Breast Cancers in Young Woman under 40 Years in Sub-Saharan Africa: Experience of the Gynecology Department of the University and Hospital Center of Treichville (Abidjan—Cote d’Ivoire)

Objective: To describe the epidemiological, clinical and therapeutic characteristics of women under 40 years followed for breast cancer. Method: This is a retrospective and cohort study with descriptive purpose conducted over 10 years on the management of breast cancer in 105 patients under 40 years in the Gynecology Service of the University and Hospital Center of Treichville. Results: The incidence of breast cancer in women under 40 years was 8.4%, and the majority of patients were over 35 years old (64.8%) and had a low socioeconomic level (61.7%). Some patients had classic risk factors for breast cancer: menarche before 12 years (48.6%), nulliparity (20%), family history of breast cancer (1.9%). The discovery of a breast abnormality was made by patients in 97.1% of the cases. Cancers were either isolated (92.4%) or associated with pregnancy (5.7%) or bilateral (1.9%). The majority of cancers were infiltrating ductal carcinomas (86.7%), of SBR II grade (69%). Patients generally benefited from a mastectomy with axillary dissection, framed by chemotherapy. The global survival at 10 years was 5%. Conclusion: This study allowed us to confirm that breast cancers in younger women were a reality in our country and posed us enormous difficulties in their management.

Therapeutic Approach out of IVF of Ovulation Disorders in Sub-Saharian African

Objectives: To describe our management strategy of ovulation disorders. Patients and methods: From a retrospective collection of data from the records, we identified over a period of one year (January 2016-December 2016), 47 patients followed in gynecology department of University and Hospital Centers of Yopougon and Treichville in Abidjan (Cote d’Ivoire) for ovulation disorders. The diagnosis of dysovulation was made following a hormonal check up and a follicular monitoring ultrasound. These patients underwent a specific treatment according to the type of dysovulation they presented. Results: The average age was 31.9 years with a significant proportion of nulliparous (66%). Body mass index was high in 44.7% of patients, of whom 19.1% were obese and 25.6% overweight. The hormonal balance was disrupted in 48.9% of cases. Polycystic ovary syndrome (WHO type IIb dysovulation) was the most common pathology (36%). The proposed treatments were dominated by clomiphene citrate (31.9%) and gonadotrophins (25.5%). 14.9% of pregnancies were obtained. Conclusion: This study allows us to offer better management of ovulation disorders, but this necessarily entails a careful exploration and an appropriate treatment.

Epidemiological Aspects of Metastatic Relapse of Breast Cancer in an African Context

Objectives: This study aimed to describe the epidemiological characteristics of metastatic relapse in breast cancer at the University and Hospital Center of Treichville. Methodology: This is a cohort and retrospective study conducted from January 2000 to December 2015 on 178 patients with metastaticrelapse in breast cancer. Results: The prevalence of metastatic relapses was 49% and the patients had an average age of 53.4 years and among them, 91.6% received school education and 88.2% did not have a high socioeconomic level. The majority of initial tumors were in Stage III (47.8%), SBR III (47.2%), High Ki 67 (46.5%), Negative RH (79.3%), and HER2 negative (58%). Metastases were generally unique (62.9%), dominated by bone sites (36.6%), with an average occurrencedelay of 2.4 years. After the occurrence of metastases, the cumulative survival rate was 5% at 3 years, and nil at 5 years. Conclusion: Metastatic relapses were common with poor prognosis.