The lack of an effective preventative vaccine against tuberculosis(TB)presents a great challenge to TB control.Since it takes an extremely long time to accurately determine the protective efficacy of TB vaccines,there...The lack of an effective preventative vaccine against tuberculosis(TB)presents a great challenge to TB control.Since it takes an extremely long time to accurately determine the protective efficacy of TB vaccines,there is a great need to identify the surrogate signatures of protection to facilitate vaccine development.Unfortunately,antigen-specific Th1 cytokines that are currently used to evaluate the protective efficacy of the TB vaccine,do not align with the protection and failure of TB vaccine candidates in clinical trials.In this review,we discuss the limitation of current Th1 cytokines as surrogates of protection and address the potential elements that should be considered to finalize the true functional signatures of protective immunity against TB.展开更多
基金This study was supported by Thirteenth-Fifth Mega-Scientific Projects(2017ZX10103004)National Natural Science Foundation of China(81501714,81525016,81471913)+3 种基金National Key R&D Program of China(2016YFE0106900)Natural Science Foundation of Guangdong(2014A030313789)Shenzhen Scientific and Technological Project(JCYJ20170307095003051,JCYJ20170412151620658 and JSGG20140701164558078)and Sanming Project of Medicine in Shenzhen(GCZX2015043015340574,ZDSYS201504301534057).
文摘The lack of an effective preventative vaccine against tuberculosis(TB)presents a great challenge to TB control.Since it takes an extremely long time to accurately determine the protective efficacy of TB vaccines,there is a great need to identify the surrogate signatures of protection to facilitate vaccine development.Unfortunately,antigen-specific Th1 cytokines that are currently used to evaluate the protective efficacy of the TB vaccine,do not align with the protection and failure of TB vaccine candidates in clinical trials.In this review,we discuss the limitation of current Th1 cytokines as surrogates of protection and address the potential elements that should be considered to finalize the true functional signatures of protective immunity against TB.
