AIM:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).METHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Coli...AIM:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).METHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Colitis Activity Index(SCCAI)>4 and<12(median:7.5),who were treated open-label with Profermintwice daily for 24 wk.Daily SCCAI was reported observer blinded via the Internet.RESULTS:In an intention to treat(ITT)analysis,the mean reduction in SCCAI score was 56.5%.Of the 39 patients,24(62%)reached the primary endpoint,which was proportion of patients with≥50%reduction in SCCAI.Our secondary endpoint,the proportion of patients in remission defined as SCCAI≤2.5,was in ITT analysis reached in 18 of the 39 patients(46%).In a repeated-measure regression analysis,the estimated mean reduction in score was 5.0 points(95%CI:4.1-5.9,P<0.001)and the estimated mean time taken to obtain half the reduction in score was 28 d(95%CI:26-30).There were no serious adverse events(AEs)or withdrawals due to AEs.Profermin was generally well tolerated.CONCLUSION:Profermin is safe and may be effective in inducing remission of active UC.展开更多
The Vehicle Routing Problem with Time Windows is a generalization of the well knowncapacity constrained Vehicle Routing Problem.A homogeneous fleet of vehicles has to service a setof customers.The service of the custo...The Vehicle Routing Problem with Time Windows is a generalization of the well knowncapacity constrained Vehicle Routing Problem.A homogeneous fleet of vehicles has to service a setof customers.The service of the customers can only start within a weU-defined time intervaldenoted the time window.The objective is to determine routes for the vehicles that minimizes theaccumulated cost(or distance).Currently the best approaches for determining optimal solutions arebased on column generation and Branch-and-Bound,also known as Branch-and-Price.This paperpresents two ideas for ran-time improvements of the Branch-and-Price framework for the VehicleRouting Problem with Time Windows.Both ideas reveal a significant potential for run-timerefinements when speeding up an exact approach without compromising optimality.展开更多
基金Supported by Danish Innovation Law Grant,J.nr.3414-06-01530from the Danish Food Industry Agency under the Ministry of Food,Agriculture and FisheriesNordisk Rebalance,who developed and manufactured Profermin,and partly financed the study
文摘AIM:To test the efficacy and safety of Profermin in inducing remission in patients with active ulcerative colitis(UC).METHODS:The study included 39 patients with mild to moderate UC defined as a Simple Clinical Colitis Activity Index(SCCAI)>4 and<12(median:7.5),who were treated open-label with Profermintwice daily for 24 wk.Daily SCCAI was reported observer blinded via the Internet.RESULTS:In an intention to treat(ITT)analysis,the mean reduction in SCCAI score was 56.5%.Of the 39 patients,24(62%)reached the primary endpoint,which was proportion of patients with≥50%reduction in SCCAI.Our secondary endpoint,the proportion of patients in remission defined as SCCAI≤2.5,was in ITT analysis reached in 18 of the 39 patients(46%).In a repeated-measure regression analysis,the estimated mean reduction in score was 5.0 points(95%CI:4.1-5.9,P<0.001)and the estimated mean time taken to obtain half the reduction in score was 28 d(95%CI:26-30).There were no serious adverse events(AEs)or withdrawals due to AEs.Profermin was generally well tolerated.CONCLUSION:Profermin is safe and may be effective in inducing remission of active UC.
文摘The Vehicle Routing Problem with Time Windows is a generalization of the well knowncapacity constrained Vehicle Routing Problem.A homogeneous fleet of vehicles has to service a setof customers.The service of the customers can only start within a weU-defined time intervaldenoted the time window.The objective is to determine routes for the vehicles that minimizes theaccumulated cost(or distance).Currently the best approaches for determining optimal solutions arebased on column generation and Branch-and-Bound,also known as Branch-and-Price.This paperpresents two ideas for ran-time improvements of the Branch-and-Price framework for the VehicleRouting Problem with Time Windows.Both ideas reveal a significant potential for run-timerefinements when speeding up an exact approach without compromising optimality.
