目的观察头电针结合强制性运动对缺血性脑卒中患者上肢功能的影响。方法采用随机数字表法将80例脑卒中患者分为常规康复组、头电针组、强制运动组(constraint-induced movement therapy,CIMT)及综合干预组(头电针+CIMT),常规康复组采用...目的观察头电针结合强制性运动对缺血性脑卒中患者上肢功能的影响。方法采用随机数字表法将80例脑卒中患者分为常规康复组、头电针组、强制运动组(constraint-induced movement therapy,CIMT)及综合干预组(头电针+CIMT),常规康复组采用神经发育疗法(Bobath技术为主,Brunnstrom技术为辅)强化患侧上肢训练;头电针组采用焦氏头针结合电刺激疗法;强制运动组限制健侧上肢,强化患肢训练;综合干预组采用头电针联合强制运动法进行治疗。分别在治疗前及治疗4、12周观察患者偏瘫上肢FuglMeyer运动功能评分(Fugl-Meyer assessment scale,FMA)、腕关节活动度及手功能分级。结果与本组治疗前比较,治疗4周后,各组患者偏瘫上肢FMA评分明显升高,腕关节活动度及手功能分级均明显改善(P<0.05,P<0.01);但除综合干预组偏瘫腕关节活动度在腕关节背伸及桡偏两个活动方向上较常规康复组明显改善(P<0.05)外,其他各组间FMA评分及手功能分级比较,差异均无统计学意义(P>0.05)。治疗12周后,与常规康复组比较,综合干预组FMA评分升高,偏瘫腕关节活动度及手功能分级均明显改善(P<0.05)。结论常规康复、头电针及强制性运动训练对缺血性脑卒中患者偏瘫上肢功能均有较好的康复效果,但头电针联合CIMT训练作用最为明显,且显效最早。展开更多
Defining seeds is the first step in assessing functional connectivity between separate brain regions.Circular analysis is often a serious concern when defining ROIs.It was considered as circular analysis that seeds we...Defining seeds is the first step in assessing functional connectivity between separate brain regions.Circular analysis is often a serious concern when defining ROIs.It was considered as circular analysis that seeds were localized on the basis of activations in fMRI data and the functional connectivity among these seeds was measured by using the same data.Such circularity was reported to contaminate results because the margin of detected activations can be affected by noise in the data.Therefore,using independent data for seed selection was advocated.For example,suppose that datasets A and B are independent.Activations are first detected in dataset A through statistical mapping,and then these activations are used to localize seeds for assessing functional connectivity in dataset B.However,localizing seeds only on the basis of an independent source without referring to the intrinsic features of the fMRI data to be analyzed may be inappropriate for assessing functional connectivity.This study demonstrates how different spatial locations and seed scopes influence the results of functional connectivity in task-state fMRI data when these choices meet independence requirements.The independence of analysis does not rely on whether seeds are exogenous or endogenous for the data to be analyzed.Activation and connectivity analyses have inherently independent natures.展开更多
文摘目的观察头电针结合强制性运动对缺血性脑卒中患者上肢功能的影响。方法采用随机数字表法将80例脑卒中患者分为常规康复组、头电针组、强制运动组(constraint-induced movement therapy,CIMT)及综合干预组(头电针+CIMT),常规康复组采用神经发育疗法(Bobath技术为主,Brunnstrom技术为辅)强化患侧上肢训练;头电针组采用焦氏头针结合电刺激疗法;强制运动组限制健侧上肢,强化患肢训练;综合干预组采用头电针联合强制运动法进行治疗。分别在治疗前及治疗4、12周观察患者偏瘫上肢FuglMeyer运动功能评分(Fugl-Meyer assessment scale,FMA)、腕关节活动度及手功能分级。结果与本组治疗前比较,治疗4周后,各组患者偏瘫上肢FMA评分明显升高,腕关节活动度及手功能分级均明显改善(P<0.05,P<0.01);但除综合干预组偏瘫腕关节活动度在腕关节背伸及桡偏两个活动方向上较常规康复组明显改善(P<0.05)外,其他各组间FMA评分及手功能分级比较,差异均无统计学意义(P>0.05)。治疗12周后,与常规康复组比较,综合干预组FMA评分升高,偏瘫腕关节活动度及手功能分级均明显改善(P<0.05)。结论常规康复、头电针及强制性运动训练对缺血性脑卒中患者偏瘫上肢功能均有较好的康复效果,但头电针联合CIMT训练作用最为明显,且显效最早。
基金This research was funded by the National Key R&D Program of China[Grant Nos.2018YFC2001400 and 2018YFC2001700]the National Natural Science Foundation of China[Grant No.81972160]the Beijing Natural Science Foundation[Grant No.17L20019].
文摘Defining seeds is the first step in assessing functional connectivity between separate brain regions.Circular analysis is often a serious concern when defining ROIs.It was considered as circular analysis that seeds were localized on the basis of activations in fMRI data and the functional connectivity among these seeds was measured by using the same data.Such circularity was reported to contaminate results because the margin of detected activations can be affected by noise in the data.Therefore,using independent data for seed selection was advocated.For example,suppose that datasets A and B are independent.Activations are first detected in dataset A through statistical mapping,and then these activations are used to localize seeds for assessing functional connectivity in dataset B.However,localizing seeds only on the basis of an independent source without referring to the intrinsic features of the fMRI data to be analyzed may be inappropriate for assessing functional connectivity.This study demonstrates how different spatial locations and seed scopes influence the results of functional connectivity in task-state fMRI data when these choices meet independence requirements.The independence of analysis does not rely on whether seeds are exogenous or endogenous for the data to be analyzed.Activation and connectivity analyses have inherently independent natures.
