New standard in locally advanced rectal cancer

In the following review we intend to ascertain the optimal neoadjuvant therapy inpatients with locally advanced rectal cancer. In 2004, a study revealed thatchemoradiotherapy (CRT) resulted in better local control when performedpreoperatively rather than postoperatively, thus neoadjuvant treatment wasestablished as a standard treatment. Subsequently, the Polish study and the Trans-Tasman Radiation Oncology Group showed no statistically significant differencebetween concomitant CRT over 5 wk vs short-course radiotherapy (RT).Therefore, both were established as standard neoadjuvant treatments. Later, theStockholm III study demonstrated that short-course RT had a higher completepathological response than long-course RT. It also showed that a delay betweenRT and surgery presented fewer complications. This opened a window of time toprovide an early and effective systemic treatment to prevent distant metastases.Studies show that short-course RT plus oxaliplatin-based chemotherapy couldachieve this. When comparing this total neoadjuvant treatment (TNT) vsconcomitant CRT, the former showed greater complete pathological response andlower acute toxicity. Studies presented during 2020 have also shown the benefitsof TNT in terms of complete pathological response, as well as disease andmetastasis-free survival. Our review suggests that probably TNT should be thenew standard treatment for these patients. However, we will have to wait for thefull text publications of these studies to confirm this statement.

ALMA observations of the circumstellar envelope around EP Aqr

Atacama Large Millimetre/sub-millimetre Array(ALMA) observations of CO(1–0) and CO(2–1) emissions from the circumstellar envelope of the asymptotic giant branch(AGB) star EP Aqr have been made with four times better spatial resolution than previously available. They are analysed with emphasis on the de-projection in space of the effective emissivity and flux of matter using as input a prescribed configuration of the velocity field, assumed to be radial. The data are found to display an intrinsic axisymmetry with respect to an axis making a small angle with respect to the line of sight. A broad range of wind configurations, from prolate(bipolar) to oblate(equatorial) has been studied and found to be accompanied by significant equatorial emission. Qualitatively, the effective emissivity is enhanced near the equator to produce the central narrow component observed in the Doppler velocity spectra and its dependence on star latitude generally follows that of the wind velocity with the exception of an omni-present depression near the poles. In particular, large equatorial expansion velocities produce a flared disc or a ring of effective emissivity and mass loss. The effect on the determination of the orientation of the star axis of radial velocity gradients, and possibly competing rotation and expansion in the equatorial disc, is discussed. In general,the flux of matter is found to reach a broad maximum at distances of the order of 500 AU from the star.Arguments are given that may be used to favour one wind velocity distribution over another. As a result of the improved quality of the data, a deeper understanding of the constraints imposed on morphology and kinematics has been obtained.

A new three-stage evolution model for millimeter to centimeter wavelength outbursts in BL Lacertae

The multi-frequency light curves of BL Lacertae during 1997.5 - 1999.5 have been modeled by four outbursts, each having a 3-stage evolution in the （Sm, vm） plane with distinct rising-plateau-decaying phases. It is shown that the observed light curves can be well fitted for the eight frequencies from 350 GHz to 4.8 GHz. The main characteristics of the model-fitting are; （1） the outbursts are found to have very flat spectra with an optically thin spectral index α （defined as Sv α u^-α） of about 0.15. This is consistent with the results previously obtained by Valtaoja et al. （1992）; （2） it is found that there is no spectral flattening between the rising-plateau phase and the decay phase. In other words, the optically thin spectral index does not change from the rising-plateau phase to the decay phase. These features are in contrast to the 3-stage shocked-in-jet model proposed by Marscher ＆ Gear （1985） for submm- IR-optical flares, in which a spectral flattening of △α = 0.5 is predicted when a transition occurs from the Compton/synchrotron phase （or rising-plateau phase） to the adiabatic phase （or decay phase） with α≥ 0.5 for the shock being non-radiative. We propose a new model to interpret the fitting results, suggesting that the 3-stage evolution of the mm-cm outbursts in BL Lacertae may be related to the process of shock formation and propagation in a highly collimated jet （for example, a ＇parabolic＇ jet）. In particular, during the rising phase, the thickness of the synchrotron-radiating region created by the shock may rapidly increase with time （relative to the jet width） due to the rapid injection of relativistic electrons and a magnetic field, and this leads to the observed behavior that the turnover flux density Sm rapidly increases while the turnover frequency um decreases. In the decay phase, the emitting plasma enters into a free expansion regime without further injection of relativistic electrons and a magnetic field （for example, when a transition from a collimated regime into a conical regime occurs）. The plateau phase is a short period between the two regimes with no distinct features determined.

Morphology of the ^(13)CO(3–2) millimetre emission across the gas disc surrounding the triple protostar GG Tau A using ALMA observations

Observations by the Atacama Large Millimetre/sub-millimetre Array of the dust continuum and ^13 CO（3–2） millimetre emissions of the triple stellar system GG Tau A are analysed,giving evidence for a rotating gas disc and a concentric and coplanar dust ring. The present work complements an earlier analysis（Tang et al.） by exploring detailed properties of the gas disc. A 95% confidence level upper limit of 0.24＂（34 au） is placed on the disc scale height at a distance of 1＂（140 au） from the central stars. Evidence for Keplerian rotation of the gas disc is presented,with the rotation velocity reaching-3.1 km s^-1 at 1＂ from the central stars,and a 99% confidence level upper limit of 9% is placed on relative contribution from a possible in-fall velocity. Variations of the intensity across the disc area are studied in detail and confirm the presence of a hot spot in the south-eastern quadrant. However several other significant intensity variations,in particular a depression in the northern direction,are also revealed. Variations of the intensity are found to be positively correlated to variations of the line width. Possible contributions to the measured line width are reviewed,suggesting an increase of the disc temperature and opacity with decreasing distance from the stars.

On the central symmetry of the circumstellar envelope of RS Cnc

We present a phenomenological study of CO（1-0） and CO（2-1） emission from the circumstellar envelope （CSE） of the Asymptotic Giant Branch （AGB） star RS Cnc. It reveals departures from central symmetry that turn out to be efficient tools for the exploration of some of the properties of the CSE. We use a wind model including a bipolar flow with a typical wind velocity of ～8 km s^-1 that decreases to ～2 km s^-1 near the equator. This wind model is used to describe Doppler velocity spectral maps obtained by merging data collected at the IRAM Plateau de Bure Interferometer and Pico Veleta single dish radio telescope. Parameters describing the wind morphology and kinematics are obtained, together with the radial dependence of the gas temperature in the domain of the CSE probed by the CO observations. Significant north-south central asymmetries are revealed by the analysis, which we quantify using a simple phenomenological description. The origin of such asymmetries is unclear.