A comparative study of acupuncture combined with rehabilitation gymnastics on postoperative anal function of lower rectal cancer

BACKGROUND From the anal function,inflammatory response and other indicators,acupuncture combined with rehabilitation gymnastics was applied to patients with cancer undergoing low resection,aiming to improve the prognosis of patients.AIM To explore the effects of acupuncture combined with rehabilitation gymnastics on anal function after lower rectal cancer surgery.METHODS From January 2020 to December 2022,128 patients who underwent rectal cancer surgery in the Department of Oncology of Hebei Provincial Hospital of Traditional Chinese Medicine Hospital were selected and divided into two groups using the random number table method,with 64 patients in each group.Patients in the control group were not treated with acupuncture or rehabilitation gymnastics and served as blank controls.Patients in the study group were treated with acupuncture and rehabilitation gymnastics from the 7th postoperative day.The anal incontinence scores,changes in serum interleukin-4,interleukin-6,and interleukin-10 Levels,and serum motilin,5-hydroxytryptamine,and vasoactive intestinal peptide levels were compared.RESULTS There were no significant differences in serum interleukin-4,interleukin-6,and interleukin-10 Levels between the groups before treatment(P>0.05).After treatment,these levels were better than those of the control group(P<0.05).There was no significant difference in the anal incontinence scores between the groups before and 7 d after surgery(P>0.05).Anal incontinence scores in the study group were lower than those in the control group at 14 d,21 d,and 28 d postoperatively(P<0.05).There were no significant differences in serum motilin,5-hydroxytryptamine,or vasoactive intestinal peptide levels between the groups before treatment(P>0.05).After treatment,these levels were higher in the study group than in the control group,and vasoactive intestinal peptide level was lower in the study group than in the control group(P<0.05).CONCLUSION Acupuncture combined with rehabilitation gymnastics can promote the recovery of anal function and reduce the inflammatory response in patients with lower rectal cancer after surgery.

Wrist-ankle acupuncture combined with pain nursing for the treatment of urinary calculi with acute pain

BACKGROUND Urological calculi often cause renal colic,which is characterized by paroxysmal or persistent severe pain in the upper abdomen or lumbar region.Development of methods to quickly relieve these pain symptoms has garnered clinical attention.Wrist-ankle acupuncture is a type of floating acupuncture therapy administered at selected points in the carpal and ankle areas,and it has good pain-relieving effects.We used wrist-ankle acupuncture combined with pain nursing for pain intervention in patients with renal calculi to confirm its application and safety.AIM To study the effect of wrist-ankle acupuncture combined with pain nursing in the treatment of urinary calculi with acute pain.METHODS Eighty-two patients with urinary calculi with acute pain as the first symptom followed at our hospital from November 2019 to June 2021 were enrolled in the study and classified into two groups according to the odd and even numbers of the visit sequences,each with 41 cases.The control group received a routine nursing intervention and intramuscular injection of nonsteroidal anti-inflammatory drugs,whereas the observation group received pain management nursing and wrist-ankle acupuncture.Subsequently,the pain-relieving effect was compared between the two groups.RESULTS The score on the visual analog scale(VAS)at 24,48,and 72 h postintervention was decreased in both groups compared with the baseline data;moreover,the observation group scored significantly lower than the control group on the VAS at each time point after the intervention(P<0.05).The clinical efficacy at 24 h postintervention was not significantly different between the two groups(P>0.05).In turn,the pain recurrence rate at 72 h postintervention was lower in the observation group compared with the control group(P<0.05).Finally,the nursing satisfaction rate in the observation group was significantly higher than that observed in the control group(P<0.05).No serious adverse reactions occurred during the treatment and the safety of treatment was high in both groups.CONCLUSION Wrist-ankle acupuncture combined with pain nursing for treating urolithiasis with acute pain effectively alleviated the degree of pain and reduced the recurrence rate,which was worthy of clinical application.

Identification of key genes and biological pathways in lung adenocarcinoma by integrated bioinformatics analysis

BACKGROUND The objectives of this study were to identify hub genes and biological pathways involved in lung adenocarcinoma(LUAD)via bioinformatics analysis,and investigate potential therapeutic targets.AIM To determine reliable prognostic biomarkers for early diagnosis and treatment of LUAD.METHODS To identify potential therapeutic targets for LUAD,two microarray datasets derived from the Gene Expression Omnibus(GEO)database were analyzed,GSE3116959 and GSE118370.Differentially expressed genes(DEGs)in LUAD and normal tissues were identified using the GEO2R tool.The Hiplot database was then used to generate a volcanic map of the DEGs.Weighted gene co-expression network analysis was conducted to cluster the genes in GSE116959 and GSE-118370 into different modules,and identify immune genes shared between them.A protein-protein interaction network was established using the Search Tool for the Retrieval of Interacting Genes database,then the CytoNCA and CytoHubba components of Cytoscape software were used to visualize the genes.Hub genes with high scores and co-expression were identified,and the Database for Annotation,Visualization and Integrated Discovery was used to perform enrichment analysis of these genes.The diagnostic and prognostic values of the hub genes were calculated using receiver operating characteristic curves and Kaplan-Meier survival analysis,and gene-set enrichment analysis was conducted.The University of Alabama at Birmingham Cancer data analysis portal was used to analyze relationships between the hub genes and normal specimens,as well as their expression during tumor progression.Lastly,validation of protein expression was conducted on the identified hub genes via the Human Protein Atlas database.RESULTS Three hub genes with high connectivity were identified;cellular retinoic acid binding protein 2(CRABP2),matrix metallopeptidase 12(MMP12),and DNA topoisomerase II alpha(TOP2A).High expression of these genes was associated with a poor LUAD prognosis,and the genes exhibited high diagnostic value.CONCLUSION Expression levels of CRABP2,MMP12,and TOP2A in LUAD were higher than those in normal lung tissue.This observation has diagnostic value,and is linked to poor LUAD prognosis.These genes may be biomarkers and therapeutic targets in LUAD,but further research is warranted to investigate their usefulness in these respects.

Forty Cases of Gastrointestinal Neurosis Treated by Acupunture

Objective: To compare the therapeutic effect of acupuncture for gastrointestinal neurosis with that of oral remedy. Methods: Eighty cases were randomly divided into the following 2 groups. In the treatment group, acupuncture was given for one month at the main points of Zhongwan (CV 12), Zusanli (ST 36), Taichong (LR 3) and Shenmen (HT 7), with the auxiliary points selected according to TCM differentiation. In the control group, Domperidone was orally administered for one month. Results: The total effective rate was 92.5% in the treatment group and 75.0% in the control group, with a significant difference between the 2 groups (χ2=4.423, P<0.05). Acupuncture was superior to the oral remedy in therapeutic effects. Conclusions: Acupuncture may show better results for gastrointestinal neurosis and with less toxic side effects.

Effect of wrist-ankle acupuncture on propofol dosage during painless colonoscopy:A randomized controlled prospective study

BACKGROUND The clinical advantages of painless colonoscopy can reduce the fear and discomfort of patients and increase the detection rate of diseases.Propofol has the characteristics of fast effect and short action time.It is a common choice for painless endoscopic sedation and anesthetics.However,propofol can cause severe respiratory and circulatory depression.Therefore,it is important to find a way to reduce the dose of propofol.AIM To explore the effect of wrist-ankle acupuncture on propofol dose during colonoscopy.METHODS Two hundred patients who were going to receive selective painless colonoscopy in Hebei Hospital of Traditional Chinese Medicine were selected and divided into wrist-ankle acupuncture group(WAA group,n=100)and control group(CON group,n=100).After entering the operation room,patients were given 0.025 mg/kg nabufine intravenously and propofol at the initial dose of 0.5 mg/kg.In patients who did not fall asleep,propofol(10 mg/time)was given until loss of consciousness.Prior to anesthesia,patients in WAA group were punctured by specialist in the inferior 1,2 and 3 regions according to the zoning principle of wrist-ankle acupuncture.The primary endpoint was required dose of propofol,and the secondary endpoints were the incidence of hypoxemia and hypotension.Furthermore,the following data were recorded:The operation time,wake-up time,incidence of nausea and vomiting,incidence of abdominal distention,post colonoscopy pain,examiners'satisfaction,patients'satisfaction and Borg fatigue index.This study has been registered in the Chinese Clinical Trial Registry(Registration Code:ChiCTR1900022177).RESULTS The induced dose of propofol and the total dose of propofol in WAA group were 80 mg and 110 mg,respectively,which were significantly lower than those in CON group(P<0.05).The incidences of hypoxemia and hypotension in the WAA group were 2.2%and 3.3%,respectively,significantly lower than those in the CON group(P<0.05).The incidence of abdominal distension in the WAA group was 8.8%,which was significantly lower than that in the CON group(P<0.05,28.9%).The waking time of WAA group was 3.26±0.87 min,which was significantly lower than that of CON group(6.06±0.88 min,P<0.05).CONCLUSION Wrist-ankle acupuncture can reduce the induction dose and total dose of propofol as well as the incidence of adverse reactions in painless colonoscopy without affecting the satisfaction of examiners and patients.This procedure is simple in operation and easy to promote in clinical practice.

Changes in neuropeptides related to food intake in the rat arcuate nucleus after chronic immobilization stress and the effect of comfortable music exposure

Stress is an inevitable interference factor that seriously affects health.Listening to music is an economical,noninvasive,and highly accepted tool for easing stress.However,physiological studies investigating the ability of music to reduce stress in daily life are limited.We established rat models of chronic immobilization stress(CIS)to observe changes in the hypothalamic arcuate nucleus(ARC)neurons involved in the regulation of food intake and the effect of comfortable classical music exposure.Twenty-one days of stress resulted in decreased food intake and delayed body weight gain,up-regulation of leptin receptor(Ob-R),cocaine-and amphetamine-regulated transcript(CART),proopiomelanocortin(POMC),and alpha-melanocyte-stimulating hormone(α-MSH)expression,and downregulation of neuropeptide Y(NPY)and agouti-related protein(AgRP)expression in the ARC.Thus,peripheral leptin entered the ARC under chronic stress conditions,bound to Ob-R,and affected downstream nerve pathways related to appetite,such as the NPY/AgRP and CART/POMC pathways.Gentle classical music played at 65 dB reversed the abnormal expression of Ob-R and NPY induced by chronic stress.Thus,listening to comfortable music improves changes in ARC neurons related to the regulation of food intake in CIS rats,and these results provide a reference for basic research regarding how music therapy alleviates stress and stress-related health issues.

Research progress on markers of urine tubular damage in idiopathic membranous nephropathy

Idiopathic membranous nephropathy is a common primary glomerular disease.Recently,it has been found that the progression and prognosis of glomerular diseases are not only related to the glomeruli itself,but also to the severity of renal tubular injury.Although blood creatinine and urinary protein are recognized biomarkers,they appear late,are insensitive,lack specificity,and are difficult to respond to IMN conditions in a timely and accurate manner.Markers such as N-acetyl-β-D-glucosaminidase,kidney injury molecule 1,neutrophil gelatinase-associated lipoprotein in urine can dynamically reflect the progress of kidney injury in the early stage,and are detected as noninvasive,so It has been applied in IMN,but such research is lacking,and the scope needs to be further expanded and discussed in depth.

Surgical management of adult hand macrodactyly in a 49-year-old patient:A case report

BACKGROUND Macrodactyly is a rare congenital malformation characterized by an increase in the size of all structures of a digit,accounting for less than 1%of all congenital upper extremity conditions.CASE SUMMARY We report a case involving a 49-year-old woman who presented for the first time with untreated,radial-sided hand macrodactyly.We performed soft tissue debulking,amputation,median nerve neurotomy and coaptation,and carpal tunnel release.At the 6-year follow-up,no significant growth was observed in the bone or soft tissue of the affected area.CONCLUSION Tissue overgrowth in patients with progressive macrodactyly can continue and progress excessively with age.Median nerve neurotomy and coaptation play a crucial role in preventing recurrence of the deformity.

调督通脑针刺法治疗中风后抑郁疗效观察（英文）

目的:观察调督通脑针刺法治疗中风后抑郁的临床疗效。方法:共纳入70例中风后抑郁患者,采用随机数字表法随机分为观察组和对照组。观察组患者接受调督通脑针刺法治疗,对照组患者口服草酸艾司西酞普兰片(Escitalopram Oxalate tablet)治疗,共治疗8星期。分别在治疗前、治疗4星期及8星期后进行汉密尔顿抑郁量表(Hamilton depression scale,HAMD)、蒙哥马利抑郁评定量表(Montgomery Asberg depression rating scale,MADRS)、Barthel指数(Barthel Index,BI)评价,同时统计不良反应。结果:治疗4星期后,两组HAMD及MADRS评分均较本组治疗前显著降低(P<0.05),BI评分较治疗前明显提高(P<0.05);组间比较,两组HAMD评分没有统计学差异(P>0.05),观察组MADRS评分明显低于对照组(P<0.05),观察组BI评分明显高于对照组(P<0.05)。治疗8星期后,两组各项评分均无统计学差异(P>0.05),但观察组不良反应发生情况明显低于对照组。结论:调督通脑针刺法治疗中风后抑郁安全有效,与艾斯西酞普兰总体疗效相当,但能较快改善抑郁核心症状及日常生活活动(activities of daily living,ADL)能力,且不良反应少。

调督安神针法治疗失眠症疗效观察（英文）

目的:观察调督安神针法对失眠症的疗效,传承燕赵高氏针灸学术思想。方法:将68例失眠症患者按随机数字表随机分为针刺组及药物组,每组34例。针刺组采用调督安神针法治疗,每日1次,每星期治疗5次,休息2d,共治疗4星期。药物组予艾司唑仑片治疗,每日1mg,睡前口服,共治疗4星期。治疗前后采用匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)评价睡眠质量,根据P SQI减分率评定疗效。结果:治疗后,针刺组PSQI总分及各单项评分均明显下降,与本组治疗前有统计学差异(均P<0.01);药物组P SQI总分明显下降,与本组治疗前差异有统计学意义(均P<0.01),除睡眠障碍外,其余各单项积分均较治疗前下降(P<0.01或P<0.05)。针刺组治疗后P SQI总分明显低于药物组(P<0.01)。除入睡时间及睡眠时间外,针刺组睡眠质量、睡眠效率、睡眠障碍及日间功能障碍评分均低于药物组,组间差异有统计学意义(均P<0.05)。针刺组愈显率显著高于药物组(P<0.05)。结论:调督安神针法治疗失眠疗效确切,疗效优于口服艾司唑仑片。

低频电针对单纯性肥胖症患者胰岛内分泌系统的影响（英文）

目的:探讨低频电针对男、女脾虚湿盛型单纯性肥胖症患者胰岛内分泌系统调节作用的差异性。方法:共纳入单纯性肥胖症患者80例,男性组37例,女性组43例,采用低频电针刺激两组患者的阴陵泉、三阴交、足三里、丰隆、曲池、天枢、中脘、水分、气海和关元,留针30 min,每天治疗1次,10次为1疗程,治疗2个疗程。观察两组患者治疗前后身体质量指数(BMI)及血清胰岛素、胰岛素抗体及瘦素的含量变化,并进行比较分析。结果:治疗后,两组患者BMI及血清胰岛素、胰岛素抗体及瘦素含量均较治疗前明显下降(P<0.01或P<0.05);男性患者BMI及血清胰岛素含量较女性患者降低明显(均P<0.01);女性患者血清瘦素含量较男性患者降低明显(P<0.01)。结论:电针对男女单纯性肥胖症患者BMI及紊乱的胰岛素内分泌系统有明显的调节作用,但存在一定的性别差异。在降低BMI及血清胰岛素方面,男性优于女性;在减低血清瘦素方面,女性优于男性。

阳明论治针法治疗面瘫疗效观察(英文)

目的:观察高玉瑃教授"阳明论治针法"治疗周围性面瘫的临床疗效,继承燕赵高氏针灸学术思想。方法:共纳入70例周围性面瘫患者,以随机数字表法随机分为两组,每组35例。治疗组采用"阳明论治针法"治疗,对照组采用传统针刺法治疗,两组均每日治疗1次,每星期治疗6次,共治疗6星期。治疗前后根据House-Brackmann(H-B)面神经功能评价分级、临床疗效和症状体征量化评分进行疗效评价。结果:治疗2星期后,治疗组H-B分级及治愈率均优于对照组(P<0.05)。治疗4星期后,治疗组H-B分级、症状体征评分及治愈率均优于对照组(P<0.05,P<0.01,P<0.05)。治疗6星期后两组各方面比较差异均没有统计学意义(P>0.05)。结论:"阳明论治针法"治疗面瘫较传统针刺法起效快,早期治愈率高,可缩短疗程。

头部及腹部推拿治疗痰浊型头痛疗效观察

目的:观察头部及腹部推拿为主治疗痰浊型头痛的临床疗效。方法:将56例痰浊型头痛患者按随机数字表法分为推拿组和中药组,每组28例。推拿组接受头部及腹部为主的推拿治疗;中药组口服半夏白术天麻汤治疗。疗程30 d,观察两组治疗前后头痛指数评分、中医证候评分及临床疗效。结果:治疗过程中两组均脱落2例。推拿组总有效率92.3%,中药组总有效率76.9%,两组临床疗效具有统计学差异(P<0.05)。两组治疗后头痛指数评分与中医证候评分均较本组治疗前下降(均P<0.05),推拿组评分均低于中药组(均P<0.05)。结论:头部及腹部为主的推拿治疗痰浊型头痛有效,且疗效优于口服半夏白术天麻汤。