Edible marine algae,or seaweeds,are a rich source of several bioactive compounds including phytosterols,carotenoids,and polysaccharides.Over the last decades,seaweed-derived constituents turned out to not only reside ...Edible marine algae,or seaweeds,are a rich source of several bioactive compounds including phytosterols,carotenoids,and polysaccharides.Over the last decades,seaweed-derived constituents turned out to not only reside in the systemic circulation,but are able to cross the blood-brain barrier to exert neuro-active functions both in homeostatic and pathological conditions.Therefore,seaweed-derived constituents have gained increasing interest for their neuro-immunomodulatory and neuroprotective properties,rendering them interesting candidates for the management of several neurodegenerative disorders.In particular seaweed-derived phytosterols gained interest for the treatment of neurodegenerative disorders as they potentiate neuroplasticity,enhance phagocytic clearance of neurotoxic peptides and have anti-inflammatory properties.Though,the anti-inflammatory and anti-oxidative properties of other constituents including carotenoids,phenols and polysaccharides have recently gained more interest.In this review,we provide an overview of a selection of the described neuro-active properties of seaweed-derived constituents with a focus on phytosterols.展开更多
基金NWO-TTW(Netherlands Organisation for Scientific Research),No.16437Alzheimer Nederland,No.WE.03-2018-06
文摘Edible marine algae,or seaweeds,are a rich source of several bioactive compounds including phytosterols,carotenoids,and polysaccharides.Over the last decades,seaweed-derived constituents turned out to not only reside in the systemic circulation,but are able to cross the blood-brain barrier to exert neuro-active functions both in homeostatic and pathological conditions.Therefore,seaweed-derived constituents have gained increasing interest for their neuro-immunomodulatory and neuroprotective properties,rendering them interesting candidates for the management of several neurodegenerative disorders.In particular seaweed-derived phytosterols gained interest for the treatment of neurodegenerative disorders as they potentiate neuroplasticity,enhance phagocytic clearance of neurotoxic peptides and have anti-inflammatory properties.Though,the anti-inflammatory and anti-oxidative properties of other constituents including carotenoids,phenols and polysaccharides have recently gained more interest.In this review,we provide an overview of a selection of the described neuro-active properties of seaweed-derived constituents with a focus on phytosterols.
