The efficient catalytic systems generated in situ from RuCl2（PPh3）3 and chiral ligands N,N-bis[2-（di-o-tolylphosphino）-benzyl]cyclohexane-1,2-diamine（2） were employed for asymmetric transfer hydrogenation of aro...The efficient catalytic systems generated in situ from RuCl2（PPh3）3 and chiral ligands N,N-bis[2-（di-o-tolylphosphino）-benzyl]cyclohexane-1,2-diamine（2） were employed for asymmetric transfer hydrogenation of aromatic ketones, giving the corresponding optically active alcohols with high activities（up to 99% conversion） and excellent enantioselectivities（up to 96% e.e.） under mild conditions. The chiral ruthenium（Ⅱ） complex （R,R）-3 has been prepared and characterized by NMR and X-ray crystallography.展开更多
[ Objective ] This study aimed to provide basic data for studying the relationship between structure and property of cellulose microspheres by measuring molecular weight of cellulose and cellulose microspheres with vi...[ Objective ] This study aimed to provide basic data for studying the relationship between structure and property of cellulose microspheres by measuring molecular weight of cellulose and cellulose microspheres with viscosity method and gel permeation chromatography （GPC） method. [ Method] In viscosity method, cadmium ethylenediamine was used as the solvent, intrinsic viscosity η of the solution was determined at 25 ℃ by using a Ubbelohde viscometer, to calculate the molecular weight of cellulose; in GPC method, 8% LiC1 / N, N-dimethylacetamide （LiC1/DMAc） was used as the solvent and 0.5% LiC1/DMAc was used as the mobile phase to determine the relative molecular weight and distribution of cellulose and cellulose microspheres. In addition, the determination results were analyzed to compare these two methods. [ Result ] Viscosity-average molecular weight Mr/ of cellulose and cellulose microspheres determined with viscosity method were 224,532 and 16,686, respectively; weight-average molecular weight Mw of cellulose and cellulose microspheres determined with GPC method were 284,196 and 22,345, respectively. [ Conclusion] The determination results of （;PC method are relatively close to the actual value and could truly reflect the characteristics of molecular weialat distribution of eellulose and cellulose mierosr, heres.展开更多
A series of acridine-1,2,3-triazole derivatives were designed, synthesized and characterized by NMR. 1-（2-methylacridinyl）-4-（4-methyl phenyl）-1,2,3-triazole（4f）, C_（23）H_（18）N_4, was structurally determined...A series of acridine-1,2,3-triazole derivatives were designed, synthesized and characterized by NMR. 1-（2-methylacridinyl）-4-（4-methyl phenyl）-1,2,3-triazole（4f）, C_（23）H_（18）N_4, was structurally determined by single-crystal X-ray diffraction. It crystallizes in the triclinic system, space group P1 with a = 9.585（4）, b = 9.684（4）, c = 11.339（5） A, β = 88.250（7）o, V = 925.3（6）, Z = 2, D_c = 1.258 g/cm^3, F（000） = 368, μ = 0.077 mm^（-1）, the final R = 0.0808 and wR = 0.2218 for 3386 observed reflections（I 〉 2σ（I））. X-ray analysis indicates that the acridine ring is almost vertical to triazole ring with the dihedral angle nearly to be 75°. The crystal packing of the compound is stabilized mainly by π-π interaction. The preliminary biological tests display that some of the title compounds possess a good anti-tumour activity against MGC-803 and T24.展开更多
The new title compound N-（2-hydroxy ethyl） tetrahydropalmatine ammonium bromide has been synthesized starting from palmatine hydrochloride.The structure of the product was confirmed by 1H NMR,MS（ESI） and single-cr...The new title compound N-（2-hydroxy ethyl） tetrahydropalmatine ammonium bromide has been synthesized starting from palmatine hydrochloride.The structure of the product was confirmed by 1H NMR,MS（ESI） and single-crystal X-ray diffraction.The title compound crystallizes in the triclinic system,space group P1 with a = 10.5887（11）,b = 10.8652（9）,c = 12.0914（12） ,β = 84.808（9）o,V = 1253.3（2） A^3,Z = 2,Dc = 1.355 g/cm^3,F（000） = 530,μ = 1.680 mm-1,the final R = 0.0833 and w R = 0.2371 for 5112 observed reflections（I 〉 2A（I））.X-ray analysis indicates that the two planar parts（C（2） C（3） C（4） C（5） C（6） C（7） N（1） C（20） C（21） C（21）） and（C（7） C（8） C（9） C（10） C（12） C（14） N（15） C（16） C（17）） are not coplanar,with the dihedral angles to be 67.9°.Weak interactions mainly between O（5）–H（5）···O from two water molecules and O（5）···Br are observed.展开更多
基金Supported by the National Natural Science Foundation of China(Nos.2042300220703034)+1 种基金the Natural Science Foundation of Fujian Province of China(No.2008J0235)the Natural Science Foundation of Guangxi Province of China(No. 0991016)
文摘The efficient catalytic systems generated in situ from RuCl2（PPh3）3 and chiral ligands N,N-bis[2-（di-o-tolylphosphino）-benzyl]cyclohexane-1,2-diamine（2） were employed for asymmetric transfer hydrogenation of aromatic ketones, giving the corresponding optically active alcohols with high activities（up to 99% conversion） and excellent enantioselectivities（up to 96% e.e.） under mild conditions. The chiral ruthenium（Ⅱ） complex （R,R）-3 has been prepared and characterized by NMR and X-ray crystallography.
基金Supported by Natural Science Foundation of Guangxi(0991024Z)
文摘[ Objective ] This study aimed to provide basic data for studying the relationship between structure and property of cellulose microspheres by measuring molecular weight of cellulose and cellulose microspheres with viscosity method and gel permeation chromatography （GPC） method. [ Method] In viscosity method, cadmium ethylenediamine was used as the solvent, intrinsic viscosity η of the solution was determined at 25 ℃ by using a Ubbelohde viscometer, to calculate the molecular weight of cellulose; in GPC method, 8% LiC1 / N, N-dimethylacetamide （LiC1/DMAc） was used as the solvent and 0.5% LiC1/DMAc was used as the mobile phase to determine the relative molecular weight and distribution of cellulose and cellulose microspheres. In addition, the determination results were analyzed to compare these two methods. [ Result ] Viscosity-average molecular weight Mr/ of cellulose and cellulose microspheres determined with viscosity method were 224,532 and 16,686, respectively; weight-average molecular weight Mw of cellulose and cellulose microspheres determined with GPC method were 284,196 and 22,345, respectively. [ Conclusion] The determination results of （;PC method are relatively close to the actual value and could truly reflect the characteristics of molecular weialat distribution of eellulose and cellulose mierosr, heres.
基金Supported by the National Natural Science Foundation of China(No.51263002)Natural Science Foundation of Guangxi Province(No.2014GXNSFBA118182)+3 种基金the Scientific Research Fund of Guangxi Provincial Education Department(No.YB2014181)the Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources(Guangxi Normal University)Ministry of Education of China(CMEMR2015-B04)the Scientific Research Fund of Guangxi University of Chinese Medicine(No.QN14017,2015MS003)
文摘A series of acridine-1,2,3-triazole derivatives were designed, synthesized and characterized by NMR. 1-（2-methylacridinyl）-4-（4-methyl phenyl）-1,2,3-triazole（4f）, C_（23）H_（18）N_4, was structurally determined by single-crystal X-ray diffraction. It crystallizes in the triclinic system, space group P1 with a = 9.585（4）, b = 9.684（4）, c = 11.339（5） A, β = 88.250（7）o, V = 925.3（6）, Z = 2, D_c = 1.258 g/cm^3, F（000） = 368, μ = 0.077 mm^（-1）, the final R = 0.0808 and wR = 0.2218 for 3386 observed reflections（I 〉 2σ（I））. X-ray analysis indicates that the acridine ring is almost vertical to triazole ring with the dihedral angle nearly to be 75°. The crystal packing of the compound is stabilized mainly by π-π interaction. The preliminary biological tests display that some of the title compounds possess a good anti-tumour activity against MGC-803 and T24.
基金Supported by the National Natural Science Foundation of China(No.51263002)Natural Science Foundation of Guangxi Province(No.2014GXNSFBA118182)+1 种基金the Scientific Research Fund of Guangxi Provincial Education Department(No.YB2014181)subject for Guangxi University of Chinese Medicine(No.QN14017)
文摘The new title compound N-（2-hydroxy ethyl） tetrahydropalmatine ammonium bromide has been synthesized starting from palmatine hydrochloride.The structure of the product was confirmed by 1H NMR,MS（ESI） and single-crystal X-ray diffraction.The title compound crystallizes in the triclinic system,space group P1 with a = 10.5887（11）,b = 10.8652（9）,c = 12.0914（12） ,β = 84.808（9）o,V = 1253.3（2） A^3,Z = 2,Dc = 1.355 g/cm^3,F（000） = 530,μ = 1.680 mm-1,the final R = 0.0833 and w R = 0.2371 for 5112 observed reflections（I 〉 2A（I））.X-ray analysis indicates that the two planar parts（C（2） C（3） C（4） C（5） C（6） C（7） N（1） C（20） C（21） C（21）） and（C（7） C（8） C（9） C（10） C（12） C（14） N（15） C（16） C（17）） are not coplanar,with the dihedral angles to be 67.9°.Weak interactions mainly between O（5）–H（5）···O from two water molecules and O（5）···Br are observed.
基金the National Natural Science Foundation of China(No21173176)the Natural Science Foundation of Guangxi Province of China(No0991016)for the financial support of this work
文摘新 polydentate mixed-N， P， O chiral ligands 被二度(o-formylphenyl ) 的冷凝作用综合了在 CHCl3 的 -phenylphosphane 和 R-phenylglycinol，并且充分由红外， NMR 和 EIMS 系列描绘了。这些 ligands 为酉同类的不对称的转移加氢作为催化系统与简单 Ni 复杂 Ni (PPhs ) 2Cl2in situ 被采用，并且相应光白酒在温和条件下面与多达 84% ee 被获得。
