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Isolation and Identification of Two Antibacterial Agents from <i>Chromolaena odorata</i>L. Active against Four Diarrheal Strains 被引量:2
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作者 Ménonvè Atindehou Latifou Lagnika +9 位作者 Bernard Guérold Jean Marc Strub Minjie Zhao Alain Van Dorsselaer Eric Marchioni Gilles Prévost Youssef Haikel Corinne Taddéi Ambaliou Sanni Marie-Hélène Metz-Boutigue 《Advances in Microbiology》 2013年第1期115-121,共7页
Chromolaena odorata L (Asteraceae) is a bad invasive plant, found in the humid tropics and sub-tropics worldwide. It is used against dysentery, diarrhea, malaria, wound healing, headache and toothache in traditional m... Chromolaena odorata L (Asteraceae) is a bad invasive plant, found in the humid tropics and sub-tropics worldwide. It is used against dysentery, diarrhea, malaria, wound healing, headache and toothache in traditional medicine. In the present study, we investigated the antibacterial activities of different leaves extracts of Chromolaena odorata L. (cyclohexane, dichloromethane, ethyl acetate and butanol) against four clinical diarrheal strains (Klebsiella oxytoca, Salmonella enterica, Shigella sonnei and Vibrio cholera). We demonstrated that C. odorata leaves extracts show an antibacterial activity between 0.156 and 1.25 mg/mL. Bioassay-guided chromatography by bioautography with iodonitrotetrazolium-based colorimetric assay allowed the isolation and identification of two active compounds. After the combination of RP-HPLC, mass spectrometry analysis, 1D and 2D-NMR spectroscopy, we isolated and characterized two active molecules corresponding to 3’,4’,5,6,7-Pentamethoxyflavone (Sinensetin) and4’,5,6,7-Tetramethoxyflavone (Scutellareintetramethyl ether). 展开更多
关键词 Chromolaena odorata 3’ 4’ 5 6 7-Pentamethoxyflavone (Sinensetin) 7-Tetramethoxyflavone (Scutellareintetramethyl ether) ANTIBACTERIAL Activity Diarrheal STRAINS
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