Effects of Yixin Jiangya Capsules on Insulin Resistance and Tumor Necrosis Factor-α in Cases of Primary Hypertension with Left Ventricular Hypertrophy

Objectives: To observe the effects of Yixin Jiangya Capsules (益心降压胶囊 capsules for nourishing the heart and lowering blood pressure) on insulin resistance (IR) and tumor necrosis factor-α (TNF-α) in patients with primary hypertension with left ventricular hypertrophy (LVH). Methods: Totally 93 cases were randomly divided into a control group of 31 cases taking Enalapril and a treatment group of 62 cases taking Enalapril and Yixin Jiangya Capsules. Results: Fasting serum insulin (FSI) and TNF-α obviously increased and insulin sensitive index (ISI) significantly decreased in both groups before treatment as compared to those of a healthy group. After treatment, FSI, TNF-α and fasting blood glucose (FBG) obviously decreased and ISI remarkably increased in the treatment group, while ISI significantly increased and TNF-α obviously decreased in the control group. The curative effect in the treatment group was remarkably superior to that in the control group. FSI was positively related to TNF-α before treatment in both groups. Conclusion: FSI and TNF-α obviously increase and ISI significantly decreases in patients with primary hypertension with LVH. FSI and TNF-α influencing each other are involved in the generation and development of hypertension. Yixin Jiangya Capsules can improve IR and decrease TNF-α.

Intratubal Methotrexate Injection Combined with Chinese Herbal Medicine for Tubal Pregnancy and Following Pregnancy Prognosis

Objective: To compare the effects of treatment of tubal pregnancy (TP)and its following second pregnancy by intratubal methotrexate injection(IMI) alone and combination of IMI with Chinese herbal medicine. Methods: Thirty-five patients suffering from unruptured TP were divided into two groups at random, to the 19 patients in the treated group, the treatment of combined IMI with Ectopic Pregnancy decoction No. 2 (EP2, a traditional Chinese medical decoction) was applied, and to the other 16 patients in the control group, IMI alone was applied for control. Serum concentrations of human chorionic gonadotro-pinβ(β-HCG), size of the gestational sac, existent time of fetal cardiac beat and peritoneal fluid were measured before and after treatment. And hysterosalpingography were performed 6 months after ending the treatment to verify the presence of tubal obstruction and the condition of relapse.Results: The treatment of all the 35 women was successful. The recovery duration of serumβ-HCG, disappearance duration of TP sac and existent time of peritoneal fluid in the treated group were 20.0±7. 8 days, 1.2±0. 7 months and 10. 7±2. 9 days respectively, which were significantly different from those in the control group (24. 4 ±8.1 days, 3.6±1.7 months and 19.1±3. 2 days respectively(P<0. 05, P<0.01 and P<0. 05 respectively), but the existent time of fetal cardiac beat in the two groups (8.8±1. 9 days vs 9.0±1. 3 days) was not significantly different (P>0.05). The post-treatment oviduct obstructive rate in the two groups was 10.5% and 43.8% respectively, that in the treatment group was less significant (P<0.05). The relapse rate of EP in the treatment group was insignificantly different from that in the control group (5.3% vs 18.8%, P>0.05). Conclusion: The two therapies (IMI alone and IMI combined with EP2) could obtain e-qual efficacy in curing TP. Compared with IMI alone, the combined therapy appears to have the effects of accelerating the resorption of gestational sac and peritoneal fluid, improving the patency of fallopian tube and ameliorating the circumstance of pregnancy, which is favorable to improvement of the re-pregnancy rate and reduction of the re-occurrence of ectopic pregnancy as well as to the enhancement of the effect of IMI in killing trophocytes. But there is not enough proof to show the potency of EP2 in killing embryo.

Research on etiology and pathogenesis of cancer based on data mining under theguidance of Neijing theory

Etiology and pathogenesis are the causes and mechanisms of disease development and change. The unification and innovation of cancer pathogenesis is the key to the breakthrough of Chinese medicine. According to the related theory in Neijing, cancer in different parts of the body could be classified based on the five elements. Chinese mainland is divided into five parts： east, south, west, north and central section. Based on the annual data of China Cancer Center, we analyzed the data of 72 cancer registries covering 32 provinces and autonomous regions for consecutive 5 years. The results showed that the total incidence of the five regions in the mainland of China was statistically significant （F = 8.561, P 〈 0.01）; the east was the highest, the west was the lowest, and the south, middle and north were in the middle level. The incidence of tumors in different parts of the human body was statistically significant （F = 523.382, P 〈 0.01）. The incidence rate from high to low was lung, spleen, kidney, liver and heart. The heat is too much in China＇s eastern and the southern, and Qi is not too enough in the northwest. Five-Qi was imbalance. The pathogenesis of cancer is due to the two aspects, deficiency of five Zang-organs and abnormal seasonal climates. The viscera weakness for a long period and abnormal seasonal climates causes the body Yin and Yang disharmony, resulting in five zang organs dysfunction.

A Clustering Method of Chinese Medicine Prescriptions Based on Modified Firefly Algorithm

This paper is aimed to study the clustering method for Chinese medicine（CM） medical cases. The traditional K-means clustering algorithm had shortcomings such as dependence of results on the selection of initial value, trapping in local optimum when processing prescriptions form CM medical cases. Therefore, a new clustering method based on the collaboration of firefly algorithm and simulated annealing algorithm was proposed. This algorithm dynamically determined the iteration of firefly algorithm and simulates sampling of annealing algorithm by fitness changes, and increased the diversity of swarm through expansion of the scope of the sudden jump, thereby effectively avoiding premature problem. The results from confirmatory experiments for CM medical cases suggested that, comparing with traditional K-means clustering algorithms, this method was greatly improved in the individual diversity and the obtained clustering results, the computing results from this method had a certain reference value for cluster analysis on CM prescriptions.

Use of electroacupuncture and transcutaneous electrical acupoint stimulation in reproductive medicine:a group consensus

Abstract： With the rapid development of assisted reproductive technology, various reproductive disorders have been effectively addressed. Acupuncture-like therapies, including electroacupuncture （EA） and transcutaneous electrical acupoint stimulation （TEAS）, become more popular world-wide. Increasing evidence has demonstrated that EA and TEAS are effective in treating gynecological disorders, especially infertility. This present paper describes how to select acupoints for the treatment of infertility from the view of theories of traditional Chinese medicine and how to determine critical parameters of electric pulses of ENTEAS based on results from animal and clinical studies. It summarizes the principles of clinical application of EA/rEAS in treating various kinds of reproductive disorders, such as polycystic ovary syndrome （PCOS）, pain induced by oocyte retrieval, diminished ovarian reserve, embryo transfer, and oligosperrnia/ asthenospermia. The possible underlying mechanisms mediating the therapeutic effects of EA/TEAS in reproductive medicine are also examined.

Preliminary Comparative Study on the Effect of Different Chinese Drugs for Strengthening Pi(脾)in Antagonizing Diet Induced Obesity

Objective：To observe the difference in fatty degree,glucose-lipid disorder and adipose-hormones between diet induced obesity（DIO） rats and diet induced obesity resistance（DIO-R） rats,and to explore the effect and acting mechanism of Chinese drugs for strengthening Pi（脾,CD-SP） and those for both strengthening Pi and dissolving phlegm（CD-SPDP） in inhibiting obesity.Methods：Excepting eight rats allocated in the blank control group,the other 54 rats were fed with high-lipid forage for 12 weeks to establish models of obesity. Finally,30 DIO rats and 8 DIO-R rats（shown by their body weight） were obtained.The DIO rats were divided into three groups,which were given gastric perfusion,respectively,with normal saline（Group A）,CD-SP（Group B）,and CD-SPDP（Group C）.Fourteen weeks later,the animals＇ body weight（BW）,length（BL）,blood levels of fasting insulin（Fln）,fasting glucose（FBG）,triglyceride（TG）,cholesterol（TC）,leptin（LP）,neuropeptide Y（NPY）, C-reactive protein（CRP）,tumor necrosis factor-α（TNF-α）,adiponectin（AN）,and resistin（RS） were measured; insulin resistance index（IRI） was calculated,and the degree of obesity and lipid content in abdominal cavity of rats were estimated.Moreover,the levels of LP,CRP,TNF-α,AN and RS in homogenate of rats＇ adipose tissues（ATH） were determined.Results：After 12 weeks of high-lipid diet,the BW of DIO rats was higher than that of normal or DIO-R rats.After a 14-week continuous high-lipid diet feeding,in DIO rats,BW,lipid coefficient （LC）,and IRI were significantly increased（P〈0.01）;serum levels of TNF-α,LP and AN were lower,NPY was higher,while the ATH levels of LP and AN were lower and TNF-αwas higher in DIO rats than in DIO-R rats （P〈0.05 or P〈0.01）;blood levels of FBG and lipids in DIO rats showed an increasing trend but was statistically insignificant（P〉0.05）;no significant difference was found in serum levels of CRP and RS due to the overly high data dispersion.Comparisons of the 3 DIO groups showed that BW,body weight index（BWI）,LC and IRI were significantly lowered after treatment（P〈0.01） in Group C,while these indexes were not significantly different between Group A and B;the serum levels of TNF-α,LP,and AN increased,NPY decreased in Group B and C, ATH levels of LP and AN increased,and TNF-αdecreased in the two groups;but NPY,LP,and AN in blood and ATH were higher in Group C than those in Group B（P〈0.05 or P〈0.01）.Conclusion：CD-SPDP could inhibit DIO and IR,showing that the effect is better than that of CD-SP,and its mechanism is related to promotion of LP and AN secretion and elevation of serum NPY.

Analgesic effect of acupuncture at Hegu (LI 4) on transvaginal oocyte retrieval with ultrasonography

OBJECTIVE: To observe the analgesic effect of acupuncture at Hegu (LI 4) in vitro fertilization-embryo transfer (IVF-ET) transvaginal oocyte retrieval using ultrasonography and explore its mechanism. METHODS: Ninety patients undergoing IVF-EF oocyte retrieval were randomly divided into three groups: an acupuncture group with needles inserted into bilateral Hegu (LI 4) points, a placebo group given placebo needles, and a control group with routine oocyte retrieval. Each group had an indometacin enema 30 min before the operation. We compared the pain-rated index (PRI), visual analogy scale (VAS), and present pain intensity (PPI) immediately after operation and 1 h after operation. We also determined the neuropeptide Y (NPY) level of the follicular fluid. RESULTS: PRI, VAS, and PPI after operation and 1 hafter operation in the acupuncture group were significantly lower than those in the control group (P< 0.01). No obvious difference (P>0.05) was observed in PRI,VAS, and PPI after operation and 1 h after operation between the placebo group and the control group.The NPY level of the follicular fluid in the acupuncture group was significantly higher than that in the control group (P<0.01). No obvious difference (P>0.05) was observed in the NPY level of the follicular fluid between the placebo group and the control group. CONCLUSION: The analgesic effect of acupuncture at Hegu in transvaginal oocyte retrieval using ultrasonography may be related to the increase in the NPY level of the follicular fluid.

Mistakes in Application of Tuina Therapy for Stroke Rehabilitation

Objective：To analyze the mistakes in the application of tuina therapy in the rehabilitation of stroke,in order to elevate the clinical effects in the treatment of stroke by tuina.Methods：The issues are found out by searching and analyzing the relevant articles on tuina treatment of stroke.Results：In the tuina treatment of stroke,mistakes exist in the intervening time of the treatment,in the emphasis of tuina with negligence of rehabilitation,in the assessment of therapeutic effects,in the selection of the manual techniques and acupoints,and in the negligence of health education.Conclusion：In the tuina treatment of stroke,it is advisable to start treatment in the early stages,use the manual techniques in different phases,to cooperate with rehabilitation at the proper time and to emphasize health education,in order to avoid or reduce the occurrence of misuse syndrome,and eliminate the appearance of disuse syndrome,for displaying the unique advantage of tuina therapy fully and promoting the innovation and development of TCM rehabilitative techniques.

Curative effect of heat-sensitive moxibustion on chronic persistent asthma: a multicenter randomized controlled trial

OBJECTIVE:To compare the curative effects of heat-sensitive moxibustion with conventional drugs on chronic persistent asthma and seek a valuable therapy to replaceWestern Medicine.METHODS:The participants in this multi-center,randomized,and controlled study were randomly divided into two groups:group A(n=144),treated with heat-sensitive moxibustion(50 sessions)and group B(n=144),treated with Seretide(salmeterol50μg/fluticasone 250μg,twice a day).The scores of asthma control test(ACT),forced expiratory volume in 1 second(FEV1),peak expiratory flow(PEF),and attack frequency were measured after 15,30,60,and 90 days of treatment.Patients followed up3 and 6 months after treatment.RESULTS:There was a significant difference(P=0.0002)in the ACT score and lung function between the two groups after 3 months of treatment and(P=0.000 03)during the follow-up visits.In addition,heat-sensitive moxibustion reduced attack frequency in the period from inclusion to the6-month follow-up visit.CONCLUSION:This study shows that heat-sensitive moxibustion may have a comparable curative effect toSeretide(salmeterol/fluticasone)on asthma.

Comparative Observation on Therapeutic Effects of Treating Menopausal Syndrome with Auricular Points Sticking-pressure and Acupuncture

Objective： To make a comparative observation on treating menopausal syndrome with auricular points sticking-pressure and acupuncture, Methods.The 86 cases were randomized into the group of auricular points sticking-pressure and acupuncture group, and then the comparative observation was made according to the modified Kupperman index. Results： The statistical analysis on the comparative observation showed there is no significant difference between the therapeutic effects of the two groups. Conclusion, Auricular points sticking-pressure and acupuncture are both effective for menopausal syndrome, and the auricular points sticking pressure is worthy to spread with its easy operation.

Clinical Observations on Electroacupuncture-induced Ovulation in Patients with Luteinized Unruptured Follicle Syndrome

Objective： To investigate the curative effect of electroacupuncture on luteinized unruptured follicle syndrome（LUFS） and its mechanism, Methods： Sixty LUFS patients were randomly allocated to treatment （electroacupuncture） group and control （hCG） group. The follicular condition and ovarian arterial flow under color Doppler ultrasonogaphy and a change in reproductive endocrine level were observed in the patients before and after treatments. The ovulation rates and pregnancy rates were compared between the two groups, and the mechanism was investigated. Results： Both ovulation rate and pregnancy rate were significantly higher in the treatment group than in the control group （P〈0.01）. There was a significant difference in the improvement in ovarian arterial flow between the treatment and control groups （P〈0.01）. The improvement in endocrine level was significantly more marked in the treatment group than in the control group（P〈0.01）. Conclusion： Electroacupuncture has a good effect on luteinized unrupture follicle syndrome. Its mechanism may be related to the improvement in ovarian arterial blood supply and the regulation of endocrine level.