MicroRNAs belong to a newly identified class of small non-coding RNAs that have been widely implicated in the fine-tuning of many physiological processes such as the pathogenesis of type 2 diabetes （T2D） and obesity...MicroRNAs belong to a newly identified class of small non-coding RNAs that have been widely implicated in the fine-tuning of many physiological processes such as the pathogenesis of type 2 diabetes （T2D） and obesity. Microarray studies have highlighted an altered profile of miRNA expression in insulin target tissues in diabetic and obese models. Emerging evidences suggest that miRNAs play significant roles in insulin production, secretion and actions, as well as in diverse aspects of glucose homeostasis and adipocyte differentiation. The identification of tissue-specific miRNAs implicated in T2D and obesity might be useful for the future development of effective strategies for early diagnosis and therapeutic intervention of obesity-related medical complications.展开更多
The neural modulation in central auditory system plays an important role in perception and processing of sound signal and auditory cognition.The inferior colliculus(IC)is both a relay station in central auditory pathw...The neural modulation in central auditory system plays an important role in perception and processing of sound signal and auditory cognition.The inferior colliculus(IC)is both a relay station in central auditory pathway and a sub-cortical auditory center doing the sound signal processing.IC is also modulated by the descending projections from the cortex and auditory thalamus,medial geniculate body,and these neural modulations not only can affect ongoing sound signal processing but can also induce plastic changes in IC.展开更多
基金supported by the National Basic Research Program of China(973 Program)(No.2011CB504004) and self-determined research funds of CCNU from the colleges' basic research and operation of MOE
文摘MicroRNAs belong to a newly identified class of small non-coding RNAs that have been widely implicated in the fine-tuning of many physiological processes such as the pathogenesis of type 2 diabetes （T2D） and obesity. Microarray studies have highlighted an altered profile of miRNA expression in insulin target tissues in diabetic and obese models. Emerging evidences suggest that miRNAs play significant roles in insulin production, secretion and actions, as well as in diverse aspects of glucose homeostasis and adipocyte differentiation. The identification of tissue-specific miRNAs implicated in T2D and obesity might be useful for the future development of effective strategies for early diagnosis and therapeutic intervention of obesity-related medical complications.
基金This work was supported by the grants(Nos.30970972 and 108096)from the National Natural Science Foundation of China(Grant Nos.30970972 and 108096)the State Education Ministry of China.
文摘The neural modulation in central auditory system plays an important role in perception and processing of sound signal and auditory cognition.The inferior colliculus(IC)is both a relay station in central auditory pathway and a sub-cortical auditory center doing the sound signal processing.IC is also modulated by the descending projections from the cortex and auditory thalamus,medial geniculate body,and these neural modulations not only can affect ongoing sound signal processing but can also induce plastic changes in IC.
