Influence of Synthesis Parameters on the Structure, Pore Morphology and Bioactivity of a New Mesoporous Glass

The main objective of the present work was to investigate the effect of surfactant type and synthesis temperature on the structure, porosity and the bioactivity of 92S6 (92% SiO2, 6% CaO, and 2% P2O5 mol %) mesoporous sol-gel glasses. The aim was to provide a basis for controlling the bioactive behavior of the different 92S6 samples used for tissue regeneration and for biomedical engineering in order to obtain sufficient performances by controlling the porosity of the glass. In this paper, a series of mesoporous bioactive glasses were synthesized using three different surfactants (C10H20BrN, C19H42BrN, C22H48BrN) at different aging temperatures (20°C, 40°C and 60°C). The surfactant was removed by calcination, which was carried out by increasing the temperature to 650°C for 6 h. A comparison among these synthesized glasses was conducted and the research emphasis was placed on the synthesis temperature and the surfactant type dependence on the textural properties and particularly porosity that were ultimately responsible for glass bioactivity.

3-(Tetrazol-5-yl)-2-imino-coumarins Derivatives: Synthesis, Characterization, and Evaluation on Tumor Cell Lines

The first report of new 3-(tetrazol-5-yl)-2-iminocoumarin derivatives is described. The title compounds were prepared in two steps and were obtained in good yields (55-93%). They have been fully characterized by 1H, 13C NMR, FTIR, UV-Visible and HRMS. They were tested for their antiproliferative activities against six representative human tumor cell lines (Huh 7-D12, Caco2, MDA-MB231, HCT 116, PC3 and NCI-H727) and HaCat keratinocytes. Among them, compound 5e was active on HCT 116 (IC50 15 μM).

Abemaciclib, a Recent Novel FDA-Approved Small Molecule Inhibiting Cyclin-Dependant Kinase 4/6 for the Treatment of Metastatic Breast Cancer: A Mini-Review

Abemaciclib (Verzerio®) is a cell cycle inhibitor of both CDK4 and CDK6. In 2017, abemaciclib was approved by the Food and Drug Administration (FDA) and, in 2018 by the European Medicines Agency (EMA) for the treatment of postmenopausal women with hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2−) advanced breast cancer. In this mini-review, we provide a series of information for respectively their targets and its selectivity, results on preclinical trial, clinical phase I, II and III trials, and some perspectives. We also describe the batch and flow steps used for the synthesis of this cancer drug.

Studies of the Chemical Reactivity of a Series of Rhodanine Derivatives by Approaches to Quantum Chemistry

This theoretical chemical reactivity study was conducted using the Density Functional Theory (DFT) method, at computational level B3LYP/6-31G (d). It involved a series of six (06) 5-arylidene rhodanines and allowed to predict the chemical reactivity of these compounds. DFT global chemical reactivity descriptors (HOMO and LUMO energies, chemical hardness, softness, electronegativity) were examined to predict the relative stability and reactivity of rhodanin derivatives. Thus, the compound 6 which has an energy gap between the orbitals of ΔEgap = 3.004 eV is the most polarizable, the most reactive, the least stable, the best electron donor and the softest molecule. Calculation of the local indices of reactivity as well as dual descriptors revealed that the sulfur heteroatom of the Rhodanine ring is the privileged site of electrophilic attack in a state of sp3 hybridization and privileged site of nucleophilic attack in a state of sp2 hybridization.

Antimicrobial Activity of Stainless Steel with a Modified Tin Upperlayer on Meat Related Contaminants

Advanced material with antibacterial properties would be a promising way to improve the disinfection process in food plants. Our objective was to combine the bactericidal effect of TiO2 with the mechanical strength of TiN coatings. A TiO2 rutile film was obtained after annealing of a supplied 316 stainless steel with a TiN coating. This TiO2 upperlayer displays a photocatalytic activity under UV light exposure. The substrates with the TiN coating and the TiO2 upperlayer are more hydrophobic than the 316 control. The adhesion of either Listeria or Pseudomonas, on 316-TIN is characterized by the presence of clusters of cells, while the oxidation of the TiN surface leads to a more hydrophilic layer where cells are individualized. After UV illumination of the adherent cells and subsequent growth, the residual bacterial population present on 316-TIO2 is lower than that present on the 316-TIN. The bactericidal effect is more important on Listeria than on Pseudomonas.

Synthesis of New 2-Phenylamino-4<i>H</i>-chromene-3-carbonitrile Derivatives and Their Effects on Tumor Cell Lines and against Protein Kinases

The synthesis of 2-phenylimino-4H-chromene-3-carbonitriles 6(a-d) in good overall yields using an efficient and practical methodology in 3 steps has been implemented in this present work. The first step was a heterocyclization between 2-hydroxybenzaldehyde 1 and propanedinitrile 2 which produced 2-iminocoumarin 3 which was submitted to nitrogen/nitrogen displacement in the presence of aromatic primary amine 4. In the third step, reduction of 5 led to the desired 2-phenylimino-4H-chromene-3-carbonitriles 6. Compounds 5(a-d) and 6(a-d) were evaluated for their potential in vitro cytotoxicity against six selected tumor cell lines (Huh7-D12, Caco2, MDA-MB231, HCT 116, PC3 and NCI-H727) and tested for their protein kinase inhibition on eight selected protein kinases. Among them, compounds 5c and 6b exhibited inhibition on HsCK1e (5c: 44% and 6b: 42% at 1 μM) and 5c for cytotoxicity on PC3 cell lines (63% at 25 μM).

Room-Temperature Electroreductiveα-Alkylation of N-Heteroarenes with Styrenes

Despite their interesting applications,direct and diverse syntheses of aryl-fused 2-alkyl cyclic amines still remain challenging.Here,the concept of incorporating a C–C coupling process into the N-heteroaryl reduction was successfully applied to fulfill such a synthetic purpose.Due to our use of controllable electroreduction coupled with proton abstraction,we can report a room-temperature reductiveα-alkylation of the inert N-heteroarenes with abundantly available styrenes in an undivided Zn(+)/C(−)cell.This proceeds with good substrate compatibility and operational simplicity,utilizes cost-effective sacrificial Zn-anode,exhibits high selectivity,and does not need pressurized H2 gas and transition-metal catalysts.This current work offers a useful platform for direct construction of valuable aryl-fused 2-alkyl cyclic amines that are difficult to access with conventional methods.