确定填埋场注气过程中气体压力分布特征可为好氧通风工程提供关键技术和理论支撑。以现场单井注气试验为依托,在渗流力学理论的基础上,开展了不同注气强度条件下气体压力分布监测试验,分析了注气过程中气体压力的径向分布特征,推导了注...确定填埋场注气过程中气体压力分布特征可为好氧通风工程提供关键技术和理论支撑。以现场单井注气试验为依托,在渗流力学理论的基础上,开展了不同注气强度条件下气体压力分布监测试验,分析了注气过程中气体压力的径向分布特征,推导了注气条件下垃圾土体内部以解析解形式表达的气体压力预测(analytical gas pressure prediction,简称AGPP)模型;结合现场气体压力监测结果,构建了以注气井压力为核心参数的经验公式形式的气体压力预测(empiricalgaspressure prediction,简称EGPP)模型。试验结果表明:低压注气强度也可以达到良好的注气效果,在较短时间内可以让气体充满注气井周围;通过现场监测数据与AGPP模型、EGPP模型的对比,初步验证了两种模型的可靠性。以上成果为预测和评估好氧通风过程中垃圾填埋场气体压力分布提供了新方法。展开更多
Large animal models of cardiac ischemia-reperfusion are critical for evaluation of the efficacy of cardioprotective interventions prior to clinical translation.Nonetheless,current cardioprotective strategies/intervent...Large animal models of cardiac ischemia-reperfusion are critical for evaluation of the efficacy of cardioprotective interventions prior to clinical translation.Nonetheless,current cardioprotective strategies/interventions formulated in preclinical cardiovascular research are often limited to small animal models,which are not transferable or reproducible in large animal models due to different factors such as:(i)complex and varied features of human ischemic cardiac disease(ICD),which are challenging to mimic in animal models,(ii)significant differences in surgical techniques applied,and(iii)differences in cardiovascular anatomy and physiology between small versus large animals.This article highlights the advantages and disadvantages of different large animal models of preclinical cardiac ischemic reperfusion injury(IRI),as well as the different methods used to induce and assess IRI,and the obstacles faced in using large animals for translational research in the settings of cardiac IR.展开更多
文摘确定填埋场注气过程中气体压力分布特征可为好氧通风工程提供关键技术和理论支撑。以现场单井注气试验为依托,在渗流力学理论的基础上,开展了不同注气强度条件下气体压力分布监测试验,分析了注气过程中气体压力的径向分布特征,推导了注气条件下垃圾土体内部以解析解形式表达的气体压力预测(analytical gas pressure prediction,简称AGPP)模型;结合现场气体压力监测结果,构建了以注气井压力为核心参数的经验公式形式的气体压力预测(empiricalgaspressure prediction,简称EGPP)模型。试验结果表明:低压注气强度也可以达到良好的注气效果,在较短时间内可以让气体充满注气井周围;通过现场监测数据与AGPP模型、EGPP模型的对比,初步验证了两种模型的可靠性。以上成果为预测和评估好氧通风过程中垃圾填埋场气体压力分布提供了新方法。
基金supported by the Early Career Scheme(ECS)2022/23(CUHK 24110822)from the Research Grants Council of Hong Kongthe Direct Grant for Research 2020/21(2020.035)+3 种基金Project Impact Enhancement Fund(PIEF)(PIEF/Ph2/COVID/08)Improvement on Competitiveness in Hiring New Faculties Funding Scheme from CUHK as well as the Centre for Cardiovascular Genomics and Medicine(CCGM)of the Lui Che Woo Institute of Innovative Medicine CUHK(to S.B.O.)a CUHK Department of Medicine&Therapeutics(MEDT)-funded PhD studenta CUHK Vice-Chancellor’s PhD Scholarship holder。
文摘Large animal models of cardiac ischemia-reperfusion are critical for evaluation of the efficacy of cardioprotective interventions prior to clinical translation.Nonetheless,current cardioprotective strategies/interventions formulated in preclinical cardiovascular research are often limited to small animal models,which are not transferable or reproducible in large animal models due to different factors such as:(i)complex and varied features of human ischemic cardiac disease(ICD),which are challenging to mimic in animal models,(ii)significant differences in surgical techniques applied,and(iii)differences in cardiovascular anatomy and physiology between small versus large animals.This article highlights the advantages and disadvantages of different large animal models of preclinical cardiac ischemic reperfusion injury(IRI),as well as the different methods used to induce and assess IRI,and the obstacles faced in using large animals for translational research in the settings of cardiac IR.
