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Prediction of Ocular Irritancy of 26 Chemicals and 26 Cosmetic Products with Isolated Rabbit Eye (IRE) Test 被引量:1
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作者 GUO Xiang YANG Xing Fen +7 位作者 YANG Ying HANS Raabe CAI Jing Heng XUE Jin Yu TAN Xiao Hua XIE Xiao Ping XIONG Xi Kun HUANG Jun Ming 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2012年第3期359-366,共8页
Objective This study aims to establish and evaluate the methodology of isolated rabbit eye (IRE) test. Methods IRE test was performed according to modifications of the in vitro toxicology (INVITTOX) Protocol No.85... Objective This study aims to establish and evaluate the methodology of isolated rabbit eye (IRE) test. Methods IRE test was performed according to modifications of the in vitro toxicology (INVITTOX) Protocol No.85: Rabbit enucleated eye test by European Centre for the Validation of Alternative Methods (ECVAM), and then 26 chemicals and 26 cosmetic products were tested in both in vitro IRE and in vivo Draize tests. A statistical analysis was conducted to determine the relevance of the IRE test to the data generated in the Draize test. Results IRE test was established successfully in our laboratory. It was shown that ranking correlation and class concordance were fairly well between the IRE test and the Draize test for 26 reference chemicals (Fisher's Exact Test X2=51.314, P〈0.001; McNemar P=0.261; Gamma=0.960, P〈0.001; Kappa=0.843, P〈0.001) and 26 cosmetic products (Fisher's Exact Test X^2=15.522, P〈0.O01; McNemar P=0.311; Gamma=0.967, P〈0.001; Kappa=0.611, P〈0.O01). Conclusion IRE test was established successfully for in vitro testing of eye irritation as an alternative to Draize test. 展开更多
关键词 Isolated rabbit eye IRE Eye irritation Alternative testing Draize test
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3D-人造皮肤模型在化妆品安全性、功效性评价中的应用 被引量:1
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作者 张春晓 杜镇建 +2 位作者 Zhi Wang Quanshun Zhang 张兴民 《北京日化》 2014年第2期38-40,共3页
人类皮肤覆盖于整个体表,被称为生命之裳,不仅因为皮肤保护我们的肌肉和内脏免受环境中有害物质的侵害,还源于它的重要审美价值。人类追寻美丽的步伐从未停止过,《齐民要术》晕就有各种关于如何配制护肤品的记载。进入21世纪,随着... 人类皮肤覆盖于整个体表,被称为生命之裳,不仅因为皮肤保护我们的肌肉和内脏免受环境中有害物质的侵害,还源于它的重要审美价值。人类追寻美丽的步伐从未停止过,《齐民要术》晕就有各种关于如何配制护肤品的记载。进入21世纪,随着我国人民生活水平不断提高,化妆品已经成为人们的生活必需品。如何保障化妆品的安全性和功效性,是政府监管部门、化妆品公司和消费者共同关注的问题。 展开更多
关键词 化妆品公司 人造皮肤 安全性 功效性 模型 应用 评价 《齐民要术》
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