Four new corynanthe-type alkaloids,meloslines C–F(1–4),together with four known ones(5–8)were isolated from the roots of Alstonia scholaris.Their structures including absolute configurations were elucidated by exte...Four new corynanthe-type alkaloids,meloslines C–F(1–4),together with four known ones(5–8)were isolated from the roots of Alstonia scholaris.Their structures including absolute configurations were elucidated by extensive spectroscopic analysis and electronic circular dichroism(ECD)calculation.Compounds 1 and 2 exhibited potent vasorelaxant activity on endothelium-intact renal arteries precontracted with KCl.展开更多
Ten known flavonoid C-glycosides identified as 2′′-O-β-D-glucopyranosyl isovitexin(1),spinosin(2),6′′′-acetyl spinosin(3),6′′′-p-hydroxycinnamoyl-2′′O-β-D-glucopyranosyl isovitexin(4),6′′′-p-hydroxy-cin...Ten known flavonoid C-glycosides identified as 2′′-O-β-D-glucopyranosyl isovitexin(1),spinosin(2),6′′′-acetyl spinosin(3),6′′′-p-hydroxycinnamoyl-2′′O-β-D-glucopyranosyl isovitexin(4),6′′′-p-hydroxy-cinnamoyl spinosin(5),6′′′-(E)-feruloyl O-β-Dglucopyranosyl isovitexin(6),isospinosin(7),isovitexin(8),swertisin(9),swertiajaponin(10)were purified from the seeds of Hovenia dulcis Thunb.Their structures were confirmed by spectroscopic data analysis and comparison with previous literature.All compounds were obtained from H.dulcis for the first time.展开更多
基金supported by the National Key R&D Program of China(No.2017YFC1703802)the National Natural Science Foundation of China(Nos.U1801287,81630095,and 81803398)+1 种基金the Science and Technology Planning Project of Guangdong Province(No.2018B020207008)the High-performance Super Computing Platform of Jinan University
文摘Four new corynanthe-type alkaloids,meloslines C–F(1–4),together with four known ones(5–8)were isolated from the roots of Alstonia scholaris.Their structures including absolute configurations were elucidated by extensive spectroscopic analysis and electronic circular dichroism(ECD)calculation.Compounds 1 and 2 exhibited potent vasorelaxant activity on endothelium-intact renal arteries precontracted with KCl.
基金National Natural Science Foundation of China(Grant Nos.81703379 and U1801287)Key-Area Research and Development Program of Guangdong Province(Grant No.2020B1111110007)+3 种基金Science and Technology Planning Project of Guangdong Province(Grant No.2018B020207008)Key Laboratory Program of Guangzhou(Grant 201902010082)the Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine(Grant Nos.YN2016QJ05 and YN2015MS03)Key Project of High-level University Construction of Guangzhou University of Chinese Medicine(Grant No.XK2018019)。
文摘Ten known flavonoid C-glycosides identified as 2′′-O-β-D-glucopyranosyl isovitexin(1),spinosin(2),6′′′-acetyl spinosin(3),6′′′-p-hydroxycinnamoyl-2′′O-β-D-glucopyranosyl isovitexin(4),6′′′-p-hydroxy-cinnamoyl spinosin(5),6′′′-(E)-feruloyl O-β-Dglucopyranosyl isovitexin(6),isospinosin(7),isovitexin(8),swertisin(9),swertiajaponin(10)were purified from the seeds of Hovenia dulcis Thunb.Their structures were confirmed by spectroscopic data analysis and comparison with previous literature.All compounds were obtained from H.dulcis for the first time.
