Objective To explore the difference of low-frequency electroacupuncture in regulating serum leptin and neuropeptide Y（NPY） of male and female patients with simple obesity due to spleen deficiency and damp exuberance...Objective To explore the difference of low-frequency electroacupuncture in regulating serum leptin and neuropeptide Y（NPY） of male and female patients with simple obesity due to spleen deficiency and damp exuberance. Methods Eighty patients with simple obesity, including 37 males and 43 females, were included in this study. In both groups（male group and female group）, Yīnlíngquán（阴陵泉 SP 9）, Sānyīnjiāo（三阴交 SP 6）, Zúsānlǐ（足三里 ST 36）, Fēnglóng（丰隆 ST 40）, Qūchí（曲池 LI 11）, Tiānshū（天枢 ST 25）, Zhōngwǎn（中脘 CV 12）, Shuǐfēn（水分 CV 9）, Qìhǎi（气海 CV 6）, and Guānyuán（关元 CV 4）. were selected, and low-frequency electroacupuncture treatment was applied. Needles were retained for 30 min. The treatment was conducted once a day, and 10 times were considered as one course of treatment. Two courses were needed. The changes of weight, BMI（body mass index）, F%（fat percentage） and serum leptin and NPY contents of patients in the two groups before and after treatment were observed and analyzed comparatively. Results After treatment, in male group, the weight lost（9.24±2.55） kg, BMI reduced by 4.19±2.30, F% reduced by 3.98±2.13, serum leptin level reduced by（0.66±0.23） ng/m L, and serum NPY level reduced by（18.56±2.89） pg/m L; in female group, the weight lost（6.77±2.31） kg, BMI reduced by 2.65±0.93, F% reduced by 4.98±2.30, serum leptin level reduced by（3.49±1.09） ng/m L, and serum NPY level reduced by（11.21±1.97） pg/m L. The results reduced significantly when compared with the level before treatment（P〈0.05, P〈0.01）. The loss of weight, BMI and serum NPY content in male group was more obvious than that in female group（all P〈0.01）, and the loss of F% and serum leptin content in female group was more obvious than that in male group（both P〈0.01）. Conclusion Low-frequency electroacupuncture can significantly regulate the weight, BMI, F% and serum leptin and NPY contents of male and female patients with simple obesity, and there are gender differences. In terms of reducing weight, BMI and serum NPY content, the efficacy of low-frequency electroacupuncture in males is superior to that in females, while in terms of reducing F% and serum leptin content, the efficacy in females is superior to that in males.展开更多
基金Supported by Science-technology support project of Hebei Provincial Administration of Traditional Chinese Medicine:2014015Youth fund project of Hebei University of Chinese Medicine:QNZ2014023
文摘Objective To explore the difference of low-frequency electroacupuncture in regulating serum leptin and neuropeptide Y（NPY） of male and female patients with simple obesity due to spleen deficiency and damp exuberance. Methods Eighty patients with simple obesity, including 37 males and 43 females, were included in this study. In both groups（male group and female group）, Yīnlíngquán（阴陵泉 SP 9）, Sānyīnjiāo（三阴交 SP 6）, Zúsānlǐ（足三里 ST 36）, Fēnglóng（丰隆 ST 40）, Qūchí（曲池 LI 11）, Tiānshū（天枢 ST 25）, Zhōngwǎn（中脘 CV 12）, Shuǐfēn（水分 CV 9）, Qìhǎi（气海 CV 6）, and Guānyuán（关元 CV 4）. were selected, and low-frequency electroacupuncture treatment was applied. Needles were retained for 30 min. The treatment was conducted once a day, and 10 times were considered as one course of treatment. Two courses were needed. The changes of weight, BMI（body mass index）, F%（fat percentage） and serum leptin and NPY contents of patients in the two groups before and after treatment were observed and analyzed comparatively. Results After treatment, in male group, the weight lost（9.24±2.55） kg, BMI reduced by 4.19±2.30, F% reduced by 3.98±2.13, serum leptin level reduced by（0.66±0.23） ng/m L, and serum NPY level reduced by（18.56±2.89） pg/m L; in female group, the weight lost（6.77±2.31） kg, BMI reduced by 2.65±0.93, F% reduced by 4.98±2.30, serum leptin level reduced by（3.49±1.09） ng/m L, and serum NPY level reduced by（11.21±1.97） pg/m L. The results reduced significantly when compared with the level before treatment（P〈0.05, P〈0.01）. The loss of weight, BMI and serum NPY content in male group was more obvious than that in female group（all P〈0.01）, and the loss of F% and serum leptin content in female group was more obvious than that in male group（both P〈0.01）. Conclusion Low-frequency electroacupuncture can significantly regulate the weight, BMI, F% and serum leptin and NPY contents of male and female patients with simple obesity, and there are gender differences. In terms of reducing weight, BMI and serum NPY content, the efficacy of low-frequency electroacupuncture in males is superior to that in females, while in terms of reducing F% and serum leptin content, the efficacy in females is superior to that in males.
