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Molecular mechanisms implicated in SARS-CoV-2 liver tropism 被引量:1
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作者 Jorge Quarleri M.Victoria Delpino 《World Journal of Gastroenterology》 SCIE CAS 2022年第48期6875-6887,共13页
The coronavirus disease 2019(COVID-19)pandemic is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Hepatic involvement is common in SARS-CoV-2-infected individuals.It is currently accepted that th... The coronavirus disease 2019(COVID-19)pandemic is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Hepatic involvement is common in SARS-CoV-2-infected individuals.It is currently accepted that the direct and indirect hepatic effects of SARS-CoV-2 infection play a significant role in COVID-19.In individuals with pre-existing infectious and non-infectious liver disease,who are at a remarkably higher risk of developing severe COVID-19 and death,this pathology is most medically relevant.This review emphasizes the current pathways regarded as contributing to the gastrointestinal and hepatic ailments linked to COVID-19-infected patients due to an imbalanced interaction among the liver,systemic inflammation,disrupted coagulation,and the lung. 展开更多
关键词 SARS-CoV-2 Viral hepatitis Non-infectious liver disease Hyperinflammation Coronavirus disease 2019
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