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Inhibin/Activin信号对卵巢癌生长调控的初步研究 被引量:6
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作者 张慧娟 刘伯宁 +1 位作者 Sanjiv Manek TravidiS.Ganesan 《现代妇产科进展》 CSCD 2003年第1期12-15,共4页
目的 :分析抑制素 (Inhibin)和激活素 (Activin)在卵巢癌上皮和间质中的表达 ,评估两种多肽信号对卵巢癌生长的调控作用 ,探讨卵巢癌发病机制。方法 :采用免疫组化法检测 10 2例卵巢癌上皮及间质中抑制素和激活素的表达。结果 :( 1)激... 目的 :分析抑制素 (Inhibin)和激活素 (Activin)在卵巢癌上皮和间质中的表达 ,评估两种多肽信号对卵巢癌生长的调控作用 ,探讨卵巢癌发病机制。方法 :采用免疫组化法检测 10 2例卵巢癌上皮及间质中抑制素和激活素的表达。结果 :( 1)激活素在卵巢癌组织上皮和间质中的总阳性表达率显著高于抑制素 ( 79/ 2 0 4vs 5 2 / 2 0 4 ,P <0 .0 0 5 ) ;( 2 )卵巢癌上皮中激活素阳性表达率显著高于抑制素 ( 61/ 10 2vs 2 2 / 10 2 ,P <0 .0 0 5 ) ,而间质中抑制素阳性表达率显著高于激活素 ( 30 / 10 2vs 18/ 10 2 ,P <0 .0 5 ) ;( 3)高分化癌组织(G1、G2 )上皮中激活素阳性表达率显著低于低分化癌组织 (G3、G4 )上皮中激活素阳性表达率 ( 4 5 / 66vs 16/ 36,P <0 .0 0 5 )。结论 :抑制素和激活素在卵巢癌组织中的不平衡表达可能是卵巢癌发生、发展的原因之一 ;低分化癌组织较高分化癌组织合成更多的激活素 ,通过与受体结合 ,激活信号放大 。 展开更多
关键词 生长调控 卵巢肿瘤 抑制素 激活素 免疫组化
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ANDROGEN REGULATION OF PROSTATIC STEROID BINDING PROTEIN GENE TRANSCRIPTION 被引量:1
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作者 ZHANGYong-Lian ZHOUZong-Xun +1 位作者 ZHANGYou-Duan PARKERMalcolmG 《Journal of Reproduction and Contraception》 CAS 1989年第1期35-35,共1页
Prostatic steroid binding protein (PSBP) is a major protein secreted in the rat ventral prostate (V.P.) and also one of the components in seminal fluid, The potential importance of this protein in male fertility emerg... Prostatic steroid binding protein (PSBP) is a major protein secreted in the rat ventral prostate (V.P.) and also one of the components in seminal fluid, The potential importance of this protein in male fertility emerged from its ability of binding cholesterol which might modulate the proportion of phospholipids and cholesterol in sperm making it 展开更多
关键词 男性荷尔蒙 前列腺 类固醇 蛋白质 基因转录
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ASSOCIATION OF HELICOBACTER PYLORI INFECTION WITH PRECANCEROUS LESIONS AND STOMACH CANCER:A CASE-CONTROL STUDY IN YANGZHONG COUNTY
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作者 施一江 黎钧耀 +8 位作者 李茂生 王理伟 郭万德 秦德兴 耿长友 FormanD NewellDG PetoR BlotWJ 《Chinese Medical Sciences Journal》 CAS CSCD 1997年第3期175-180,共6页
Previous study has raised H. pylori infection as a suspected biologic risk factor for gastric cancer. A comparative case-control study involving precancerous lesions and gastric cancer was conducted in Yanzhong county... Previous study has raised H. pylori infection as a suspected biologic risk factor for gastric cancer. A comparative case-control study involving precancerous lesions and gastric cancer was conducted in Yanzhong county, an area with one of the highest rates of gastric cancer in China to study the relationship between the H. pylori infection and gastric cancer. Subjects in the study were all randomly selected participants of a screening program for gastric cancer sponsored by the Cancer Institute of CAMS in cooperation with Yangzhong county Hospital. Totally, 125 normal controls, 108 superficial gastritis, 111 atrophic gastritis and 110 gastric cancer patients were included in our study according to endoscopy and pathology, result. Status of H. pylori infection was evaluated by measuring Ig G antibody in plasma with ELISA assay.Our result showed Odds ratios of H. pylori infection were higher among gastritis and cancer groups, 4.5(95% CI 2. 5-7.9) for superficial gastritis, 6.3 (95% CI 3.4-12) for atrophic gastritis, 3. 3 (95% CI 1.9-5.9) for gastric cancer. It was found in our study that consumption of pickled vegetables and drinking dirty water increased the relative risk of H. pylori infection for both precancerous lesions and gastric cancer and that H. pylori infection had higher risk of atrophic gastritis and gastric cancer for males and also higher risk of atrophic gastritis for olders. Our results strongly support the casual role played by H, pylori infection in the carcinogenic process of gastric mucosa. 展开更多
关键词 胃癌 癌前病变 幽门螺杆菌感染 流行病学 危险因素
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