Background Green tea is a popular beverage worldwide and epigallocatechin-3-gallate(EGCG)is the most bioactive polyphenol in green tea.Our study aims to investigate the anti-proliferation and anti-migration effects of...Background Green tea is a popular beverage worldwide and epigallocatechin-3-gallate(EGCG)is the most bioactive polyphenol in green tea.Our study aims to investigate the anti-proliferation and anti-migration effects of EGCG against colorectal-cancer SW480,SW620,and LS411N cells,and elucidate the underlying mechanism.Methods The in vitro anti-proliferation and anti-migration effects of EGCG against colon-cancer cells were evaluated using MTT,scratch-wound-healing,and transwell-migration assays.The effects of EGCG on apoptosis were assessed by Annexin V-FITC/PI double staining and JC-1 staining.Besides,Western blotting was employed to detect the protein-expression level and elucidate the underlying pathways.Real-time qPCR and dual-luciferase reporter assay were adopted to determine the mRNA level and promoter activity.Results Our results demonstrated that treatment with EGCG resulted in significant inhibition of cell proliferation by the induction of apoptosis.EGCG also inhibited SW480 cell migration in a dose-dependent manner as assessed by wound-healing and transwell-migration assays.Western blot confirmed that EGCG induced apoptosis by the activation of Caspase-3 and PARP.In addition,both STAT3 and phosphorylated STAT3(p-STAT3)were downregulated significantly by EGCG in three selected colorectal-cancer cell lines.EGCG treatment also resulted in a significant decrease in Bcl-2,MCL-1,and Vimentin,and an increase in E-cadherin.When STAT3 was inhibited,EGCG showed no obvious effect on cell proliferation and migration.Further investigation by luciferase-reporter-activity assay showed that EGCG suppressed the promoter activity of STAT3 and downregulated the transcription of STAT3.Conclusion Our study presents evidence on the anti-proliferation and anti-migration effects of EGCG against colorectalcancer SW480,SW620,and LS411N cells by downregulating the expression of STAT3 and suggests that EGCG could be an effective and natural supplement for colon-cancer treatment.展开更多
Fabricating low-strain and fast-charging silicon-carbon composite anodes is highly desired but remains a huge challenge for lithium-ion batteries.Herein,we report a unique silicon-carbon composite fabricated by unifor...Fabricating low-strain and fast-charging silicon-carbon composite anodes is highly desired but remains a huge challenge for lithium-ion batteries.Herein,we report a unique silicon-carbon composite fabricated by uniformly dis-persing amorphous Si nanodots(SiNDs)in carbon nanospheres(SiNDs/C)that are welded on the wall of the macroporous carbon framework(MPCF)by vertical graphene(VG),labeled as MPCF@VG@SiNDs/C.The high dispersity and amor-phous features of ultrasmall SiNDs(~0.7 nm),the flexible and directed electron/Li+transport channels of VG,and the MPCF impart the MPCF@VG@SiNDs/C more lithium storage sites,rapid Li+transport path,and unique low-strain property during Li+storage.Consequently,the MPCF@VG@SiNDs/C exhibits high cycle stability(1301.4 mAh g^(-1) at 1 A g^(-1) after 1000 cycles without apparent decay)and high rate capacity(910.3 mAh g^(-1),20 A g^(-1))in half cells based on industrial electrode standards.The assembled pouch full cell delivers a high energy density(1694.0 Wh L^(-1);602.8 Wh kg^(-1))and an excellent fast-charging capability(498.5 Wh kg^(-1),charging for 16.8 min at 3 C).This study opens new possibilities for preparing advanced silicon-carbon com-posite anodes for practical applications.展开更多
About a decade ago,the unveiling of generalized Snell’s laws heralded a significant advancement in nanophotonics,leading to the emergence of metasurfaces1−6.This revolutionary milestone has set the stage for the deve...About a decade ago,the unveiling of generalized Snell’s laws heralded a significant advancement in nanophotonics,leading to the emergence of metasurfaces1−6.This revolutionary milestone has set the stage for the development of advanced optical devices,particularly metalens7−11.Researchers are already well-versed in the fundamental principles and functions of meta-lenses,which exemplify the concept of phase discontinuities with clarity.However,the exploration of meta-lenses is far from over.展开更多
Photonic signal processing offers a versatile and promising toolkit for contemporary scenarios ranging from digital optical communication to analog microwave operation.Compared to its electronic counterpart,it elimina...Photonic signal processing offers a versatile and promising toolkit for contemporary scenarios ranging from digital optical communication to analog microwave operation.Compared to its electronic counterpart,it eliminates inherent bandwidth limitations and meanwhile exhibits the potential to provide unparalleled scalability and flexibility,particularly through integrated photonics.However,by far the on-chip solutions for optical signal processing are often tailored to specific tasks,which lacks versatility across diverse applications.Here,we propose a streamlined chip-level signal processing architecture that integrates different active and passive building blocks in silicon-on-insulator(SOI)platform with a compact and efficient manner.Comprehensive and in-depth analyses for the architecture are conducted at levels of device,system,and application.Accompanied by appropriate configuring schemes,the photonic circuitry supports loading and processing both analog and digital signals simultaneously.Three distinct tasks are facilitated with one single chip across several mainstream fields,spanning optical computing,microwave photonics,and optical communications.Notably,it has demonstrated competitive performance in functions like image processing,spectrum filtering,and electro-optical bandwidth equalization.Boasting high universality and a compact form factor,the proposed architecture is poised to be instrumental for next-generation functional fusion systems.展开更多
铕掺杂钒酸钇(YVO_4:Eu^(3+))作为常用的下转换发光材料一直受到广泛的关注和研究,但是YVO_4:Eu^(3+)的表面缺陷会严重影响材料的发光效率。为了进一步改善YVO_4:Eu^(3+)纳米粉体材料的粒度分布和形貌特点,在亚微米级别的SiO_2微球表面...铕掺杂钒酸钇(YVO_4:Eu^(3+))作为常用的下转换发光材料一直受到广泛的关注和研究,但是YVO_4:Eu^(3+)的表面缺陷会严重影响材料的发光效率。为了进一步改善YVO_4:Eu^(3+)纳米粉体材料的粒度分布和形貌特点,在亚微米级别的SiO_2微球表面涂覆一层YVO_4:Eu^(3+),制成YVO_4:Eu^(3+)@SiO_2核–壳结构,得到单分散的球形YVO_4:Eu^(3+)下转换发光材料,实现YVO_4:Eu^(3+)的发光性能和SiO_2球形特性的有机结合。研究发现,当壳核比为0.6时,YVO_4:Eu^(3+)@SiO_2核–壳结构材料的发光强度可达到纯纳米粉体材料发光强度的90%以上。将改性后的YVO_4:Eu^(3+)@SiO_2核–壳结构材料涂覆在硅基薄膜太阳电池上,可使电池的短路电流密度和转化效率分别由6.694 m A/cm^2和9.40%提升至8.417 m A/cm^2和10.15%,增益效果较为明显。实验结果表明,采用溶液法制备的YVO_4:Eu^(3+)@SiO_2纳米粉体材料由于具有形貌规则、团聚小和尺寸分布均匀等特点,可用作硅基薄膜太阳电池下转换发光层材料。展开更多
基金supported by grants from Shenzhen Longhua District Science and Technology Innovation Breau[201801 to K.W.L.]Shenzhen Municipal Science and Technology program of China[JCYJ20160425100840929 to K.W.L.]the Natural Science Foundation of Guangdong province[2019A1515011009 to H.C.G.].
文摘Background Green tea is a popular beverage worldwide and epigallocatechin-3-gallate(EGCG)is the most bioactive polyphenol in green tea.Our study aims to investigate the anti-proliferation and anti-migration effects of EGCG against colorectal-cancer SW480,SW620,and LS411N cells,and elucidate the underlying mechanism.Methods The in vitro anti-proliferation and anti-migration effects of EGCG against colon-cancer cells were evaluated using MTT,scratch-wound-healing,and transwell-migration assays.The effects of EGCG on apoptosis were assessed by Annexin V-FITC/PI double staining and JC-1 staining.Besides,Western blotting was employed to detect the protein-expression level and elucidate the underlying pathways.Real-time qPCR and dual-luciferase reporter assay were adopted to determine the mRNA level and promoter activity.Results Our results demonstrated that treatment with EGCG resulted in significant inhibition of cell proliferation by the induction of apoptosis.EGCG also inhibited SW480 cell migration in a dose-dependent manner as assessed by wound-healing and transwell-migration assays.Western blot confirmed that EGCG induced apoptosis by the activation of Caspase-3 and PARP.In addition,both STAT3 and phosphorylated STAT3(p-STAT3)were downregulated significantly by EGCG in three selected colorectal-cancer cell lines.EGCG treatment also resulted in a significant decrease in Bcl-2,MCL-1,and Vimentin,and an increase in E-cadherin.When STAT3 was inhibited,EGCG showed no obvious effect on cell proliferation and migration.Further investigation by luciferase-reporter-activity assay showed that EGCG suppressed the promoter activity of STAT3 and downregulated the transcription of STAT3.Conclusion Our study presents evidence on the anti-proliferation and anti-migration effects of EGCG against colorectalcancer SW480,SW620,and LS411N cells by downregulating the expression of STAT3 and suggests that EGCG could be an effective and natural supplement for colon-cancer treatment.
基金All authors acknowledge fund support from Guangdong Basic and Applied Basic Research Foundation(2020A1515110762)National Natural Science Foundation of China(52172084).
文摘Fabricating low-strain and fast-charging silicon-carbon composite anodes is highly desired but remains a huge challenge for lithium-ion batteries.Herein,we report a unique silicon-carbon composite fabricated by uniformly dis-persing amorphous Si nanodots(SiNDs)in carbon nanospheres(SiNDs/C)that are welded on the wall of the macroporous carbon framework(MPCF)by vertical graphene(VG),labeled as MPCF@VG@SiNDs/C.The high dispersity and amor-phous features of ultrasmall SiNDs(~0.7 nm),the flexible and directed electron/Li+transport channels of VG,and the MPCF impart the MPCF@VG@SiNDs/C more lithium storage sites,rapid Li+transport path,and unique low-strain property during Li+storage.Consequently,the MPCF@VG@SiNDs/C exhibits high cycle stability(1301.4 mAh g^(-1) at 1 A g^(-1) after 1000 cycles without apparent decay)and high rate capacity(910.3 mAh g^(-1),20 A g^(-1))in half cells based on industrial electrode standards.The assembled pouch full cell delivers a high energy density(1694.0 Wh L^(-1);602.8 Wh kg^(-1))and an excellent fast-charging capability(498.5 Wh kg^(-1),charging for 16.8 min at 3 C).This study opens new possibilities for preparing advanced silicon-carbon com-posite anodes for practical applications.
文摘About a decade ago,the unveiling of generalized Snell’s laws heralded a significant advancement in nanophotonics,leading to the emergence of metasurfaces1−6.This revolutionary milestone has set the stage for the development of advanced optical devices,particularly metalens7−11.Researchers are already well-versed in the fundamental principles and functions of meta-lenses,which exemplify the concept of phase discontinuities with clarity.However,the exploration of meta-lenses is far from over.
基金supported by the National Key Research and Development Program of China(2022YFB2803700)the National Natural Science Foundation of China(62235002,62322501,12204021,62105008,62235003,and 62105260)+5 种基金Beijing Municipal Science and Technology Commission(Z221100006722003)Beijing Municipal Natural Science Foundation(Z210004)China Postdoctoral Science Foundation(2021T140004)Major Key Project of PCL,the Natural Science Basic Research Program of Shaanxi Province(2022 JQ-638)Young Talent fund of University Association for Science and Technology in Shaanxi,China(20220135)Young Talent fund of Xi'an Association for science and technology(095920221308).
文摘Photonic signal processing offers a versatile and promising toolkit for contemporary scenarios ranging from digital optical communication to analog microwave operation.Compared to its electronic counterpart,it eliminates inherent bandwidth limitations and meanwhile exhibits the potential to provide unparalleled scalability and flexibility,particularly through integrated photonics.However,by far the on-chip solutions for optical signal processing are often tailored to specific tasks,which lacks versatility across diverse applications.Here,we propose a streamlined chip-level signal processing architecture that integrates different active and passive building blocks in silicon-on-insulator(SOI)platform with a compact and efficient manner.Comprehensive and in-depth analyses for the architecture are conducted at levels of device,system,and application.Accompanied by appropriate configuring schemes,the photonic circuitry supports loading and processing both analog and digital signals simultaneously.Three distinct tasks are facilitated with one single chip across several mainstream fields,spanning optical computing,microwave photonics,and optical communications.Notably,it has demonstrated competitive performance in functions like image processing,spectrum filtering,and electro-optical bandwidth equalization.Boasting high universality and a compact form factor,the proposed architecture is poised to be instrumental for next-generation functional fusion systems.
文摘铕掺杂钒酸钇(YVO_4:Eu^(3+))作为常用的下转换发光材料一直受到广泛的关注和研究,但是YVO_4:Eu^(3+)的表面缺陷会严重影响材料的发光效率。为了进一步改善YVO_4:Eu^(3+)纳米粉体材料的粒度分布和形貌特点,在亚微米级别的SiO_2微球表面涂覆一层YVO_4:Eu^(3+),制成YVO_4:Eu^(3+)@SiO_2核–壳结构,得到单分散的球形YVO_4:Eu^(3+)下转换发光材料,实现YVO_4:Eu^(3+)的发光性能和SiO_2球形特性的有机结合。研究发现,当壳核比为0.6时,YVO_4:Eu^(3+)@SiO_2核–壳结构材料的发光强度可达到纯纳米粉体材料发光强度的90%以上。将改性后的YVO_4:Eu^(3+)@SiO_2核–壳结构材料涂覆在硅基薄膜太阳电池上,可使电池的短路电流密度和转化效率分别由6.694 m A/cm^2和9.40%提升至8.417 m A/cm^2和10.15%,增益效果较为明显。实验结果表明,采用溶液法制备的YVO_4:Eu^(3+)@SiO_2纳米粉体材料由于具有形貌规则、团聚小和尺寸分布均匀等特点,可用作硅基薄膜太阳电池下转换发光层材料。
