期刊文献+
共找到123篇文章
< 1 2 7 >
每页显示 20 50 100
Multi-Organ Pathogenesis and Therapeutic Strategies for Cystic Fibrosis
1
作者 Oluwaseun Babatunde Ogonna William David +1 位作者 Richard Ifeanyichukwu Ikwugbado Oluwaseyi Oyewole 《Journal of Biosciences and Medicines》 2024年第5期312-329,共18页
Cystic Fibrosis (CF) is the most common lethal autosomal inherited disorder that affects all races and ethnicities in the United States. However, it is mostly predominant in the Caucasian populace accounting for about... Cystic Fibrosis (CF) is the most common lethal autosomal inherited disorder that affects all races and ethnicities in the United States. However, it is mostly predominant in the Caucasian populace accounting for about 80% of all CF cases. CF most severe complication can be referred to as pulmonary bronchiectasis and infections of the airways, nonetheless, the devastating effects of the disease have far-reaching consequences beyond lung damage. CF is a heterogeneous disease that is caused by mutations in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. The impairment or absence of this gene can affect multiple organs and systems and is characterized not only by chronic lung blockage, infections, and inflammation but also by exocrine gland dysfunction, intestinal obstruction, liver pathology, elevated sweat chloride concentration, and in males, infertility due to the congenital bilateral absence of the vas deferens. To this end, we briefly explore the pathological effects of CF and how CF mediates the destruction of several critical organs in the body and some of the gene therapeutical approaches such as gene editing and viral-based strategies available for the treatment of this multi-organ disease. 展开更多
关键词 Cystic Fibrosis Gene Therapy Organ Damage
下载PDF
Esophagus and regenerative medicine 被引量:4
2
作者 Ricardo Londono Blair A Jobe +1 位作者 Toshitaka Hoppo Stephen F Badylak 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第47期6894-6899,共6页
In addition to squamous cell carcinoma,the incidence of Barrett's esophagus with high-grade dysplasia and esophageal adenocarcinoma is rapidly increasing worldwide.Unfortunately,the current standard of care for es... In addition to squamous cell carcinoma,the incidence of Barrett's esophagus with high-grade dysplasia and esophageal adenocarcinoma is rapidly increasing worldwide.Unfortunately,the current standard of care for esophageal pathology involves resection of the affected tissue,sometimes involving radical esophagectomy.Without exception,these procedures are associated with a high morbidity,compromised quality of life,and unacceptable mortality rates.Regenerative medicine approaches to functional tissue replacement include the use of biological and synthetic scaffolds to promote tissue remodeling and growth.In the case of esophageal repair,extracellular matrix(ECM) scaffolds have proven to be effective for the reconstruction of small patch defects,anastomosis reinforcement,and the prevention of stricture formation after endomucosal resection(EMR).More so,esophageal cancer patients treated with ECM scaffolds have shown complete restoration of a normal,functional,and disease-free epithelium after EMR.These studies provide evidence that a regenerative medicine approach may enable aggressive resection of neoplastic tissue without the need for radical esophagectomy and its associated complications. 展开更多
关键词 Esophageal repair Biomaterial mediated esophageal repair Extracellular matrix Extracellular matrix scaffold
下载PDF
Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives 被引量:2
3
作者 Yubo Wang Tingli Yuan +5 位作者 Tianjie Lyu Ling Zhang Meng Wang Zhiying He Yongjun Wang Zixiao Li 《Neural Regeneration Research》 SCIE CAS 2025年第1期67-81,共15页
Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger age.China,in particular,bears a high burden of stroke cases.In recent years,the inflamm... Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger age.China,in particular,bears a high burden of stroke cases.In recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its treatment.This review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and astrocytes.Additionally,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell therapy.Overall,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient outcomes.Stem cell therapy may potentially become an important component of ischemic stroke treatment. 展开更多
关键词 cell therapy immune cell INFLAMMATORY ischemic stroke stem cell
下载PDF
Marital Status as a Moderator:Exploring the Relationship between Social Engagement and Depressive Symptoms in China’s Older Adult Population
4
作者 Jianlun Wu Yaping Ye +4 位作者 Man Zhang Ruichen Cong Yitao Chen Pengfei Yu Qing Guo 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第10期1142-1157,共16页
Objective This study aims to explore the complex relationship between social engagement and depressive symptoms among older adults in China,focusing particularly on the moderating role of marital status.Methods This s... Objective This study aims to explore the complex relationship between social engagement and depressive symptoms among older adults in China,focusing particularly on the moderating role of marital status.Methods This study used data from the latest Chinese Longitudinal Healthy Longevity Survey(CLHLS).The analysis used the latent class analysis to delineate personality clusters and hierarchical linear regression,supplemented by the PROCESS macro,to investigate the effects of social engagement and marital status on depressive symptoms.Results The analysis encompassed 7,789 respondents(mean age:82.53[s=11.20]years),with 54%female.The personality analysis categorized participants into four clusters,with the majority(77.60%)classified as Confident Idealists,who exhibited the lowest levels of depressive symptoms.Hierarchical linear regression analysis yielded several significant findings:Higher levels of social engagement were significantly associated with fewer depressive symptoms(t=-7.932,P<0.001,B=-0.463).Marital status was a significant factor;married individuals reported fewer depressive symptoms compared to their unmarried counterparts(t=-6.368,P<0.001,B=-0.750).There was a significant moderating effect of marital status on the relationship between social engagement and depressive symptoms(t=-2.092,P=0.037,B=-0.217).Conclusion This study demonstrates that,among Chinese older adults,both social engagement and marital status significantly influence depressive symptoms.Higher social engagement,particularly in other activities like doing household chores,gardening,reading newspapers or books,and playing cards or Mahjong,is associated with fewer depressive symptoms,especially among married individuals. 展开更多
关键词 Social engagement Depressive symptoms Marital status MODERATOR Older adults
下载PDF
Advances in non-invasive imaging of proteinopathies in animal models of neurodegenerative diseases
5
作者 Lei Cao Bin Ji Ruiqing Ni 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第10期2115-2116,共2页
Neurodegenerative diseases,including Alzheimer's disease(AD),frontotemporal dementia,Parkinson's disease,and dementia with Lewy bodies,represent tremendous unmet clinical needs.A common feature of these diseas... Neurodegenerative diseases,including Alzheimer's disease(AD),frontotemporal dementia,Parkinson's disease,and dementia with Lewy bodies,represent tremendous unmet clinical needs.A common feature of these diseases is the aberrant cerebral accumulation of pathological protein aggregates,affecting selectively vulnerable circuits in a disease-specific pattern.Earlier studies have established a relationship between abnormal aggregation and neuronal dysfunction or loss,suggesting multifactorial pathogenesis mechanisms in these neurodegenerative disorders. 展开更多
关键词 DISEASES DEGENERATIVE CLINICAL
下载PDF
Esophageal tissue engineering:A new approach for esophageal replacement 被引量:5
6
作者 Giorgia Totonelli Panagiotis Maghsoudlou +7 位作者 Jonathan M Fishman Giuseppe Orlando Tahera Ansari Paul Sibbons Martin A Birchall Agostino Pierro Simon Eaton Paolo De Coppi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第47期6900-6907,共8页
A number of congenital and acquired disorders require esophageal tissue replacement.Various surgical techniques,such as gastric and colonic interposition,are standards of treatment,but frequently complicated by stenos... A number of congenital and acquired disorders require esophageal tissue replacement.Various surgical techniques,such as gastric and colonic interposition,are standards of treatment,but frequently complicated by stenosis and other problems.Regenerative medicine approaches facilitate the use of biological constructs to replace or regenerate normal tissue function.We review the literature of esophageal tissue engineering,discuss its implications,compare the methodologies that have been employed and suggest possible directions for the future.Medline,Embase,the Cochrane Library,National Research Register and ClinicalTrials.gov databases were searched with the following search terms:stem cell and esophagus,esophageal replacement,esophageal tissue engineering,esophageal substitution.Reference lists of papers identified were also examined and experts in this field contacted for further information.All full-text articles in English of all potentially relevant abstracts were reviewed.Tissue engineering has involved acellular scaffolds that were either transplanted with the aim of being repopulated by host cells or seeded prior to transplantation.When acellular scaffolds were used to replace patch and short tubular defects they allowed epithelial and partial muscular migration whereas when employed for long tubular defects the results were poor leading to an increased rate of stenosis and mortality.Stenting has been shown as an effective means to reduce stenotic changes and promote cell migration,whilst omental wrapping to induce vascularization of the construct has an uncertain benefit.Decellularized matrices have been recently suggested as the optimal choice for scaffolds,but smart polymers that will incorporate signalling to promote cell-scaffold interaction may provide a more reproducible and available solution.Results in animal models that have used seeded scaffolds strongly suggest that seeding of both muscle and epithelial cells on scaffolds prior to implantation is a prerequisite for complete esophageal replacement.Novel approaches need to be designed to allow for peristalsis and vascularization in the engineered esophagus.Although esophageal tissue engineering potentially offers a real alternative to conventional treatments for severe esophageal disease,important barriers remain that need to be addressed. 展开更多
关键词 ESOPHAGUS Regenerative medicine Tissue engineering Scaffolds TRANSPLANTATION
下载PDF
Tissue engineering for neuromuscular disorders of the gastrointestinal tract 被引量:2
7
作者 Kenneth L Koch Khalil N Bitar +1 位作者 John E Fortunato Khalil N Bitar 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第47期6918-6925,共8页
The digestive tract is designed for the optimal processing of food that nourishes all organ systems.The esophagus,stomach,small bowel,and colon are sophisticated neuromuscular tubes with specialized sphincters that tr... The digestive tract is designed for the optimal processing of food that nourishes all organ systems.The esophagus,stomach,small bowel,and colon are sophisticated neuromuscular tubes with specialized sphincters that transport ingested food-stuffs from one region to another.Peristaltic contractions move ingested solids and liquids from the esophagus into the stomach;the stomach mixes the ingested nutrients into chyme and empties chyme from the stomach into the duodenum.The to-and-fro movement of the small bowel maximizes absorption of fat,protein,and carbohydrates.Peristaltic contractions are necessary for colon function and defecation. 展开更多
关键词 Neuromuscular disorders Gastrointestinal tract DYSFUNCTION ESOPHAGUS STOMACH Small bowel COLON
下载PDF
In vitro study of the PLLA-Mg_(65)Zn_(30)Ca_(5)composites as potential biodegradable materials for bone implants 被引量:2
8
作者 Taolei Wang Chao Lin +3 位作者 Dan Batalu Lu Zhang Jingzhou Hu Wei Lu 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2021年第6期2009-2018,共10页
PLLA-magnesium composites have been widely investigated as potential biodegradable materials for bone implants.Lower/higher corrosion resistance of the crystalized/amorphous magnesium alloys allows tailoring of biodeg... PLLA-magnesium composites have been widely investigated as potential biodegradable materials for bone implants.Lower/higher corrosion resistance of the crystalized/amorphous magnesium alloys allows tailoring of biodegradability rate.In this work,the amorphous Mg_(65)Zn_(30)Ca_(5)was investigated versus traditional crystalized Mg_(65)Zn_(30)Ca_(5),and a PLLA-Mg_(65)Zn_(30)Ca_(5)composite has been successfully fabricated using hot injection process.Furthermore,the high corrosion resistance of the amorphous Mg_(65)Zn_(30)Ca_(5)prevented the high alkalization and deterioration of mechanical strength.In addition,the high Zn content intended to improve the glass forming ability,also enhances the anti-bacterial property of the PLLA-Mg_(65)Zn_(30)Ca_(5)composite.The remarkable performance of the PLLA-Mg_(65)Zn_(30)Ca_(5)composite shows its promising application in bone repair and tissue regeneration. 展开更多
关键词 Polymer-matrix composites(PMCs) Magnesium glasses Corrosion Mechanical properties
下载PDF
Promise of metformin for preventing age-related cognitive dysfunction 被引量:1
9
作者 Leelavathi N.Madhu Maheedhar Kodali Ashok K.Shetty 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第3期503-507,共5页
The expanded lifespan of people,while a positive advance,has also amplified the prevalence of age-related disorders,which include mild cognitive impairment,dementia,and Alzheimer's disease.Therefore,competent ther... The expanded lifespan of people,while a positive advance,has also amplified the prevalence of age-related disorders,which include mild cognitive impairment,dementia,and Alzheimer's disease.Therefore,competent therapies that could improve the healthspan of people have great significance.Some of the dietary and pharmacological approaches that augment the lifespan could also preserve improved cognitive function in old age.Metformin,a drug widely used for treating diabetes,is one such candidate that could alleviate age-related cognitive dysfunction.However,the possible use of metformin to alleviate age-related cognitive dysfunction has met with conflicting results in human and animal studies.While most clinical studies have suggested the promise of metformin to maintain better cognitive function and reduce the risk for developing dementia and Alzheimer's disease in aged diabetic people,its efficacy in the nondiabetic population is still unclear.Moreover,a previous animal model study implied that metformin could adversely affect cognitive function in the aged.However,a recent animal study using multiple behavioral tests has reported that metformin treatment in late middle age improved cognitive function in old age.The study also revealed that cognitionenhancing effects of metformin in aged animals were associated with the activation of the energy regulator adenosine monophosphate-activated protein kinase,diminished neuroinflammation,inhibition of the mammalian target of rapamycin signaling,and augmented autophagy in the hippocampus.The proficiency of metformin to facilitate these favorable modifications in the aged hippocampus likely underlies its positive effect on cognitive function.Nonetheless,additional studies probing the outcomes of different doses and durations of metformin treatment at specific windows in the middle and old age across sex in nondiabetic and non-obese prototypes are required to substantiate the promise of metformin to maintain better cognitive function in old age. 展开更多
关键词 activated microglia aging AUTOPHAGY cognitive dysfunction memory METFORMIN mTOR signaling NEUROINFLAMMATION
下载PDF
Use of sensory substitution devices as a model system for investigating cross-modal neuroplasticity in humans 被引量:1
10
作者 Amy C.Nau Matthew C.Murphy Kevin C.Chan 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第11期1717-1719,共3页
Blindness provides an unparalleled opportunity to study plasticity of the nervous system in humans.Seminal work in this area examined the often dramatic modifications to the visual cortex that result when visual input... Blindness provides an unparalleled opportunity to study plasticity of the nervous system in humans.Seminal work in this area examined the often dramatic modifications to the visual cortex that result when visual input is completely absent from birth or very early in life(Kupers and Ptito,2014).More recent studies explored what happens to the visual pathways in the context of acquired blindness.This is particularly relevant as the majority of diseases that cause vision loss occur in the elderly. 展开更多
关键词 Use of sensory substitution devices as a model system for investigating cross-modal neuroplasticity in humans BOLD
下载PDF
Adenosine-treated bioprinted muscle constructs prolong cell survival and improve tissue formation
11
作者 Dongxu Ke Adam M.Jorgensen +2 位作者 Sang J.Lee James J.Yoo Sean V.Murphy 《Bio-Design and Manufacturing》 SCIE EI CSCD 2021年第3期441-451,共11页
It is crucial to maintaining the viability of biofabricated human-sized tissues to ensure their successful survival and function after transplantation.Adenosine is a purine nucleoside that has the function to suppress... It is crucial to maintaining the viability of biofabricated human-sized tissues to ensure their successful survival and function after transplantation.Adenosine is a purine nucleoside that has the function to suppress cellular metabolism and has been previously proposed as a method to prolong cell viability under hypoxia.In this study,we optimized the dose concentration of adenosine for incorporation into bioprinted constructs to preserve long-term cell viability in vitro.Our results showed that muscle cells(C2C12)containing 6,7,or 8 mM adenosine maintained high cell viability for 20 days under hypoxic conditions(0.1%O2),whereas cells without adenosine treatment showed 100%cell death after 11 days.After 20 days under hypoxic conditions,muscle cells treated with adenosine proliferated and differentiated when transferred to normoxic conditions.From these adenosine concentrations,6 mM was picked as the optimized adenosine concentration for further investigations due to its most effective results on improving cell viability.The bioprinted muscle constructs containing adenosine(6 mM)maintained high cell viability for 11 days under hypoxic conditions,while the control constructs without adenosine had no live cells.For in vivo validation,the bioprinted constructs with adenosine implanted under the dorsal subcutaneous space in mice,showed the enhanced formation of muscle tissue with minimal central necrosis and apoptosis,when compared to the constructs without adenosine.These positive in vitro and in vivo results demonstrate that the use of adenosine is an effective approach to preventing the challenge of hypoxia-induced necrosis in bioprinted tissues for clinical translation. 展开更多
关键词 BIOPRINTING HYPOXIA ADENOSINE Cell viability In vivo
下载PDF
Bioreactor design and validation for manufacturing strategies in tissue engineering
12
作者 Diana Lim Eric S.Renteria +10 位作者 Drake S.Sime Young Min Ju Ji Hyun Kim Tracy Criswell Thomas D.Shupe Anthony Atala Frank C.Marini Metin N.Gurcan Shay Soker Joshua Hunsberger James J.Yoo 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2022年第1期43-63,共21页
The fields of regenerative medicine and tissue engineering offer new therapeutic options to restore,maintain or improve tissue function following disease or injury.To maximize the biological function of a tissue-engin... The fields of regenerative medicine and tissue engineering offer new therapeutic options to restore,maintain or improve tissue function following disease or injury.To maximize the biological function of a tissue-engineered clinical product,specific conditions must be maintained within a bioreactor to allow the maturation of the product in preparation for implantation.Specifically,the bioreactor should be designed to mimic the mechanical,electrochemical and biochemical environment that the product will be exposed to in vivo.Real-time monitoring of the functional capacity of tissue-engineered products during manufacturing is a critical component of the quality management process.The present review provides a brief overview of bioreactor engineering considerations.In addition,strategies for bioreactor automation,in-line product monitoring and quality assurance are discussed. 展开更多
关键词 BIOREACTOR Monitoring sensors and automation MANUFACTURING Tissue engineering Regenerative medicine
下载PDF
Terahertz technology in intraoperative neurodiagnostics:A review 被引量:3
13
作者 Nikita V.Chernomyrdin Guzel R.Musina +8 位作者 Pavel V.Nikitin Irina N.Dolganova Anna S.Kucheryavenko Anna I.Alekseeva Yuye Wang Degang Xu Qiwu Shi Valery V.Tuchin Kirill I.Zaytsev 《Opto-Electronic Advances》 SCIE EI CAS CSCD 2023年第5期41-67,共27页
Terahertz(THz)technology offers novel opportunities in biology and medicine,thanks to the unique features of THzwave interactions with tissues and cells.Among them,we particularly notice strong sensitivity of THz wave... Terahertz(THz)technology offers novel opportunities in biology and medicine,thanks to the unique features of THzwave interactions with tissues and cells.Among them,we particularly notice strong sensitivity of THz waves to the tissue water,as a medium for biochemical reactions and a main endogenous marker for THz spectroscopy and imaging.Tissues of the brain have an exceptionally high content of water.This factor,along with the features of the structural organization and biochemistry of neuronal and glial tissues,makes the brain an exciting subject to study in the THz range.In this paper,progress and prospects of THz technology in neurodiagnostics are overviewed,including diagnosis of neurodegenerative disease,myelin deficit,tumors of the central nervous system(with an emphasis on brain gliomas),and traumatic brain injuries.Fundamental and applied challenges in study of the THz-wave–brain tissue interactions and development of the THz biomedical tools and systems for neurodiagnostics are discussed. 展开更多
关键词 THz technology THz spectroscopy and imaging superresolution imaging BIOPHOTONICS brain neurodiagnosis tumor GLIOMA neurodegenerative diseases brain injury light scattering
下载PDF
Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression 被引量:3
14
作者 Aoyuan Fan Genbin Wu +18 位作者 Jianfang Wang Laiya Lu Jingyi Wang Hanjing Wei Yuxi Sun Yanhua Xu Chunyang Mo Xiaoying Zhang Zhiying Pang Zhangyi Pan Yiming Wang Liangyu Lu Guojian Fu Mengqiu Ma Qiaoling Zhu Dandan Cao Jiachen Qin Feng Yin Rui Yue 《Bone Research》 SCIE CAS CSCD 2023年第1期136-147,共12页
Fibroblast activation protein(Fap)is a serine protease that degrades denatured type I collagen,α2-antiplasmin and FGF21.Fap is highly expressed in bone marrow stromal cells and functions as an osteogenic suppressor a... Fibroblast activation protein(Fap)is a serine protease that degrades denatured type I collagen,α2-antiplasmin and FGF21.Fap is highly expressed in bone marrow stromal cells and functions as an osteogenic suppressor and can be inhibited by the bone growth factor Osteolectin(Oln).Fap is also expressed in synovial fibroblasts and positively correlated with the severity of rheumatoid arthritis(RA).However,whether Fap plays a critical role in osteoarthritis(OA)remains poorly understood.Here,we found that Fap is significantly elevated in osteoarthritic synovium,while the genetic deletion or pharmacological inhibition of Fap significantly ameliorated posttraumatic OA in mice.Mechanistically,we found that Fap degrades denatured type II collagen(Col II)and Mmp13-cleaved native Col II.Intra-articular injection of r Fap significantly accelerated Col II degradation and OA progression.In contrast,Oln is expressed in the superficial layer of articular cartilage and is significantly downregulated in OA.Genetic deletion of Oln significantly exacerbated OA progression,which was partially rescued by Fap deletion or inhibition.Intra-articular injection of r Oln significantly ameliorated OA progression.Taken together,these findings identify Fap as a critical pathogenic factor in OA that could be targeted by both synthetic and endogenous inhibitors to ameliorate articular cartilage degradation. 展开更多
关键词 CARTILAGE SUPERFICIAL inhibited
下载PDF
Premature aging of skeletal stem/progenitor cells rather than osteoblasts causes bone loss with decreased mechanosensation 被引量:2
15
作者 Ruici Yang Dandan Cao +6 位作者 Jinlong Suo Lingli Zhang Chunyang Mo Miaomiao Wang Ningning Niu Rui Yue Weiguo Zou 《Bone Research》 SCIE CAS CSCD 2023年第3期560-573,共14页
A distinct population of skeletal stem/progenitor cells(SSPCs)has been identified that is indispensable for the maintenance and remodeling of the adult skeleton.However,the cell types that are responsible for age-rela... A distinct population of skeletal stem/progenitor cells(SSPCs)has been identified that is indispensable for the maintenance and remodeling of the adult skeleton.However,the cell types that are responsible for age-related bone loss and the characteristic changes in these cells during aging remain to be determined.Here,we established models of premature aging by conditional depletion of Zmpste24(Z24)in mice and found that Prx1-dependent Z24 deletion,but not Osx-dependent Z24 deletion,caused significant bone loss.However,Acan-associated Z24 depletion caused only trabecular bone loss.Single-cell RNA sequencing(sc RNA-seq)revealed that two populations of SSPCs,one that differentiates into trabecular bone cells and another that differentiates into cortical bone cells,were significantly decreased in Prx1-Cre;Z24^(f/f)mice.Both premature SSPC populations exhibited apoptotic signaling pathway activation and decreased mechanosensation.Physical exercise reversed the effects of Z24depletion on cellular apoptosis,extracellular matrix expression and bone mass.This study identified two populations of SSPCs that are responsible for premature aging-related bone loss.The impairment of mechanosensation in Z24-deficient SSPCs provides new insight into how physical exercise can be used to prevent bone aging. 展开更多
关键词 SENSATION PROGENITOR mec
下载PDF
Primary cilia support cartilage regeneration after injury 被引量:2
16
作者 Dike Tao Lei Zhang +8 位作者 Yunpeng Ding Na Tang Xiaoqiao Xu Gongchen Li Pingping Niu Rui Yue Xiaogang Wang Yidong Shen Yao Sun 《International Journal of Oral Science》 SCIE CAS CSCD 2023年第2期291-303,共13页
In growing children,growth plate cartilage has limited self-repair ability upon fracture injury always leading to limb growth arrest.Interestingly,one type of fracture injuries within the growth plate achieve amazing ... In growing children,growth plate cartilage has limited self-repair ability upon fracture injury always leading to limb growth arrest.Interestingly,one type of fracture injuries within the growth plate achieve amazing self-healing,however,the mechanism is unclear.Using this type of fracture mouse model,we discovered the activation of Hedgehog(Hh)signaling in the injured growth plate,which could activate chondrocytes in growth plate and promote cartilage repair. 展开更多
关键词 FRACTURE PLATE INJURIES
下载PDF
Peripheral actions and direct central-local communications of melanocortin 4 receptor signaling 被引量:1
17
作者 Lei Li Jinye Liang +2 位作者 Cong Zhang Tiemin Liu Chao Zhang 《Journal of Sport and Health Science》 SCIE CSCD 2023年第1期45-51,共7页
Melanocortin 4 receptor(MC4R),the most important monogenetic cause of human metabolic disorders,has been of great interest to many researchers in the field of energy homeostasis and public health.Because MC4R is a vit... Melanocortin 4 receptor(MC4R),the most important monogenetic cause of human metabolic disorders,has been of great interest to many researchers in the field of energy homeostasis and public health.Because MC4R is a vital pharmaceutical target for maintaining controllable appetite and body weight for professional athletes,previous studies have mainly focused on the central,rather than the peripheral,roles of MC4R.Thus,the local expression of MC4R and its behavioral regulation remain unclear.In an attempt to shed light on different directions for future studies of MC4R signaling,we review a series of recent and important studies exploring the peripheral functions of MC4R and the direct physiological interaction between peripheral organs and central MC4R neurons in this article. 展开更多
关键词 Body weight Energy homeostasis GPCR Melanocortin-4 receptor
下载PDF
Mechanotransduction pathways in articular chondrocytes and the emerging role of estrogen receptor-α 被引量:1
18
作者 Ning Wang Yangfan Lu +6 位作者 Benjamin B.Rothrauff Aojie Zheng Alexander Lamb Youzhen Yan Katelyn E.Lipa Guanghua Lei Hang Lin 《Bone Research》 SCIE CAS CSCD 2023年第2期229-247,共19页
In the synovial joint,mechanical force creates an important signal that influences chondrocyte behavior.The conversion of mechanical signals into biochemical cues relies on different elements in mechanotransduction pa... In the synovial joint,mechanical force creates an important signal that influences chondrocyte behavior.The conversion of mechanical signals into biochemical cues relies on different elements in mechanotransduction pathways and culminates in changes in chondrocyte phenotype and extracellular matrix composition/structure.Recently,several mechanosensors,the first responders to mechanical force,have been discovered.However,we still have limited knowledge about the downstream molecules that enact alterations in the gene expression profile during mechanotransduction signaling.Recently,estrogen receptorα(ERα)has been shown to modulate the chondrocyte response to mechanical loading through a ligand-independent mechanism,in line with previous research showing that ERαexerts important mechanotransduction effects on other cell types,such as osteoblasts.In consideration of these recent discoveries,the goal of this review is to position ERαinto the mechanotransduction pathways known to date.Specifically,we first summarize our most recent understanding of the mechanotransduction pathways in chondrocytes on the basis of three categories of actors,namely mechanosensors,mechanotransducers,and mechanoimpactors.Then,the specific roles played by ERαin mediating the chondrocyte response to mechanical loading are discussed,and the potential interactions of ERαwith other molecules in mechanotransduction pathways are explored.Finally,we propose several future research directions that may advance our understanding of the roles played by ERαin mediating biomechanical cues under physiological and pathological conditions. 展开更多
关键词 STRUCTURE LOADING DIRECTIONS
下载PDF
Urine-derived stem cells:A novel and versatile progenitor source for cell-based therapy and regenerative medicine 被引量:36
19
作者 Deying Zhang Guanghui Wei +2 位作者 Peng Li Xiaobo Zhou Yuanyuan Zhang 《Genes & Diseases》 SCIE 2014年第1期8-17,共10页
Engineered functional organs or tissues,created with autologous somatic cells and seeded on biodegradable or hydrogel scaffolds,have been developed for use in individualswith tissue damage suffered fromcongenital diso... Engineered functional organs or tissues,created with autologous somatic cells and seeded on biodegradable or hydrogel scaffolds,have been developed for use in individualswith tissue damage suffered fromcongenital disorders,infection,irradiation,or cancer.However,in those patients,abnormal cells obtained by biopsy fromthe compromised tissue could potentially contaminate the engineered tissues.Thus,an alternative cell source for construction of the neo-organ or functional recovery of the injured or diseased tissues would be useful.Recently,we have found stem cells existing in the urine.These cells are highly expandable,and have self-renewal capacity,paracrine properties,and multi-differentiation potential.As a novel cell source,urine-derived stem cells(USCs)provide advantages for cell therapy and tissue engineering applications in regeneration of various tissues,particularly in the genitourinary tract,because they originate from the urinary tract system.Importantly,USCs can be obtained via a non-invasive,simple,and low-cost approach and induced with high efficiency to differentiate into three dermal cell lineages. 展开更多
关键词 Cell therapy Genitourinary tract Stem cells Tissue regeneration URINE
原文传递
Comparative DNA-methylome and transcriptome analysis reveals heterosis-and polyploidy-associated epigenetic changes in rice
20
作者 Xiaolan Rao Jun Ren +12 位作者 Wei Wang Rongrong Chen Qian Xie Yanqing Xu Dongmei Li Zhaojian Song Yuchi He Detian Cai Pingfang Yang Shiyou Lyu Li Li Wei Liu Xianhua Zhang 《The Crop Journal》 SCIE CSCD 2023年第2期427-437,共11页
Heterosis and polyploidy have an overwhelming influence on plant evolution.Recently,polyploid rice hybrids have been used to breed new rice varieties because they combine the advantages of both heterosis and polyploid... Heterosis and polyploidy have an overwhelming influence on plant evolution.Recently,polyploid rice hybrids have been used to breed new rice varieties because they combine the advantages of both heterosis and polyploidy.In this study,we generated six rice lines:autotetraploid rice hybrids and their autotetraploid parents,diploid donors,and hybrids of the diploid donors.To investigate the molecular mechanism controlling the effects of both hybridization and polyploidization,we performed bisulfite and RNA sequencing on young panicles at the pollen meiosis stage to compare the DNA metabolomes and transcriptomes among the six rice lines.The hybrids lines were hypermethylated compared to their corresponding parents and the autotetraploid lines showed globally increased DNA methylation of their transposable elements compared to the diploid donors.The alteration in DNA methylation level corresponded to the differential gene expressions among the rice genotypes,suggesting that methylation changes induced by polyploidization and hybridization may affect gene expression.Groups of gene candidates were identified that may be associated with heterosis and polyploidy.Our results provide DNA information that can be used to investigate epigenetic modification during heterosis and polyploidy in rice. 展开更多
关键词 Oryza sativa Neotetraploid rice HETEROSIS Whole genome duplication Epigenetic changes
下载PDF
上一页 1 2 7 下一页 到第
使用帮助 返回顶部