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Antisense oligonucleotides as gene expression modulators
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作者 Sudhir Agrawal 《中国实验血液学杂志》 CAS CSCD 1997年第3期333-334,共2页
Antisense oligonucleotides have been shown to beunique drugs that achieve their effect by targetingmRNA with which they can hybridize and specificallyblock gene expression, offering the possibility ofspecific, rationa... Antisense oligonucleotides have been shown to beunique drugs that achieve their effect by targetingmRNA with which they can hybridize and specificallyblock gene expression, offering the possibility ofspecific, rational drug design. However, there havebeen many concerns that have limited enthusiasm forthe development of these drugs from the preclinical 展开更多
关键词 hybridize POSSIBILITY offering RATIONAL metabolism targeted ADMINISTRATION ANTISENSE OVERCOME ALTERNATE
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