Classic mechanisms and experimental models for the anti-inflammatory effect of traditional Chinese medicine

Inflammation is a common disease involved in the pathogenesis,complications,and sequelae of a large number of related diseases,and therefore considerable research has been directed toward developing anti-inflammatory drugs for the prevention and treatment of these diseases.Traditional Chinese medicine(TCM)has been used to treat inflammatory and related diseases since ancient times.According to the re-view of abundant modern scientific researches,it is suggested that TCM exhibit anti-inflammatory effects at different levels,and via multiple pathways with various targets,and recently a series of in vitro and in vivo anti-inflammatory models have been developed for anti-inflammation research in TCM.Currently,the reported classic mechanisms of TCM and experimental models of its anti-inflammatory effects pro-vide reference points and guidance for further research and development of TCM.Importantly,the research clearly confirms that TCM is now and will continue to be an effective form of treatment for many types of inflammation and inflammation-related diseases.

SDN-Enabled Content Dissemination Scheme for the Internet of Vehicles

The content-centric networking(CCN)architecture allows access to the content through name,instead of the physical location where the content is stored,which makes it a more robust and flexible content-based architecture.Nevertheless,in CCN,the broadcast nature of vehicles on the Internet of Vehicles(IoV)results in latency and network congestion.The IoVbased content distribution is an emerging concept in which all the vehicles are connected via the internet.Due to the high mobility of vehicles,however,IoV applications have different network requirements that differ from those of many other networks,posing new challenges.Considering this,a novel strategy mediator framework is presented in this paper for managing the network resources efficiently.Software-defined network(SDN)controller is deployed for improving the routing flexibility and facilitating in the interinteroperability of heterogeneous devices within the network.Due to the limited memory of edge devices,the delectable bloom filters are used for caching and storage.Finally,the proposed scheme is compared with the existing variants for validating its effectiveness.

An IoT Environment Based Framework for Intelligent Intrusion Detection

Software-defined networking(SDN)represents a paradigm shift in network traffic management.It distinguishes between the data and control planes.APIs are then used to communicate between these planes.The controller is central to the management of an SDN network and is subject to security concerns.This research shows how a deep learning algorithm can detect intrusions in SDN-based IoT networks.Overfitting,low accuracy,and efficient feature selection is all discussed.We propose a hybrid machine learning-based approach based on Random Forest and Long Short-Term Memory(LSTM).In this study,a new dataset based specifically on Software Defined Networks is used in SDN.To obtain the best and most relevant features,a feature selection technique is used.Several experiments have revealed that the proposed solution is a superior method for detecting flow-based anomalies.The performance of our proposed model is also measured in terms of accuracy,recall,and precision.F1 rating and detection time Furthermore,a lightweight model for training is proposed,which selects fewer features while maintaining the model’s performance.Experiments show that the adopted methodology outperforms existing models.

酵母细胞自然衰老分子作用机理的研究进展

衰老是任何生物都无法避免的生理现象,它由多种因素引起,其过程极其复杂.酵母细胞是目前衰老研究领域公认的模式生物,一系列影响衰老的分子作用机理及调控因素的发现均源自于对酵母细胞的研究.自然衰老是酵母细胞的衰老模式之一,由于该衰老过程与其他高等真核细胞(特别是哺乳动物细胞)极为相似,近年来受到广泛关注.全面比较酵母细胞衰老的两种模式,详细介绍自然衰老过程中分子作用机理的研究进展,重点阐述其复杂的自然寿命调控通路,包括卡路里限制以及药物添加对Ras/PKA、Sch9、Tor等营养依赖型调控通路的影响,并展望未来该领域需要解决的重要科学问题,为全面深入了解高等生物,特别是人类自身的衰老机理提供参考.

Efficacy of S-1 vs capecitabine for the treatment of gastric cancer: A meta-analysis

AIM: To rationally evaluate the effect of S-1 vs capecitabine for the treatment of gastric cancer.METHODS: MEDLINE, EMBASE, Cochrane Controlled Trials Register, Google Scholar, and China Journal Full Text Database were accessed to collect clinical randomized controlled trials regarding the effect of S-1 vs capecitabine for the treatment of gastric cancer patients.Statistical analysis was performed by metaanalysis.Four randomized controlled trials met the inclusion criteria.RESULTS: Compared with capecitabine regimens, the 1-year survival rate in gastric cancer patients was 0.80(95%CI: 0.52-1.21, P = 0.29).The overall response rate of S-1 vs capecitabine was 0.94(95%CI: 0.59-1.51, P = 0.93).Compared with capecitabine regimens, the most frequent hematologic toxicities were neutropenia( O R = 0.9 9, 9 5 % C I : 0.6 5- 1.4 9, P = 0.9 4) a n d thrombocytopenia(OR = 0.72, 95%CI: 0.31-1.67, P = 0.44).The most frequent non-hematologic toxicities included nausea(OR = 0.85, 95%CI: 0.56-1.28, P = 0.43) and hand-foot syndrome(OR = 0.16, 95%CI: 0.10-0.27, P < 0.00001).CONCLUSION: The existing studies suggest that S-1 is not more effective than capecitabine in the treatment of gastric cancer patients, but does exhibit less toxicity with regard to hand-foot syndrome.

Knockdown of liver-intestine cadherin decreases BGC823 cell invasiveness and metastasis in vivo

AIM:To assess BGC823 gastric cancer(GC) cell metastasis after knockdown of liver-intestine cadherin(CDH17) and the therapeutic value of CDH17-RNAilentivirus in vivo.METHODS:We evaluated primary tumor growth and assessed local infiltration and systemic tumor dissemination using an orthotopic implantation technique.The therapeutic value of CDH17 knockdown was examined by intratumoral administration of CDH17-RNA interference(RNAi)-lentivirus in an established GC tumor xenograft mouse model.Furthermore,a comparative proteomic approach was utilized to identify differentially expressed proteins in BGC823 and lenti-CDH17-miRneg cells following CDH17 knockdown.RESULTS:Metastases in the liver and lung appeared earlier and more frequently in animals with tumors derived from BGC823 or lenti-CDH17-miR-neg cells than in tumors derived from lenti-CDH17-miR-B cells.Average tumor weight and volume in the CDH17-RNAi-lentivirus-treated group were significantly lower than those in the control group(tumor volume:0.89 ± 0.04 cm 3 vs 1.16 ± 0.06 cm 3,P < 0.05;tumor weight:1.15 ± 0.58 g vs 2.09 ± 0.08 g,P < 0.05).Fifteen differentially expressed proteins were identified after CDH17 silencing in BGC823 cells,including a variety of cytoskeletal and chaperone proteins as well as proteins involved in metabolism,immunity/defense,cell proliferation and differentiation,cell cycle,and signal transduction.CONCLUSION:Our data establish a foundation for future studies of the comprehensive protein expression patterns and effects of CDH17 in GC.

Formation behavior of anodic TiO_2 nanotubes in fluoride containing electrolytes

TiO2 nanotube layers can be formed with titanium in the electrolytes containing fluoride by electrochemical method.The role of fluoride ion,the crystallinity of the anodic oxide,and the chemical state were investigated.The results show the anodic film is composed of oxide and a little amount of hydroxide.The presence of F- ions leads to chemical dissolution of Ti oxide layer and prevents hydroxide precipitation.Consequently,chemical dissolution rate increases with increasing the fluoride content in the range of 0-2%(in mass fraction) because F- ions in electrolyte attack the interface and allow the ions of the electrolyte to easily penetrate into the interface.The as-anodized TiO2 nanotubes exhibit an amorphous structure.Thermally treated nanotubes are composed of mixtures of the anatase and rutile phases.

Purifying behavior of photocatalytic TiO_2 anodized in nitrate ion containing solution

Mesoporous titanium dioxide films were fabricated on titanium plates by micro-arc oxidation method.To increase the photocatalytic activity of the films,NH4NO3 was added to the H2SO4 solution,and anodizing was carried out at high voltages using a DC power supply.The crystal structure,chemical composition,surface morphology and the optical property of the films were investigated by XPS,XRD,UV-VIS spectroscopy and SEM.The photocatalytic activity of the films was evaluated by the decomposition of aniline blue,and the activity of the films for the degradation turned out to be improved by the additives to the electrolyte solution.The enhanced photocatalytic activity might result from the increased porosity and nitrate ion incorporation into the anodic films by micro arcing,and thereby the TiO2 layer might exhibit an improved absorption property for the visible light.

ANTIMONY GRAIN BOUNDARY SEGREGATION AND ITS SUPPRESSION BY CERIUM IN Fe-2%Mn-Sb STRUCTURAL STEELS

Antimony grain boundary segregation in Fe-2%Mn-Sb structure steels has been studied through measurements of the ductile-brittle transition temperature in conjunction with scanning electron microscopy, Auger electron spectroscopy and secondary ion mass spectroscopy. The research result reveals that during tempering or ageing after quenching at 980℃, Sb segregates to grain boundaries with both equilibrium and non-equilibrium natures and brings about temper embrittlement in the steels. Cerium can relieve temper embrittlement of the steels and its segregation to grain boundaries may play an important role in reducing this embrittlement.

五氟苯乙烯的位置和立体选择性地硅羰基化(英文)

五氟苯乙烯与三乙基硅烷、一氧化碳在八羰基钴催化下反应得一个位置和立体异体 (五氟苯基烯基硅醚 )的混和物 .

Characteristics of non-conveyance ambulance runs: A retrospective study in the Netherlands

Dear editor,Emergency medical services(EMS)have developed from conveyance facilities into providers of advanced pre-hospital care.[1,2]Alongside this development there is a growing demand for EMS care,and the number of ambulance deployments is increasing.[3,4]Suggested reasons for this growing demand are changes in social support of people,accessibility of healthcare and social facilities,and the aging population.

SU(n,l)/S(U(n) × U(1))上的中心极限定理(英文)

Let G = SU(n,1),K = S(U(n)×U(1)),and for 1∈Z,let {η}_(1∈)Z be a one- Dimensional K-type and let E_l be the line bundle over G/K associated to n.In this work we obtain a central limit theorem for the space E_l.

Clinical observation of kidney tonifying and collateral tonifying acupuncture combined with thermosensitive moxibustion in the treatment of knee osteoarthritis and its effect on TRACP and CTX-I

Objective:To observe the clinical effect of kidney-tonifying and colllateral-tonifying acupuncture combined with thermosensitive moxibustion in the treatment of knee osteoarthritis and cold congealing syndrome and the effect on Tartrate-resistant Acid Phosphatase(TRACP)andⅠcollagen C-terminal foreign body peptide(CTX-I).Methods:Totally 90 patients with knee osteoarthritis were divided into three groups:acupuncture group,thermosensitive moxibustion group and routine group with 30 cases in each group.In the conventional group,sodium hyaluronate was injected into the joint cavity and diclofenac sustained release tablets were taken orally.Thermosensitive moxibustion group was given thermosensitive moxibustion on the basis of conventional treatment.Acupuncture and moxibustion group in the heat sensitive moxibustion group treatment was given kidney tonifying acupuncture.VAS score,JKOM score and Ly-Sholm knee score were observed before and after treatment and followed up for 2 weeks.The levels of TRACP and CTX-I in serum before and after treatment.Results:Before treatment,there were statistically significant differences in VAS score,JKOM score and Ly-Sholm knee score among all groups(P>0.05).After treatment,the VAS score and JKOM score decreased,and the decrease degree was the greatest in the acupuncture group(P<0.05).Ly-Sholm knee score increased,and the change degree was the greatest in acupuncture group(P<0.05).Before treatment,the levels of TRACP and CTX-I in serum of all groups were significantly different(P>0.05).After treatment,serum TRACP and CTX-I levels were decreased,and the decrease degree was the greatest in acupuncture group(P<0.05).The total effective rates of the acupuncture group,the thermal sensitive moxibustion group and the conventional group were 96.7%,80%and 66.7%,respectively,and the difference between each group was statistically significant(P<0.05).Conclusion:Kidney-tonifying and collature-tonifying acupuncture combined with thermosensitive moxibustion can significantly relieve knee pain and other symptoms of knee osteoarthritis in patients and cold congealing syndrome,which is worthy of clinical promotion.

Comparison of Different Control Algorithms for a Gantry Crane System

For a gantry crane system, this paper presents a comparison between four control algorithms. These algo-rithms are being compared on simplicity, stability and robustness. Goal for the controller is to move the load on a gantry crane to a new position with minimal overshoot of the load and maximal speed of the load. An-other goal is to provide an insight in the behaviour of the possible controllers. In this article a parallel P-controller, cascade P-controller, fuzzy controller and an internal model controller are used. To be able to validate and design the controllers a model is derived from the gantry crane. The controllers and the model are being implemented in Matlab Simulink. Finally the controllers are validated and tuned in Labview on a laboratory gantry scrane scale model. Main conclusion is that all presented controllers can be used as a con-troller for the gantry crane system but the fuzzy controller is showing the best performance.

Diagnosis and therapy of lacrimal system diseases by micro lacrimal endoscope

The lacrimal endoscope is applied to the diagnosis and therapy of the disorders of the lacrimal system in combination with laser or micro drills under orthophoria.The changes of mucous membranes,the characteristics of pathological changes and the predilection sites of lacrimal system diseases were initially approached.One hundred and forty six pairs of eyes of 128 patients with lacrimal system disease were observed by the lacrimal endoscope in the Ophthalmology Department of Tongji Hospital from June 2006 to March 2007.The dynamic changes in mucous membranes,lesion sites,secreted substances and formation of membrane could be observed under orthophoria.Combined with laser or micro drill,the endoscope was applied to the therapy of lacrimal system disorders and the difference before and after the treatment was observed.Results are as follows:(1)The examination and therapy using the lacrimal endoscope were completed under topical anesthesia in 122 patients,and 6 patients of neonatorum dacryocystitis were examined and treated under general anaesthesia.All patients reported painless.(2)Sharp images of the lacrimal system were obtained by the endoscope.Normal lacrimal mucosal membrane was smooth and light pink,expanded and unobstructed during irrigation.In chronic dacryocystitis patients,the inhomo-geneous colour of mucosal membranes was red and white,with different degrees offibrotic membranes at the superior,middle and inferior parts of the nasolacrimal canals and secreted substances at sac could be observed.The lacrimal ducts could not be expanded and obstructed during irrigation.The patients with lacrimal system obstruction had different extents of membrane formation,and stenosis or complete obstruction of the lacrimal duct could be observed,and the corresponding mucosal membrane was not smooth which could not be expanded and obstructed during irrigation.(3)After the treatment by the endoscope combined with laser or micro drill,the major proliferation of the membrane disappeared and the lacrimal duct was unobstructed during irrigation.The cure rate and effective rate were 80.1%and 93.1%,respectively.The lacrimal endoscope is a new method in the diagnosis of lacrimal system diseases.Through a combination with laser or micro drill to carry out the therapy under orthophoria,it will bring a great change to the diagnosis and therapy of lacrimal system diseases.

Performance of LHAASO-WCDA and observation of the Crab Nebula as a standard candle

The first Water Cherenkov detector of the LHAASO experiment(WCDA-1)has been operating since April 2019.The data for the first year have been analyzed to test its performance by observing the Crab Nebula as a standard candle.The WCDA-1 achieves a sensitivity of 65 mCU per year,with a statistical threshold of 5 cr.To accomplish this,a 97.7%cosmic-ray background rejection rate around 1 TeV and 99.8%around 6 TeV with an ap proximate photon acceptance of 50%is achieved after applying an algorithm to separate gamma-induced showers.The angular resolution is measured using the Crab Nebula as a point source to be approximately 0.45°at 1 TeV and better than 0.2°above 6 TeV,with a pointing accuracy better than 0.05°.These values all match the design specifications.The energy resolution is found to be 33%for gamma rays around 6 TeV.The spectral energy distribution of the Crab Nebula in the range from 500 GeV to 15.8 TeV is measured and found to be in agreement with the results from other TeV gamma ray observatories.