The Korean Republic nationwide cohort study by Yun et al.reveals a stepwise increase in hepatocellular carcinoma(HCC)risk,progressing from“pure”metabolic dysfunction-associated steatotic liver disease(MASLD)to MASLD...The Korean Republic nationwide cohort study by Yun et al.reveals a stepwise increase in hepatocellular carcinoma(HCC)risk,progressing from“pure”metabolic dysfunction-associated steatotic liver disease(MASLD)to MASLD with increased alcohol intake(MetALD)and then to alcohol-associated liver disease[1].These data also highlight the significant impact of age and gender,underscoring the importance of tailoring prevention strategies to address not only metabolic dysfunction but also alcohol consumption in liver disease management[1].This Korean cohort study also illustrates the characteristics of MASLD-related HCC,providing new insights into the natural history of this liver disease.展开更多
Metabolic dysfunction-associated fatty liver disease(MAFLD),previously termed non-alcoholic fatty liver disease,is one of the most common causes of chronic liver disease,affecting around 30%of the world’s adults(1).M...Metabolic dysfunction-associated fatty liver disease(MAFLD),previously termed non-alcoholic fatty liver disease,is one of the most common causes of chronic liver disease,affecting around 30%of the world’s adults(1).MAFLD encompasses a spectrum of liver conditions,ranging from simple steatosis to metabolic dysfunction-associated steatohepatitis(MASH),which can progress to cirrhosis and hepatocellular carcinoma(HCC)(2,3).展开更多
基金supported by grants from the Young Talent Support Program of Xi'an City Association for Science and Technology[959202413081]Scientific Research Plan Project of Shaanxi Provincial Department of Education[23JK0646]+1 种基金Shaanxi Province“Fourteenth Five-Year Plan”educational scientific planning project[SGH23Y2464]supported in part by the Southampton National Institute for Health and Care Research,Biomedical Research Centre[NIHR203319].
文摘The Korean Republic nationwide cohort study by Yun et al.reveals a stepwise increase in hepatocellular carcinoma(HCC)risk,progressing from“pure”metabolic dysfunction-associated steatotic liver disease(MASLD)to MASLD with increased alcohol intake(MetALD)and then to alcohol-associated liver disease[1].These data also highlight the significant impact of age and gender,underscoring the importance of tailoring prevention strategies to address not only metabolic dysfunction but also alcohol consumption in liver disease management[1].This Korean cohort study also illustrates the characteristics of MASLD-related HCC,providing new insights into the natural history of this liver disease.
基金supported by grants from the National Natural Science Foundation of China (No.82070588,No.82370577)supported in part by grants from the School of Medicine,University of Verona,Verona,Italysupported in part by the Southampton NIHR Biomedical Research Centre,UK (NIHR203319).
文摘Metabolic dysfunction-associated fatty liver disease(MAFLD),previously termed non-alcoholic fatty liver disease,is one of the most common causes of chronic liver disease,affecting around 30%of the world’s adults(1).MAFLD encompasses a spectrum of liver conditions,ranging from simple steatosis to metabolic dysfunction-associated steatohepatitis(MASH),which can progress to cirrhosis and hepatocellular carcinoma(HCC)(2,3).
