Schwannomas are benign neoplasms arising from Schwann cells of the peripheral,cranial and autonomic nerves.We report a case of schwannoma in the sino-nasal tract,a very rare site of tumour origin with unusual pseudoan...Schwannomas are benign neoplasms arising from Schwann cells of the peripheral,cranial and autonomic nerves.We report a case of schwannoma in the sino-nasal tract,a very rare site of tumour origin with unusual pseudoangiomatous histopathological changes,which we came across in a 22 years male with progressive nasal obstruction.展开更多
Dear editor, In India, it is high time to focus on one health approach to address the emerging/reemerging disease. The fight between microbe and man influence the inexorable archenemy that needs to be dealt. Since Sec...Dear editor, In India, it is high time to focus on one health approach to address the emerging/reemerging disease. The fight between microbe and man influence the inexorable archenemy that needs to be dealt. Since Second World War, there has been an average increase in emergence or reemergence of new diseases particularly from an animal source (75%)(1)India is identified as a major hotspot area for infectious diseases in South Asia regarding zoonoses(2)As this emergence of India as a Zoonotic hotspot, the consequence of it to further on other region and global health raises queries to global preparedness concerning epidemic potential.展开更多
Background:Nephrolithiasis is a global health problem.The recurrence rate after the first stone clearance is approximately 50%at 5 years.Metabolic abnormalities are an important factor responsible for stone recurrence...Background:Nephrolithiasis is a global health problem.The recurrence rate after the first stone clearance is approximately 50%at 5 years.Metabolic abnormalities are an important factor responsible for stone recurrence.Our prevalidated study aimed to evaluate metabolic abnormalities associated with first-time uncomplicated renal stone formers(FTURSF).Materials and methods:In this prospective,exploratory,time-bound,descriptive study,30 first-time renal stone formers were evaluated for metabolic abnormalities.High-risk stone formers were excluded from the study.Data were collected in a predefined proforma,transferred to an Excel sheet,and analyzed using the Statistical Package for Social Sciences 20 and Epi Info 7.Fisher exact test,Mann-Whitney U test,paired t test,and Pearson correlation coefficient were used for statistical analyses.Results:The mean age of the participants was 35.57±11.07 years,with a male-to-female ratio of 1.72.The most common abnormality was a 24-hour urine volume of<2.5 L in 73.33%of the participants.One or more metabolic abnormalities were detected in 76.67%of the participants.Other common metabolic abnormalities detected were hypocitraturia(60%),hypercalciuria(16.67%),hyperoxaluria(13.33%),and hyperuricosuria(3.33%).Parathyroid adenoma was detected in one participant(3.33%).Conclusions:Our study documented significant metabolic abnormalities in FTURSF.Therefore,a simplified metabolic evaluation protocol should be adopted while evaluating FTURSF.Detection of an underlying metabolic abnormality would enable the early institution of preventive measures to reduce stone recurrence and related complications.展开更多
The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological cargo.This study investigates u...The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological cargo.This study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ultrasound.Herein,we show that exosomes(EXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of payloads.NAF-derived EXs(NAF-EXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model drug.We found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a CAF-like phenotype,which may be due to regulation of Ca^(2+) influx in fibroblast cells.NAF-EXs-ORM effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EMT)and repressed tumor growth in xenograft mouse model.In conclusion,our data suggests preferential tropism of NAF-EXs for PDAC tumors,thus imply feasibility of developing a novel personalized medicine for PDAC patients using autologous NAF-EXs for improved therapeutic outcome of anti-cancer drugs.Additionally,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.展开更多
文摘Schwannomas are benign neoplasms arising from Schwann cells of the peripheral,cranial and autonomic nerves.We report a case of schwannoma in the sino-nasal tract,a very rare site of tumour origin with unusual pseudoangiomatous histopathological changes,which we came across in a 22 years male with progressive nasal obstruction.
文摘Dear editor, In India, it is high time to focus on one health approach to address the emerging/reemerging disease. The fight between microbe and man influence the inexorable archenemy that needs to be dealt. Since Second World War, there has been an average increase in emergence or reemergence of new diseases particularly from an animal source (75%)(1)India is identified as a major hotspot area for infectious diseases in South Asia regarding zoonoses(2)As this emergence of India as a Zoonotic hotspot, the consequence of it to further on other region and global health raises queries to global preparedness concerning epidemic potential.
文摘Background:Nephrolithiasis is a global health problem.The recurrence rate after the first stone clearance is approximately 50%at 5 years.Metabolic abnormalities are an important factor responsible for stone recurrence.Our prevalidated study aimed to evaluate metabolic abnormalities associated with first-time uncomplicated renal stone formers(FTURSF).Materials and methods:In this prospective,exploratory,time-bound,descriptive study,30 first-time renal stone formers were evaluated for metabolic abnormalities.High-risk stone formers were excluded from the study.Data were collected in a predefined proforma,transferred to an Excel sheet,and analyzed using the Statistical Package for Social Sciences 20 and Epi Info 7.Fisher exact test,Mann-Whitney U test,paired t test,and Pearson correlation coefficient were used for statistical analyses.Results:The mean age of the participants was 35.57±11.07 years,with a male-to-female ratio of 1.72.The most common abnormality was a 24-hour urine volume of<2.5 L in 73.33%of the participants.One or more metabolic abnormalities were detected in 76.67%of the participants.Other common metabolic abnormalities detected were hypocitraturia(60%),hypercalciuria(16.67%),hyperoxaluria(13.33%),and hyperuricosuria(3.33%).Parathyroid adenoma was detected in one participant(3.33%).Conclusions:Our study documented significant metabolic abnormalities in FTURSF.Therefore,a simplified metabolic evaluation protocol should be adopted while evaluating FTURSF.Detection of an underlying metabolic abnormality would enable the early institution of preventive measures to reduce stone recurrence and related complications.
基金UTRGV School of medicine start up,CPRIT TREC Award RP230419 and Integrated Cancer Research Core(ICRC)-RP210180Herb Kosten foundation for pancreatic cancer researchNational Institutes of Health grants R01CA206069,SC1GM139727,SC2GM139715,R01CA210192 and R01CA204552.
文摘The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological cargo.This study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ultrasound.Herein,we show that exosomes(EXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of payloads.NAF-derived EXs(NAF-EXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model drug.We found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a CAF-like phenotype,which may be due to regulation of Ca^(2+) influx in fibroblast cells.NAF-EXs-ORM effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EMT)and repressed tumor growth in xenograft mouse model.In conclusion,our data suggests preferential tropism of NAF-EXs for PDAC tumors,thus imply feasibility of developing a novel personalized medicine for PDAC patients using autologous NAF-EXs for improved therapeutic outcome of anti-cancer drugs.Additionally,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.
