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Nanotechnology applications for the therapy of liver fibrosis 被引量:12
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作者 Lydia Giannitrapani Maurizio Soresi +2 位作者 Maria Luisa Bondì Giuseppe Montalto Melchiorre Cervello 《World Journal of Gastroenterology》 SCIE CAS 2014年第23期7242-7251,共10页
Chronic liver diseases represent a major global health problem both for their high prevalence worldwide and,in the more advanced stages,for the limited available curative treatment options.In fact,when lesions of diff... Chronic liver diseases represent a major global health problem both for their high prevalence worldwide and,in the more advanced stages,for the limited available curative treatment options.In fact,when lesions of different etiologies chronically affect the liver,triggering the fibrogenesis mechanisms,damage has already occurred and the progression of fibrosis will have a major clinical impact entailing severe complications,expensive treatments and death in end-stage liver disease.Despite significant advances in the understanding of the mechanisms of liver fibrinogenesis,the drugs used in liver fibrosis treatment still have a limited therapeutic effect.Many drugs showing potent antifibrotic activities in vitro often exhibit only minor effects in vivo because insufficient concentrations accumulate around the target cell and adverse effects result as other non-target cells are affected.Hepatic stellate cells play a critical role in liver fibrogenesis,thus they are the target cells of antifibrotic therapy.The application of nanoparticles has emerged as a rapidly evolving area for the safe delivery of various therapeutic agents(including drugs and nucleic acid)in the treatment of various pathologies,including liver disease.In this review,we give an overview of the various nanotechnology approaches used in the treatment of liver fibrosis. 展开更多
关键词 Liver fibrosis NANOTECHNOLOGY Nanoparticles Hepatic stellate cells Antifibrotic drugs CIRRHOSIS
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Local Role of Food Producers' Communities for a Global One-Health Framework: The Experience of Translational Research in an Italian Dairy Chain
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作者 Chiara Frazzoli Alberto Mantovani Roberto Dragone 《Journal of Agricultural Chemistry and Environment》 2014年第2期14-19,共6页
Community is the foundation of public health: the present paper reports the approach and strategy for intervention on the dairy production community developed by the Italian project ALERT (www.alert2015.it), which imp... Community is the foundation of public health: the present paper reports the approach and strategy for intervention on the dairy production community developed by the Italian project ALERT (www.alert2015.it), which implements the transfer of technical innovation and technological know-how from public research. Starting from the local role of primary producers, North-South and South-South networking (www.noodlesonlus.org) is needed to share solutions for transnational problems like climatic change, contaminated agro-farming sites and food waste and losses in the era of food crisis. Based on risk analysis, science-society dialogue and global health, the main drivers of this experience of translational research are One Health, i.e. the web of inter-relationships among environment, farm animals and human health, and sustainable food safety (prevention actions on diet of young women, today, to protect next generation’s health) to increase population life expectancy in good health. 展开更多
关键词 Contaminated Sites Ecology FOOD Losses Sustainable FOOD Safety Technological Transfer TRACEABILITY
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