Metastasis to distant sites is a severe treatment challenge and a major cause of death for breast cancer patients.Laser immunotherapy(LIT)is a novel technique,combining a selective photothermal therapy with local appl...Metastasis to distant sites is a severe treatment challenge and a major cause of death for breast cancer patients.Laser immunotherapy(LIT)is a novel technique,combining a selective photothermal therapy with local application of glycated chitosan,a potent immunoadjuvant.The pre-clinical studies of LIT have shown its unique characteristics in generating specific antitumor immunity.The clinical application of LIT in the treatment of melanoma patients has achieved preliminary success.Recently,LIT has been used to treat late-stage breast cancer patients.Here we report for the first time the clinical results of this combination therapy in breast cancer patients.The LIT treatment procedures are presented and the medical history of two stage Ⅳ breast cancer patients is reviewed.Most of the breast cancer lesions and the metastasis of lung and brain disappeared after repeated treatments of LIT.One patient achieved complete response;the other achieved partial response at the time of this report.Although there is still a long way for LIT to become a standard modality for breast cancer treatment,the results of this study indicated its promising future.展开更多
Photonics immunotherapy is a novel cancer treatment strategy that combines local phototherapy and immunotherapy.Phototherapy is a noninvasive or minimally invasive therapeutic strategy for local treatment of cancer,wh...Photonics immunotherapy is a novel cancer treatment strategy that combines local phototherapy and immunotherapy.Phototherapy is a noninvasive or minimally invasive therapeutic strategy for local treatment of cancer,which can destroy tumor cells and release tumor antigens,inducing an in situ antitumor immune response.Immunotherapy,including the use of antibodies,vaccines,immunoadjuvants and cytokines,when combined with phototherapy,could bring a synergistic effect to stimulate a host immune response that effectuates a long-term antitumor immunity.This review will focus on the development of photonics immunotherapy and its systemic antitumor immunological effects.展开更多
基金supported in part by a grant from the US National Institutes of Health(P20 RR016478 from the INBRE Program of the National Center for Research Resources).
文摘Metastasis to distant sites is a severe treatment challenge and a major cause of death for breast cancer patients.Laser immunotherapy(LIT)is a novel technique,combining a selective photothermal therapy with local application of glycated chitosan,a potent immunoadjuvant.The pre-clinical studies of LIT have shown its unique characteristics in generating specific antitumor immunity.The clinical application of LIT in the treatment of melanoma patients has achieved preliminary success.Recently,LIT has been used to treat late-stage breast cancer patients.Here we report for the first time the clinical results of this combination therapy in breast cancer patients.The LIT treatment procedures are presented and the medical history of two stage Ⅳ breast cancer patients is reviewed.Most of the breast cancer lesions and the metastasis of lung and brain disappeared after repeated treatments of LIT.One patient achieved complete response;the other achieved partial response at the time of this report.Although there is still a long way for LIT to become a standard modality for breast cancer treatment,the results of this study indicated its promising future.
基金This study was supported in part by a grant from the US National Institutes of Health (R21 EB0155091-01).
文摘Photonics immunotherapy is a novel cancer treatment strategy that combines local phototherapy and immunotherapy.Phototherapy is a noninvasive or minimally invasive therapeutic strategy for local treatment of cancer,which can destroy tumor cells and release tumor antigens,inducing an in situ antitumor immune response.Immunotherapy,including the use of antibodies,vaccines,immunoadjuvants and cytokines,when combined with phototherapy,could bring a synergistic effect to stimulate a host immune response that effectuates a long-term antitumor immunity.This review will focus on the development of photonics immunotherapy and its systemic antitumor immunological effects.
