This journal article delves into the future of distance learning in Cambodia and the potential for collaboration with the Mekong-Lancang Open Education initiative. It explores how distance learning can successfully ad...This journal article delves into the future of distance learning in Cambodia and the potential for collaboration with the Mekong-Lancang Open Education initiative. It explores how distance learning can successfully address the current issues the Cambodian educational system is currently facing. The article discusses the goals and opportunities for collaboration that the Mekong-Lancang Open Education initiative presents, as well as the difficulties and potential solutions involved in implementing distance learning in Cambodia. Moreover,the article also offers insightful case studies and best practices from other countries, offering valuable insights and lessons for Cambodia. Lastly, the article concludes with policy recommendations for the future of distance learning in Cambodia. Future research and studies should concentrate on continually evaluating and improving the Mekong-Lancang Open Education Initiative to ensure that it effectively meets the educational needs of students and educators.展开更多
In Europe, computation of displacement demand for seismic assessment of existing buildings is essentially based on a simplified formulation of the N2 method as prescribed by Eurocode 8(EC8). However, a lack of accurac...In Europe, computation of displacement demand for seismic assessment of existing buildings is essentially based on a simplified formulation of the N2 method as prescribed by Eurocode 8(EC8). However, a lack of accuracy of the N2 method in certain conditions has been pointed out by several studies. This paper addresses the assessment of effectiveness of the N2 method in seismic displacement demand determination in non-linear domain. The objective of this work is to investigate the accuracy of the N2 method through comparison with displacement demands computed using non-linear timehistory analysis(NLTHA). Results show that the original N2 method may lead to overestimation or underestimation of displacement demand predictions. This may affect results of mechanical model-based assessment of seismic vulnerability at an urban scale. Hence, the second part of this paper addresses an improvement of the N2 method formula by empirical evaluation of NLTHA results based on EC8 ground-classes. This task is formulated as a mathematical programming problem in which coefficients are obtained by minimizing the overall discrepancy between NLTHA and modified formula results. Various settings of the mathematical programming problem have been solved using a global optimization metaheuristic. An extensive comparison between the original N2 method formulation and optimized formulae highlights benefits of the strategy.展开更多
In this paper, we will explain the relevance of the starant graphs, graphs created by us in the year of 2002. They were basically circulant graphs with a star graph that connects to all the vertices of the circulant g...In this paper, we will explain the relevance of the starant graphs, graphs created by us in the year of 2002. They were basically circulant graphs with a star graph that connects to all the vertices of the circulant graphs from inside of them, but they did not exist as a separate object of study in the year of 2002, as for all we knew. We now know that they can be used to model even social networking interactions, and they do that job better than any other graph we could be trying to use there. With the development of our mathematical tools, lots of conclusions will be made much more believable and therefore will become much more likely to get support from the relevant industries when attached to new queries.展开更多
People normally believe that Arithmetic is not complete because GÖdel launched this idea a long time ago, and it looks as if nobody has presented sound evidence on the contrary. We here intend to do that perh...People normally believe that Arithmetic is not complete because GÖdel launched this idea a long time ago, and it looks as if nobody has presented sound evidence on the contrary. We here intend to do that perhaps for the first time in history. We prove that what Stanford Encyclopedia has referred to as Theorem 3 cannot be true, and, therefore, if nothing else is presented in favour of GÖdel’s thesis, we actually do not have evidence on the incompleteness of Arithmetic: All available evidence seems to point at the extremely opposite direction.展开更多
The North-East region of Mexican Republic has a semi-arid weather condition;this area covers partially Tamaulipas, Nuevo León and Coahuila states. Pablillo River Basin (PRB) is located close to Nuevo León so...The North-East region of Mexican Republic has a semi-arid weather condition;this area covers partially Tamaulipas, Nuevo León and Coahuila states. Pablillo River Basin (PRB) is located close to Nuevo León south border and its catchment area involves Linares City (LC), Hualahuises City (HC) and Cerro-Prieto dam (CP). This reservoir captures drinking water to Monterrey Metropolitan Zone (MMZ) the major urban center on the north-east Mexican region. More than 50% of the potable water for LC comes from groundwater stockpiles. A combination of GIS maps and major ion chemistry analysis has been assessed, to know the origin, geochemical evolution, and hydraulic interconnection of groundwater. During 2008-2009, 46 groundwater samples were taken and analyzed around LC and HC. GIS technology was use to analyze the spatial distribution of the constituents of groundwater through thematic maps. The major ion analysis and its results suggest the presences of two aquifers;shallow porous aquifer on the top and fractured aquifer on the bottom. General water mineralization was discovered, including dissolution of halite, dolomites and carbonates through the aquifers. Water quality varies widely through the aquifers, and the general pathways go from southwest to northeast direction. The overexploitation of groundwater increases the water mixing of groundwater between shallow and deeper aquifers. Natural origin of groundwater and groundwater pollution by anthropogenic activities should be considered in the groundwater quality analysis for drinking water purpose.展开更多
The aim of this study was to test if previous ingestion of compounds containing resveratrol or hydroxytyrosol, followed by an exhausting hand grip exercise, could induce an acute post-exercise increase in brachial blo...The aim of this study was to test if previous ingestion of compounds containing resveratrol or hydroxytyrosol, followed by an exhausting hand grip exercise, could induce an acute post-exercise increase in brachial blood flow. Six healthy subjects (three males and three females, 35 ± 7 years), 60 minutes after ingestion of a capsule containing 200 mg of resveratrol or 30 ml of extra virgin olive oil enriched with tyrosol, oleuropein and hydroxytyrosol, performed a hand grip exercise equal to half of their maximum strength until they were no longer able to express the same force (2-day interval between tests). The nonparametric Wilcoxon signed rank test was used for statistical evaluations. Brachial artery blood flow (Fba) and both blood velocity (Vba) and artery diameter (Dba) were assessed immediately after exercise cessation by means of colour Doppler ultrasound. After ingestion of the oil mixture the post-exercise value of Fba median was 2.4 times higher than that after ingestion of the resveratrol compound (P = 0.03), and also the Vba median concerning the hydroxytyrosol was 1.9 times higher than that of the resveratrol (P = 0.03). Both functional foods did not lead to a significant difference in the Dba medians. These results indicate that hydroxytyrosol, but not resveratrol, may be an effective adjuvant of recreational or agonistic, long-lasting sports performances, thanks to the powerful blood flow increment which can be obtained as soon as one hour from its oral intake.展开更多
Increasingly,Wireless Sensor Networks(WSNs)are contributing enormous amounts of data.Since the recent deployments of wireless sensor networks in Smart City infrastructures,significant volumes of data have been produce...Increasingly,Wireless Sensor Networks(WSNs)are contributing enormous amounts of data.Since the recent deployments of wireless sensor networks in Smart City infrastructures,significant volumes of data have been produced every day in several domains ranging from the environment to the healthcare system to transportation.Using wireless sensor nodes,a Smart City environment may now be shown for the benefit of residents.The Smart City delivers intelligent infrastructure and a stimulating environment to citizens of the Smart Society,including the elderly and others.Weak,Quality of Service(QoS)and poor data performance are common problems in WSNs,caused by the data fusion method,where a small amount of bad data can significantly impact the total fusion outcome.In our proposed research,a WSN multisensor data fusion technique employing fuzzy logic for event detection.Using the new proposed Algorithm,sensor nodes will collect less repeated data,and redundant data will be used to increase the data’s overall reliability.The network’s fusion delay problem is investigated,and a minimum fusion delay approach is provided based on the nodes’fusion waiting time.The proposed algorithm performs well in fusion,according to the results of the experiment.As a result of these discoveries,It is concluded that the algorithm describe here is effective and dependable instrument with a wide range of applications.展开更多
Ultra-wideband(UWB)is highly preferred for short distance communication.As a result of this significance,this project targets the design of a compact UWB antennas.This paper describes a printed UWB rhombusshaped anten...Ultra-wideband(UWB)is highly preferred for short distance communication.As a result of this significance,this project targets the design of a compact UWB antennas.This paper describes a printed UWB rhombusshaped antenna with a partial ground plane.To achieve wideband response,two stubs and a notch are incorporated at both sides of the rhombus design and ground plane respectively.To excite the antenna,a simple microstrip feed line is employed.The suggested antenna is built on a 1.6 mm thick FR4 substrate.The proposed design is very compact with overall electrical size of 0.18λ×0.25λ(14×18 mm2).The rhombus shaped antenna covers frequency ranging from 3.5 to 11 GHz with 7.5 GHz impedance bandwidth.The proposed design simulated and measured bandwidths are 83.33%and 80%,respectively.Radiation pattern in terms of E-field and H-field are discussed at 4,5.5 and 10 GHz respectively.The proposed design has 65%radiation efficiency and 1.5 dBi peak gain.The proposed design is simulated in CST(Computer Simulation Technology)simulator and the simulated design is fabricated for the measured results.The simulated and measured findings are in close resemblance.The obtained results confirm the application of the proposed design for the ultra-wide band applications.展开更多
The recent advancements made in the realms of Artificial Intelligence(AI)and Artificial Intelligence of Things(AIoT)have unveiled transformative prospects and opportunities to enhance and optimize the environmental pe...The recent advancements made in the realms of Artificial Intelligence(AI)and Artificial Intelligence of Things(AIoT)have unveiled transformative prospects and opportunities to enhance and optimize the environmental performance and efficiency of smart cities.These strides have,in turn,impacted smart eco-cities,catalyzing ongoing improvements and driving solutions to address complex environmental challenges.This aligns with the visionary concept of smarter eco-cities,an emerging paradigm of urbanism characterized by the seamless integration of advanced technologies and environmental strategies.However,there remains a significant gap in thoroughly understanding this new paradigm and the intricate spectrum of its multifaceted underlying dimensions.To bridge this gap,this study provides a comprehensive systematic review of the burgeoning landscape of smarter eco-cities and their leadingedge AI and AIoT solutions for environmental sustainability.To ensure thoroughness,the study employs a unified evidence synthesis framework integrating aggregative,configurative,and narrative synthesis approaches.At the core of this study lie these subsequent research inquiries:What are the foundational underpinnings of emerging smarter eco-cities,and how do they intricately interrelate,particularly urbanism paradigms,environmental solutions,and data-driven technologies?What are the key drivers and enablers propelling the materialization of smarter eco-cities?What are the primary AI and AIoT solutions that can be harnessed in the development of smarter eco-cities?In what ways do AI and AIoT technologies contribute to fostering environmental sustainability practices,and what potential benefits and opportunities do they offer for smarter eco-cities?What challenges and barriers arise in the implementation of AI and AIoT solutions for the development of smarter eco-cities?The findings significantly deepen and broaden our understanding of both the significant potential of AI and AIoT technologies to enhance sustainable urban development practices,as well as the formidable nature of the challenges they pose.Beyond theoretical enrichment,these findings offer invaluable insights and new perspectives poised to empower policymakers,practitioners,and researchers to advance the integration of eco-urbanism and AI-and AIoT-driven urbanism.Through an insightful exploration of the contemporary urban landscape and the identification of successfully applied AI and AIoT solutions,stakeholders gain the necessary groundwork for making well-informed decisions,implementing effective strategies,and designing policies that prioritize environmental well-being.展开更多
In the last forty years,the rise of HIV has undoubtedly become a major concern in the field of public health,imposing significant economic burdens on affected regions.Consequently,it becomes imperative to undertake co...In the last forty years,the rise of HIV has undoubtedly become a major concern in the field of public health,imposing significant economic burdens on affected regions.Consequently,it becomes imperative to undertake comprehensive investigations into the mechanisms governing the dissemination of HIV within the human body.In this work,we have devised a mathematical model that elucidates the intricate interplay between CD4^(+)T-cells and viruses of HIV,employing the principles of fractional calculus.The production rate of CD4^(+)T-cells,like other immune cells depends on certain factors such as age,health status,and the presence of infections or diseases.Therefore,we incorporate a variable source term in the dynamics of HIV infection with a saturated incidence rate to enhance the precision of our findings.We introduce the fundamental concepts of fractional operators as a means of scrutinizing the proposed HIV model.To facilitate a deeper understanding of our system,we present an iterative scheme that elucidates the trajectories of the solution pathways of the system.We show the time series analysis of our model through numerical findings to conceptualize and understand the key factors of the system.In addition to this,we present the phase portrait and the oscillatory behavior of the system with the variation of different input parameters.This information can be utilized to predict the long-term behavior of the system,including whether it will converge to a steady state or exhibit periodic or chaotic oscillations.展开更多
All-reflective optical systems,due to their material absorption and low refractive index,are used to create the most suitable devices in extreme ultraviolet lithography (EUVL).In this letter,we present a design for ...All-reflective optical systems,due to their material absorption and low refractive index,are used to create the most suitable devices in extreme ultraviolet lithography (EUVL).In this letter,we present a design for an all-reflective lithographic projection lens.We also discuss its design idea and structural system.After analysis of the four-mirror optical system,the initial structural parameters are determined,the optical system is optimized,and the tolerances of the system are analyzed.We also show the implementation of optimal layout and desired imaging performance.展开更多
Mechanical, physical and manufacturing properties of east iron make it attractive for many fields of application, such as cranks and cylinder holds. As in design of all metals, fatigue life prediction is an intrinsic ...Mechanical, physical and manufacturing properties of east iron make it attractive for many fields of application, such as cranks and cylinder holds. As in design of all metals, fatigue life prediction is an intrinsic part of the design process of structural sections that are made of cast iron. A methodology to predict high-cycle fatigue life of cast iron is proposed. Stress amplitude-strain amplitude, strain amplitude-number of loading cycles relationships of cast iron are investigated. Also, fatigue life prediction in terms of Smith, Watson and Topper parameter is carried out using the proposed method. Results indicate that the analytical outcomes of the proposed methodology are in good accordance with the experimental data for the two studied types of cast iron: EN-GJS-400 and EN-GJS-600.展开更多
The incorporation of gallium into bioactive materials has been reported to enhance osteogenesis,to influence blood clotting,and to induce anti-cancer and anti-bacterial activity.Gallium-doped biomaterials prepared by ...The incorporation of gallium into bioactive materials has been reported to enhance osteogenesis,to influence blood clotting,and to induce anti-cancer and anti-bacterial activity.Gallium-doped biomaterials prepared by various techniques include melt-derived and sol-gel-derived bioactive glasses,calcium phosphate bioceramics,metals and coatings.In this review,we summarize the recently reported developments in antibacterial,anti-cancer,osteogenesis,and hemostasis properties of Ga-doped biomaterials and briefly outline the mechanisms leading to Ga biological effects.The key finding is that gallium addition to biomaterials has great potential for treating bone-related diseases since it can be efficiently transferred to the desired region at a controllable rate.Besides,it can be used as a potential substitute for antibiotics for the inhibition of infections during the initial and advanced phases of the wound healing process.Ga is also used as an anticancer agent due to the increased concentration of gallium around excessive cell proliferation(tumor)sites.Moreover,we highlight the possibility to design different therapeutic approaches aimed at increasing the efficiency of the use of gallium containing bioactive materials for multifunctional applications.展开更多
文摘This journal article delves into the future of distance learning in Cambodia and the potential for collaboration with the Mekong-Lancang Open Education initiative. It explores how distance learning can successfully address the current issues the Cambodian educational system is currently facing. The article discusses the goals and opportunities for collaboration that the Mekong-Lancang Open Education initiative presents, as well as the difficulties and potential solutions involved in implementing distance learning in Cambodia. Moreover,the article also offers insightful case studies and best practices from other countries, offering valuable insights and lessons for Cambodia. Lastly, the article concludes with policy recommendations for the future of distance learning in Cambodia. Future research and studies should concentrate on continually evaluating and improving the Mekong-Lancang Open Education Initiative to ensure that it effectively meets the educational needs of students and educators.
文摘In Europe, computation of displacement demand for seismic assessment of existing buildings is essentially based on a simplified formulation of the N2 method as prescribed by Eurocode 8(EC8). However, a lack of accuracy of the N2 method in certain conditions has been pointed out by several studies. This paper addresses the assessment of effectiveness of the N2 method in seismic displacement demand determination in non-linear domain. The objective of this work is to investigate the accuracy of the N2 method through comparison with displacement demands computed using non-linear timehistory analysis(NLTHA). Results show that the original N2 method may lead to overestimation or underestimation of displacement demand predictions. This may affect results of mechanical model-based assessment of seismic vulnerability at an urban scale. Hence, the second part of this paper addresses an improvement of the N2 method formula by empirical evaluation of NLTHA results based on EC8 ground-classes. This task is formulated as a mathematical programming problem in which coefficients are obtained by minimizing the overall discrepancy between NLTHA and modified formula results. Various settings of the mathematical programming problem have been solved using a global optimization metaheuristic. An extensive comparison between the original N2 method formulation and optimized formulae highlights benefits of the strategy.
文摘In this paper, we will explain the relevance of the starant graphs, graphs created by us in the year of 2002. They were basically circulant graphs with a star graph that connects to all the vertices of the circulant graphs from inside of them, but they did not exist as a separate object of study in the year of 2002, as for all we knew. We now know that they can be used to model even social networking interactions, and they do that job better than any other graph we could be trying to use there. With the development of our mathematical tools, lots of conclusions will be made much more believable and therefore will become much more likely to get support from the relevant industries when attached to new queries.
文摘People normally believe that Arithmetic is not complete because GÖdel launched this idea a long time ago, and it looks as if nobody has presented sound evidence on the contrary. We here intend to do that perhaps for the first time in history. We prove that what Stanford Encyclopedia has referred to as Theorem 3 cannot be true, and, therefore, if nothing else is presented in favour of GÖdel’s thesis, we actually do not have evidence on the incompleteness of Arithmetic: All available evidence seems to point at the extremely opposite direction.
文摘The North-East region of Mexican Republic has a semi-arid weather condition;this area covers partially Tamaulipas, Nuevo León and Coahuila states. Pablillo River Basin (PRB) is located close to Nuevo León south border and its catchment area involves Linares City (LC), Hualahuises City (HC) and Cerro-Prieto dam (CP). This reservoir captures drinking water to Monterrey Metropolitan Zone (MMZ) the major urban center on the north-east Mexican region. More than 50% of the potable water for LC comes from groundwater stockpiles. A combination of GIS maps and major ion chemistry analysis has been assessed, to know the origin, geochemical evolution, and hydraulic interconnection of groundwater. During 2008-2009, 46 groundwater samples were taken and analyzed around LC and HC. GIS technology was use to analyze the spatial distribution of the constituents of groundwater through thematic maps. The major ion analysis and its results suggest the presences of two aquifers;shallow porous aquifer on the top and fractured aquifer on the bottom. General water mineralization was discovered, including dissolution of halite, dolomites and carbonates through the aquifers. Water quality varies widely through the aquifers, and the general pathways go from southwest to northeast direction. The overexploitation of groundwater increases the water mixing of groundwater between shallow and deeper aquifers. Natural origin of groundwater and groundwater pollution by anthropogenic activities should be considered in the groundwater quality analysis for drinking water purpose.
文摘The aim of this study was to test if previous ingestion of compounds containing resveratrol or hydroxytyrosol, followed by an exhausting hand grip exercise, could induce an acute post-exercise increase in brachial blood flow. Six healthy subjects (three males and three females, 35 ± 7 years), 60 minutes after ingestion of a capsule containing 200 mg of resveratrol or 30 ml of extra virgin olive oil enriched with tyrosol, oleuropein and hydroxytyrosol, performed a hand grip exercise equal to half of their maximum strength until they were no longer able to express the same force (2-day interval between tests). The nonparametric Wilcoxon signed rank test was used for statistical evaluations. Brachial artery blood flow (Fba) and both blood velocity (Vba) and artery diameter (Dba) were assessed immediately after exercise cessation by means of colour Doppler ultrasound. After ingestion of the oil mixture the post-exercise value of Fba median was 2.4 times higher than that after ingestion of the resveratrol compound (P = 0.03), and also the Vba median concerning the hydroxytyrosol was 1.9 times higher than that of the resveratrol (P = 0.03). Both functional foods did not lead to a significant difference in the Dba medians. These results indicate that hydroxytyrosol, but not resveratrol, may be an effective adjuvant of recreational or agonistic, long-lasting sports performances, thanks to the powerful blood flow increment which can be obtained as soon as one hour from its oral intake.
文摘Increasingly,Wireless Sensor Networks(WSNs)are contributing enormous amounts of data.Since the recent deployments of wireless sensor networks in Smart City infrastructures,significant volumes of data have been produced every day in several domains ranging from the environment to the healthcare system to transportation.Using wireless sensor nodes,a Smart City environment may now be shown for the benefit of residents.The Smart City delivers intelligent infrastructure and a stimulating environment to citizens of the Smart Society,including the elderly and others.Weak,Quality of Service(QoS)and poor data performance are common problems in WSNs,caused by the data fusion method,where a small amount of bad data can significantly impact the total fusion outcome.In our proposed research,a WSN multisensor data fusion technique employing fuzzy logic for event detection.Using the new proposed Algorithm,sensor nodes will collect less repeated data,and redundant data will be used to increase the data’s overall reliability.The network’s fusion delay problem is investigated,and a minimum fusion delay approach is provided based on the nodes’fusion waiting time.The proposed algorithm performs well in fusion,according to the results of the experiment.As a result of these discoveries,It is concluded that the algorithm describe here is effective and dependable instrument with a wide range of applications.
基金Taif University Researchers are supporting project number(TURSP-2020/216),Taif University,Taif,Saudi Arabia.
文摘Ultra-wideband(UWB)is highly preferred for short distance communication.As a result of this significance,this project targets the design of a compact UWB antennas.This paper describes a printed UWB rhombusshaped antenna with a partial ground plane.To achieve wideband response,two stubs and a notch are incorporated at both sides of the rhombus design and ground plane respectively.To excite the antenna,a simple microstrip feed line is employed.The suggested antenna is built on a 1.6 mm thick FR4 substrate.The proposed design is very compact with overall electrical size of 0.18λ×0.25λ(14×18 mm2).The rhombus shaped antenna covers frequency ranging from 3.5 to 11 GHz with 7.5 GHz impedance bandwidth.The proposed design simulated and measured bandwidths are 83.33%and 80%,respectively.Radiation pattern in terms of E-field and H-field are discussed at 4,5.5 and 10 GHz respectively.The proposed design has 65%radiation efficiency and 1.5 dBi peak gain.The proposed design is simulated in CST(Computer Simulation Technology)simulator and the simulated design is fabricated for the measured results.The simulated and measured findings are in close resemblance.The obtained results confirm the application of the proposed design for the ultra-wide band applications.
基金funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No.101034260.
文摘The recent advancements made in the realms of Artificial Intelligence(AI)and Artificial Intelligence of Things(AIoT)have unveiled transformative prospects and opportunities to enhance and optimize the environmental performance and efficiency of smart cities.These strides have,in turn,impacted smart eco-cities,catalyzing ongoing improvements and driving solutions to address complex environmental challenges.This aligns with the visionary concept of smarter eco-cities,an emerging paradigm of urbanism characterized by the seamless integration of advanced technologies and environmental strategies.However,there remains a significant gap in thoroughly understanding this new paradigm and the intricate spectrum of its multifaceted underlying dimensions.To bridge this gap,this study provides a comprehensive systematic review of the burgeoning landscape of smarter eco-cities and their leadingedge AI and AIoT solutions for environmental sustainability.To ensure thoroughness,the study employs a unified evidence synthesis framework integrating aggregative,configurative,and narrative synthesis approaches.At the core of this study lie these subsequent research inquiries:What are the foundational underpinnings of emerging smarter eco-cities,and how do they intricately interrelate,particularly urbanism paradigms,environmental solutions,and data-driven technologies?What are the key drivers and enablers propelling the materialization of smarter eco-cities?What are the primary AI and AIoT solutions that can be harnessed in the development of smarter eco-cities?In what ways do AI and AIoT technologies contribute to fostering environmental sustainability practices,and what potential benefits and opportunities do they offer for smarter eco-cities?What challenges and barriers arise in the implementation of AI and AIoT solutions for the development of smarter eco-cities?The findings significantly deepen and broaden our understanding of both the significant potential of AI and AIoT technologies to enhance sustainable urban development practices,as well as the formidable nature of the challenges they pose.Beyond theoretical enrichment,these findings offer invaluable insights and new perspectives poised to empower policymakers,practitioners,and researchers to advance the integration of eco-urbanism and AI-and AIoT-driven urbanism.Through an insightful exploration of the contemporary urban landscape and the identification of successfully applied AI and AIoT solutions,stakeholders gain the necessary groundwork for making well-informed decisions,implementing effective strategies,and designing policies that prioritize environmental well-being.
文摘In the last forty years,the rise of HIV has undoubtedly become a major concern in the field of public health,imposing significant economic burdens on affected regions.Consequently,it becomes imperative to undertake comprehensive investigations into the mechanisms governing the dissemination of HIV within the human body.In this work,we have devised a mathematical model that elucidates the intricate interplay between CD4^(+)T-cells and viruses of HIV,employing the principles of fractional calculus.The production rate of CD4^(+)T-cells,like other immune cells depends on certain factors such as age,health status,and the presence of infections or diseases.Therefore,we incorporate a variable source term in the dynamics of HIV infection with a saturated incidence rate to enhance the precision of our findings.We introduce the fundamental concepts of fractional operators as a means of scrutinizing the proposed HIV model.To facilitate a deeper understanding of our system,we present an iterative scheme that elucidates the trajectories of the solution pathways of the system.We show the time series analysis of our model through numerical findings to conceptualize and understand the key factors of the system.In addition to this,we present the phase portrait and the oscillatory behavior of the system with the variation of different input parameters.This information can be utilized to predict the long-term behavior of the system,including whether it will converge to a steady state or exhibit periodic or chaotic oscillations.
文摘All-reflective optical systems,due to their material absorption and low refractive index,are used to create the most suitable devices in extreme ultraviolet lithography (EUVL).In this letter,we present a design for an all-reflective lithographic projection lens.We also discuss its design idea and structural system.After analysis of the four-mirror optical system,the initial structural parameters are determined,the optical system is optimized,and the tolerances of the system are analyzed.We also show the implementation of optimal layout and desired imaging performance.
文摘Mechanical, physical and manufacturing properties of east iron make it attractive for many fields of application, such as cranks and cylinder holds. As in design of all metals, fatigue life prediction is an intrinsic part of the design process of structural sections that are made of cast iron. A methodology to predict high-cycle fatigue life of cast iron is proposed. Stress amplitude-strain amplitude, strain amplitude-number of loading cycles relationships of cast iron are investigated. Also, fatigue life prediction in terms of Smith, Watson and Topper parameter is carried out using the proposed method. Results indicate that the analytical outcomes of the proposed methodology are in good accordance with the experimental data for the two studied types of cast iron: EN-GJS-400 and EN-GJS-600.
基金This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agree-ment No 739566.
文摘The incorporation of gallium into bioactive materials has been reported to enhance osteogenesis,to influence blood clotting,and to induce anti-cancer and anti-bacterial activity.Gallium-doped biomaterials prepared by various techniques include melt-derived and sol-gel-derived bioactive glasses,calcium phosphate bioceramics,metals and coatings.In this review,we summarize the recently reported developments in antibacterial,anti-cancer,osteogenesis,and hemostasis properties of Ga-doped biomaterials and briefly outline the mechanisms leading to Ga biological effects.The key finding is that gallium addition to biomaterials has great potential for treating bone-related diseases since it can be efficiently transferred to the desired region at a controllable rate.Besides,it can be used as a potential substitute for antibiotics for the inhibition of infections during the initial and advanced phases of the wound healing process.Ga is also used as an anticancer agent due to the increased concentration of gallium around excessive cell proliferation(tumor)sites.Moreover,we highlight the possibility to design different therapeutic approaches aimed at increasing the efficiency of the use of gallium containing bioactive materials for multifunctional applications.