Amyloid fibrils are highly organized protein or peptide aggregates,often characterized by a distinctive supramolecular cross-β-sheet structure.The formation and accumulation of these structures have been traditionall...Amyloid fibrils are highly organized protein or peptide aggregates,often characterized by a distinctive supramolecular cross-β-sheet structure.The formation and accumulation of these structures have been traditionally associated with neural or systemic human diseases,such as Alzheimer’s disease,Parkinson’s disease,type-2 diabetes,or amyotrophic lateral sclerosis(Wei et al.,2017;Wittung-Stafshede,2023).展开更多
Asthma in school-aged children is a major public health problem worldwide[1,2].Inhaled medications are the mainstay of its pharmacological management[2],but only 8%-22%of children with asthma use their inhalers correc...Asthma in school-aged children is a major public health problem worldwide[1,2].Inhaled medications are the mainstay of its pharmacological management[2],but only 8%-22%of children with asthma use their inhalers correctly[3].Asthma clinical outcomes are poor in children[4],largely due to inhaler technique[5,6].展开更多
文摘Amyloid fibrils are highly organized protein or peptide aggregates,often characterized by a distinctive supramolecular cross-β-sheet structure.The formation and accumulation of these structures have been traditionally associated with neural or systemic human diseases,such as Alzheimer’s disease,Parkinson’s disease,type-2 diabetes,or amyotrophic lateral sclerosis(Wei et al.,2017;Wittung-Stafshede,2023).
基金Financial support for this study was provided through Grants by the Instituto de Salud Carlos III FEDER:Fondo Europeo de Desarrollo Regional(PI15/00449)Generalitat de Catalunya(AGAUR 2021 SGR 00624,2017 SGR 452)+2 种基金The following researchers have worked on this manuscript while funded by Grants:CLB(University of Costa Rica OAICE-85-2019)KM(Instituto de Salud Carlos III FEDER:Fondo Europeo de Desarrollo Regional FI16/00071)ALD(Miguel Servet research contract from the Instituto de Salud Carlos III CP21/00062).
文摘Asthma in school-aged children is a major public health problem worldwide[1,2].Inhaled medications are the mainstay of its pharmacological management[2],but only 8%-22%of children with asthma use their inhalers correctly[3].Asthma clinical outcomes are poor in children[4],largely due to inhaler technique[5,6].
