Amyotrophic lateral sclerosis(ALS)is a rare neurological disease,featuring gradual loss of muscle controls due to degeneration of motor neurons.Unfortunately,there is currently no cure for ALS.The available therapies ...Amyotrophic lateral sclerosis(ALS)is a rare neurological disease,featuring gradual loss of muscle controls due to degeneration of motor neurons.Unfortunately,there is currently no cure for ALS.The available therapies only offer a limited extension of survival by several months,begging for more options of therapeutics.展开更多
The worldwide paucity of transplantable organs for patients is a devastating problem.While different approaches have been conceived to address this donor organ shortage,one strategy that has garnered significant atten...The worldwide paucity of transplantable organs for patients is a devastating problem.While different approaches have been conceived to address this donor organ shortage,one strategy that has garnered significant attention recently is the prospect of producing human organs in animals through a technique called interspecies blastocyst complementation based on the generation of interspecies chimeras.Interspecies blastocyst complementation works by injecting pluripotent stem(PS)cells from one species into organogenesis-disabled blastocysts of another species(Kobayashi et al.,2010).As the chimeric embryo develops,donor cells can fill the vacated developmental organ niche and enrich in a target organ of interest.In principle,interspecies blastocyst complementation may one day allow the generation of human organs inside animals.However,some ethical issues concerning research and potential human clinical use with chimeras persist(Hyun,2019).展开更多
基金supported by the TARCC,Welch Foundation Award(1-1724)the Decherd Foundation,the Pope Adarms FoundationNIH grants NS092616,NS127375,NS117065,and NS111776(to CLZ)。
文摘Amyotrophic lateral sclerosis(ALS)is a rare neurological disease,featuring gradual loss of muscle controls due to degeneration of motor neurons.Unfortunately,there is currently no cure for ALS.The available therapies only offer a limited extension of survival by several months,begging for more options of therapeutics.
文摘The worldwide paucity of transplantable organs for patients is a devastating problem.While different approaches have been conceived to address this donor organ shortage,one strategy that has garnered significant attention recently is the prospect of producing human organs in animals through a technique called interspecies blastocyst complementation based on the generation of interspecies chimeras.Interspecies blastocyst complementation works by injecting pluripotent stem(PS)cells from one species into organogenesis-disabled blastocysts of another species(Kobayashi et al.,2010).As the chimeric embryo develops,donor cells can fill the vacated developmental organ niche and enrich in a target organ of interest.In principle,interspecies blastocyst complementation may one day allow the generation of human organs inside animals.However,some ethical issues concerning research and potential human clinical use with chimeras persist(Hyun,2019).
