Parkinson’s disease(PD)is a prevalent neurological disorder around the globe,currently affecting over 6 million people globally[1].It is estimated that by 2040,this number may double to more than 12 million[2].Aging ...Parkinson’s disease(PD)is a prevalent neurological disorder around the globe,currently affecting over 6 million people globally[1].It is estimated that by 2040,this number may double to more than 12 million[2].Aging is strongly associated with PD,as it is a significant risk factor for its development[3].Clinically,PD presents with various motor and non-motor signs.Movement-related issues mainly consist of slowed motion,involuntary shaking at rest,stiff muscles,and balance difficulties.At the same time,non-movement-related issues include impaired sense of smell,sleep disturbances,bowel irregularities,feelings of sadness,and problems with the body’s automatic functions[4].The typical pathological features of PD patients include the gradual loss of dopaminergic neurons within the substantia nigra pars compacta,coupled with the buildup ofα-synuclein(α-Syn)in neurons,the aggregates of which form inclusions known as Lewy bodies[5].The A53T mutant of humanα-Syn has a propensity to aggregate,a characteristic closely associated with the neurotoxicity seen in familial PD[6].A synthesis of both in vitro and in vivo research indicates that the misfolding and aggregation ofα-Syn are key pathogenic mechanisms in the development of PD[7-9].展开更多
基金This study was financially supported by the National Natural Science Foundation of China(No.82271563 and No.82204786)The Natural Science Foundation of Guangdong Province of China(No.2022A1515012512)The Academic Promotion Program of Shandong First Medical University.
文摘Parkinson’s disease(PD)is a prevalent neurological disorder around the globe,currently affecting over 6 million people globally[1].It is estimated that by 2040,this number may double to more than 12 million[2].Aging is strongly associated with PD,as it is a significant risk factor for its development[3].Clinically,PD presents with various motor and non-motor signs.Movement-related issues mainly consist of slowed motion,involuntary shaking at rest,stiff muscles,and balance difficulties.At the same time,non-movement-related issues include impaired sense of smell,sleep disturbances,bowel irregularities,feelings of sadness,and problems with the body’s automatic functions[4].The typical pathological features of PD patients include the gradual loss of dopaminergic neurons within the substantia nigra pars compacta,coupled with the buildup ofα-synuclein(α-Syn)in neurons,the aggregates of which form inclusions known as Lewy bodies[5].The A53T mutant of humanα-Syn has a propensity to aggregate,a characteristic closely associated with the neurotoxicity seen in familial PD[6].A synthesis of both in vitro and in vivo research indicates that the misfolding and aggregation ofα-Syn are key pathogenic mechanisms in the development of PD[7-9].
