Residual bacteria and microleakage in a complicated root canal can often result in reinfection of the periapical tissues.To promote the antibacterial and sealing eftects of a root canal filling,core-shell structured C...Residual bacteria and microleakage in a complicated root canal can often result in reinfection of the periapical tissues.To promote the antibacterial and sealing eftects of a root canal filling,core-shell structured CaO/ZnO nanospheres were synthesized using a precipitation method based on a traditional root canal sealer,zinc oxide-eugenol(ZOE).The obtained CaO/ZnO particles had a size of 80—90 nm and a core-shell structure.The film thickness,flow rate,pH,and calcium ion release of the core-shell structured CaO/ZnO nanospheres-eugenol paste were tested.The pH and calcium ion release results showed a slight increase in the prepared nanospheres,with a flow rate of 24.22 mm and a formed film thickness of 30 pm,which are basically consistent with ISO 6876:2001 standards(regarding dental root canal sealing materials).Cytotoxicity tests showed that the cytocompatibility of the CaO/ZnO nanospheres-eugenol paste was much higher than that of the ZOE or iRoot SP groups(P<0.05).A comparison of the sealing ability and antibacterial activity showed that the core-shell structured CaO/ZnO nano spheres-eugenol paste had significantly better effects than the ZOE and iRoot SP sealers(P<0.05).The core-shell structured CaO/ZnO nano sphere paste displayed excellent sealing and antibacterial properties,and it has promising application potential in endodontics.展开更多
基金Supported by the Jilin Provincial Health Department Research Projects,China(No.2017J065)the Jilin Provincial Education Department Research Projects,China(No.JJKII20180229KJ).
文摘Residual bacteria and microleakage in a complicated root canal can often result in reinfection of the periapical tissues.To promote the antibacterial and sealing eftects of a root canal filling,core-shell structured CaO/ZnO nanospheres were synthesized using a precipitation method based on a traditional root canal sealer,zinc oxide-eugenol(ZOE).The obtained CaO/ZnO particles had a size of 80—90 nm and a core-shell structure.The film thickness,flow rate,pH,and calcium ion release of the core-shell structured CaO/ZnO nanospheres-eugenol paste were tested.The pH and calcium ion release results showed a slight increase in the prepared nanospheres,with a flow rate of 24.22 mm and a formed film thickness of 30 pm,which are basically consistent with ISO 6876:2001 standards(regarding dental root canal sealing materials).Cytotoxicity tests showed that the cytocompatibility of the CaO/ZnO nanospheres-eugenol paste was much higher than that of the ZOE or iRoot SP groups(P<0.05).A comparison of the sealing ability and antibacterial activity showed that the core-shell structured CaO/ZnO nano spheres-eugenol paste had significantly better effects than the ZOE and iRoot SP sealers(P<0.05).The core-shell structured CaO/ZnO nano sphere paste displayed excellent sealing and antibacterial properties,and it has promising application potential in endodontics.
