Background: Respiratory tract infections were associated with acute exacerbations of heart failure (HF). However, the role of the influenza virus, a major agent of such infections, in this population remained unclear....Background: Respiratory tract infections were associated with acute exacerbations of heart failure (HF). However, the role of the influenza virus, a major agent of such infections, in this population remained unclear. Method: During the influenza virus seasons of 2013 and 2014 we prospectively assessed influenza respiratory illnesses in a cohort of adults primarily hospitalized for management of acute decompensated HF and a cohort of HF outpatients. Qualitative RT-PCR for?influenza?A (A/H1, A/H12009pdm, A/H3) and B virus testing was performed on nasopharyngeal swab samples. Result: A total of 121 patients were included, 58.3% males (n?= 70), mean age 57.7 years old (±14.0), mean left ejection fraction 35.3 (±9.8). Of these, 50.4% were inpatients (n?= 61). The prevalence of symptoms of respiratory infections was 28.0% (n?= 34) and 4.9% (n?= 6) of all samples were positive for influenza virus. Only influenza A was detected and all cases were among inpatients. Influenza-positive patients had a greater need for antimicrobials (83.3%,?n?= 5;16.3%,?n= 9;?p?= 0.001) and for mechanical ventilation (50.0%,?n?= 3;3.6%,?n?= 2;?p?< 0.001) than Influenza-negative patients. The prevalence of influenza virus was not related to mortality (OR 4.58;?p?= 0.16). Conclusion:?Although not common, the influenza virus infection resulted in worst outcomes, with a greater need for antimicrobials and mechanical ventilation. Immunization and antiviral treatment in high risk patients may positively impact their outcomes.展开更多
文摘Background: Respiratory tract infections were associated with acute exacerbations of heart failure (HF). However, the role of the influenza virus, a major agent of such infections, in this population remained unclear. Method: During the influenza virus seasons of 2013 and 2014 we prospectively assessed influenza respiratory illnesses in a cohort of adults primarily hospitalized for management of acute decompensated HF and a cohort of HF outpatients. Qualitative RT-PCR for?influenza?A (A/H1, A/H12009pdm, A/H3) and B virus testing was performed on nasopharyngeal swab samples. Result: A total of 121 patients were included, 58.3% males (n?= 70), mean age 57.7 years old (±14.0), mean left ejection fraction 35.3 (±9.8). Of these, 50.4% were inpatients (n?= 61). The prevalence of symptoms of respiratory infections was 28.0% (n?= 34) and 4.9% (n?= 6) of all samples were positive for influenza virus. Only influenza A was detected and all cases were among inpatients. Influenza-positive patients had a greater need for antimicrobials (83.3%,?n?= 5;16.3%,?n= 9;?p?= 0.001) and for mechanical ventilation (50.0%,?n?= 3;3.6%,?n?= 2;?p?< 0.001) than Influenza-negative patients. The prevalence of influenza virus was not related to mortality (OR 4.58;?p?= 0.16). Conclusion:?Although not common, the influenza virus infection resulted in worst outcomes, with a greater need for antimicrobials and mechanical ventilation. Immunization and antiviral treatment in high risk patients may positively impact their outcomes.
