,weather systems(tropical cyclones,frontal systems and the summer monsoon) and precipitation types on DSD characteristics are also considered.The results are shown as follows.1) Convective precipitation has a broader N(D) and larger mean particle diameter than the stratiform precipitation,and the DSD observations in Guangdong are consistent with the three-parameter gamma distribution.The relationships between the Z and R for stratiform and convective precipitation are also derived for the province,i.e.,Z=332.34 R1.32and Z=366.26R1.42which is distinctly different from that of the Next-generation Weather Radar(NEXRAD) Z-R relationship in United States.2) In the rainy season(April-September),the Dm, R and LWC are larger than those in the dry season(OctoberMarch).Moreover the above parameters are larger,especially in mid-May,which is the onset of the South China Sea summer monsoon.3) The spatial analysis of DSD shows that the coastal station observations indicate a smaller Dmand a larger normalized intercept parameter(log10Nw),suggestive of maritime-like rainfall.Dmis larger and log10Nwis smaller in the inland area,suggestive of continental-like rainfall.4) Affected by such weather systems as the tropical cyclone,frontal system and summer monsoon,the DSD shows characteristics with distinct differences.Furthermore,frontal system rainfall tends to present a continental-like rainfall,tropical cyclone rainfall tends to have a maritime-like rainfall,and summer monsoon rainfall characteristic are between maritime-and continental-like cluster(raindrop concentration and diameter are higher than continental cluster and maritime cluster,respectively.)展开更多
Shanbei Village is a village in Yunfu of Guangdong,which has been seriously affected by flood disasters.In the context of the construction of beautiful countryside,utilizing the concept of resilience stormwater,constr...Shanbei Village is a village in Yunfu of Guangdong,which has been seriously affected by flood disasters.In the context of the construction of beautiful countryside,utilizing the concept of resilience stormwater,construction ideas of beautiful countryside of combining the prevention and control of village flood disasters with economic and social development and cultural heritage are proposed.The planning methods of adjusting the planting way of crops,demolition of dwellings in submerged areas and development and utilization of ancient dwellings,sorting out drainage systems and planning“large,medium and small sponges”,and improving the drainage capacity of culverts are summarized.展开更多
Guangzhou,a significant hub city in the Guangdong-Hong Kong-Macao Greater Bay Area,has seen fast social and economic growth as well as steady progress in the degree of urbanization.This research,taking Guangzhou city ...Guangzhou,a significant hub city in the Guangdong-Hong Kong-Macao Greater Bay Area,has seen fast social and economic growth as well as steady progress in the degree of urbanization.This research,taking Guangzhou city as an example,aims to provide an understanding of how land resources,urbanization,and spatial planning are coordinated in the study area.It also aims to explore how the coordination degree of land resources,urbanization,and spatial planning changes over time.It seeks to provide effective suggestions for land resource protection,national spatial planning,and urban transformation development to promote the coordinated development of the Guangdong-Hong Kong-Macao Greater Bay Area into a world-class Bay Area.展开更多
The Luxi-Xianrenzhang diabase dikes were emplaced into the eastern part of the Guidong composite granitoids in northern Guangdong Province at the end of the Early Cretaceous. They show tholeiitic features, enrichment ...The Luxi-Xianrenzhang diabase dikes were emplaced into the eastern part of the Guidong composite granitoids in northern Guangdong Province at the end of the Early Cretaceous. They show tholeiitic features, enrichment in large ion lithophile elements, slight enrichment in light rare earth elements, depletion in Zr and Hf, and basically no depletion in Nb and Ta and no Eu anomaly. They are similar to intraplate basalt in terms of trace element characteristics. They have high εNd(t) values (3.6-4.9), initial ^87Sr/^86Sr ratios (0.70530-70641) and δ^18O values and Dupal anomaly of Pb isotope compositions. Their Sr-Nd, Pb-Sr, Pb-Nd and Pb-Pb isotopes plot between DMM and EMII, with Pb similar to EMII, Nd relatively close to DMM and Sr in between. This profile suggests that the diabase dikes studied were derived from partial melting of a mantle source that had been subjected to metasomatism by fluids originated from a subduction zone under a tectonic environment of crustal extension and lithosphere thinning in the late Yanshanian.展开更多
Thalassemia is a group of genetically heterogeneous diseases characterized by hemolytic anemia.To investigate molecular characteristics ofα-andβ-thalassemia among young individuals of marriageable age in Guangdong P...Thalassemia is a group of genetically heterogeneous diseases characterized by hemolytic anemia.To investigate molecular characteristics ofα-andβ-thalassemia among young individuals of marriageable age in Guangdong Province,24,788 subjects with suspected thalassemia were genetically tested forα-andβ-thalassemia by GapPCR and reverse dot blot during 2018–2019.For suspected rare thalassemia cases,DNA sequencing was performed to identify rare and unknown thalassemia gene mutations.A total of 14,346 thalassemia carriers were detected,including 7,556 cases ofα-thalassemia with 25 genotypes and 8α-gene mutations identified,5,860 cases ofβ-thalassemia with 18 genotypes and 18β-gene mutations identified,and 930 cases of compoundα/β-thalassemia.Among them,the frequency of--SEA deletion was the highest inα-thalassemia(66.01%),followed by-α3.7(17.98%)and-α.24(8.22%),and the frequency of CD41-42(-TCTT)mutation was the highest inβ-thalassemia(38.38%),followed by IVS-II-654(C>T)(25.67%),-28(A>G)(15.76%),and CD17(10.01%).In addition,5 rare mutations(--THAI and HKαα,CD113,-90,and CD56)were found in the study population.Our results revealed molecular epidemiological background ofα-andβ-thalassemia in Guangdong Province,which can support optimization of thalassemia prevention and control strategies.We demonstrated that thalassemia is heterogeneous with significant geographical differences and population specificity.展开更多
基金supported by the National Key Research and Development Program of China(2021YFC2900300)the National Natural Science Foundation of China(42022020 and 41872193)+1 种基金the Guangdong Province Introduced of Innovative R&D Team(2021ZT09H399)the Zhongjin Lingnan Fankou Lead-zinc Mine Enterprise Entrusted Project(2022.J005).
文摘1.Objective The Fankou giant zinc(Zn)-lead(Pb)deposit in Guangdong Province is well-known for its huge reserves of over 10 Mt(million ton)Zn+Pb metals and high ore-grade with Zn+Pb exceeding 15%(Guangdong Fankou Deposit Investigation Group,1980;Zhu XY et al.,2017).After 60 years of exploration and exploitation,the deposit has accumulated millions of tons of tailings.One interesting question is that what components are hosted in these tailings,and whether some key and critical metals such as gallium and germanium are extremely enriched and worth further comprehensive utilization.This motivated us to conduct an integrated set of field investigation,sampling,major-trace element analyses and reserve assessments about the Fankou tailings.In this contribution,we discover that the tailings contain a variety of metal elements such as zinc,lead and gallium with comprehensive utilization potential.These data can act as a scientific guidance for further exploration and utilization of the Fankou tailings,and aid to enhance the utilization efficiency of the key mineral resource in China.Our study also provide demonstration for future green mine construction in China.
基金Guangdong Province Philosophy and Social Sciences Co-Construction Project(GD23XGL051)Guangdong University of Science and Technology(GKY-2023KYZDW-2)。
文摘Guangdong Supply and Marketing Cooperative serves as an important institution for the“Three Rural Areas”in the Guangdong-Hong Kong-Macao Greater Bay Area.Its digital transformation and optimization serve as powerful supports for rural revitalization.This paper systematically reviews the main practices and effectiveness of the digital transformation within the Guangdong Supply and Marketing Cooperative.It also analyzes the current development dilemmas faced in the construction of digital supply and marketing.Additionally,it proposes targeted solutions,including building a big data resource base,optimizing the digital supply and marketing cloud platform,developing digital publictype agricultural social service applications,establishing a new model of rural e-commerce,enhancing the traceability management system for agricultural products,and strengthening the construction of the digital human resources system.These proposals aim to further promote the strategy for revitalizing the countryside.
基金funded by the grant National Key R&D Program of China(2017ZX10103011-004 and 2018YFC1603804)the Science and Technology Program of Guangdong Province(2018B020207013 and 2019B030316013).
文摘Objective This study aimed to understand the epidemic status and phylogenetic relationships of rotavirus group A(RVA)in the Pearl River Delta region of Guangdong Province,China.Methods This study included individuals aged 28 days–85 years.A total of 706 stool samples from patients with acute gastroenteritis collected between January 2019 and January 2020 were analyzed for 17 causative pathogens,including RVA,using a Gastrointestinal Pathogen Panel,followed by genotyping,virus isolation,and complete sequencing to assess the genetic diversity of RVA.Results The overall RVA infection rate was 14.59%(103/706),with an irregular epidemiological pattern.The proportion of co-infection with RVA and other pathogens was 39.81%(41/103).Acute gastroenteritis is highly prevalent in young children aged 0–1 year,and RVA is the key pathogen circulating in patients 6–10 months of age with diarrhea.G9P[8](58.25%,60/103)was found to be the predominant genotype in the RVA strains,and the 41 RVA-positive strains that were successfully sequenced belonged to three different RVA genotypes in the phylogenetic analysis.Recombination analysis showed that gene reassortment events,selection pressure,codon usage bias,gene polymorphism,and post-translational modifications(PTMs)occurred in the G9P[8]and G3P[8]strains.Conclusion This study provides molecular evidence of RVA prevalence in the Pearl River Delta region of China,further enriching the existing information on its genetics and evolutionary characteristics and suggesting the emergence of genetic diversity.Strengthening the surveillance of genotypic changes and gene reassortment in RVA strains is essential for further research and a better understanding of strain variations for further vaccine development.
基金supported by the Project of Background Survey of Biosafety in Guangdong Province(STST-2021-10)the Project of Study on Optimal Allocation and Sustainable Development of Typical Urban and Rural Ecological Resources(K610222062406).
文摘A new horned toad species,Boulenophrys elongata sp.nov.,is described from Mt.Lianhua,Huidong County,eastern Guangdong,China.The new species is phylogenetically closest to B.brachykolos,which is restricted to the east of the Pearl River Estuary(i.e.,Shenzhen City and Hong Kong SAR).The new species can be distinguished from all recognized congeners by a combination of morphological characters and genetic divergences in the combined mitochondrial 16S,12S and CO1 genes.We recommend the new species be listed as Data Deficient(DD)in the IUCN categorization,pending further investigation.
文摘In this paper, the CMA-TRAMS tropical high-resolution system was used to forecast a typical hot weather process in Guangdong, China with different horizontal resolutions and surface coverage. The results of resolutions of 0.02° and 0.06° were presented with the same surface coverage of the GlobeLand30 V2020, companies with the results of resolution 0.02° with the USGS global surface coverage. The results showed that, on the overall assessment the 2 km model performed better in forecasting 2 m temperature, while the 6 km model was more accurate in predicting 10 m wind speed. In the evaluation of representative stations, the 2 km model performed better in forecasting 2 m temperature and 2 m relative humidity at the coastal stations, and the 2 km model was also better in forecasting 2 m pressure at the representative stations. However, the 6 km model performed better in forecasting 10 m wind speed at the representative stations. Furthermore, the 2 km model, owing to its higher horizontal resolution, presented a more detailed stratification of various meteorological field maps, allowing for a more pronounced simulation of local meteorological element variations. And the use of the surface coverage data of the GlobeLand30 V2020 improved the forecasting of 2 m temperature, and 10 m wind speed compared to the USGS surface coverage data.
基金2023 Guangdong Provincial Education Science Planning Project(Higher Education Special Project)“Empirical Study on the Spatial Optimization of the Relationship between Human Capital and Industrial Structure in Guangdong Province under the Support of Higher Education Services”(No.2023GXJK144)。
文摘This study explores the development trajectory of digital financial inclusion in 21 cities in Guangdong Province through fuzzy-set qualitative comparative analysis(fsQCA).The findings emphasize that the success of digital financial inclusion goes beyond individual dimensions,forming a systematic initiative marked by multifaceted interaction among different disciplines.In the trajectory of high-level digital inclusive finance development,the study identifies economic prosperity and technological innovation as crucial elements,highlighting their centrality,and elucidates the synergistic collaboration between market mechanisms and government guidance.Furthermore,the study emphasizes the government’s pivotal role in supporting market mechanisms and guiding policies,highlighting the need to achieve a nuanced equilibrium in the digital financial inclusion strategy.In contrast,non-high-level development paths of digital inclusive finance show a spectrum of diversities,emphasizing the critical roles played by economic fundamentals,government regulation,market mechanisms,and other contextual factors in different trajectories.Regarding policy implications,the study emphasizes the comprehensive and systemic nature inherent in the development of digital inclusive finance.It proposes four policy recommendations,including integrating development strategies,emphasizing scientific and technological innovation and economic development,achieving a delicate balance between market mechanisms and government guidance,and providing precise policy support.These insights provide valuable lessons for shaping digital inclusive financial policies in Guangdong Province and beyond,offering profound insights for strategically constructing robust digital financial ecosystems.
基金Guangdong University of Science and Technology 2023 school-level“quality project”“National Fitness Campaign and College Physical Education Deep Integration Mechanism Research”(Project number:GKZLGC2023142)。
文摘By using the methods of literature review,questionnaire survey,and expert interview,this paper discusses and analyzes the deep integration mechanism of national fitness campaign and college physical education teaching,in order to promote the development of college physical education teaching reform,expand ideas,explore new fields,and provide novel development directions.The purpose is to enhance the national physical quality,improve the public service system,enhance the health awareness of the citizens,and provide guidelines for promoting the development of sports.
基金2020 Guangdong Province Higher Education Teaching Reform Project(Guangdong Education Gaohan[2020]No.20)。
文摘The comprehensive reform of“three-wide education”is important to achieve inheritance and innovation in ideological education in colleges and universities.The Guangdong University of Petrochemical Technology aims to address the practical problems of a weak ideological education team,incomplete system and mechanism,and insufficient resource mobilization in“three-wide education.”It actively explores the“three-wide education”based on the university’s existing foundation and advantages.Comprehensive,innovative ideas for reform,practice,and promotion of unique practices and paths are necessary,to continuously deepen education reforms and strive to build a new“three-wide education”work pattern to help the country’s modern talent cultivation work.
基金Guangdong Basic and Applied Basic Research Foundation(2019A1515011808)Science and Technology Planning Program of Guangdong Province(2021B1212020016)。
文摘The impact of sea surface temperature(SST)on winter haze in Guangdong province(WHDGD)was analyzed on the interannual scale.It was pointed out that the northern Indian Ocean and the northwest Pacific SST play a leading role in the variation of WHDGD.Cold(warm)SST anomalies over the northern Indian Ocean and the Northwest Pacific stimulate the eastward propagation of cold(warm)Kelvin waves through the Gill forced response,causing Ekman convergence(divergence)in the western Pacific,inducing abnormal cyclonic(anticyclonic)circulation.It excites the positive(negative)Western Pacific teleconnection pattern(WP),which results in the temperature and the precipitation decrease(increase)in Guangdong and forms the meteorological variables conditions that are conducive(not conducive)to the formation of haze.ENSO has an asymmetric influence on WHDGD.In El Niño(La Niña)winters,there are strong(weak)coordinated variations between the northern Indian Ocean,the northwest Pacific,and the eastern Pacific,which stimulate the negative(positive)phase of WP teleconnection.In El Niño winters,the enhanced moisture is attributed to the joint effects of the horizontal advection from the surrounding ocean,vertical advection from the moisture convergence,and the increased atmospheric apparent moisture sink(Q2)from soil evaporation.The weakening of the atmospheric apparent heat source(Q1)in the upper layer is not conducive to the formation of inversion stratification.In contrast,in La Niña winters,the reduced moisture is attributed to the reduced upward water vapor transport and Q2 loss.Due to the Q1 increase in the upper layer,the temperature inversion forms and suppresses the diffusion of haze.
基金Supported by the Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(No.GML2019ZD0402)。
文摘The ecological suitability of marine resources and environmental conditions for marine ranching in Guangdong,South China was evaluated.Niche theory was used to establish an ecological suitability evaluation model for marine ranching site selection,and suitability evaluation of marine ranching was conducted in.Results show that the ecological suitability index of marine ranching site selection was greater than 64.0 in 20 sites,including offshore Shantou Bay,offshore Zhanjiang Port,and Longdou Bay etc.,which are the priority areas for marine ranching.In other 13 sites,the ecological suitability index ranged between 8.0 and 32.0,including Houjiang Bay,Haimen Bay,and Jieshi Bay etc.,indicating the suitability for marine ranching.However,the ecological suitability index was 0 in Shantou Bay,Zhujiang(Pearl)River estuary,Huangmao Sea,Guanghai Bay,Zhanjiang Port,Qiongzhou Strait,and Anpu Port.These sites are thus unsuitable for marine ranching.This study provides a theoretical basis for site selection and planning of marine ranching in Guangdong Province.
基金This paper is funded by the National Social Science Foundation of China entitled“A Study on the Role of Digital Technology in Facilitating the Integration of Modern Services and Advanced Manufacturing Sectors”(21BJY144)Major project supported by the Key Research Base of Humanities and Social Sciences in Universities of the Ministry of Education entitled“An Exploration of the Paths for Promoting High-level Opening Up in Guangdong-Hong Kong-Macao Greater Bay Area and Corresponding Measures”(22JD790056)Key project of Universities in Guangdong Province entitled“Research on Mechanism and Effect of Co-agglomeration of Producer Services and Manufacturing in Guangdong-Hong Kong-Macao Greater Bay Area”(2019WZDXM029).
文摘The Guangdong-Hong Kong-Macao Greater Bay Area is witnessing a surge in economic development,showcasing robust resilience in the co-agglomeration of producer services and manufacturing industries,along with the increasingly evident impact generated by such co-agglomeration.Based on the panel data collected from ten cities in the Guangdong-Hong Kong-Macao Greater Bay Area(excluding Zhaoqing)spanning from 2010 to 2020,we examined the formation mechanism for industrial co-agglomeration in the area from three dimensions:industrial correlation,spatial correlation,and policy guidance.Our analysis was based on a vertical correlation model and was validated using the seemingly unrelated regressions(SUR)method.The findings are as follows:(a)There currently exists no spatial correlation between the producer services and manufacturing sectors in the area,and the correlation between the two remains limited to the former providing specialized services to the latter.(b)Policy guidance has a positive impact on the location selection of industries within the area.By implementing a comprehensive range of favorable policies,local governments can provide effective and scientifically guided recommendations regarding the location of producer services and manufacturing sectors.Therefore,it is crucial to foster the collaboration between producer services and manufacturing sectors and further enhance the co-agglomeration between the two sectors.In addition,the government authorities should also strive to enhance its economic governance capacity,thereby facilitating the formation of such co-agglomeration.
基金Under the auspices of the National Natural Science Foundation of China (No.42101182,41871150)Guangdong Academy of Sciences (GDSA)Special Project of Science and Technology Development (No.2021GDASYL-20210103004,2020GDASYL-20200102002,2020GDASYL-20200104001)the Natural Science Foundation of Guangdong (No.2023A1515012399)。
文摘Innovation capitalization is a new concept in innovation geography research.Extant research on a city scale has proven that innovation is an important factor affecting housing prices and verified that innovation has a capitalization effect.However,few studies investigate the spatial heterogeneity of innovation capitalization.Thus,case verification at the urban agglomeration scale is needed.Therefore,this study proposes a theoretical framework for the spatial heterogeneity of innovation capitalization at the urban agglomeration scale.Examining the Guangdong-Hong Kong-Macao Greater Bay Area(GHMGBA),China as a case study,the study investigated the spatial heterogeneity of the influence of high-tech firms,representing innovation,on housing prices.This work verified the spatial heterogeneity of innovation capitalization.The study constructed a data set influencing housing prices,comprising 11 factors in 5 categories(high-tech firms,convenience of living facilities,built environment,the natural environment,and the fundamentals of the districts)for 419 subdistricts in the GHMGBA.On the global scale,the study finds that high-tech firms have a significant and positive influence on housing prices,with the housing price increasing by 0.0156%when high-tech firm density increases by 1%.Furthermore,a semi-geographically weighted regression(SGWR)analysis shows that the influence of high-tech firms on housing prices has spatial heterogeneity.The areas where high-tech firms have a significant and positive influence on housing prices are mainly in the GuangzhouFoshan metropolitan area,western Shenzhen-Dongguan,north-central Zhongshan-Nansha district,and Guangzhou—all areas with densely distributed high-tech firms.These results confirm the spatial heterogeneity of innovation capitalization and the need for further discussion of its scale and spatial limitations.The study offers implications for relevant GHMGBA administrative authorities for spatially differentiated development strategies and housing policies that consider the role of innovation in successful urban development.
基金Sponsored by Zhaoqing University Students Entrepreneurship Training Program Project(X202310580167).
文摘By deconstructing the dimensions of rural tourism and rural revitalization and constructing a coupled conceptual model,a coupled evaluation model is constructed.Yannanfei Tea Field Resort in Guangdong is taken as a research case for empirical analysis,to explore the coupled development trend of the two.The results show that①the tourism development of Guangdong Yannanfei Tea Field Resort has a good synergistic relationship with rural revitalization.The two complement and promote each other,and rural tourism has significantly promoted the development of rural revitalization.②The coupling development of tourism development and rural revitalization in Guangdong Yannanfei Tea Field Resort is divided into coupling imbalance period and coupling coordination period.The results indicate that the coordination between the two has not yet reached a level of good coordination and high-quality coordination.It is recommended that the resort should fully utilize the opportunity of rural revitalization strategy,increase investment in rural tourism,promote the transformation and upgrading of the resort,impel the integration of tea and tourism,and develop new business model of tea-tourism rural vacation.
基金Supported by the National Natural Science Foundation of China(No.42076071)the Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(No.GML2019ZD0204)+2 种基金the Guangdong Key Project(No.2019BT02H594)the Key Research and Development Plan of Hainan Province(No.ZDYF2020198)the Rising Star Foundation of the South China Sea Institute of Oceanology(No.NHXX2017DZ0101)。
文摘As one of the four largest bay areas with strong economic activities in the world,the Guangdong-Hong Kong-Macao Greater Bay Area(GHMGBA)is located in the zone of interaction between the South China Block(SCB)and the South China Sea(SCS).Under the influence of complex geologic evolution,basin-range structures,fault systems and hot springs are well developed here.However,the characteristics of geological structures and the genetic mechanism of these geological phenomena are still unclear.Therefore,we performed ambient noise tomography to obtain 3-D upper crust(0-7.5 km)S-wave velocity structures of the GHMGBA by using 40-day continuous waveform data from 130 seismic stations in the GHMGBA.Our results show that sedimentary basins in the GHMGBA are mainly characterized by low-velocity anomalies.S-wave velocities of sediment formation in basins are about 2.8-3.1 km/s.Rapid changes in velocity appear at the edges of the basins,which correspond to the NE-,NEE-,and NW-trending faults,indicating prominent basin-controlling effects of the faults.The Sanshui Basin(SSB),the largest in the GHMGBA,has a developmental depth of about 4 km,and there is a significant difference in velocity gradient between the east and west sides of the basin,indicating that SSB has experienced east-west asymmetric expansion.Moreover,there are prominent low-velocity anomalies at a depth of about 4.5 km beneath the hot springs at the west of the Zhujiang(Pearl)River estuary(ZRE).We infer that the low-velocity anomalies are fluid reservoirs of the hot springs,which lead to the development of the hot springs on the surface.In addition,the distribution of main cities in the GHMGBA shows a spatial correlation with low-velocity areas at shallow depths(<3 km).The population development trend in the GHMGBA in the past 20 years is also mainly concentrated in the structural province of relatively low-velocity.In combination with the GHMGBA basin structures and drainage distribution characteristics,we suggest that the basic geological environment to some extent affects the habitability of the human settlement and thus determines the distribution and development trend of the main urban context.We believe that the 3-D S-wave velocity structure of the upper crust of the GHMGBA obtained in this study,as well as the deep structural characteristics of the basins and hot springs,will provide support to urban construction planning and geological hazards research of the GHMGBA.
基金Supported by the Natural Science Foundation of Guangdong Province,No.2016A030307035Special Research Plan 2019 of Chaozhou,No.2020xg01High-Level Development Plan of People’s Hospital of Yangjiang,No.G2020007.
文摘BACKGROUND Neonatal hyperbilirubinemia is one of the common diseases of newborns that typically presents with yellow staining of skin,resulting in sequelaes such as hearing loss,motor and intellectual development disorders,and even death.The pathogenic factors of neonatal hyperbilirubinemia are complex.Different cases of hyperbilirubinemia may have a single or mixed etiology.AIM To explore the etiological characteristics of severe hyperbilirubinemia in term newborns of eastern Guangdong of China.METHODS Term newborns with severe hyperbilirubinemia in one hospital from January 2012 to December 2021 were retrospectively analyzed.The etiology was determined according to the laboratory results and clinical manifestations.RESULTS Among 1602 term newborns with hyperbilirubinemia in eastern Guangdong of China,32.20%(580/1602)was severe hyperbilirubinemia.Among the causes of severe hyperbilirubinemia,neonatal hemolysis accounted for 15.17%,breast milk jaundice accounted for 12.09%,infection accounted for 10.17%,glucose-6-phosphate dehydrogenase(G6PD)deficiency accounted for 9.14%,and the coexistence of multiple etiologies accounted for 6.55%,unknown etiology accounted for 41.72%.ABO hemolysis and G6PD deficiency were the most common causes in the 20 cases with bilirubin encephalopathy.94 severe hyperbilirubinemia newborns were tested for uridine diphosphate glucuronosyl transferase 1A1(UGT1A1)*6 variant(rs4148323,c.211G>A,p.Arg71Gly),9 cases were 211 G to A homozygous variant,37 cases were 211 G to A heterozygous variant,and 48 cases were wild genotypes.CONCLUSION The main cause for severe hyperbilirubinemia and bilirubin encephalopathy in eastern Guangdong of China were the hemolytic disease of the newborns,G6PD deficiency and infection.UGT1A1 gene variant was also a high-risk factor for neonatal hyperbilirubinemia.Targeted prevention and treatment according to the etiology may reduce the occurrence of bilirubin encephalopathy and kernicterus.
基金National Natural Science Foundation of China(42075014,41975138)Natural Science Foundation of Guangdong Province(2022A1515011814,2021A1515011539,2020A1515010602)+3 种基金Open Grants of State Key Laboratory of Severe Weather(2022LASW-B15)Radar Application and Short-term Severe-weather Predictions and Warnings Technology Program(GRMCTD202002)Key Scientific and Technological Research Project of GRMC(GRMC2020Z03)Water Resource Science and Technology Innovation Program of Guangdong Province(2022-02)。
文摘While heavy rainfall frequently takes place in southern China during summer monsoon seasons,quantitative precipitation forecast skills are relatively poor.Therefore,detailed knowledge about the raindrop size distribution(DSD)is useful in improving the quantitative precipitation estimation and forecast.Based on the data during 2018-2022 from 86stations in a ground-based optical disdrometer measurement network,the characteristics of the DSD in Guangdong province are investigated in terms of the particle size distribution(N(D)),mass-weighted mean diameter(Dm) and other integral DSD parameters such as radar reflectivity(Z),rainfall rate(R) and liquid water content(LWC).In addition,the effects of geographical locations,weather systems(tropical cyclones,frontal systems and the summer monsoon) and precipitation types on DSD characteristics are also considered.The results are shown as follows.1) Convective precipitation has a broader N(D) and larger mean particle diameter than the stratiform precipitation,and the DSD observations in Guangdong are consistent with the three-parameter gamma distribution.The relationships between the Z and R for stratiform and convective precipitation are also derived for the province,i.e.,Z=332.34 R1.32and Z=366.26R1.42which is distinctly different from that of the Next-generation Weather Radar(NEXRAD) Z-R relationship in United States.2) In the rainy season(April-September),the Dm, R and LWC are larger than those in the dry season(OctoberMarch).Moreover the above parameters are larger,especially in mid-May,which is the onset of the South China Sea summer monsoon.3) The spatial analysis of DSD shows that the coastal station observations indicate a smaller Dmand a larger normalized intercept parameter(log10Nw),suggestive of maritime-like rainfall.Dmis larger and log10Nwis smaller in the inland area,suggestive of continental-like rainfall.4) Affected by such weather systems as the tropical cyclone,frontal system and summer monsoon,the DSD shows characteristics with distinct differences.Furthermore,frontal system rainfall tends to present a continental-like rainfall,tropical cyclone rainfall tends to have a maritime-like rainfall,and summer monsoon rainfall characteristic are between maritime-and continental-like cluster(raindrop concentration and diameter are higher than continental cluster and maritime cluster,respectively.)
文摘Shanbei Village is a village in Yunfu of Guangdong,which has been seriously affected by flood disasters.In the context of the construction of beautiful countryside,utilizing the concept of resilience stormwater,construction ideas of beautiful countryside of combining the prevention and control of village flood disasters with economic and social development and cultural heritage are proposed.The planning methods of adjusting the planting way of crops,demolition of dwellings in submerged areas and development and utilization of ancient dwellings,sorting out drainage systems and planning“large,medium and small sponges”,and improving the drainage capacity of culverts are summarized.
文摘Guangzhou,a significant hub city in the Guangdong-Hong Kong-Macao Greater Bay Area,has seen fast social and economic growth as well as steady progress in the degree of urbanization.This research,taking Guangzhou city as an example,aims to provide an understanding of how land resources,urbanization,and spatial planning are coordinated in the study area.It also aims to explore how the coordination degree of land resources,urbanization,and spatial planning changes over time.It seeks to provide effective suggestions for land resource protection,national spatial planning,and urban transformation development to promote the coordinated development of the Guangdong-Hong Kong-Macao Greater Bay Area into a world-class Bay Area.
基金This study was supported by National Natural Science Foundation of China(grants 4022 1301 and 40132010).
文摘The Luxi-Xianrenzhang diabase dikes were emplaced into the eastern part of the Guidong composite granitoids in northern Guangdong Province at the end of the Early Cretaceous. They show tholeiitic features, enrichment in large ion lithophile elements, slight enrichment in light rare earth elements, depletion in Zr and Hf, and basically no depletion in Nb and Ta and no Eu anomaly. They are similar to intraplate basalt in terms of trace element characteristics. They have high εNd(t) values (3.6-4.9), initial ^87Sr/^86Sr ratios (0.70530-70641) and δ^18O values and Dupal anomaly of Pb isotope compositions. Their Sr-Nd, Pb-Sr, Pb-Nd and Pb-Pb isotopes plot between DMM and EMII, with Pb similar to EMII, Nd relatively close to DMM and Sr in between. This profile suggests that the diabase dikes studied were derived from partial melting of a mantle source that had been subjected to metasomatism by fluids originated from a subduction zone under a tectonic environment of crustal extension and lithosphere thinning in the late Yanshanian.
基金the Data quality evaluation study of the national free preconception eugenics health screening program[No.C2018033]。
文摘Thalassemia is a group of genetically heterogeneous diseases characterized by hemolytic anemia.To investigate molecular characteristics ofα-andβ-thalassemia among young individuals of marriageable age in Guangdong Province,24,788 subjects with suspected thalassemia were genetically tested forα-andβ-thalassemia by GapPCR and reverse dot blot during 2018–2019.For suspected rare thalassemia cases,DNA sequencing was performed to identify rare and unknown thalassemia gene mutations.A total of 14,346 thalassemia carriers were detected,including 7,556 cases ofα-thalassemia with 25 genotypes and 8α-gene mutations identified,5,860 cases ofβ-thalassemia with 18 genotypes and 18β-gene mutations identified,and 930 cases of compoundα/β-thalassemia.Among them,the frequency of--SEA deletion was the highest inα-thalassemia(66.01%),followed by-α3.7(17.98%)and-α.24(8.22%),and the frequency of CD41-42(-TCTT)mutation was the highest inβ-thalassemia(38.38%),followed by IVS-II-654(C>T)(25.67%),-28(A>G)(15.76%),and CD17(10.01%).In addition,5 rare mutations(--THAI and HKαα,CD113,-90,and CD56)were found in the study population.Our results revealed molecular epidemiological background ofα-andβ-thalassemia in Guangdong Province,which can support optimization of thalassemia prevention and control strategies.We demonstrated that thalassemia is heterogeneous with significant geographical differences and population specificity.